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The map label for this gene is ykcC [H]

Identifier: 13474720

GI number: 13474720

Start: 4560740

End: 4561765

Strand: Reverse

Name: ykcC [H]

Synonym: mll5672

Alternate gene names: 13474720

Gene position: 4561765-4560740 (Counterclockwise)

Preceding gene: 13474721

Following gene: 13474719

Centisome position: 64.83

GC content: 63.16

Gene sequence:

>1026_bases
GTGGGAACGGGAAAAATCGGCGCGCACCGCGCGGTCAAGCTGTCGGTCGTCGTGCCATGCTACAATGAGCGCGACGGCGT
GGCCGAGCTTCATCGACGCGTCAGCGCCGTATGCCTCGAGCAAAGCCCTTTCTACGAGATCGTGCTTGTCATCGACGGGG
CGACCGACGGCACCCGCGAGGCCATTTTCGAACTGGCCGAAAAGGACGACCATGTGGTCGCCATCGACCTTGCCCGCAAC
TATGGCCACCAGATCGCCTTGAGCGCGGGGCTGGAGTTCTGCCGCGGCGAGCGCATCCTCATTCTCGACGCCGACCTCCA
GGATCCGCCCGAACTGCTCGGCGCGATGATGGCAAAGATGGATGAAGGCTTCGATGTCGTCTACGGACAGAGGGTCAAGC
GCGACGGCGAAGGCTGGTTCAAGCTGGCTTCCGCCTCGATGTTCTACCGCCTGCTCGGCCGGATGGTCGATGTCGAGATC
GCACCGGACTCCGGAGACTTCCGGCTGATGAGTCGCCGGGCCCTCGACCATCTGAACGCGATGCCCGAACGCTACAGGTT
CATTCGCGGCATGGTGAGCTGGATCGGGCTCAGGCAGGTCGCCTTCCCCTATGAGAGGCACCGGCGCTTTGCCGGCACCA
CCCACTATCCGCTGAGGAAGATGATTCTTCTGGCGGTCGACGCGATGACCAGCTTTTCGATCGTGCCGCTGCGGTTTGCC
TCGCTGCTGGGGATGATGTTCGGTCTGCTCGGCCTGGTCGTGCTCGGCTATACGCTGCTTGAATGGTCCAGGGGCAACGT
GGTGCCCGGCTGGACGAGCCTTGCCGCGATCATGCTGATCCTGGGCAGTGTCCAGCTTCTGGTGCTCGGCATCTTCGGCG
AGTATCTCGGCCGCATGTACATGGAGACGAAGCGGCGGCCGCTCTACTTCGTCAACGAAATCGTTTCGCGCGACCAGCCG
GCCAAGGACAGCGACCTGCCCGTCCATCGCCTGCAGGAGATGGCAAAGAGAGCCGCGCGTGGTTGA

Upstream 100 bases:

>100_bases
CCCATGGCGTCGGCCGGCCGAAGCCCATGTCGATCCCCGGCTTATCTGTTTTCTAACCAATTGCCGCTATTGCCATTGCA
AGAGCGGGAGCCAGGCTTTG

Downstream 100 bases:

>100_bases
GGTCGGGCGGATGCAACGGGAACGGCATGGGCAGGATGCGGTCGGCTCTTCCGTCTGATCTCTCGCGGATGCTGCGCTTT
GGCGCCGCCATGTCTGCCGG

Product: sugar transferase

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MGTGKIGAHRAVKLSVVVPCYNERDGVAELHRRVSAVCLEQSPFYEIVLVIDGATDGTREAIFELAEKDDHVVAIDLARN
YGHQIALSAGLEFCRGERILILDADLQDPPELLGAMMAKMDEGFDVVYGQRVKRDGEGWFKLASASMFYRLLGRMVDVEI
APDSGDFRLMSRRALDHLNAMPERYRFIRGMVSWIGLRQVAFPYERHRRFAGTTHYPLRKMILLAVDAMTSFSIVPLRFA
SLLGMMFGLLGLVVLGYTLLEWSRGNVVPGWTSLAAIMLILGSVQLLVLGIFGEYLGRMYMETKRRPLYFVNEIVSRDQP
AKDSDLPVHRLQEMAKRAARG

Sequences:

>Translated_341_residues
MGTGKIGAHRAVKLSVVVPCYNERDGVAELHRRVSAVCLEQSPFYEIVLVIDGATDGTREAIFELAEKDDHVVAIDLARN
YGHQIALSAGLEFCRGERILILDADLQDPPELLGAMMAKMDEGFDVVYGQRVKRDGEGWFKLASASMFYRLLGRMVDVEI
APDSGDFRLMSRRALDHLNAMPERYRFIRGMVSWIGLRQVAFPYERHRRFAGTTHYPLRKMILLAVDAMTSFSIVPLRFA
SLLGMMFGLLGLVVLGYTLLEWSRGNVVPGWTSLAAIMLILGSVQLLVLGIFGEYLGRMYMETKRRPLYFVNEIVSRDQP
AKDSDLPVHRLQEMAKRAARG
>Mature_340_residues
GTGKIGAHRAVKLSVVVPCYNERDGVAELHRRVSAVCLEQSPFYEIVLVIDGATDGTREAIFELAEKDDHVVAIDLARNY
GHQIALSAGLEFCRGERILILDADLQDPPELLGAMMAKMDEGFDVVYGQRVKRDGEGWFKLASASMFYRLLGRMVDVEIA
PDSGDFRLMSRRALDHLNAMPERYRFIRGMVSWIGLRQVAFPYERHRRFAGTTHYPLRKMILLAVDAMTSFSIVPLRFAS
LLGMMFGLLGLVVLGYTLLEWSRGNVVPGWTSLAAIMLILGSVQLLVLGIFGEYLGRMYMETKRRPLYFVNEIVSRDQPA
KDSDLPVHRLQEMAKRAARG

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: COG0463

COG function: function code M; Glycosyltransferases involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=176, Percent_Identity=31.25, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788692, Length=304, Percent_Identity=36.1842105263158, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788588, Length=313, Percent_Identity=33.2268370607029, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71999402, Length=176, Percent_Identity=31.25, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 38373; Mature: 38242

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTGKIGAHRAVKLSVVVPCYNERDGVAELHRRVSAVCLEQSPFYEIVLVIDGATDGTRE
CCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHH
AIFELAEKDDHVVAIDLARNYGHQIALSAGLEFCRGERILILDADLQDPPELLGAMMAKM
HHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
DEGFDVVYGQRVKRDGEGWFKLASASMFYRLLGRMVDVEIAPDSGDFRLMSRRALDHLNA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHC
MPERYRFIRGMVSWIGLRQVAFPYERHRRFAGTTHYPLRKMILLAVDAMTSFSIVPLRFA
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
SLLGMMFGLLGLVVLGYTLLEWSRGNVVPGWTSLAAIMLILGSVQLLVLGIFGEYLGRMY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
METKRRPLYFVNEIVSRDQPAKDSDLPVHRLQEMAKRAARG
HHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
GTGKIGAHRAVKLSVVVPCYNERDGVAELHRRVSAVCLEQSPFYEIVLVIDGATDGTRE
CCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHH
AIFELAEKDDHVVAIDLARNYGHQIALSAGLEFCRGERILILDADLQDPPELLGAMMAKM
HHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
DEGFDVVYGQRVKRDGEGWFKLASASMFYRLLGRMVDVEIAPDSGDFRLMSRRALDHLNA
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHC
MPERYRFIRGMVSWIGLRQVAFPYERHRRFAGTTHYPLRKMILLAVDAMTSFSIVPLRFA
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
SLLGMMFGLLGLVVLGYTLLEWSRGNVVPGWTSLAAIMLILGSVQLLVLGIFGEYLGRMY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
METKRRPLYFVNEIVSRDQPAKDSDLPVHRLQEMAKRAARG
HHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]