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The map label for this gene is copR [H]

Identifier: 13474809

GI number: 13474809

Start: 4658254

End: 4658931

Strand: Reverse

Name: copR [H]

Synonym: mll5778

Alternate gene names: 13474809

Gene position: 4658931-4658254 (Counterclockwise)

Preceding gene: 13474810

Following gene: 13474808

Centisome position: 66.21

GC content: 60.77

Gene sequence:

>678_bases
GTGATTAAGGTCCTGGTCGTCGAAGACGATGCAGATACGGCCGATGAGATCGTCGACGAATTCTGTGCGGCGGGGTTCGA
AGTCGAGCGCGCCGCGACCGGGCCGGACGGGTTGACTAAAGCCAAAACCCAGGCCTTTGACGTGATCACGCTCGATCGCC
TACTGCCTGGCCTAGACGGTCTGAGCCTTCTCGAAAACTTGCGCGGAGGCGGCGTGGATACGCCGGTTATGGTCCTCAGT
GCACTGTCCAGTGTTGACGAGCGCATAAGAGGATTGCGGGCGGGCGGGGACGACTACCTCGTGAAACCGTTCTCGCTGGC
TGAACTGCGGACGCGCATCGAGGTGCTGGCGCGCCGCACTCCCGATCAGCGAGCCACGGTCCTGCGGCTCGCCGACCTGG
AACTTGACCTTTTGACCCGCACGGTACGACGCGGTACCCGCATCGTCGAACTCGTACCGCGCGAGATCACCCTGCTCGAA
TATCTGCTTCGGCATGCCGAGCAAGTCGTCACGCGAGGGATGCTTTTCGAGCATGTCTGGCACTATCGCTTCGATCCAGG
AACGAACCTCGTCGACGTTCATATCGGCCGGTTGCGCCGTAAGATCGATCTGGCAGATGAGTTGCCGCTGATCCATACGA
TTCGTGGTCGGGGGTTTGTCCTTCGTGCACAGGACTAG

Upstream 100 bases:

>100_bases
CGCAGTCCCGGCAGAATAGGTTGGGGAGCGGCCGTGCTTGGCCCGCTGACGCCCGCCGGGGTGCAGCAACAACGTGGCCA
ATGGGAGAGGACAACACGCT

Downstream 100 bases:

>100_bases
GATCTTCCAAACGGCCAGCTTCCGCCGCACGATCGGCGCGGCGGGGATCCTTGCCCTCGCGCTTCTGCTGATGGCTGGGT
TTTTCTACAGGGAGACAGTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIKVLVVEDDADTADEIVDEFCAAGFEVERAATGPDGLTKAKTQAFDVITLDRLLPGLDGLSLLENLRGGGVDTPVMVLS
ALSSVDERIRGLRAGGDDYLVKPFSLAELRTRIEVLARRTPDQRATVLRLADLELDLLTRTVRRGTRIVELVPREITLLE
YLLRHAEQVVTRGMLFEHVWHYRFDPGTNLVDVHIGRLRRKIDLADELPLIHTIRGRGFVLRAQD

Sequences:

>Translated_225_residues
MIKVLVVEDDADTADEIVDEFCAAGFEVERAATGPDGLTKAKTQAFDVITLDRLLPGLDGLSLLENLRGGGVDTPVMVLS
ALSSVDERIRGLRAGGDDYLVKPFSLAELRTRIEVLARRTPDQRATVLRLADLELDLLTRTVRRGTRIVELVPREITLLE
YLLRHAEQVVTRGMLFEHVWHYRFDPGTNLVDVHIGRLRRKIDLADELPLIHTIRGRGFVLRAQD
>Mature_225_residues
MIKVLVVEDDADTADEIVDEFCAAGFEVERAATGPDGLTKAKTQAFDVITLDRLLPGLDGLSLLENLRGGGVDTPVMVLS
ALSSVDERIRGLRAGGDDYLVKPFSLAELRTRIEVLARRTPDQRATVLRLADLELDLLTRTVRRGTRIVELVPREITLLE
YLLRHAEQVVTRGMLFEHVWHYRFDPGTNLVDVHIGRLRRKIDLADELPLIHTIRGRGFVLRAQD

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=41.1504424778761, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=37.9464285714286, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=35.9090909090909, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=33.6283185840708, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=33.4821428571429, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=30.9090909090909, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=35.609756097561, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=34.9557522123894, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.3964757709251, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=30.8370044052863, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.4782608695652, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.4336283185841, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=29.2035398230088, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25227; Mature: 25227

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLVVEDDADTADEIVDEFCAAGFEVERAATGPDGLTKAKTQAFDVITLDRLLPGLDG
CEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHEEHHHHCCCCCH
LSLLENLRGGGVDTPVMVLSALSSVDERIRGLRAGGDDYLVKPFSLAELRTRIEVLARRT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHCC
PDQRATVLRLADLELDLLTRTVRRGTRIVELVPREITLLEYLLRHAEQVVTRGMLFEHVW
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYRFDPGTNLVDVHIGRLRRKIDLADELPLIHTIRGRGFVLRAQD
HEEECCCCCEEEHHHHHHHHHHCHHHCCCHHEEECCCEEEEEECC
>Mature Secondary Structure
MIKVLVVEDDADTADEIVDEFCAAGFEVERAATGPDGLTKAKTQAFDVITLDRLLPGLDG
CEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHEEHHHHCCCCCH
LSLLENLRGGGVDTPVMVLSALSSVDERIRGLRAGGDDYLVKPFSLAELRTRIEVLARRT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHCC
PDQRATVLRLADLELDLLTRTVRRGTRIVELVPREITLLEYLLRHAEQVVTRGMLFEHVW
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYRFDPGTNLVDVHIGRLRRKIDLADELPLIHTIRGRGFVLRAQD
HEEECCCCCEEEHHHHHHHHHHCHHHCCCHHEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]