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The map label for this gene is mprB [H]

Identifier: 13474808

GI number: 13474808

Start: 4656885

End: 4658267

Strand: Reverse

Name: mprB [H]

Synonym: mll5777

Alternate gene names: 13474808

Gene position: 4658267-4656885 (Counterclockwise)

Preceding gene: 13474809

Following gene: 13474805

Centisome position: 66.21

GC content: 60.09

Gene sequence:

>1383_bases
GTGCACAGGACTAGGATCTTCCAAACGGCCAGCTTCCGCCGCACGATCGGCGCGGCGGGGATCCTTGCCCTCGCGCTTCT
GCTGATGGCTGGGTTTTTCTACAGGGAGACAGTTGGCTATCTCACCAAACAGATCGACGATTCGCTGATCGGCGATGCGC
GTTCTTTCGCACGGGATGATCCGGCATCCCTTCCAGCCCGCATCGAGAAAGCATTGGCTATCGACAAGCGGCAGGAAAAG
GCCTTCGGCATCTTCTCAGCCGATCGCACGCGGCTCGCCGGTAACATCGCAATACTGCCATCAACATTGCCGGAGCTCGA
TATCCCGACAACTCTGGTGCTATCCCTGGACAACGGTGCGGAGAAGCGATCGGAGAGCGTACGCGGCGTCGCGACCATCC
TCACCAATGGCAGCATACTTATACTGGGGCGTGCAACGGCATCGCTGGACGAAATAAAAGAAATCGTCGCTAGGGCCATG
GCGCTCGCAATCATCCCTGCGATCGCGCTTTCGTTGATCGGCGGGCTGGTGATGAGCCGGGCGATGTTACGGCGCGTCGA
GGCTGTGCGCCGAGCCTGTAGTTCCATCATGGAGGGCCATTTCGACCGAAGATTGCCGGTTCATAAGCGCCAAGACGAAT
TCGACAAGCTGTCGGTGATCGTCAACACGATGCTGGACGAGATCGAGCGGCTCATAGCGGAAGTGAAAGGGGTCGGCGAT
TCCATTGCCCATGACCTCCGAACGCCGCTGACGCGCTTGCGCGCACGCCTTGAGCGCAGTTTGCGTGCAATTTCGGGTGA
TGCACCTGTCAGGGCTGCGATGCAGAAGTCCTTGGCGGACATCGACCAGCTGCTGGCGACGATCGCTGCCCTGATGCGGA
TTGCCGAGGTGGAGCAGAGCCGCCGCCGTGAGAATTTTTCACGTGTCGATCTCGGCGACATCGTGACCGCGTTGGCTGAA
TTCTATGGGCCGATCGCAGAAGAAGGCGGCCTCGATTTCGCAGTCGTTTGCCAGCCGGCGGTGCCGATAGACGCTGATGG
CGACTTGCTGTTCGAGGCGTTAGCTAATCTCGTCGACAACGCAATAAAATTCACCCCGCCGGGCGGGCGGGTCGGGCTAG
AGCTTGTTGGCACGCCGACAGCAGCGGTCGTGCGGGTTTGGGATACGGGACCCGGCATTCCCTTCGAGGAGCGGGGCAAC
GTGCTCCGGCGCTTCTATCGCCTCGACCGCAGCCGCCATGATCCGGGATATGGGCTCGGATTGAGCCTTGTCGCAGCCAT
AGCGCGGCTGCATCAATTTTCATTAAGCCTTCGCGATCACGAGGGCGGCGGACTGAGTGCTGAACTATCCTGTCCGGCGG
CCCGAGTGAGTAATAGGCTTTGA

Upstream 100 bases:

>100_bases
AACCTCGTCGACGTTCATATCGGCCGGTTGCGCCGTAAGATCGATCTGGCAGATGAGTTGCCGCTGATCCATACGATTCG
TGGTCGGGGGTTTGTCCTTC

Downstream 100 bases:

>100_bases
TAAAAAGGGCGATGTGATGGCGACGTCAAGTCCGGGCTTTTAGAGCCTCACTTTCGGCAGAGTCGGCGTAGTGCGGCCAT
GGACATCCCGGCGTCTCCTG

Product: two-component sensor

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MHRTRIFQTASFRRTIGAAGILALALLLMAGFFYRETVGYLTKQIDDSLIGDARSFARDDPASLPARIEKALAIDKRQEK
AFGIFSADRTRLAGNIAILPSTLPELDIPTTLVLSLDNGAEKRSESVRGVATILTNGSILILGRATASLDEIKEIVARAM
ALAIIPAIALSLIGGLVMSRAMLRRVEAVRRACSSIMEGHFDRRLPVHKRQDEFDKLSVIVNTMLDEIERLIAEVKGVGD
SIAHDLRTPLTRLRARLERSLRAISGDAPVRAAMQKSLADIDQLLATIAALMRIAEVEQSRRRENFSRVDLGDIVTALAE
FYGPIAEEGGLDFAVVCQPAVPIDADGDLLFEALANLVDNAIKFTPPGGRVGLELVGTPTAAVVRVWDTGPGIPFEERGN
VLRRFYRLDRSRHDPGYGLGLSLVAAIARLHQFSLSLRDHEGGGLSAELSCPAARVSNRL

Sequences:

>Translated_460_residues
MHRTRIFQTASFRRTIGAAGILALALLLMAGFFYRETVGYLTKQIDDSLIGDARSFARDDPASLPARIEKALAIDKRQEK
AFGIFSADRTRLAGNIAILPSTLPELDIPTTLVLSLDNGAEKRSESVRGVATILTNGSILILGRATASLDEIKEIVARAM
ALAIIPAIALSLIGGLVMSRAMLRRVEAVRRACSSIMEGHFDRRLPVHKRQDEFDKLSVIVNTMLDEIERLIAEVKGVGD
SIAHDLRTPLTRLRARLERSLRAISGDAPVRAAMQKSLADIDQLLATIAALMRIAEVEQSRRRENFSRVDLGDIVTALAE
FYGPIAEEGGLDFAVVCQPAVPIDADGDLLFEALANLVDNAIKFTPPGGRVGLELVGTPTAAVVRVWDTGPGIPFEERGN
VLRRFYRLDRSRHDPGYGLGLSLVAAIARLHQFSLSLRDHEGGGLSAELSCPAARVSNRL
>Mature_460_residues
MHRTRIFQTASFRRTIGAAGILALALLLMAGFFYRETVGYLTKQIDDSLIGDARSFARDDPASLPARIEKALAIDKRQEK
AFGIFSADRTRLAGNIAILPSTLPELDIPTTLVLSLDNGAEKRSESVRGVATILTNGSILILGRATASLDEIKEIVARAM
ALAIIPAIALSLIGGLVMSRAMLRRVEAVRRACSSIMEGHFDRRLPVHKRQDEFDKLSVIVNTMLDEIERLIAEVKGVGD
SIAHDLRTPLTRLRARLERSLRAISGDAPVRAAMQKSLADIDQLLATIAALMRIAEVEQSRRRENFSRVDLGDIVTALAE
FYGPIAEEGGLDFAVVCQPAVPIDADGDLLFEALANLVDNAIKFTPPGGRVGLELVGTPTAAVVRVWDTGPGIPFEERGN
VLRRFYRLDRSRHDPGYGLGLSLVAAIARLHQFSLSLRDHEGGGLSAELSCPAARVSNRL

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787894, Length=299, Percent_Identity=31.438127090301, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788279, Length=289, Percent_Identity=24.9134948096886, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=252, Percent_Identity=25.7936507936508, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790861, Length=340, Percent_Identity=27.0588235294118, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790551, Length=236, Percent_Identity=29.6610169491525, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.9406392694064, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=26.1029411764706, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788713, Length=221, Percent_Identity=25.7918552036199, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=26.027397260274, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=26.7206477732794, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=22.6618705035971, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789403, Length=214, Percent_Identity=28.9719626168224, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50011; Mature: 50011

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRTRIFQTASFRRTIGAAGILALALLLMAGFFYRETVGYLTKQIDDSLIGDARSFARDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PASLPARIEKALAIDKRQEKAFGIFSADRTRLAGNIAILPSTLPELDIPTTLVLSLDNGA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCCCCCCCCCCCEEEEEECCCH
EKRSESVRGVATILTNGSILILGRATASLDEIKEIVARAMALAIIPAIALSLIGGLVMSR
HHHHHHHHHHHHHEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLRRVEAVRRACSSIMEGHFDRRLPVHKRQDEFDKLSVIVNTMLDEIERLIAEVKGVGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SIAHDLRTPLTRLRARLERSLRAISGDAPVRAAMQKSLADIDQLLATIAALMRIAEVEQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRRENFSRVDLGDIVTALAEFYGPIAEEGGLDFAVVCQPAVPIDADGDLLFEALANLVDN
HHHCCCCCCCHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHC
AIKFTPPGGRVGLELVGTPTAAVVRVWDTGPGIPFEERGNVLRRFYRLDRSRHDPGYGLG
CEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
LSLVAAIARLHQFSLSLRDHEGGGLSAELSCPAARVSNRL
HHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHCCCC
>Mature Secondary Structure
MHRTRIFQTASFRRTIGAAGILALALLLMAGFFYRETVGYLTKQIDDSLIGDARSFARDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PASLPARIEKALAIDKRQEKAFGIFSADRTRLAGNIAILPSTLPELDIPTTLVLSLDNGA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCCCCCCCCCCCEEEEEECCCH
EKRSESVRGVATILTNGSILILGRATASLDEIKEIVARAMALAIIPAIALSLIGGLVMSR
HHHHHHHHHHHHHEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLRRVEAVRRACSSIMEGHFDRRLPVHKRQDEFDKLSVIVNTMLDEIERLIAEVKGVGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SIAHDLRTPLTRLRARLERSLRAISGDAPVRAAMQKSLADIDQLLATIAALMRIAEVEQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRRENFSRVDLGDIVTALAEFYGPIAEEGGLDFAVVCQPAVPIDADGDLLFEALANLVDN
HHHCCCCCCCHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHC
AIKFTPPGGRVGLELVGTPTAAVVRVWDTGPGIPFEERGNVLRRFYRLDRSRHDPGYGLG
CEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
LSLVAAIARLHQFSLSLRDHEGGGLSAELSCPAARVSNRL
HHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA