Click here to switch to the map view.

The map label for this gene is mutM

Identifier: 13474651

GI number: 13474651

Start: 4481051

End: 4481941

Strand: Reverse

Name: mutM

Synonym: mll5585

Alternate gene names: 13474651

Gene position: 4481941-4481051 (Counterclockwise)

Preceding gene: 13474652

Following gene: 13474650

Centisome position: 63.7

GC content: 64.2

Gene sequence:

>891_bases
ATGCCTGAATTACCCGAAGTCGAAACGGTCCGGCGTGGCCTGCAGCCGGTCCTGGAAGGTGCCCGTCTGACCAGGGTCGA
GGCGCGAAGGCCAGACCTGCGGTTCCCCTTTCCCGAACGGTTTTCGGAAAGGCTGACCGGCAAGACCATCACGGCGCTCG
GTCGCCGGGCCAAATATCTGACCATGCATGTGCAGGACGGCCCGGTGCTTATCTGCCATCTCGGCATGTCGGGATCCTTT
CGCATCGAGACCGACGACGACGGCGAGACACCTGGCGTGTTCCACCACGAGCGCTCGAAAAGCACGGCGCACGACCATGT
CGTGTTCGATGTCGTCGCCGCCGACGGCGCCCGGTCCCGCGTGATCTTCAACGACCCGCGCCGCTTCGGTTTCATGCTGT
TTGCGGAAGGATCGCCGGAGACGCATCCAATGCTGGCCGGACTGGGCGTGGAGCCAACGGGCAATACGCTGGACGGCGTG
CTGCTCGCCTCGTTGCTGAAAGGTCGCGGATCGCCGCTAAAGGCAGCACTTCTTGACCAGAAGCTGATCGCGGGACTTGG
CAATATTTATGTCTCGGAGGCGCTTTGGCGCGCCGGCCTGTCGCCTTTGCGCGAGGCGGGCACCATCGCCAGGCCGAGCA
AGAAGGCCAGACAACAAAGCGAACGCCTGGCCGAGGCGATCCGTTCGGTCATATCGGATGCCATCGCCGCCGGCGGGTCG
TCGCTGCGCGACTACATGCACACCGACGGATCGCTGGGCTATTTCCAGCATTCTTTCGCCGTCTACGACCGCGAGGGCGA
GCCCTGCCCGAAGCCCGGCTGCGGCGGACATATCGAGCGCGTCGTGCAGAGCGGACGCTCGACCTTCTATTGCCGGACGT
GTCAGAGCTGA

Upstream 100 bases:

>100_bases
CTGAGAACGACATTCGCCGATATCGGCGAGACCGTCGCCGAACACCTCGGGCTGGCGCCCGGCCGCCACGGCACTTCTTT
CCATGCGATGATTGGCGGCC

Downstream 100 bases:

>100_bases
GTTAGACCGACGCAAGCGAGGAGAAGCAGCCATGGCCTATGAAACGATCATCACCGAGACACGCGGCAAGGTCGGGCTGG
TCACGCTGAACCGGCCAAAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPELPEVETVRRGLQPVLEGARLTRVEARRPDLRFPFPERFSERLTGKTITALGRRAKYLTMHVQDGPVLICHLGMSGSF
RIETDDDGETPGVFHHERSKSTAHDHVVFDVVAADGARSRVIFNDPRRFGFMLFAEGSPETHPMLAGLGVEPTGNTLDGV
LLASLLKGRGSPLKAALLDQKLIAGLGNIYVSEALWRAGLSPLREAGTIARPSKKARQQSERLAEAIRSVISDAIAAGGS
SLRDYMHTDGSLGYFQHSFAVYDREGEPCPKPGCGGHIERVVQSGRSTFYCRTCQS

Sequences:

>Translated_296_residues
MPELPEVETVRRGLQPVLEGARLTRVEARRPDLRFPFPERFSERLTGKTITALGRRAKYLTMHVQDGPVLICHLGMSGSF
RIETDDDGETPGVFHHERSKSTAHDHVVFDVVAADGARSRVIFNDPRRFGFMLFAEGSPETHPMLAGLGVEPTGNTLDGV
LLASLLKGRGSPLKAALLDQKLIAGLGNIYVSEALWRAGLSPLREAGTIARPSKKARQQSERLAEAIRSVISDAIAAGGS
SLRDYMHTDGSLGYFQHSFAVYDREGEPCPKPGCGGHIERVVQSGRSTFYCRTCQS
>Mature_295_residues
PELPEVETVRRGLQPVLEGARLTRVEARRPDLRFPFPERFSERLTGKTITALGRRAKYLTMHVQDGPVLICHLGMSGSFR
IETDDDGETPGVFHHERSKSTAHDHVVFDVVAADGARSRVIFNDPRRFGFMLFAEGSPETHPMLAGLGVEPTGNTLDGVL
LASLLKGRGSPLKAALLDQKLIAGLGNIYVSEALWRAGLSPLREAGTIARPSKKARQQSERLAEAIRSVISDAIAAGGSS
LRDYMHTDGSLGYFQHSFAVYDREGEPCPKPGCGGHIERVVQSGRSTFYCRTCQS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=296, Percent_Identity=39.527027027027, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1786932, Length=304, Percent_Identity=27.3026315789474, Blast_Score=88, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_RHILO (Q98BG6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106220.1
- ProteinModelPortal:   Q98BG6
- GeneID:   1228881
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll5585
- NMPDR:   fig|266835.1.peg.4324
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32367; Mature: 32236

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 286-286 BINDING 104-104 BINDING 127-127 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLQPVLEGARLTRVEARRPDLRFPFPERFSERLTGKTITALGRRAKYL
CCCCCCHHHHHHHHHHHHCCCHHEEHHCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCEEE
TMHVQDGPVLICHLGMSGSFRIETDDDGETPGVFHHERSKSTAHDHVVFDVVAADGARSR
EEEECCCCEEEEEECCCCCEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEEECCCCCCE
VIFNDPRRFGFMLFAEGSPETHPMLAGLGVEPTGNTLDGVLLASLLKGRGSPLKAALLDQ
EEEECCCCEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
KLIAGLGNIYVSEALWRAGLSPLREAGTIARPSKKARQQSERLAEAIRSVISDAIAAGGS
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SLRDYMHTDGSLGYFQHSFAVYDREGEPCPKPGCGGHIERVVQSGRSTFYCRTCQS
HHHHHHHCCCCCCHHHHEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
PELPEVETVRRGLQPVLEGARLTRVEARRPDLRFPFPERFSERLTGKTITALGRRAKYL
CCCCCHHHHHHHHHHHHCCCHHEEHHCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCEEE
TMHVQDGPVLICHLGMSGSFRIETDDDGETPGVFHHERSKSTAHDHVVFDVVAADGARSR
EEEECCCCEEEEEECCCCCEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEEECCCCCCE
VIFNDPRRFGFMLFAEGSPETHPMLAGLGVEPTGNTLDGVLLASLLKGRGSPLKAALLDQ
EEEECCCCEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
KLIAGLGNIYVSEALWRAGLSPLREAGTIARPSKKARQQSERLAEAIRSVISDAIAAGGS
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SLRDYMHTDGSLGYFQHSFAVYDREGEPCPKPGCGGHIERVVQSGRSTFYCRTCQS
HHHHHHHCCCCCCHHHHEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968