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The map label for this gene is stp [H]

Identifier: 13474732

GI number: 13474732

Start: 4571145

End: 4572653

Strand: Reverse

Name: stp [H]

Synonym: mll5686

Alternate gene names: 13474732

Gene position: 4572653-4571145 (Counterclockwise)

Preceding gene: 13474734

Following gene: 13474729

Centisome position: 64.99

GC content: 64.48

Gene sequence:

>1509_bases
ATGCCCACTGCCCTGACCCGTCGAGGCATCGTCGTTCTGTCTGCCGCCTGCCTGGCATGCCTGATGTTCGGGCTGGAGAT
TTCGAGCGTTCCCACCATCCTGCCGACATTGGAGCAAGAGCTGCACGCCGACTTCAGGCAATTGCAATGGGTGATGAACG
CCTACACGATCGCGGTCACCACAGTGCTGATGGCAGTCGGCACCATCGCGGACCGCTACGGACGCAAGCGCGTCTTCCTG
ATCTCCATCGCCGCCTTCGGCCTGACATCGCTGATCTGCGGCTTGGCTGACGATGTATCGACCTTGATCGTCGCCAGGTT
CCTGCAGGGTTTGAGCGGCGGCGCGGTGCTGATCTGCCAGCTCGCCGTACTGTCACACGAATTCAGGGAAGGGCGTGAGC
GCGCCGTCGCCTGGGGCTGGTGGGGCGTCATCTTCGGTGTCGGCCTCGGCTTCGGACCCATCATCGGCGGTGGCATAGTC
GCGGCATCGAGCTGGGAATGGGTGTTCCTCATCCACGGGCCGGCGGCGGCCGTGGCGTTCGTGCTGGCGTGGACCGGCGT
CCATGAATCGAAGGACCCGGAGGCGGGCAAGCTCGACCTGGCGGGCATCGTGACGCTGTCGCCGTCGGTATTCTGCCTGG
TCTTCTACATCACACAGGGACCGGATCTCGGCTTCGCCAGCCCGGTCGCGCTGACGATCCTCGGCGTGTCGATCGCGAGC
TTCATCGCCTTCCTCATCGCCGAGCGGATCAGCAAGCGGCCAATGTTCGACTTCTCGGTCTTCCGGATCCGGCCCTTTTC
CGGCGCCATCGTCGGCTCGGCGGCGATGAACCTCTCCTATTGGCCGTTCATGATCTACCTGCCGATCTGGTTCCATGCCG
GACTGGGCTATGACAGCATCTCCACCGGTCTTGCCTTGCTTGCCTACACGCTGCCGACGCTCGTCATGCCGCCCCTCGCG
GAGCGGCTTTCGCTGCGCTACCAGCCCGGCATCATCATTCCGGCCGGGCTCGCCGTCATCGGTGTCGGTTTCATCCTGAT
GAAGTTCGGCAGCGCCGCCGCGCGGCCGGACTGGCTGACGATGTTGCCCGGCTGCCTGATCGCCGGAGCCGGCCTTGGCA
TCACCAACACGCCCGTCACCAACACGACGACAGGCTCCGTTTCGAGTGACCGGGCAGGCATGGCGTCGGGCATCGACATG
AGCGCCCGCATGGTTTCGCTGGCGGTGAACATAGCGGTGATGGGCTTCATCTTGGCAGGCGGCGTGCTGGCGCATCTGAG
CACAGCGCTGCCCGACCTCGACGCCAGCCAGCTGCGTCTCTTCGCCGACGGGATCGCGGCCGGAAATCCCAGCCCCCGTC
TTGCTGATTCCGTTGTCCACAATGCGCTGCGCAACGGCTTTGGCTGGGTGATGCTCTACGGCGGCATCGGCGTCTGGATC
ATGGCCGCCATCAGCTTTGTGAGCTTCAACGCCCGGAGGGTGCAGACAGAGGTTCAGTGTCCCGATTGA

Upstream 100 bases:

>100_bases
ATTCCAAAATGATCAAGCCTCACCTACCGTGGTCACGTCAGCACAAGCGAGCCGCCCTTGCGGGCCTGCCGGTGCCGTCT
ACAGATCGAAAGGTTGAATC

Downstream 100 bases:

>100_bases
ACGGGCGACGCAGGCACTCAGCCGTTGGCCTGCAACGGGTCGGTGCCGATCTTGGACAGAAGGATCACCGCCTGGGTGCG
GCTGTCGACGCCGAGCTTCT

Product: transmembrane efflux protein

Products: NA

Alternate protein names: Spectinomycin tetracycline efflux pump [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPTALTRRGIVVLSAACLACLMFGLEISSVPTILPTLEQELHADFRQLQWVMNAYTIAVTTVLMAVGTIADRYGRKRVFL
ISIAAFGLTSLICGLADDVSTLIVARFLQGLSGGAVLICQLAVLSHEFREGRERAVAWGWWGVIFGVGLGFGPIIGGGIV
AASSWEWVFLIHGPAAAVAFVLAWTGVHESKDPEAGKLDLAGIVTLSPSVFCLVFYITQGPDLGFASPVALTILGVSIAS
FIAFLIAERISKRPMFDFSVFRIRPFSGAIVGSAAMNLSYWPFMIYLPIWFHAGLGYDSISTGLALLAYTLPTLVMPPLA
ERLSLRYQPGIIIPAGLAVIGVGFILMKFGSAAARPDWLTMLPGCLIAGAGLGITNTPVTNTTTGSVSSDRAGMASGIDM
SARMVSLAVNIAVMGFILAGGVLAHLSTALPDLDASQLRLFADGIAAGNPSPRLADSVVHNALRNGFGWVMLYGGIGVWI
MAAISFVSFNARRVQTEVQCPD

Sequences:

>Translated_502_residues
MPTALTRRGIVVLSAACLACLMFGLEISSVPTILPTLEQELHADFRQLQWVMNAYTIAVTTVLMAVGTIADRYGRKRVFL
ISIAAFGLTSLICGLADDVSTLIVARFLQGLSGGAVLICQLAVLSHEFREGRERAVAWGWWGVIFGVGLGFGPIIGGGIV
AASSWEWVFLIHGPAAAVAFVLAWTGVHESKDPEAGKLDLAGIVTLSPSVFCLVFYITQGPDLGFASPVALTILGVSIAS
FIAFLIAERISKRPMFDFSVFRIRPFSGAIVGSAAMNLSYWPFMIYLPIWFHAGLGYDSISTGLALLAYTLPTLVMPPLA
ERLSLRYQPGIIIPAGLAVIGVGFILMKFGSAAARPDWLTMLPGCLIAGAGLGITNTPVTNTTTGSVSSDRAGMASGIDM
SARMVSLAVNIAVMGFILAGGVLAHLSTALPDLDASQLRLFADGIAAGNPSPRLADSVVHNALRNGFGWVMLYGGIGVWI
MAAISFVSFNARRVQTEVQCPD
>Mature_501_residues
PTALTRRGIVVLSAACLACLMFGLEISSVPTILPTLEQELHADFRQLQWVMNAYTIAVTTVLMAVGTIADRYGRKRVFLI
SIAAFGLTSLICGLADDVSTLIVARFLQGLSGGAVLICQLAVLSHEFREGRERAVAWGWWGVIFGVGLGFGPIIGGGIVA
ASSWEWVFLIHGPAAAVAFVLAWTGVHESKDPEAGKLDLAGIVTLSPSVFCLVFYITQGPDLGFASPVALTILGVSIASF
IAFLIAERISKRPMFDFSVFRIRPFSGAIVGSAAMNLSYWPFMIYLPIWFHAGLGYDSISTGLALLAYTLPTLVMPPLAE
RLSLRYQPGIIIPAGLAVIGVGFILMKFGSAAARPDWLTMLPGCLIAGAGLGITNTPVTNTTTGSVSSDRAGMASGIDMS
ARMVSLAVNIAVMGFILAGGVLAHLSTALPDLDASQLRLFADGIAAGNPSPRLADSVVHNALRNGFGWVMLYGGIGVWIM
AAISFVSFNARRVQTEVQCPD

Specific function: Contributes to spectinomycin and tetracycline resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=28.6802030456853, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790195, Length=407, Percent_Identity=24.3243243243243, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788710, Length=311, Percent_Identity=29.5819935691318, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789042, Length=410, Percent_Identity=24.390243902439, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788392, Length=395, Percent_Identity=25.5696202531646, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325455, Length=157, Percent_Identity=28.6624203821656, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=226, Percent_Identity=25.6637168141593, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53115; Mature: 52984

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTALTRRGIVVLSAACLACLMFGLEISSVPTILPTLEQELHADFRQLQWVMNAYTIAVT
CCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLMAVGTIADRYGRKRVFLISIAAFGLTSLICGLADDVSTLIVARFLQGLSGGAVLICQ
HHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAVLSHEFREGRERAVAWGWWGVIFGVGLGFGPIIGGGIVAASSWEWVFLIHGPAAAVAF
HHHHHHHHHHHHHHEEEHHHHHHHHHHHCCHHHHHCCCEEEECCCCEEEEEECHHHHHHH
VLAWTGVHESKDPEAGKLDLAGIVTLSPSVFCLVFYITQGPDLGFASPVALTILGVSIAS
HHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
FIAFLIAERISKRPMFDFSVFRIRPFSGAIVGSAAMNLSYWPFMIYLPIWFHAGLGYDSI
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCHH
STGLALLAYTLPTLVMPPLAERLSLRYQPGIIIPAGLAVIGVGFILMKFGSAAARPDWLT
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCHHH
MLPGCLIAGAGLGITNTPVTNTTTGSVSSDRAGMASGIDMSARMVSLAVNIAVMGFILAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GVLAHLSTALPDLDASQLRLFADGIAAGNPSPRLADSVVHNALRNGFGWVMLYGGIGVWI
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHH
MAAISFVSFNARRVQTEVQCPD
HHHHHHHHCCHHHEEEECCCCC
>Mature Secondary Structure 
PTALTRRGIVVLSAACLACLMFGLEISSVPTILPTLEQELHADFRQLQWVMNAYTIAVT
CCCCCCCCHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLMAVGTIADRYGRKRVFLISIAAFGLTSLICGLADDVSTLIVARFLQGLSGGAVLICQ
HHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAVLSHEFREGRERAVAWGWWGVIFGVGLGFGPIIGGGIVAASSWEWVFLIHGPAAAVAF
HHHHHHHHHHHHHHEEEHHHHHHHHHHHCCHHHHHCCCEEEECCCCEEEEEECHHHHHHH
VLAWTGVHESKDPEAGKLDLAGIVTLSPSVFCLVFYITQGPDLGFASPVALTILGVSIAS
HHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
FIAFLIAERISKRPMFDFSVFRIRPFSGAIVGSAAMNLSYWPFMIYLPIWFHAGLGYDSI
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCHH
STGLALLAYTLPTLVMPPLAERLSLRYQPGIIIPAGLAVIGVGFILMKFGSAAARPDWLT
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCHHH
MLPGCLIAGAGLGITNTPVTNTTTGSVSSDRAGMASGIDMSARMVSLAVNIAVMGFILAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GVLAHLSTALPDLDASQLRLFADGIAAGNPSPRLADSVVHNALRNGFGWVMLYGGIGVWI
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHH
MAAISFVSFNARRVQTEVQCPD
HHHHHHHHCCHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]