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The map label for this gene is pucD [H]

Identifier: 13474282

GI number: 13474282

Start: 4072364

End: 4074712

Strand: Direct

Name: pucD [H]

Synonym: mlr5135

Alternate gene names: 13474282

Gene position: 4072364-4074712 (Clockwise)

Preceding gene: 13474281

Following gene: 13474283

Centisome position: 57.88

GC content: 63.73

Gene sequence:

>2349_bases
ATGATGAACAAGCACGCCACATCAAACCTCAAAGCCGAGAAGATCGTCGGCGGCGTCGCCACCGATCAGCGGCATGATTC
CGCCCACAAGCATGTCAGCGGCACCGCCGTCTACATCGACGACATGCCGGAACCATCAGGCACGCTGCATGGCTGCCTCG
GTCTCTCGGCCGCCGCGCATGCCACCATAACCCGCATGGACCTTTCGGCGGTGCGCGCTGCTTCCGGCGTCGTCGATGTG
CTCACGGCAAAGGATGTGCCGGGCGAGAACGACATTTCGCCGACCGGCCGGCATGATGAGCCGGTGCTCGCCGACGGCAA
GGTCGAGTTCTTCGGCCAGTCGATCTTCTGCGTTATCGCCGAAACCCGCGAACAGGCACGCCGCGCCACCAGGCTGGCCA
AGGTCGAATACAGTCAATTGCCCTTCGTCACCGACATTGGCGAACTCGATCCGAGGAAGGACAAGCTCGTGACGCCGCCG
CTTACCTTGAAGCGCGGCGATGCCGCCGCTGCGATCAAGGCGGCGCCGCGCCGGCTGAAGGGAAAGATGCGCGTCGGCGG
TCAGGAGCATTTCTATCTTGAAGGCCATATTGCCATGGCCGTTCCCGGCGAGGATCAGGACGTCACCATCTATTCCTCGA
CCCAGCATCCGAGCGAAGTCCAGCACATGGTGAGCCATGCGCTCGGCGTACCCAGCAATGCCATCACGGTGGAGATCCGC
CGCATGGGCGGCGGTTTCGGCGGCAAGGAAACGCAAGGCAATCAGTTTGCCGCGCTCGCGGCCATCGCTGCCAAGAAACA
CCATCGCGCGGTAAAAATCCGGCCCGACCGTGACGACGACATGATCGCCACCGGCAAGCGTCACGATTTCCTCGTCGACT
ACGAAGTCGGCTTCGACGACGAGGGCAACATTCTCGGTGTGGATTTCATGTTCGCCGCGCGTTGCGGCTTCTCGTCGGAT
CTGTCAGGCCCGGTGACGGATCGCGCGCTGTTCCATTGCGACAACACCTATTTCTGGCCGGCCGTGCACGCGCAATCGGC
GCCGCTCTACACCAACACCGTGTCGAACACCGCCTTCCGGGGCTTCGGCGGCCCGCAAGGCATGGTCGGCGCCGAACGCG
TCATCGACGAGGTTGCCTTCGCGGTCGGCAAGGATCCGCTCGAGATCCGCAAGAAGAATTTCTACGGCACCAGCGACCGC
AACATCACGCCCTACCACCAGACGGTCGAGGACAACATCATCCAGCGCATCGTCGCCGAACTCGAGGAGAGCGCCGGCTA
TGCGCGACGGCGGCGCGAAATTTCGGCCTTCAATGCCAACAGCCGTTTCATCAAGCGCGGCCTGGCGCTGACGCCGGTCA
AGTTCGGCATTTCCTTCACCGCCACGCACTACAACCAGGCCGGCGCGCTGGTGCATGTCTACACCGATGGTTCGGTGCAT
CTGAACCACGGCGGCACCGAGATGGGGCAGGGGCTCTACCTCAAGGTCGCGCAGGTGGTGGCGGAAGAATTCCAGATCGA
TCTCGACCAGGTGAAGATCACCGCGACCACCACCGGCAAGGTGCCCAACACCTCGGCCACCGCGGCATCGTCCGGTTCGG
ACCTCAATGGCATGGCGGCACAGAACGGCGCCCGCCAGATCAAGAACCGGCTGACCGATTTCGCTGCCGAAAAATACCAG
GTGCCGCGCGATCAGGTGCTGTTCCTGCCCAACCGGGTGCGCATCGGCAACCAGGAGATCGCCTTCGCCGATCTCGTCAA
GCAGGCCTATATGGCGCGCATCCAGCTCTCGGCCGCGGGCTTCTACAAAACGCCGAAAATCCACTGGAACCGCGACAAGG
GCGAGGGCCGCCCTTTCTACTATTTCGCTTACGGCGCCTCGTGCTCGGAAGTGTCGGTCGACACGCTGACCGGCGAATAT
GTGGTCGAGCGCACCGATATCCTGCACGAGACCGGCCGTTCGCTGAACCGCGCCATCGATCTCGGCCAGATCGAGGGCGG
CTTCATCCAGGGCATGGGCTGGCTGACGACGGAGGAATTGTGGTGGGACGACAAGGGCCGGCTGCGCACCCACGCGCCGT
CGACCTACAAGATCCCGCTCGCCTCGGACCGACCGAAGATCTTCAACGTCGCTTTGGCCGACTGGCCGGAAGCCGGAGAG
CCGACGATCCACCGCTCCAAGGCGGTCGGCGAGCCGCCCTTCCCGCTCGGCATGTCGGTGCTGCACGCGCTGTCGGATGC
GGTGGCCAGCGTCGCCGATCACAGGATCTGTCCGCGCCTTGATGCTCCGGCGACGCCCGAACGTGTGCTGATGACGATCG
AGCGGCTGAAAGGCGAGGCGAAGGCCTGA

Upstream 100 bases:

>100_bases
CCGAATACCGGGCTCTGGCAGCCAAGAATTTGTTGTTGCGTTTCTTCGTCGAAACCACCGGCACCAGGGCACCCTTCCAG
GTGTCCCGCAACGAGGCGGC

Downstream 100 bases:

>100_bases
ATCCGGCAAAACGTGCAATTCAGGCCGAAAAACCCTATGTTTCCCGCACGGGAATGCAAATGATGACTTCGAAAGTGCAA
AGCCTGAAAGACTTCCTGGC

Product: xanthine dehydrogenase, xdhB

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 782; Mature: 782

Protein sequence:

>782_residues
MMNKHATSNLKAEKIVGGVATDQRHDSAHKHVSGTAVYIDDMPEPSGTLHGCLGLSAAAHATITRMDLSAVRAASGVVDV
LTAKDVPGENDISPTGRHDEPVLADGKVEFFGQSIFCVIAETREQARRATRLAKVEYSQLPFVTDIGELDPRKDKLVTPP
LTLKRGDAAAAIKAAPRRLKGKMRVGGQEHFYLEGHIAMAVPGEDQDVTIYSSTQHPSEVQHMVSHALGVPSNAITVEIR
RMGGGFGGKETQGNQFAALAAIAAKKHHRAVKIRPDRDDDMIATGKRHDFLVDYEVGFDDEGNILGVDFMFAARCGFSSD
LSGPVTDRALFHCDNTYFWPAVHAQSAPLYTNTVSNTAFRGFGGPQGMVGAERVIDEVAFAVGKDPLEIRKKNFYGTSDR
NITPYHQTVEDNIIQRIVAELEESAGYARRRREISAFNANSRFIKRGLALTPVKFGISFTATHYNQAGALVHVYTDGSVH
LNHGGTEMGQGLYLKVAQVVAEEFQIDLDQVKITATTTGKVPNTSATAASSGSDLNGMAAQNGARQIKNRLTDFAAEKYQ
VPRDQVLFLPNRVRIGNQEIAFADLVKQAYMARIQLSAAGFYKTPKIHWNRDKGEGRPFYYFAYGASCSEVSVDTLTGEY
VVERTDILHETGRSLNRAIDLGQIEGGFIQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVALADWPEAGE
PTIHRSKAVGEPPFPLGMSVLHALSDAVASVADHRICPRLDAPATPERVLMTIERLKGEAKA

Sequences:

>Translated_782_residues
MMNKHATSNLKAEKIVGGVATDQRHDSAHKHVSGTAVYIDDMPEPSGTLHGCLGLSAAAHATITRMDLSAVRAASGVVDV
LTAKDVPGENDISPTGRHDEPVLADGKVEFFGQSIFCVIAETREQARRATRLAKVEYSQLPFVTDIGELDPRKDKLVTPP
LTLKRGDAAAAIKAAPRRLKGKMRVGGQEHFYLEGHIAMAVPGEDQDVTIYSSTQHPSEVQHMVSHALGVPSNAITVEIR
RMGGGFGGKETQGNQFAALAAIAAKKHHRAVKIRPDRDDDMIATGKRHDFLVDYEVGFDDEGNILGVDFMFAARCGFSSD
LSGPVTDRALFHCDNTYFWPAVHAQSAPLYTNTVSNTAFRGFGGPQGMVGAERVIDEVAFAVGKDPLEIRKKNFYGTSDR
NITPYHQTVEDNIIQRIVAELEESAGYARRRREISAFNANSRFIKRGLALTPVKFGISFTATHYNQAGALVHVYTDGSVH
LNHGGTEMGQGLYLKVAQVVAEEFQIDLDQVKITATTTGKVPNTSATAASSGSDLNGMAAQNGARQIKNRLTDFAAEKYQ
VPRDQVLFLPNRVRIGNQEIAFADLVKQAYMARIQLSAAGFYKTPKIHWNRDKGEGRPFYYFAYGASCSEVSVDTLTGEY
VVERTDILHETGRSLNRAIDLGQIEGGFIQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVALADWPEAGE
PTIHRSKAVGEPPFPLGMSVLHALSDAVASVADHRICPRLDAPATPERVLMTIERLKGEAKA
>Mature_782_residues
MMNKHATSNLKAEKIVGGVATDQRHDSAHKHVSGTAVYIDDMPEPSGTLHGCLGLSAAAHATITRMDLSAVRAASGVVDV
LTAKDVPGENDISPTGRHDEPVLADGKVEFFGQSIFCVIAETREQARRATRLAKVEYSQLPFVTDIGELDPRKDKLVTPP
LTLKRGDAAAAIKAAPRRLKGKMRVGGQEHFYLEGHIAMAVPGEDQDVTIYSSTQHPSEVQHMVSHALGVPSNAITVEIR
RMGGGFGGKETQGNQFAALAAIAAKKHHRAVKIRPDRDDDMIATGKRHDFLVDYEVGFDDEGNILGVDFMFAARCGFSSD
LSGPVTDRALFHCDNTYFWPAVHAQSAPLYTNTVSNTAFRGFGGPQGMVGAERVIDEVAFAVGKDPLEIRKKNFYGTSDR
NITPYHQTVEDNIIQRIVAELEESAGYARRRREISAFNANSRFIKRGLALTPVKFGISFTATHYNQAGALVHVYTDGSVH
LNHGGTEMGQGLYLKVAQVVAEEFQIDLDQVKITATTTGKVPNTSATAASSGSDLNGMAAQNGARQIKNRLTDFAAEKYQ
VPRDQVLFLPNRVRIGNQEIAFADLVKQAYMARIQLSAAGFYKTPKIHWNRDKGEGRPFYYFAYGASCSEVSVDTLTGEY
VVERTDILHETGRSLNRAIDLGQIEGGFIQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVALADWPEAGE
PTIHRSKAVGEPPFPLGMSVLHALSDAVASVADHRICPRLDAPATPERVLMTIERLKGEAKA

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=753, Percent_Identity=42.3638778220452, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI71773480, Length=785, Percent_Identity=37.1974522292994, Blast_Score=494, Evalue=1e-139,
Organism=Escherichia coli, GI1789230, Length=771, Percent_Identity=25.6809338521401, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI1789246, Length=764, Percent_Identity=26.3089005235602, Blast_Score=170, Evalue=3e-43,
Organism=Escherichia coli, GI1786478, Length=750, Percent_Identity=25.2, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540638, Length=767, Percent_Identity=39.6349413298566, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI32566215, Length=717, Percent_Identity=31.1018131101813, Blast_Score=322, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17539860, Length=732, Percent_Identity=30.327868852459, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI17737937, Length=787, Percent_Identity=39.5171537484117, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24647199, Length=756, Percent_Identity=31.3492063492063, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24647201, Length=763, Percent_Identity=31.1926605504587, Blast_Score=312, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24647193, Length=762, Percent_Identity=30.5774278215223, Blast_Score=302, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24647195, Length=766, Percent_Identity=28.8511749347258, Blast_Score=281, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24647197, Length=766, Percent_Identity=28.7206266318538, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85371; Mature: 85371

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKHATSNLKAEKIVGGVATDQRHDSAHKHVSGTAVYIDDMPEPSGTLHGCLGLSAAAH
CCCCCCCCCCCHHHHHCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCHHHHHHCCHHHH
ATITRMDLSAVRAASGVVDVLTAKDVPGENDISPTGRHDEPVLADGKVEFFGQSIFCVIA
HEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEECCEEEEEEE
ETREQARRATRLAKVEYSQLPFVTDIGELDPRKDKLVTPPLTLKRGDAAAAIKAAPRRLK
HHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHC
GKMRVGGQEHFYLEGHIAMAVPGEDQDVTIYSSTQHPSEVQHMVSHALGVPSNAITVEIR
CCEECCCCEEEEEEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEE
RMGGGFGGKETQGNQFAALAAIAAKKHHRAVKIRPDRDDDMIATGKRHDFLVDYEVGFDD
ECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCCEEEEEEECCCC
EGNILGVDFMFAARCGFSSDLSGPVTDRALFHCDNTYFWPAVHAQSAPLYTNTVSNTAFR
CCCEEEEEHHHHHHCCCCCCCCCCCCCCEEEEECCEEEECEECCCCCCEEEECCCCCCCC
GFGGPQGMVGAERVIDEVAFAVGKDPLEIRKKNFYGTSDRNITPYHQTVEDNIIQRIVAE
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LEESAGYARRRREISAFNANSRFIKRGLALTPVKFGISFTATHYNQAGALVHVYTDGSVH
HHHHCCHHHHHHHHHEECCCHHHHHCCCEECEEEECEEEEEEEECCCCCEEEEEECCEEE
LNHGGTEMGQGLYLKVAQVVAEEFQIDLDQVKITATTTGKVPNTSATAASSGSDLNGMAA
ECCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
QNGARQIKNRLTDFAAEKYQVPRDQVLFLPNRVRIGNQEIAFADLVKQAYMARIQLSAAG
HHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHHHHHHEEEEECC
FYKTPKIHWNRDKGEGRPFYYFAYGASCSEVSVDTLTGEYVVERTDILHETGRSLNRAID
CCCCCCEEECCCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
LGQIEGGFIQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVALADWPEAGE
CCCCCCCEEECCCCEEEHHEEECCCCCEEECCCCEEEEECCCCCCCEEEEEEECCCCCCC
PTIHRSKAVGEPPFPLGMSVLHALSDAVASVADHRICPRLDAPATPERVLMTIERLKGEA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
KA
CC
>Mature Secondary Structure
MMNKHATSNLKAEKIVGGVATDQRHDSAHKHVSGTAVYIDDMPEPSGTLHGCLGLSAAAH
CCCCCCCCCCCHHHHHCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCHHHHHHCCHHHH
ATITRMDLSAVRAASGVVDVLTAKDVPGENDISPTGRHDEPVLADGKVEFFGQSIFCVIA
HEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEECCEEEEEEE
ETREQARRATRLAKVEYSQLPFVTDIGELDPRKDKLVTPPLTLKRGDAAAAIKAAPRRLK
HHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHHC
GKMRVGGQEHFYLEGHIAMAVPGEDQDVTIYSSTQHPSEVQHMVSHALGVPSNAITVEIR
CCEECCCCEEEEEEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEE
RMGGGFGGKETQGNQFAALAAIAAKKHHRAVKIRPDRDDDMIATGKRHDFLVDYEVGFDD
ECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCCEEEEEEECCCC
EGNILGVDFMFAARCGFSSDLSGPVTDRALFHCDNTYFWPAVHAQSAPLYTNTVSNTAFR
CCCEEEEEHHHHHHCCCCCCCCCCCCCCEEEEECCEEEECEECCCCCCEEEECCCCCCCC
GFGGPQGMVGAERVIDEVAFAVGKDPLEIRKKNFYGTSDRNITPYHQTVEDNIIQRIVAE
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LEESAGYARRRREISAFNANSRFIKRGLALTPVKFGISFTATHYNQAGALVHVYTDGSVH
HHHHCCHHHHHHHHHEECCCHHHHHCCCEECEEEECEEEEEEEECCCCCEEEEEECCEEE
LNHGGTEMGQGLYLKVAQVVAEEFQIDLDQVKITATTTGKVPNTSATAASSGSDLNGMAA
ECCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHH
QNGARQIKNRLTDFAAEKYQVPRDQVLFLPNRVRIGNQEIAFADLVKQAYMARIQLSAAG
HHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHHHHHHEEEEECC
FYKTPKIHWNRDKGEGRPFYYFAYGASCSEVSVDTLTGEYVVERTDILHETGRSLNRAID
CCCCCCEEECCCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
LGQIEGGFIQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVALADWPEAGE
CCCCCCCEEECCCCEEEHHEEECCCCCEEECCCCEEEEECCCCCCCEEEEEEECCCCCCC
PTIHRSKAVGEPPFPLGMSVLHALSDAVASVADHRICPRLDAPATPERVLMTIERLKGEA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]