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The map label for this gene is yedX [C]

Identifier: 13474280

GI number: 13474280

Start: 4070508

End: 4070882

Strand: Direct

Name: yedX [C]

Synonym: mlr5133

Alternate gene names: 13474280

Gene position: 4070508-4070882 (Clockwise)

Preceding gene: 13474265

Following gene: 13474281

Centisome position: 57.85

GC content: 64.53

Gene sequence:

>375_bases
GTGGCAGAAACGTCGAAAGCCGATGGCGGACGTCTGACGACGCATGTCCTCGACACCGCGACCGGCAAGCCGGCGGCGGG
CTTGTCGATCGCGCTCTATCGTCTCGACGGTTCGGCCAGGACGCATTTGAAGACGGTCGCGACCAATGCCGACGGTCGTT
GCGACGCGGCACTGCTGGCGGGCGCTGAGTTCCGCGCCGGCGAATATGAACTGGTGTTCGCGGCCGGCGATTATCTGCGC
GGCCAGGGCACAAAACTGCCCGAGCCGGCCTTCCTTGACAGCGTGCCGATCCGTTTCGGCATGGCGGAGGCGGTGCACTA
TCACGTGCCATTGCTGATCTCGCCCTATGGCTATTCGACCTACAGGGGGAGCTGA

Upstream 100 bases:

>100_bases
GTGTTTTTGTGCCGCTCCGCTCGACCGGGACTTATGCATCGCCTTTAATTGGCGCACAATTCATTGCTTTGTTCGACTGT
ACCGGAAATGGGAGGCGCCA

Downstream 100 bases:

>100_bases
GGCATGGCCAAGGTCAACATTCGTAACGAGATCCGGTTCATCCTCAATGGCAGGGATGTCGTGCTGTCCTCGGTGGCGCC
GGACGCGACCCTGCTCGACT

Product: hypothetical protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MAETSKADGGRLTTHVLDTATGKPAAGLSIALYRLDGSARTHLKTVATNADGRCDAALLAGAEFRAGEYELVFAAGDYLR
GQGTKLPEPAFLDSVPIRFGMAEAVHYHVPLLISPYGYSTYRGS

Sequences:

>Translated_124_residues
MAETSKADGGRLTTHVLDTATGKPAAGLSIALYRLDGSARTHLKTVATNADGRCDAALLAGAEFRAGEYELVFAAGDYLR
GQGTKLPEPAFLDSVPIRFGMAEAVHYHVPLLISPYGYSTYRGS
>Mature_123_residues
AETSKADGGRLTTHVLDTATGKPAAGLSIALYRLDGSARTHLKTVATNADGRCDAALLAGAEFRAGEYELVFAAGDYLRG
QGTKLPEPAFLDSVPIRFGMAEAVHYHVPLLISPYGYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily

Homologues:

Organism=Escherichia coli, GI1788281, Length=119, Percent_Identity=39.4957983193277, Blast_Score=91, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115532922, Length=116, Percent_Identity=35.3448275862069, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115532920, Length=116, Percent_Identity=35.3448275862069, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115534555, Length=116, Percent_Identity=35.3448275862069, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24652571, Length=118, Percent_Identity=38.135593220339, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIUH_RHILO (Q98CI7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105848.1
- ProteinModelPortal:   Q98CI7
- SMR:   Q98CI7
- GeneID:   1228509
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5133
- NMPDR:   fig|266835.1.peg.3952
- HOGENOM:   HBG445217
- OMA:   RCDQPLL
- ProtClustDB:   CLSK506288
- GO:   GO:0006810
- InterPro:   IPR014306
- InterPro:   IPR000895
- Gene3D:   G3DSA:2.60.40.180
- PRINTS:   PR00189
- TIGRFAMs:   TIGR02962

Pfam domain/function: PF00576 Transthyretin; SSF49472 Transthyretin

EC number: =3.5.2.17

Molecular weight: Translated: 13119; Mature: 12988

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00768 TRANSTHYRETIN_1; PS00769 TRANSTHYRETIN_2

Important sites: BINDING 15-15 BINDING 53-53 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETSKADGGRLTTHVLDTATGKPAAGLSIALYRLDGSARTHLKTVATNADGRCDAALLA
CCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEEE
GAEFRAGEYELVFAAGDYLRGQGTKLPEPAFLDSVPIRFGMAEAVHYHVPLLISPYGYST
CCCCCCCCEEEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEECCCCCCC
YRGS
CCCC
>Mature Secondary Structure 
AETSKADGGRLTTHVLDTATGKPAAGLSIALYRLDGSARTHLKTVATNADGRCDAALLA
CCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEEE
GAEFRAGEYELVFAAGDYLRGQGTKLPEPAFLDSVPIRFGMAEAVHYHVPLLISPYGYST
CCCCCCCCEEEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEECCCCCCC
YRGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968