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The map label for this gene is hslU [H]

Identifier: 13474176

GI number: 13474176

Start: 3967343

End: 3968674

Strand: Reverse

Name: hslU [H]

Synonym: mll5004

Alternate gene names: 13474176

Gene position: 3968674-3967343 (Counterclockwise)

Preceding gene: 13474177

Following gene: 13474175

Centisome position: 56.4

GC content: 61.86

Gene sequence:

>1332_bases
GTGGCAAAGTGGAATTTAGCTATGACGACTTTTTCTCCCCGCGAAATCGTTTCGGAACTCGACCGCTTCATCATCGGCCA
GAAGGACGCCAAGCGCGCCGTGGCCATCGCCTTGCGCAACCGCTGGCGCCGCCAGCAGCTGGAAGGCCAGATGCGCGAAG
AGGTGATGCCGAAGAACATCCTGATGATCGGGCCAACCGGCGTCGGCAAGACCGAAATCTCGCGCCGCCTGGCGCGGCTG
GCAGGCGCGCCTTTCGTCAAGGTCGAGGCCACCAAATTCACCGAGGTCGGCTATGTCGGCCGTGACGTCGAGCAGATCAT
CCGCGATCTCGTCGAGATCGCCATCGGCCTGGTGCGCGAAAAGATGCGTGAGGACGTCAAGGCACGTGCCCACATCAATG
CCGAGGAACGCGTCCTGGAAGCGCTGGTCGGCAAGACTGCCAGCCCGGCGACCCGCGACTCTTTCCGCAAGAAGCTGCGC
GACGGCGAACTCGACGACAAGGAAATCGAGATCGAAGTGGCCGACACCGGCAATGGCGGCATGCCCGGCTTCGAGATTCC
CGGCATGCCGGGCGCCAATATCGGCGTGCTCAACATCAACGACATGCTGTCGAAGGCGATGGGCGGCAAGAAGACCAAAT
CGCGCAAGACGACGGTGAAGGAGTCCTACGATCTGCTGGTCAGCGACGAGTCCGACAAGCTGCTCGACCAGGACGAGGTG
GTGCGCCGGGCGCTTGACGCGACGGAAAATGACGGCATCGTCTTCCTCGACGAGATCGACAAGATCGCCGCGAGATCCGA
CATTTCCGGCGGCCCTTCGCGCGAAGGCGTGCAGCGCGACCTGCTGCCGCTGGTCGAAGGCACCACGGTGGCGACCAAAT
ACGGACCGGTGAAGACGGACCACATATTGTTCATCGCCTCGGGCGCGTTCCACGTGTCGAAGCCGTCCGATCTGTTGCCG
GAATTGCAGGGCCGCCTGCCGATTCGCGTCGAACTGCGGGCCTTGGAGAAGCAAGATTTCGTCCGCATCCTGACCGAGAC
GGAAGCCAGCCTGATCAAGCAATATATCGCGCTGATGAAGACCGAGGGTGTCGACCTGACCTTCACCGACGACGCCATCG
ATTCGCTGGCCGGCATTGCCGTCGACCTCAATGACAGCGTCGAGAATATCGGCGCCCGGCGGCTGCAGACCGTGATGGAG
CGGGTGCTGGACGAGATTTCCTACGACGCGCCCGACCGCAACGGCACATCGGTCACCATCGACGCCGCCTATGTGGAAAA
GCATGTCGGCGACCTCTCGCGAAACACAGATTTGTCGCGATTCATCCTTTAA

Upstream 100 bases:

>100_bases
GCCTCGCCATCCTTTTCGAACTCGGTACCGGCTATCTCATCCGGGACAATCTGACACTCAACGTGATCATGCTGCTGCAT
CCGTTCGAGGCCATCAAGCA

Downstream 100 bases:

>100_bases
AGCACGACGCCGGCTATTTCGGCGCCGGTTCAGGCAACCCGGCAGAACAATCATGTGTGGCCAGATGGTACCATCTGGCC
ACCTTTCGTCTTGCCGGGTG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAKWNLAMTTFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLARL
AGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIGLVREKMREDVKARAHINAEERVLEALVGKTASPATRDSFRKKLR
DGELDDKEIEIEVADTGNGGMPGFEIPGMPGANIGVLNINDMLSKAMGGKKTKSRKTTVKESYDLLVSDESDKLLDQDEV
VRRALDATENDGIVFLDEIDKIAARSDISGGPSREGVQRDLLPLVEGTTVATKYGPVKTDHILFIASGAFHVSKPSDLLP
ELQGRLPIRVELRALEKQDFVRILTETEASLIKQYIALMKTEGVDLTFTDDAIDSLAGIAVDLNDSVENIGARRLQTVME
RVLDEISYDAPDRNGTSVTIDAAYVEKHVGDLSRNTDLSRFIL

Sequences:

>Translated_443_residues
MAKWNLAMTTFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLARL
AGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIGLVREKMREDVKARAHINAEERVLEALVGKTASPATRDSFRKKLR
DGELDDKEIEIEVADTGNGGMPGFEIPGMPGANIGVLNINDMLSKAMGGKKTKSRKTTVKESYDLLVSDESDKLLDQDEV
VRRALDATENDGIVFLDEIDKIAARSDISGGPSREGVQRDLLPLVEGTTVATKYGPVKTDHILFIASGAFHVSKPSDLLP
ELQGRLPIRVELRALEKQDFVRILTETEASLIKQYIALMKTEGVDLTFTDDAIDSLAGIAVDLNDSVENIGARRLQTVME
RVLDEISYDAPDRNGTSVTIDAAYVEKHVGDLSRNTDLSRFIL
>Mature_442_residues
AKWNLAMTTFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNILMIGPTGVGKTEISRRLARLA
GAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIGLVREKMREDVKARAHINAEERVLEALVGKTASPATRDSFRKKLRD
GELDDKEIEIEVADTGNGGMPGFEIPGMPGANIGVLNINDMLSKAMGGKKTKSRKTTVKESYDLLVSDESDKLLDQDEVV
RRALDATENDGIVFLDEIDKIAARSDISGGPSREGVQRDLLPLVEGTTVATKYGPVKTDHILFIASGAFHVSKPSDLLPE
LQGRLPIRVELRALEKQDFVRILTETEASLIKQYIALMKTEGVDLTFTDDAIDSLAGIAVDLNDSVENIGARRLQTVMER
VLDEISYDAPDRNGTSVTIDAAYVEKHVGDLSRNTDLSRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=109, Percent_Identity=34.8623853211009, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1790366, Length=449, Percent_Identity=58.7973273942094, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1786642, Length=237, Percent_Identity=32.4894514767932, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=37.3983739837398, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648289, Length=278, Percent_Identity=30.9352517985612, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648291, Length=278, Percent_Identity=30.9352517985612, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49056; Mature: 48925

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKWNLAMTTFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNI
CCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LMIGPTGVGKTEISRRLARLAGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIGLVRE
EEECCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KMREDVKARAHINAEERVLEALVGKTASPATRDSFRKKLRDGELDDKEIEIEVADTGNGG
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCC
MPGFEIPGMPGANIGVLNINDMLSKAMGGKKTKSRKTTVKESYDLLVSDESDKLLDQDEV
CCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHCCCEEEECCCHHHCCHHHH
VRRALDATENDGIVFLDEIDKIAARSDISGGPSREGVQRDLLPLVEGTTVATKYGPVKTD
HHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCC
HILFIASGAFHVSKPSDLLPELQGRLPIRVELRALEKQDFVRILTETEASLIKQYIALMK
EEEEEEECCEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEGVDLTFTDDAIDSLAGIAVDLNDSVENIGARRLQTVMERVLDEISYDAPDRNGTSVTI
CCCCEEEECHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
DAAYVEKHVGDLSRNTDLSRFIL
EHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
AKWNLAMTTFSPREIVSELDRFIIGQKDAKRAVAIALRNRWRRQQLEGQMREEVMPKNI
CCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LMIGPTGVGKTEISRRLARLAGAPFVKVEATKFTEVGYVGRDVEQIIRDLVEIAIGLVRE
EEECCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KMREDVKARAHINAEERVLEALVGKTASPATRDSFRKKLRDGELDDKEIEIEVADTGNGG
HHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCC
MPGFEIPGMPGANIGVLNINDMLSKAMGGKKTKSRKTTVKESYDLLVSDESDKLLDQDEV
CCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHCCCEEEECCCHHHCCHHHH
VRRALDATENDGIVFLDEIDKIAARSDISGGPSREGVQRDLLPLVEGTTVATKYGPVKTD
HHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCC
HILFIASGAFHVSKPSDLLPELQGRLPIRVELRALEKQDFVRILTETEASLIKQYIALMK
EEEEEEECCEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEGVDLTFTDDAIDSLAGIAVDLNDSVENIGARRLQTVMERVLDEISYDAPDRNGTSVTI
CCCCEEEECHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
DAAYVEKHVGDLSRNTDLSRFIL
EHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]