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The map label for this gene is lhr [C]

Identifier: 13474670

GI number: 13474670

Start: 4499509

End: 4502043

Strand: Direct

Name: lhr [C]

Synonym: mlr5610

Alternate gene names: 13474670

Gene position: 4499509-4502043 (Clockwise)

Preceding gene: 13474669

Following gene: 13474671

Centisome position: 63.95

GC content: 62.8

Gene sequence:

>2535_bases
GTGACAGTTGAGCCGCGCCTTGCCGAGCAGAATGCCGCTATTGCCCTGCCTGAGCCATTCCTCAGATGGTTCGGCGAGAA
AGGCTGGTCGCCGCGCGCTCATCAGGTCGAATTGCTGGCGAAGGCCCAAGGCGGCCAATCGGTGCTGTTGATCGCCCCGA
CCGGGGCCGGCAAGACGCTGGCCGGTTTCCTGCCTTCGCTGATCGAACTGGCGGTGAGGCCAAGGCGTAAGCCCGGGCAG
GCGCATCGCGGCATCCACACGCTTTACATCTCGCCGCTCAAGGCGCTCGCCGTCGACATCGAGCGCAATCTCGGCAAGCC
GGTCGAGGAGATCGGTCTGCCGATCAGCATCGAGACGCGCACCGGCGACACGCCCTCCCACAAGCGCCAGCGCCAGAAGC
TGGTGCCGCCGGATATTTTGCTGACCACCCCGGAACAACTGGCGCTTCTGATTGCTGCAGGCGACGCCAGACGCTTCTTC
CAGGACCTGCGCTACGTCGTCCTCGATGAGTTGCATTCGCTGGTAACGTCCAAACGTGGACACCTTCTGGCGCTTGGCCT
GGCACGGCTGCGCAGCTTTGTTCCAGGCTTGCAGACGATAGGCCTGTCGGCGACGGTGGCCGAGCCGGACGAACTGCGAC
GCTGGTTGGTCAACCAGAATCCACCCGGCGACATGTCCGAATTGATCGTCGTCACGGGTGGGGCGAAGCCTGAGATTTCC
ATCCTCGATTCCGAAGAGCGCGTGCCTTGGGCGGGACACTCGGCGCGCTACGCCACGCCGGAGATCTACCGCGAGATCAA
GCGCCACAAGACGACCCTGCTGTTCGTCAACACCCGCAGCCAGGCGGAGCTGCTTTTCCAGGAATTGTGGCGGGTCAACG
AGGACACCTTGCCGATCGCGCTTCATCACGGCTCTCTCGATGTCGGCCAGCGGCGGCGCGTCGAGAAGGCGATGGGCGAG
AACGCGTTGCGCGCCATTGTCGCGACATCGACGCTCGATCTCGGCATCGACTGGGGCGATGTCGATCTGGTCGTGCATGT
CGGCGCGCCGAAGGGGGCGAGCCGGCTGGCGCAGCGCATTGGCCGTGCCAACCACCGGATGGATGAACCGTCCAAGGCGA
TCTTGATCCCTGCCAACCGTTTCGAGGTGCTCGAATGCCGGGCTGCCCTCGATGCCAACTATCTTGGCGCGCAGGACACG
CCGCCGCTGGTCGATGGCGGCCTCGATGTGCTGGCGCAACATGTGCTCGGCTGCGCCTGCGGCGCACCGTTCCGTGCCGA
CGATCTTTATGACGAAGTACGAGCGGCGGCACCCTACACCAGCCTCGATAGGATTACCTTCGACCGCGTCATCGATTTCG
TCGCCACCGGCGGCTATGCGCTGAAGAATTACGAGCGCTATGCTCGTATCCGCCTGAACAAGGACGGGTTGTGGCGCGTC
TCCAACCCGCGCGTGGCTCAGCAATACCGGCTGAATGTCGGCACCATCATCGAAGTGCCGGCACTCAACGTGCGTTACGT
CAAAGCAGGCAGCAAAGGCTCGGCCACACGCGGCGGCGCCGTCCTCGGCAAGATCGAGGAGGCCTTCCTCGAAACGCTGA
CGCATGGCGACACCTTCATGTTCGCCGGCAAAGTGCTGCGCTTCGAAGGCATTCGCGAGAATGAATGCTTCGTGTCGAAC
GCGCCCGGCAGCGACGCCAAGGTGCCCTATTATGGCGGCGGCAAGTTCCCGCTTTCGACCTACCTTGCCGAGCAGGTCCG
CATGATGCTGGACGATCCGCAGCGCTGGAAGAAGCTGCCGGAGCAGGTGGCCGACTGGCTGCGATTCCAGGCCGACAAAT
CGGTTCTGCCCAAACGCGATGACCTGCTGATCGAGACCTTTCCACGCGGCAACCGCTACTATCTGGTCGCTTATCCCTTT
GAAGGCAGGCTGGCCCACCAGACGCTCGGCATGTTGCTTACCCGGCGCCTCGACAGGGCAGGCGCCAGGCCGCTTGGCTT
TGTCGCCACTGATTACGCCCTTGCCATATGGTCGCTGGGCGATATGGGCGCGATGTTCAAATCCAGGAAACCGTCTCTCG
GCGCATTGTTCGACGAGGATATGCTGGGCGACGACCTCGAAGCCTGGCTGGCCGACAGCTGGCTTCTCAAGCGCACCTTC
CGCAATTGCGCGCTGATTTCGGGGCTGATCGAGAAACGCCATCCGGGCCAGGAGAAGAGCGGCCGTCAGGTCACCGTGTC
GACCGACCTGATCTACGATGTGCTGCGCAGCCATGAGCCGGACCATATTCTGCTGCAGGCGACACGTGCCGATGCGGCGG
CCGGTCTGCTCGATGTCAGCAGACTTGCCGACATGCTCTCGCGCGTCCAGGGTCGAATCATGCATAAGAATCTCGAGCAG
ATTTCGCCACTAGCCGTGCCGATCATGCTCGAGATCGGCAAGATGCCGGTGAACGGCGAAGCCGATGAAACACTGCTGAT
GGATGCGGCGACTTTGGTCGAAGAGGCTATGGGGCCGGAAATGAGTGAGAAATGA

Upstream 100 bases:

>100_bases
CAAGCGCCTGTCCTTCCCCCAAAAGGGGAGAAGGGAAGAGCGATCCCCTTTTGTTCCGATTTTCCTTGGCGATCGCCCGT
AGCCGCGCTAACTCTGGCGC

Downstream 100 bases:

>100_bases
ATTTTTCGCTGGCGCGCACGTCGCTGATTGCCGAGGCTGAGATGATAGGCGTCGCCGGCGAACGTGCGGTCTGCGATCCG
CGCGGCGTGCTCTATTTTCC

Product: ATP dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 844; Mature: 843

Protein sequence:

>844_residues
MTVEPRLAEQNAAIALPEPFLRWFGEKGWSPRAHQVELLAKAQGGQSVLLIAPTGAGKTLAGFLPSLIELAVRPRRKPGQ
AHRGIHTLYISPLKALAVDIERNLGKPVEEIGLPISIETRTGDTPSHKRQRQKLVPPDILLTTPEQLALLIAAGDARRFF
QDLRYVVLDELHSLVTSKRGHLLALGLARLRSFVPGLQTIGLSATVAEPDELRRWLVNQNPPGDMSELIVVTGGAKPEIS
ILDSEERVPWAGHSARYATPEIYREIKRHKTTLLFVNTRSQAELLFQELWRVNEDTLPIALHHGSLDVGQRRRVEKAMGE
NALRAIVATSTLDLGIDWGDVDLVVHVGAPKGASRLAQRIGRANHRMDEPSKAILIPANRFEVLECRAALDANYLGAQDT
PPLVDGGLDVLAQHVLGCACGAPFRADDLYDEVRAAAPYTSLDRITFDRVIDFVATGGYALKNYERYARIRLNKDGLWRV
SNPRVAQQYRLNVGTIIEVPALNVRYVKAGSKGSATRGGAVLGKIEEAFLETLTHGDTFMFAGKVLRFEGIRENECFVSN
APGSDAKVPYYGGGKFPLSTYLAEQVRMMLDDPQRWKKLPEQVADWLRFQADKSVLPKRDDLLIETFPRGNRYYLVAYPF
EGRLAHQTLGMLLTRRLDRAGARPLGFVATDYALAIWSLGDMGAMFKSRKPSLGALFDEDMLGDDLEAWLADSWLLKRTF
RNCALISGLIEKRHPGQEKSGRQVTVSTDLIYDVLRSHEPDHILLQATRADAAAGLLDVSRLADMLSRVQGRIMHKNLEQ
ISPLAVPIMLEIGKMPVNGEADETLLMDAATLVEEAMGPEMSEK

Sequences:

>Translated_844_residues
MTVEPRLAEQNAAIALPEPFLRWFGEKGWSPRAHQVELLAKAQGGQSVLLIAPTGAGKTLAGFLPSLIELAVRPRRKPGQ
AHRGIHTLYISPLKALAVDIERNLGKPVEEIGLPISIETRTGDTPSHKRQRQKLVPPDILLTTPEQLALLIAAGDARRFF
QDLRYVVLDELHSLVTSKRGHLLALGLARLRSFVPGLQTIGLSATVAEPDELRRWLVNQNPPGDMSELIVVTGGAKPEIS
ILDSEERVPWAGHSARYATPEIYREIKRHKTTLLFVNTRSQAELLFQELWRVNEDTLPIALHHGSLDVGQRRRVEKAMGE
NALRAIVATSTLDLGIDWGDVDLVVHVGAPKGASRLAQRIGRANHRMDEPSKAILIPANRFEVLECRAALDANYLGAQDT
PPLVDGGLDVLAQHVLGCACGAPFRADDLYDEVRAAAPYTSLDRITFDRVIDFVATGGYALKNYERYARIRLNKDGLWRV
SNPRVAQQYRLNVGTIIEVPALNVRYVKAGSKGSATRGGAVLGKIEEAFLETLTHGDTFMFAGKVLRFEGIRENECFVSN
APGSDAKVPYYGGGKFPLSTYLAEQVRMMLDDPQRWKKLPEQVADWLRFQADKSVLPKRDDLLIETFPRGNRYYLVAYPF
EGRLAHQTLGMLLTRRLDRAGARPLGFVATDYALAIWSLGDMGAMFKSRKPSLGALFDEDMLGDDLEAWLADSWLLKRTF
RNCALISGLIEKRHPGQEKSGRQVTVSTDLIYDVLRSHEPDHILLQATRADAAAGLLDVSRLADMLSRVQGRIMHKNLEQ
ISPLAVPIMLEIGKMPVNGEADETLLMDAATLVEEAMGPEMSEK
>Mature_843_residues
TVEPRLAEQNAAIALPEPFLRWFGEKGWSPRAHQVELLAKAQGGQSVLLIAPTGAGKTLAGFLPSLIELAVRPRRKPGQA
HRGIHTLYISPLKALAVDIERNLGKPVEEIGLPISIETRTGDTPSHKRQRQKLVPPDILLTTPEQLALLIAAGDARRFFQ
DLRYVVLDELHSLVTSKRGHLLALGLARLRSFVPGLQTIGLSATVAEPDELRRWLVNQNPPGDMSELIVVTGGAKPEISI
LDSEERVPWAGHSARYATPEIYREIKRHKTTLLFVNTRSQAELLFQELWRVNEDTLPIALHHGSLDVGQRRRVEKAMGEN
ALRAIVATSTLDLGIDWGDVDLVVHVGAPKGASRLAQRIGRANHRMDEPSKAILIPANRFEVLECRAALDANYLGAQDTP
PLVDGGLDVLAQHVLGCACGAPFRADDLYDEVRAAAPYTSLDRITFDRVIDFVATGGYALKNYERYARIRLNKDGLWRVS
NPRVAQQYRLNVGTIIEVPALNVRYVKAGSKGSATRGGAVLGKIEEAFLETLTHGDTFMFAGKVLRFEGIRENECFVSNA
PGSDAKVPYYGGGKFPLSTYLAEQVRMMLDDPQRWKKLPEQVADWLRFQADKSVLPKRDDLLIETFPRGNRYYLVAYPFE
GRLAHQTLGMLLTRRLDRAGARPLGFVATDYALAIWSLGDMGAMFKSRKPSLGALFDEDMLGDDLEAWLADSWLLKRTFR
NCALISGLIEKRHPGQEKSGRQVTVSTDLIYDVLRSHEPDHILLQATRADAAAGLLDVSRLADMLSRVQGRIMHKNLEQI
SPLAVPIMLEIGKMPVNGEADETLLMDAATLVEEAMGPEMSEK

Specific function: Unknown

COG id: COG1201

COG function: function code R; Lhr-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI169218225, Length=390, Percent_Identity=25.3846153846154, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI40217847, Length=390, Percent_Identity=24.8717948717949, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI76880486, Length=395, Percent_Identity=26.8354430379747, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1787942, Length=869, Percent_Identity=26.8124280782509, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320497, Length=425, Percent_Identity=24.4705882352941, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI9755332, Length=334, Percent_Identity=24.8502994011976, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574898, Length=361, Percent_Identity=24.3767313019391, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR013701
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR017170 [H]

Pfam domain/function: PF00270 DEAD; PF08494 DEAD_assoc; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 93474; Mature: 93343

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEPRLAEQNAAIALPEPFLRWFGEKGWSPRAHQVELLAKAQGGQSVLLIAPTGAGKTL
CCCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCHHHHEEEECCCCCEEEEEEECCCCCHH
AGFLPSLIELAVRPRRKPGQAHRGIHTLYISPLKALAVDIERNLGKPVEEIGLPISIETR
HHHHHHHHHHHHCCCCCCCHHHCCEEEEEECHHHHHHHHHHHHCCCCHHHHCCCEEEECC
TGDTPSHKRQRQKLVPPDILLTTPEQLALLIAAGDARRFFQDLRYVVLDELHSLVTSKRG
CCCCCHHHHHHHCCCCCCEEEECHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
HLLALGLARLRSFVPGLQTIGLSATVAEPDELRRWLVNQNPPGDMSELIVVTGGAKPEIS
CEEHHHHHHHHHHCCCHHHCCCEEEECCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEE
ILDSEERVPWAGHSARYATPEIYREIKRHKTTLLFVNTRSQAELLFQELWRVNEDTLPIA
EECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHCCCCCCEEEE
LHHGSLDVGQRRRVEKAMGENALRAIVATSTLDLGIDWGDVDLVVHVGAPKGASRLAQRI
EECCCCCHHHHHHHHHHHCHHHHHHHHHHCEEEECCCCCCEEEEEEECCCCCHHHHHHHH
GRANHRMDEPSKAILIPANRFEVLECRAALDANYLGAQDTPPLVDGGLDVLAQHVLGCAC
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GAPFRADDLYDEVRAAAPYTSLDRITFDRVIDFVATGGYALKNYERYARIRLNKDGLWRV
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCHHEEEEEEECCCCCEEE
SNPRVAQQYRLNVGTIIEVPALNVRYVKAGSKGSATRGGAVLGKIEEAFLETLTHGDTFM
CCCCHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
FAGKVLRFEGIRENECFVSNAPGSDAKVPYYGGGKFPLSTYLAEQVRMMLDDPQRWKKLP
ECCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
EQVADWLRFQADKSVLPKRDDLLIETFPRGNRYYLVAYPFEGRLAHQTLGMLLTRRLDRA
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GARPLGFVATDYALAIWSLGDMGAMFKSRKPSLGALFDEDMLGDDLEAWLADSWLLKRTF
CCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHH
RNCALISGLIEKRHPGQEKSGRQVTVSTDLIYDVLRSHEPDHILLQATRADAAAGLLDVS
HHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
RLADMLSRVQGRIMHKNLEQISPLAVPIMLEIGKMPVNGEADETLLMDAATLVEEAMGPE
HHHHHHHHHHHHHHHHHHHHHCCHHEEHEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCC
MSEK
CCCC
>Mature Secondary Structure 
TVEPRLAEQNAAIALPEPFLRWFGEKGWSPRAHQVELLAKAQGGQSVLLIAPTGAGKTL
CCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCHHHHEEEECCCCCEEEEEEECCCCCHH
AGFLPSLIELAVRPRRKPGQAHRGIHTLYISPLKALAVDIERNLGKPVEEIGLPISIETR
HHHHHHHHHHHHCCCCCCCHHHCCEEEEEECHHHHHHHHHHHHCCCCHHHHCCCEEEECC
TGDTPSHKRQRQKLVPPDILLTTPEQLALLIAAGDARRFFQDLRYVVLDELHSLVTSKRG
CCCCCHHHHHHHCCCCCCEEEECHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
HLLALGLARLRSFVPGLQTIGLSATVAEPDELRRWLVNQNPPGDMSELIVVTGGAKPEIS
CEEHHHHHHHHHHCCCHHHCCCEEEECCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEE
ILDSEERVPWAGHSARYATPEIYREIKRHKTTLLFVNTRSQAELLFQELWRVNEDTLPIA
EECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHCCCCCCEEEE
LHHGSLDVGQRRRVEKAMGENALRAIVATSTLDLGIDWGDVDLVVHVGAPKGASRLAQRI
EECCCCCHHHHHHHHHHHCHHHHHHHHHHCEEEECCCCCCEEEEEEECCCCCHHHHHHHH
GRANHRMDEPSKAILIPANRFEVLECRAALDANYLGAQDTPPLVDGGLDVLAQHVLGCAC
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GAPFRADDLYDEVRAAAPYTSLDRITFDRVIDFVATGGYALKNYERYARIRLNKDGLWRV
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCHHEEEEEEECCCCCEEE
SNPRVAQQYRLNVGTIIEVPALNVRYVKAGSKGSATRGGAVLGKIEEAFLETLTHGDTFM
CCCCHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
FAGKVLRFEGIRENECFVSNAPGSDAKVPYYGGGKFPLSTYLAEQVRMMLDDPQRWKKLP
ECCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
EQVADWLRFQADKSVLPKRDDLLIETFPRGNRYYLVAYPFEGRLAHQTLGMLLTRRLDRA
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GARPLGFVATDYALAIWSLGDMGAMFKSRKPSLGALFDEDMLGDDLEAWLADSWLLKRTF
CCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHH
RNCALISGLIEKRHPGQEKSGRQVTVSTDLIYDVLRSHEPDHILLQATRADAAAGLLDVS
HHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
RLADMLSRVQGRIMHKNLEQISPLAVPIMLEIGKMPVNGEADETLLMDAATLVEEAMGPE
HHHHHHHHHHHHHHHHHHHHHCCHHEEHEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCC
MSEK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]