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The map label for this gene is acxB [H]

Identifier: 13474373

GI number: 13474373

Start: 4175730

End: 4177934

Strand: Direct

Name: acxB [H]

Synonym: mlr5246

Alternate gene names: 13474373

Gene position: 4175730-4177934 (Clockwise)

Preceding gene: 13474372

Following gene: 13474374

Centisome position: 59.35

GC content: 62.49

Gene sequence:

>2205_bases
ATGCTGGACAAACCCGCCTCCGCGCTGCGCATCCGCGAACGGCTGATCGAATCCGAACGGCTCATGGAAGAGACCGGCTG
CTATGACGGCATCACGGAACTCCATCTGCGCAACCAGGATCCGCTGAAATTCGAGACGCTGCACACCAAGCTGCGCGCCT
ATTGCGTCTCGGCGCGCGAAATGGCCCGCCGCATCTCGGCTTCGCCCGGCGTGCGCGAAGTCGGCGAAATGGTCGTCGCC
ATCTACACGCCGGAAGGCGATGCGATCGCGCTCTCCAACGGCATCATGGTGCATGTGCACACGATGAGCCGCTTCATCAA
ATGGATGATCCGCAACGGTTACGAGGAAAATCCTTGCATCCGCGACGGCGACATCTTCGCCAACAACGATGCCTTCATCG
GCACCGTTCAGGTGCCCGACGTCATGGACGTGGTGCCGATCTTTCACTCCGGCAAGCTGGTCGGCTGGGCCGGCGCGGTC
TGCCACGAACTCGAGGCCGGCGGCATCACTCCCGGCGGTGACGTGGCGCTGGCCCAGGAGCGCTTCACCGAGGGTCTCTT
CGTCTGCGCTGAAAAGGTCGGCGAGAACGACGAGATCCGTCGCGACTATGTCATCCGCTGCGAGCGCAATTTGCGCATGC
CGATCTACTGGGTGCTCGACGAGAAGGCCAAGGTCGCCTCCTGCATCGACATGCGTGAAAGCGTCAAGGCGTTGATCGAC
GAGATCGGCCTGGACTACTGGATGCAGGTGTCGAAGGAGTTCATCGAGGAAGGCCGCCGTGCCCAGCTCGCCCGCACGCG
CCAGCTCACGGTTCCCGGCATCTATCGCGGCCACACTTTCTACGGCCATGTCACCGCGGGCAAGCCGGGCTACCAGCCGC
TCGGCGATCCCGACTGGCTCTACAACATGCCGATCGAAATGGAGATCACCACCGACGGCAAGATCATCATGGATTTCGAG
GGCACGCAGCCCTGGGGCTACCATTCGATGAACTGCACGCCGGCCGGCATGGATGGCGGCATGTTCGTGACCTTGACCCA
GCACATGAATTTCGAAGGTCTGGTCAATGACGGCGCCTGGATGGCGACCGAGCTGAAGCTGCCGCATGGCACCTGGACCA
ATCCGGACAATGAGATGGTGGCGACCGCCACCTCATGGGCCTTGCTGCTGCCGGCCTATGGCGTGTTCCAGCGGCTGTTG
TCGCGCTCCTTCATCGGCCGTGGCTTTGTCGAGGAAGCCTTCGTCGGCCAGGTCAACAGCCCGATGATCGAGATGGGCGG
CACCAGCCAGTACGGCAAGCTGTTCGGCATGGCGCATTTCGAATGCGCCGCCGCCGGCTCCGGCGCGCTGGCGATCAAGG
ATGGGCTGGACACAGCCTATGTCGGGTGGAACCCCGAATCCGACATGGGCAATATCGAAATCTGGGAACAGAACATGCCG
ATGCTCTATATCGGCCGCTCGATCGTTCCCAATTCCGGCGGCGCCGGCAAGTATCGCGGCGGCTGCTCCTTCGTCTCGAC
CTGGCTGGTCAGCAAGACCGATCATCTCAGGCTGGTTACGTCAGAGCATTCCTCCCGCGTGTTCGACAATGGCGGCATGT
GCGGCGGCTACCCGGCGCCGACCTGCCAAAAGCACCGCGCCGTGCGCGATAGCGACATCTTCGAACTCGCCGAAAAGCGG
GCGCCGCTGGCGCATCACACCGGCACCAACCCGCATCGCTCGGAACTCGAACTGCGGCTGCAGGGCGAGCATGTGACGAT
GGAGGGGCCCTACATCACCGCCCCGCACAAGACCGGCGACGTCTTCACCCATTCCTACAATGGCGGTGGCGGTTATGGCG
ACGTGCTGGAACGCGATCCGCTCAAGACGGCCATGGATGTCGAGAACGGCTATCTCACCAAGGAAGCGGCCGAGGGCATT
TTCGGCATCATGCTCGATGAGGACGAGGACGGCTATCCCGTCGCCAACCTCGAGGCCACCAAGCGCCACCGCGCCGAAAT
GCGCGCCAATCGCCTGGCCAAGGCAAAGCCGGTCTCCGAGTGGATCGCCAGCGAACGCGGCCGTGTCGAAAAGGCCGATT
TCGCTCCGGAAGTGAAGAAAATGTATGCCAGCGCGATCAAGCTGTCGTCGCGCTTCACCAGGGAATTCAGCGATTTCTGG
AACGTCGACGCCAGATCGATCTTCATGCCGGGAGCAAAGCCATGA

Upstream 100 bases:

>100_bases
AACATCCCGCCACCACGCTCGTCGTTCATCCGCAGGACCGTGTCCATGTCGATGAATGGACGCTGCTACACTACACCCAC
GCTTGAGAAGGGCGAACGCC

Downstream 100 bases:

>100_bases
CCTCGTACAGCAAGGAAGTCATCGCCGATCTGGTCGCGGGCACTTTGCCCTGGCCGCAGACACGCCGCGTCATGAGCGCC
TACAAGGATGACGACCGCTT

Product: hydantoin utilization protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 734; Mature: 734

Protein sequence:

>734_residues
MLDKPASALRIRERLIESERLMEETGCYDGITELHLRNQDPLKFETLHTKLRAYCVSAREMARRISASPGVREVGEMVVA
IYTPEGDAIALSNGIMVHVHTMSRFIKWMIRNGYEENPCIRDGDIFANNDAFIGTVQVPDVMDVVPIFHSGKLVGWAGAV
CHELEAGGITPGGDVALAQERFTEGLFVCAEKVGENDEIRRDYVIRCERNLRMPIYWVLDEKAKVASCIDMRESVKALID
EIGLDYWMQVSKEFIEEGRRAQLARTRQLTVPGIYRGHTFYGHVTAGKPGYQPLGDPDWLYNMPIEMEITTDGKIIMDFE
GTQPWGYHSMNCTPAGMDGGMFVTLTQHMNFEGLVNDGAWMATELKLPHGTWTNPDNEMVATATSWALLLPAYGVFQRLL
SRSFIGRGFVEEAFVGQVNSPMIEMGGTSQYGKLFGMAHFECAAAGSGALAIKDGLDTAYVGWNPESDMGNIEIWEQNMP
MLYIGRSIVPNSGGAGKYRGGCSFVSTWLVSKTDHLRLVTSEHSSRVFDNGGMCGGYPAPTCQKHRAVRDSDIFELAEKR
APLAHHTGTNPHRSELELRLQGEHVTMEGPYITAPHKTGDVFTHSYNGGGGYGDVLERDPLKTAMDVENGYLTKEAAEGI
FGIMLDEDEDGYPVANLEATKRHRAEMRANRLAKAKPVSEWIASERGRVEKADFAPEVKKMYASAIKLSSRFTREFSDFW
NVDARSIFMPGAKP

Sequences:

>Translated_734_residues
MLDKPASALRIRERLIESERLMEETGCYDGITELHLRNQDPLKFETLHTKLRAYCVSAREMARRISASPGVREVGEMVVA
IYTPEGDAIALSNGIMVHVHTMSRFIKWMIRNGYEENPCIRDGDIFANNDAFIGTVQVPDVMDVVPIFHSGKLVGWAGAV
CHELEAGGITPGGDVALAQERFTEGLFVCAEKVGENDEIRRDYVIRCERNLRMPIYWVLDEKAKVASCIDMRESVKALID
EIGLDYWMQVSKEFIEEGRRAQLARTRQLTVPGIYRGHTFYGHVTAGKPGYQPLGDPDWLYNMPIEMEITTDGKIIMDFE
GTQPWGYHSMNCTPAGMDGGMFVTLTQHMNFEGLVNDGAWMATELKLPHGTWTNPDNEMVATATSWALLLPAYGVFQRLL
SRSFIGRGFVEEAFVGQVNSPMIEMGGTSQYGKLFGMAHFECAAAGSGALAIKDGLDTAYVGWNPESDMGNIEIWEQNMP
MLYIGRSIVPNSGGAGKYRGGCSFVSTWLVSKTDHLRLVTSEHSSRVFDNGGMCGGYPAPTCQKHRAVRDSDIFELAEKR
APLAHHTGTNPHRSELELRLQGEHVTMEGPYITAPHKTGDVFTHSYNGGGGYGDVLERDPLKTAMDVENGYLTKEAAEGI
FGIMLDEDEDGYPVANLEATKRHRAEMRANRLAKAKPVSEWIASERGRVEKADFAPEVKKMYASAIKLSSRFTREFSDFW
NVDARSIFMPGAKP
>Mature_734_residues
MLDKPASALRIRERLIESERLMEETGCYDGITELHLRNQDPLKFETLHTKLRAYCVSAREMARRISASPGVREVGEMVVA
IYTPEGDAIALSNGIMVHVHTMSRFIKWMIRNGYEENPCIRDGDIFANNDAFIGTVQVPDVMDVVPIFHSGKLVGWAGAV
CHELEAGGITPGGDVALAQERFTEGLFVCAEKVGENDEIRRDYVIRCERNLRMPIYWVLDEKAKVASCIDMRESVKALID
EIGLDYWMQVSKEFIEEGRRAQLARTRQLTVPGIYRGHTFYGHVTAGKPGYQPLGDPDWLYNMPIEMEITTDGKIIMDFE
GTQPWGYHSMNCTPAGMDGGMFVTLTQHMNFEGLVNDGAWMATELKLPHGTWTNPDNEMVATATSWALLLPAYGVFQRLL
SRSFIGRGFVEEAFVGQVNSPMIEMGGTSQYGKLFGMAHFECAAAGSGALAIKDGLDTAYVGWNPESDMGNIEIWEQNMP
MLYIGRSIVPNSGGAGKYRGGCSFVSTWLVSKTDHLRLVTSEHSSRVFDNGGMCGGYPAPTCQKHRAVRDSDIFELAEKR
APLAHHTGTNPHRSELELRLQGEHVTMEGPYITAPHKTGDVFTHSYNGGGGYGDVLERDPLKTAMDVENGYLTKEAAEGI
FGIMLDEDEDGYPVANLEATKRHRAEMRANRLAKAKPVSEWIASERGRVEKADFAPEVKKMYASAIKLSSRFTREFSDFW
NVDARSIFMPGAKP

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901900, Length=521, Percent_Identity=23.0326295585413, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 81682; Mature: 81682

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKPASALRIRERLIESERLMEETGCYDGITELHLRNQDPLKFETLHTKLRAYCVSARE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHHH
MARRISASPGVREVGEMVVAIYTPEGDAIALSNGIMVHVHTMSRFIKWMIRNGYEENPCI
HHHHHCCCCCHHHHCCEEEEEECCCCCEEEECCCEEEEEHHHHHHHHHHHHCCCCCCCCC
RDGDIFANNDAFIGTVQVPDVMDVVPIFHSGKLVGWAGAVCHELEAGGITPGGDVALAQE
CCCCEEECCCCEEEEEECCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCEEEHHH
RFTEGLFVCAEKVGENDEIRRDYVIRCERNLRMPIYWVLDEKAKVASCIDMRESVKALID
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
EIGLDYWMQVSKEFIEEGRRAQLARTRQLTVPGIYRGHTFYGHVTAGKPGYQPLGDPDWL
HHCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCEEEEEEECCCCCCCCCCCCCCE
YNMPIEMEITTDGKIIMDFEGTQPWGYHSMNCTPAGMDGGMFVTLTQHMNFEGLVNDGAW
EECCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEECCCCE
MATELKLPHGTWTNPDNEMVATATSWALLLPAYGVFQRLLSRSFIGRGFVEEAFVGQVNS
EEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
PMIEMGGTSQYGKLFGMAHFECAAAGSGALAIKDGLDTAYVGWNPESDMGNIEIWEQNMP
CEEEECCCCHHHHHHCCHHHEEECCCCCEEEEECCCCEEEECCCCCCCCCCEEEEECCCC
MLYIGRSIVPNSGGAGKYRGGCSFVSTWLVSKTDHLRLVTSEHSSRVFDNGGMCGGYPAP
EEEECCEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCC
TCQKHRAVRDSDIFELAEKRAPLAHHTGTNPHRSELELRLQGEHVTMEGPYITAPHKTGD
CHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEEEECCCEEECCCCCCC
VFTHSYNGGGGYGDVLERDPLKTAMDVENGYLTKEAAEGIFGIMLDEDEDGYPVANLEAT
EEEEECCCCCCCCCCCCCCCCHHHHCCCCCEECHHHHCCEEEEEEECCCCCCCCCCCHHH
KRHRAEMRANRLAKAKPVSEWIASERGRVEKADFAPEVKKMYASAIKLSSRFTREFSDFW
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NVDARSIFMPGAKP
CCCCCEEECCCCCC
>Mature Secondary Structure
MLDKPASALRIRERLIESERLMEETGCYDGITELHLRNQDPLKFETLHTKLRAYCVSARE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHHHH
MARRISASPGVREVGEMVVAIYTPEGDAIALSNGIMVHVHTMSRFIKWMIRNGYEENPCI
HHHHHCCCCCHHHHCCEEEEEECCCCCEEEECCCEEEEEHHHHHHHHHHHHCCCCCCCCC
RDGDIFANNDAFIGTVQVPDVMDVVPIFHSGKLVGWAGAVCHELEAGGITPGGDVALAQE
CCCCEEECCCCEEEEEECCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCEEEHHH
RFTEGLFVCAEKVGENDEIRRDYVIRCERNLRMPIYWVLDEKAKVASCIDMRESVKALID
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
EIGLDYWMQVSKEFIEEGRRAQLARTRQLTVPGIYRGHTFYGHVTAGKPGYQPLGDPDWL
HHCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCEEEEEEECCCCCCCCCCCCCCE
YNMPIEMEITTDGKIIMDFEGTQPWGYHSMNCTPAGMDGGMFVTLTQHMNFEGLVNDGAW
EECCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEECCCCE
MATELKLPHGTWTNPDNEMVATATSWALLLPAYGVFQRLLSRSFIGRGFVEEAFVGQVNS
EEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
PMIEMGGTSQYGKLFGMAHFECAAAGSGALAIKDGLDTAYVGWNPESDMGNIEIWEQNMP
CEEEECCCCHHHHHHCCHHHEEECCCCCEEEEECCCCEEEECCCCCCCCCCEEEEECCCC
MLYIGRSIVPNSGGAGKYRGGCSFVSTWLVSKTDHLRLVTSEHSSRVFDNGGMCGGYPAP
EEEECCEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCC
TCQKHRAVRDSDIFELAEKRAPLAHHTGTNPHRSELELRLQGEHVTMEGPYITAPHKTGD
CHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEEEECCCEEECCCCCCC
VFTHSYNGGGGYGDVLERDPLKTAMDVENGYLTKEAAEGIFGIMLDEDEDGYPVANLEAT
EEEEECCCCCCCCCCCCCCCCHHHHCCCCCEECHHHHCCEEEEEEECCCCCCCCCCCHHH
KRHRAEMRANRLAKAKPVSEWIASERGRVEKADFAPEVKKMYASAIKLSSRFTREFSDFW
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NVDARSIFMPGAKP
CCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]