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The map label for this gene is mdtE [H]

Identifier: 13474602

GI number: 13474602

Start: 4429871

End: 4430929

Strand: Reverse

Name: mdtE [H]

Synonym: mll5520

Alternate gene names: 13474602

Gene position: 4430929-4429871 (Counterclockwise)

Preceding gene: 13474604

Following gene: 13474601

Centisome position: 62.97

GC content: 67.61

Gene sequence:

>1059_bases
ATGTGCGTCTGCGCAGCCGCATTGCTGCTGGCCGGCTGCCAGAAGCAGGAAGCGGCGGACAAGAAACTGCCGATCATGGT
GCGCACCGAAACGGTAGCGATGGCCGACTATGCGCCGAGAACCTCGCTGACCGGTGTGATCGCGGCGCGCACGCTGAACA
ATCTGTCGTTCCGGGTCGGCGGCCGTATTGCCGAGCGGCTTGTCGATGTCGGCCAGCATGTCGACCAGGGTGCGGTGCTT
GCCCGCATCGATCCGCAGGAGCAGCAATCCGATCTGCGCTCCGCACAAGCCGATCTCGACGCAGCACGAGCGCAGCTGAC
CCAGTCCGCCGCCGCCTTCGAGCGGCAGAAGACGCTGCTTGCCCAGGGCTTCACCACCAGGCGCGACTATGACGCCGCCG
ACCAGGCGCTGAAAGTGGCGCAAGGCAGCGTCGATGCGGCGCAGAGCGCATTCGCCAACGCCCAGCAGAACCTGTCCTTC
ACCGAACTCAAGGCGGGCGCACCCGGCGTCATCACCGCCCGTCAGGTCGAAACCGGCCAGGTGGTGCAGGCGGCGCAAAC
CGTCTTCACCGTCGCCGAGGATGGCGACCGCGACGCCGTCTTCAACGTGCAGGAGACGCTGGTCGCCAGGACGCCGGCCT
CGCCGGCGGTGACGATCACGCTGTTGTCCGATCCGCAGGTCAGGGCGACAGGCAAGGTGCGCGAAATCTCGCCGGTGGTC
GACCAAGCCTCCGGTTCGATCCGGGTCAAGGTCGGCATTGCCGACACGCCAGCCGGCATGCCGCTGGGGGCGGCCGTCAT
CGGCTCGGTCAGCGCCAAGCCGGCGAAGGCGATCCTGCTGCCCTGGCAGGCGCTGACATCCAGCGCCGGCAAACCGGCAG
TCTGGATCGTCGACCCCTCGACCAAGGCGGTGGCGACGACGCCGGTCGAGGTGCTGGCTTTCGATTCAGGCACGGTCGTC
ATCGCCAGCGGGCTGAACGAAGGCCAAAGCGTCGTGACCGCAGGCGGGCAGTTGCTCAGTCCCGGCCAGACGGTCGAGAT
ATCGGGGGCGGCCCAATGA

Upstream 100 bases:

>100_bases
CCCGCAGCTGGGGGAGCCCATGATGAGGAACGCGACATCGTCCGTCTCGCCGCCATCCGTCAGAACCTCCAGCCTTTTGT
CATTTCCAATCGCCTCGGCA

Downstream 100 bases:

>100_bases
ACCGGTCCATCGTGTTTGGCCTGTTCGCGCTTGGCGTGCTCGCCGCATGCTCGAAATCGGATGAAAAGCCGCCGGAGATC
ATCCGGCCTGTTCTGTCGGT

Product: RND efflux membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MCVCAAALLLAGCQKQEAADKKLPIMVRTETVAMADYAPRTSLTGVIAARTLNNLSFRVGGRIAERLVDVGQHVDQGAVL
ARIDPQEQQSDLRSAQADLDAARAQLTQSAAAFERQKTLLAQGFTTRRDYDAADQALKVAQGSVDAAQSAFANAQQNLSF
TELKAGAPGVITARQVETGQVVQAAQTVFTVAEDGDRDAVFNVQETLVARTPASPAVTITLLSDPQVRATGKVREISPVV
DQASGSIRVKVGIADTPAGMPLGAAVIGSVSAKPAKAILLPWQALTSSAGKPAVWIVDPSTKAVATTPVEVLAFDSGTVV
IASGLNEGQSVVTAGGQLLSPGQTVEISGAAQ

Sequences:

>Translated_352_residues
MCVCAAALLLAGCQKQEAADKKLPIMVRTETVAMADYAPRTSLTGVIAARTLNNLSFRVGGRIAERLVDVGQHVDQGAVL
ARIDPQEQQSDLRSAQADLDAARAQLTQSAAAFERQKTLLAQGFTTRRDYDAADQALKVAQGSVDAAQSAFANAQQNLSF
TELKAGAPGVITARQVETGQVVQAAQTVFTVAEDGDRDAVFNVQETLVARTPASPAVTITLLSDPQVRATGKVREISPVV
DQASGSIRVKVGIADTPAGMPLGAAVIGSVSAKPAKAILLPWQALTSSAGKPAVWIVDPSTKAVATTPVEVLAFDSGTVV
IASGLNEGQSVVTAGGQLLSPGQTVEISGAAQ
>Mature_352_residues
MCVCAAALLLAGCQKQEAADKKLPIMVRTETVAMADYAPRTSLTGVIAARTLNNLSFRVGGRIAERLVDVGQHVDQGAVL
ARIDPQEQQSDLRSAQADLDAARAQLTQSAAAFERQKTLLAQGFTTRRDYDAADQALKVAQGSVDAAQSAFANAQQNLSF
TELKAGAPGVITARQVETGQVVQAAQTVFTVAEDGDRDAVFNVQETLVARTPASPAVTITLLSDPQVRATGKVREISPVV
DQASGSIRVKVGIADTPAGMPLGAAVIGSVSAKPAKAILLPWQALTSSAGKPAVWIVDPSTKAVATTPVEVLAFDSGTVV
IASGLNEGQSVVTAGGQLLSPGQTVEISGAAQ

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=305, Percent_Identity=28.8524590163934, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=25.625, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081951, Length=167, Percent_Identity=29.3413173652695, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 36320; Mature: 36320

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVCAAALLLAGCQKQEAADKKLPIMVRTETVAMADYAPRTSLTGVIAARTLNNLSFRVG
CHHHHHHHHHHCCCHHHHCCCCCCEEEEECEEEEECCCCCCCHHHHHHHHHHCCCEEEHH
GRIAERLVDVGQHVDQGAVLARIDPQEQQSDLRSAQADLDAARAQLTQSAAAFERQKTLL
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGFTTRRDYDAADQALKVAQGSVDAAQSAFANAQQNLSFTELKAGAPGVITARQVETGQ
HCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCHH
VVQAAQTVFTVAEDGDRDAVFNVQETLVARTPASPAVTITLLSDPQVRATGKVREISPVV
HHHHHHHHEEEECCCCCCEEEEHHHHHHCCCCCCCEEEEEEECCCCEECCCCCHHHHHHH
DQASGSIRVKVGIADTPAGMPLGAAVIGSVSAKPAKAILLPWQALTSSAGKPAVWIVDPS
HCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCCCCEEEEEEHHHHHCCCCCCEEEEECCC
TKAVATTPVEVLAFDSGTVVIASGLNEGQSVVTAGGQLLSPGQTVEISGAAQ
CCEEEECCEEEEEECCCCEEEEECCCCCCEEEECCCEEECCCCEEEECCCCC
>Mature Secondary Structure
MCVCAAALLLAGCQKQEAADKKLPIMVRTETVAMADYAPRTSLTGVIAARTLNNLSFRVG
CHHHHHHHHHHCCCHHHHCCCCCCEEEEECEEEEECCCCCCCHHHHHHHHHHCCCEEEHH
GRIAERLVDVGQHVDQGAVLARIDPQEQQSDLRSAQADLDAARAQLTQSAAAFERQKTLL
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGFTTRRDYDAADQALKVAQGSVDAAQSAFANAQQNLSFTELKAGAPGVITARQVETGQ
HCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCHH
VVQAAQTVFTVAEDGDRDAVFNVQETLVARTPASPAVTITLLSDPQVRATGKVREISPVV
HHHHHHHHEEEECCCCCCEEEEHHHHHHCCCCCCCEEEEEEECCCCEECCCCCHHHHHHH
DQASGSIRVKVGIADTPAGMPLGAAVIGSVSAKPAKAILLPWQALTSSAGKPAVWIVDPS
HCCCCEEEEEEEECCCCCCCCCCHHHHCCCCCCCCEEEEEEHHHHHCCCCCCEEEEECCC
TKAVATTPVEVLAFDSGTVVIASGLNEGQSVVTAGGQLLSPGQTVEISGAAQ
CCEEEECCEEEEEECCCCEEEEECCCCCCEEEECCCEEECCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]