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The map label for this gene is hisE

Identifier: 13474187

GI number: 13474187

Start: 3974987

End: 3975310

Strand: Direct

Name: hisE

Synonym: mlr5018

Alternate gene names: 13474187

Gene position: 3974987-3975310 (Clockwise)

Preceding gene: 13474186

Following gene: 13474188

Centisome position: 56.49

GC content: 62.35

Gene sequence:

>324_bases
ATGGCTGAATTTTCGTTCTCCGATCTGGAGGCAATCATCAGGGACCGCGCCCATTCCGGCGACCCGGATTCCTGGACGGC
GAAACTGTTCGCGCGCGGCATCGACAAGGCGGCCCAGAAACTCGGCGAGGAGGCGGTCGAGACGGCGATTGCCGCCGTCA
AGGGCGACAGACAGGGCCTCGTTTCCGAAAGTGCCGATCTTATATATCATTGGCTCGTCGTTCTCGGCCTCTCGGGTGTT
CCGTTGAGCGACGTGCTCAAGGAGCTCGAAAGCCGCACCGGGCGTTCGGGCATCGCCGAAAAGGCGTCACGGCCCAAGGG
CTGA

Upstream 100 bases:

>100_bases
GGCCAAGGCGCATATGGCCGCCGCGGGCCTGCCGATGCGGCTGGACTCCTCGGGCGATCGGCCCTAGAGCCTGTCCGGCT
AAGAAAAGGGCCCAGGCGCC

Downstream 100 bases:

>100_bases
CCGCGAGGGAGGGCAGGTATCTCGATGGATCAGCTCGCGCAAACCGAGAAATATTCCCCCTTTCGTTTCTTTTCGGCCGA
GCAATGGTCGCGATTCCGCG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MAEFSFSDLEAIIRDRAHSGDPDSWTAKLFARGIDKAAQKLGEEAVETAIAAVKGDRQGLVSESADLIYHWLVVLGLSGV
PLSDVLKELESRTGRSGIAEKASRPKG

Sequences:

>Translated_107_residues
MAEFSFSDLEAIIRDRAHSGDPDSWTAKLFARGIDKAAQKLGEEAVETAIAAVKGDRQGLVSESADLIYHWLVVLGLSGV
PLSDVLKELESRTGRSGIAEKASRPKG
>Mature_106_residues
AEFSFSDLEAIIRDRAHSGDPDSWTAKLFARGIDKAAQKLGEEAVETAIAAVKGDRQGLVSESADLIYHWLVVLGLSGVP
LSDVLKELESRTGRSGIAEKASRPKG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=85, Percent_Identity=48.2352941176471, Blast_Score=75, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_RHILO (Q98CT0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105755.1
- ProteinModelPortal:   Q98CT0
- SMR:   Q98CT0
- GeneID:   1228416
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5018
- NMPDR:   fig|266835.1.peg.3859
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11466; Mature: 11335

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFSFSDLEAIIRDRAHSGDPDSWTAKLFARGIDKAAQKLGEEAVETAIAAVKGDRQGL
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VSESADLIYHWLVVLGLSGVPLSDVLKELESRTGRSGIAEKASRPKG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCC
>Mature Secondary Structure 
AEFSFSDLEAIIRDRAHSGDPDSWTAKLFARGIDKAAQKLGEEAVETAIAAVKGDRQGL
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VSESADLIYHWLVVLGLSGVPLSDVLKELESRTGRSGIAEKASRPKG
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968