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The map label for this gene is acxA [H]

Identifier: 13474372

GI number: 13474372

Start: 4173574

End: 4175715

Strand: Direct

Name: acxA [H]

Synonym: mlr5245

Alternate gene names: 13474372

Gene position: 4173574-4175715 (Clockwise)

Preceding gene: 13474367

Following gene: 13474373

Centisome position: 59.32

GC content: 64.61

Gene sequence:

>2142_bases
GTGGACCAGATCACTACCAACCCCATCGTCATCGGCATCGACGCCGGCGGCACCATGACCGACACGATCCTTGTCGATCA
GGACGGCCACTTCAAGATCGGCAAGTCGGCGACCACGCCGAAGAACGAGGCCGAAGGTTTCCTTGCCTCGGCCGAGGACG
CGGCCGATGCCTGGGGCATCTCGCTGGAGCAGCTGTTCTCCGGCGTCAACGTCGTGCTCTATTCCGGCACCGGCATGCTC
AACACACTGTTGTCGCGCACCGGCCGCCGGCTCGGCCTCATCACCACCAAGGGCCTGGAAGACATGATCCTGATGGGCCG
CGGCCTGCAGGCCTGGGCCGACTATTCCTATGCTGATCGGCTCCACGCGGTGACGCACCAGCATCCCGACCCGCTGGTGC
CGCGCCGCCGCACCCATGGCGTCACCGAGCGCATCGACCAGTTCGGCGACATCATCCTGCCGCTCTACGAGCACGAGGTC
GCTGCGGCCGCCAGGAAGCTGATCGCCGACAAGGTCGAGGCGATCTGCATCATGACCATCTTCTCGCACGTCAATCCCGT
GCACGAGAAGCGCATTGCCGAGATCTGCCGCGAGGAGATCGCCAAGGCCGGCGCCGACATCCTCGTCTACACCAGCCACG
AGGTGCGCCCGGTCATCCGCGAACAGTCGCGGCTGAACTCCGTGCTGATCGAGGCCTATGCCACCTCGCGCGGCCGCAAG
CAGCTCAAGGGCATCGAGGACGTCTCCAAGAAATACGGCTTCAAATATGGCGTGCAGACGCTGCTCTCCTTCGGCGGCCT
GACATCAATCAACCATCCGCGCCTGCATGAGACGATGATCTCCGGCCCGATCGGCGGCATTCTGGGCGCGGCCTATGTCG
GCAAGCTGATCGGCAACGACTCGCTGATCTGCTCGGACATGGGTGGCACCTCCTTCGACATGGGCGTCATCACCCGCGGC
CAGACCCGGATCGAGAACGAGCCGCTGATGGACCGCTTCAAGCTCAATGTGCCGACGCTGCATCTCGACACGATCGGCGC
CGGCGCCGGCATGATCCTGAAAGTCGATCCGCTGACCAAGAAGGTTTCGCTCGGACCGGAAAGCGCCGGCTCCGATCCCG
GTCCGATCTGCTTCGCCAAGGGCGGCACCGAGCCGACCATCGCCGATTGCGACGCCATCCTCGGCCGCCTCAATCCGCAC
TATTTCCTTGGCGGCAAGGTCGTGTTGCAGGTCGAGAAGGCGAGGGCGGCCTTCGAGGAAAAATGTTCGCGCCTGCTTGG
CGTCGGTGTCGAGGAAGCCGCCGAAGGCATGATCGAGATGCTGGAGGCCGACGCCAACAACGCGCTGCGCCGCGTCATCT
CCGGCCAGGGCATCCACCCCTCGGAATTCACGCTGCTCTCCTATGGCGGTTCGGGCCCGCTGCATCTGGCCGGCTGCTCT
AGGGGCATCGGCTTCAAGGACATCATCACCTTCCAGTTCGCCGCCGCCTTCTCGGCCTTCGGCTGCACCACCGCCGATTT
CATGCGCCGCCACTCCGTGTCGACGCAGCACGACATCGGTGCGCGCGCCGGCGACGACGAGCTGCTCGCCTTCGGCAAGA
AGGTCACCGATGTCTGGGATGATCTCACAAGGGCGGCGGTCGACGAGATGATCGTGGACGGCCACGCGCGCGACAAGATC
AAGACCGTGCCGTTCCTGATGATGCGCTACACCGGCCAGCTCGAGGACGTCGAGGTGATGGCGCCGCTGCCGGCCATCCA
ATCGGCCGACGACATGCGCAGGGTCATCGACGAGTTCGAGGCGGTCTACGCCAAGGTCAACCATCGCGTTTCGCGCTATG
GCGAAGCCGGCTTCTCGATCACCGAGCTCGGCCTCATCGCCACCGCCGACAAGGTCAAGCCGGTGCTGCTCAAGCGCCCG
CTCGGCAAGTCGGATCCTTCCGCTGCCCACAAGGGGGTGCGCGAGGCCTATATTGGCGGCCGCTGGCACAAGGCCAATCT
CTACGAGATGGACCGTCTGCAGCCCGGCCACGAGGTCATCGGCCCGGCCATTATCGAACATCCCGCCACCACGCTCGTCG
TTCATCCGCAGGACCGTGTCCATGTCGATGAATGGACGCTGCTACACTACACCCACGCTTGA

Upstream 100 bases:

>100_bases
CGGCGAACCGCGCCGCGCAGTCATTGTGTCTTTAGGCATATGGCGCGATCCGCGCGATCGAATCTAGCCTGCGGTCATTC
TCGAAGAGGGAAGGCGACCC

Downstream 100 bases:

>100_bases
GAAGGGCGAACGCCATGCTGGACAAACCCGCCTCCGCGCTGCGCATCCGCGAACGGCTGATCGAATCCGAACGGCTCATG
GAAGAGACCGGCTGCTATGA

Product: hydantoin utilization protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MDQITTNPIVIGIDAGGTMTDTILVDQDGHFKIGKSATTPKNEAEGFLASAEDAADAWGISLEQLFSGVNVVLYSGTGML
NTLLSRTGRRLGLITTKGLEDMILMGRGLQAWADYSYADRLHAVTHQHPDPLVPRRRTHGVTERIDQFGDIILPLYEHEV
AAAARKLIADKVEAICIMTIFSHVNPVHEKRIAEICREEIAKAGADILVYTSHEVRPVIREQSRLNSVLIEAYATSRGRK
QLKGIEDVSKKYGFKYGVQTLLSFGGLTSINHPRLHETMISGPIGGILGAAYVGKLIGNDSLICSDMGGTSFDMGVITRG
QTRIENEPLMDRFKLNVPTLHLDTIGAGAGMILKVDPLTKKVSLGPESAGSDPGPICFAKGGTEPTIADCDAILGRLNPH
YFLGGKVVLQVEKARAAFEEKCSRLLGVGVEEAAEGMIEMLEADANNALRRVISGQGIHPSEFTLLSYGGSGPLHLAGCS
RGIGFKDIITFQFAAAFSAFGCTTADFMRRHSVSTQHDIGARAGDDELLAFGKKVTDVWDDLTRAAVDEMIVDGHARDKI
KTVPFLMMRYTGQLEDVEVMAPLPAIQSADDMRRVIDEFEAVYAKVNHRVSRYGEAGFSITELGLIATADKVKPVLLKRP
LGKSDPSAAHKGVREAYIGGRWHKANLYEMDRLQPGHEVIGPAIIEHPATTLVVHPQDRVHVDEWTLLHYTHA

Sequences:

>Translated_713_residues
MDQITTNPIVIGIDAGGTMTDTILVDQDGHFKIGKSATTPKNEAEGFLASAEDAADAWGISLEQLFSGVNVVLYSGTGML
NTLLSRTGRRLGLITTKGLEDMILMGRGLQAWADYSYADRLHAVTHQHPDPLVPRRRTHGVTERIDQFGDIILPLYEHEV
AAAARKLIADKVEAICIMTIFSHVNPVHEKRIAEICREEIAKAGADILVYTSHEVRPVIREQSRLNSVLIEAYATSRGRK
QLKGIEDVSKKYGFKYGVQTLLSFGGLTSINHPRLHETMISGPIGGILGAAYVGKLIGNDSLICSDMGGTSFDMGVITRG
QTRIENEPLMDRFKLNVPTLHLDTIGAGAGMILKVDPLTKKVSLGPESAGSDPGPICFAKGGTEPTIADCDAILGRLNPH
YFLGGKVVLQVEKARAAFEEKCSRLLGVGVEEAAEGMIEMLEADANNALRRVISGQGIHPSEFTLLSYGGSGPLHLAGCS
RGIGFKDIITFQFAAAFSAFGCTTADFMRRHSVSTQHDIGARAGDDELLAFGKKVTDVWDDLTRAAVDEMIVDGHARDKI
KTVPFLMMRYTGQLEDVEVMAPLPAIQSADDMRRVIDEFEAVYAKVNHRVSRYGEAGFSITELGLIATADKVKPVLLKRP
LGKSDPSAAHKGVREAYIGGRWHKANLYEMDRLQPGHEVIGPAIIEHPATTLVVHPQDRVHVDEWTLLHYTHA
>Mature_713_residues
MDQITTNPIVIGIDAGGTMTDTILVDQDGHFKIGKSATTPKNEAEGFLASAEDAADAWGISLEQLFSGVNVVLYSGTGML
NTLLSRTGRRLGLITTKGLEDMILMGRGLQAWADYSYADRLHAVTHQHPDPLVPRRRTHGVTERIDQFGDIILPLYEHEV
AAAARKLIADKVEAICIMTIFSHVNPVHEKRIAEICREEIAKAGADILVYTSHEVRPVIREQSRLNSVLIEAYATSRGRK
QLKGIEDVSKKYGFKYGVQTLLSFGGLTSINHPRLHETMISGPIGGILGAAYVGKLIGNDSLICSDMGGTSFDMGVITRG
QTRIENEPLMDRFKLNVPTLHLDTIGAGAGMILKVDPLTKKVSLGPESAGSDPGPICFAKGGTEPTIADCDAILGRLNPH
YFLGGKVVLQVEKARAAFEEKCSRLLGVGVEEAAEGMIEMLEADANNALRRVISGQGIHPSEFTLLSYGGSGPLHLAGCS
RGIGFKDIITFQFAAAFSAFGCTTADFMRRHSVSTQHDIGARAGDDELLAFGKKVTDVWDDLTRAAVDEMIVDGHARDKI
KTVPFLMMRYTGQLEDVEVMAPLPAIQSADDMRRVIDEFEAVYAKVNHRVSRYGEAGFSITELGLIATADKVKPVLLKRP
LGKSDPSAAHKGVREAYIGGRWHKANLYEMDRLQPGHEVIGPAIIEHPATTLVVHPQDRVHVDEWTLLHYTHA

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=735, Percent_Identity=25.3061224489796, Blast_Score=130, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI133901900, Length=738, Percent_Identity=23.3062330623306, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322634, Length=757, Percent_Identity=24.7027741083223, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45550492, Length=757, Percent_Identity=25.7595772787318, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 77579; Mature: 77579

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQITTNPIVIGIDAGGTMTDTILVDQDGHFKIGKSATTPKNEAEGFLASAEDAADAWGI
CCCCCCCCEEEEECCCCCEEEEEEEECCCCEEECCCCCCCCCHHCCCEECCCHHHHHHCC
SLEQLFSGVNVVLYSGTGMLNTLLSRTGRRLGLITTKGLEDMILMGRGLQAWADYSYADR
CHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCHHHHHCCHHHHH
LHAVTHQHPDPLVPRRRTHGVTERIDQFGDIILPLYEHEVAAAARKLIADKVEAICIMTI
HHHHHCCCCCCCCCCHHHCCHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSHVNPVHEKRIAEICREEIAKAGADILVYTSHEVRPVIREQSRLNSVLIEAYATSRGRK
HHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCHHH
QLKGIEDVSKKYGFKYGVQTLLSFGGLTSINHPRLHETMISGPIGGILGAAYVGKLIGND
HHHCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCC
SLICSDMGGTSFDMGVITRGQTRIENEPLMDRFKLNVPTLHLDTIGAGAGMILKVDPLTK
CEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCEEEEECCCCC
KVSLGPESAGSDPGPICFAKGGTEPTIADCDAILGRLNPHYFLGGKVVLQVEKARAAFEE
EECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEECCEEEEEEHHHHHHHHH
KCSRLLGVGVEEAAEGMIEMLEADANNALRRVISGQGIHPSEFTLLSYGGSGPLHLAGCS
HHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEECCC
RGIGFKDIITFQFAAAFSAFGCTTADFMRRHSVSTQHDIGARAGDDELLAFGKKVTDVWD
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHH
DLTRAAVDEMIVDGHARDKIKTVPFLMMRYTGQLEDVEVMAPLPAIQSADDMRRVIDEFE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHH
AVYAKVNHRVSRYGEAGFSITELGLIATADKVKPVLLKRPLGKSDPSAAHKGVREAYIGG
HHHHHHHHHHHHHCCCCCCHHHHHHEEEHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCC
RWHKANLYEMDRLQPGHEVIGPAIIEHPATTLVVHPQDRVHVDEWTLLHYTHA
EEEECCCHHHHCCCCCHHHHCCHHHCCCCCEEEECCCCCEEECCEEEEEEECC
>Mature Secondary Structure
MDQITTNPIVIGIDAGGTMTDTILVDQDGHFKIGKSATTPKNEAEGFLASAEDAADAWGI
CCCCCCCCEEEEECCCCCEEEEEEEECCCCEEECCCCCCCCCHHCCCEECCCHHHHHHCC
SLEQLFSGVNVVLYSGTGMLNTLLSRTGRRLGLITTKGLEDMILMGRGLQAWADYSYADR
CHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCHHHHHCCHHHHH
LHAVTHQHPDPLVPRRRTHGVTERIDQFGDIILPLYEHEVAAAARKLIADKVEAICIMTI
HHHHHCCCCCCCCCCHHHCCHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSHVNPVHEKRIAEICREEIAKAGADILVYTSHEVRPVIREQSRLNSVLIEAYATSRGRK
HHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCHHH
QLKGIEDVSKKYGFKYGVQTLLSFGGLTSINHPRLHETMISGPIGGILGAAYVGKLIGND
HHHCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCC
SLICSDMGGTSFDMGVITRGQTRIENEPLMDRFKLNVPTLHLDTIGAGAGMILKVDPLTK
CEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCEEEEECCCCC
KVSLGPESAGSDPGPICFAKGGTEPTIADCDAILGRLNPHYFLGGKVVLQVEKARAAFEE
EECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEECCEEEEEEHHHHHHHHH
KCSRLLGVGVEEAAEGMIEMLEADANNALRRVISGQGIHPSEFTLLSYGGSGPLHLAGCS
HHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEECCC
RGIGFKDIITFQFAAAFSAFGCTTADFMRRHSVSTQHDIGARAGDDELLAFGKKVTDVWD
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHH
DLTRAAVDEMIVDGHARDKIKTVPFLMMRYTGQLEDVEVMAPLPAIQSADDMRRVIDEFE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHH
AVYAKVNHRVSRYGEAGFSITELGLIATADKVKPVLLKRPLGKSDPSAAHKGVREAYIGG
HHHHHHHHHHHHHCCCCCCHHHHHHEEEHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCC
RWHKANLYEMDRLQPGHEVIGPAIIEHPATTLVVHPQDRVHVDEWTLLHYTHA
EEEECCCHHHHCCCCCHHHHCCHHHCCCCCEEEECCCCCEEECCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]