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The map label for this gene is mtlK [H]

Identifier: 13474111

GI number: 13474111

Start: 3905440

End: 3906918

Strand: Reverse

Name: mtlK [H]

Synonym: mll4920

Alternate gene names: 13474111

Gene position: 3906918-3905440 (Counterclockwise)

Preceding gene: 13474112

Following gene: 13474110

Centisome position: 55.53

GC content: 63.35

Gene sequence:

>1479_bases
ATGACCGTGAAACTCTCGTCTTCAAACCTCTCCAGCCTGCCCGGCAATGTTGCCGGTCCGAAATACGACCGCTCGAAGCT
CAAGGCCGGCATCGTGCATTTCGGCGTCGGCAATTTCCATCGCTCGCACCAGGCGGTCTACCTCGACGATCTGTTCAATT
CAGGTGTCGGCCATGACTGGGCGCTGGTCGGCGCAGGCGTGTTCGAGGGCGAGAAGATCGGTCGCGGCAAGCTCGAAGAG
CAGGACTGGCTGACCACGGTTGTCGAGCAGGATGAAGGCCATATGAGCGCCCGTGTCACCGGCGCGATGATCGATTTCCT
GATGCCTGGCGATGCGGCCGGCATCATCGACCGGTTGGCCGACCCGGCGATCAAGATCGTTTCGCTGACCATCACCGAAG
GCGGCTATTTCATCGACCCGGCGTCGGGCAAGTTCAACCCAGCCCATCCGGATATCGTCGCCGACGCCCAACCGGGCGCC
ACCCCAAAGACAGTGTTTGGCATCATCCTGGCAGGACTGCTGCGCCGGCGCGACGAAGGCACCGTGCCGTTTACCGTGAT
GTCCTGCGACAACATTCCCCACAACGGCCATGTCACCTCGGATGGCGTCATTGGTCTGGCGCGGCTGATCGATGAGGATT
TGGCCGGTTGGGTGAGCAGCAACGTCGCCTTTCCAAACGGCATGGTGGACCGCATTACGCCGGCCACCACAGACCGCGAG
CGCGGCATACTGGCCAAGGATTTCGGCGTCGAGGATGCCTGGCCGGTGTTCTGCGAGCCGTTCCGGCAATGGGTGCTGGA
AGACCATTTCACCGATGGCCGTCCGCCGCTGGAAAAGGTCGGTGTACAGTTCGTCAGGGATGTCGCGCCCTACGAGTTGA
TGAAGATCCGCATCCTCAATGGCGGCCATGCCACGATCGCCTATCCGGCCGGGCTGATGGACATCCATTTCGTTCATGAG
GCGATGCAGGAGCCGCTGGTGCGCGGCTTTCTCGACAAGCTCGAGCACGACGAGATCATCCCGACGGTGCCGCCGGTGCC
GGACACGGTGCTGGAGGATTATTACCAGCTCATCGAGAAGCGCTTTTCCAACCCCAAGATCGGCGACACCATCCGCCGGC
TCTGCCTCGACGGCTCCAACCGCCAGCCGAAATTCATCATCCCGACAATCGCCGACCGCCTGAAGGCGGGAAAGGGCGTC
GCCGGCCTGGCGCTGGAATCGGCGCTGTGGTGCCGCTACTGTTTCGGCACATCAGACAGCGGCGCCGTCATCGAACCCAA
CGACCCGAGCTGGGACCGGCTGCAGGCGACGGCAAAGGCGGCGAAGGACGCGCCCGCCGCCTGGCTCGCCATGGAGGACA
TCTATGGCGATGTCGGCCGCGCCACGGCATTCGTCGAGGCCTTCGGCCACGCGCTCAACGTGCTGTGGGCCAATGGCGCC
CGCGCCACGTTGACACGCTACATCGCCGGCAAGCTCTGA

Upstream 100 bases:

>100_bases
CCGCATCGGCCTCGCAAGGCATATGCCGTCCCTTACCCTCTCCCGAGAGGACGGGGAGAGGCGGAGTAACGAGGCCGAAG
CCGGCCAAAGGGTAAAACAG

Downstream 100 bases:

>100_bases
AAGCTATCAGCCATCATGACGCCTGAACTGGTCATCTTCGACTGCGATGGCGTGCTGGTCGACAGCGAGGCGCTCTCCGT
CTCGGCGCTGCTCGGCATGA

Product: mannitol dehydrogenase

Products: NA

Alternate protein names: M2DH; MDH [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MTVKLSSSNLSSLPGNVAGPKYDRSKLKAGIVHFGVGNFHRSHQAVYLDDLFNSGVGHDWALVGAGVFEGEKIGRGKLEE
QDWLTTVVEQDEGHMSARVTGAMIDFLMPGDAAGIIDRLADPAIKIVSLTITEGGYFIDPASGKFNPAHPDIVADAQPGA
TPKTVFGIILAGLLRRRDEGTVPFTVMSCDNIPHNGHVTSDGVIGLARLIDEDLAGWVSSNVAFPNGMVDRITPATTDRE
RGILAKDFGVEDAWPVFCEPFRQWVLEDHFTDGRPPLEKVGVQFVRDVAPYELMKIRILNGGHATIAYPAGLMDIHFVHE
AMQEPLVRGFLDKLEHDEIIPTVPPVPDTVLEDYYQLIEKRFSNPKIGDTIRRLCLDGSNRQPKFIIPTIADRLKAGKGV
AGLALESALWCRYCFGTSDSGAVIEPNDPSWDRLQATAKAAKDAPAAWLAMEDIYGDVGRATAFVEAFGHALNVLWANGA
RATLTRYIAGKL

Sequences:

>Translated_492_residues
MTVKLSSSNLSSLPGNVAGPKYDRSKLKAGIVHFGVGNFHRSHQAVYLDDLFNSGVGHDWALVGAGVFEGEKIGRGKLEE
QDWLTTVVEQDEGHMSARVTGAMIDFLMPGDAAGIIDRLADPAIKIVSLTITEGGYFIDPASGKFNPAHPDIVADAQPGA
TPKTVFGIILAGLLRRRDEGTVPFTVMSCDNIPHNGHVTSDGVIGLARLIDEDLAGWVSSNVAFPNGMVDRITPATTDRE
RGILAKDFGVEDAWPVFCEPFRQWVLEDHFTDGRPPLEKVGVQFVRDVAPYELMKIRILNGGHATIAYPAGLMDIHFVHE
AMQEPLVRGFLDKLEHDEIIPTVPPVPDTVLEDYYQLIEKRFSNPKIGDTIRRLCLDGSNRQPKFIIPTIADRLKAGKGV
AGLALESALWCRYCFGTSDSGAVIEPNDPSWDRLQATAKAAKDAPAAWLAMEDIYGDVGRATAFVEAFGHALNVLWANGA
RATLTRYIAGKL
>Mature_491_residues
TVKLSSSNLSSLPGNVAGPKYDRSKLKAGIVHFGVGNFHRSHQAVYLDDLFNSGVGHDWALVGAGVFEGEKIGRGKLEEQ
DWLTTVVEQDEGHMSARVTGAMIDFLMPGDAAGIIDRLADPAIKIVSLTITEGGYFIDPASGKFNPAHPDIVADAQPGAT
PKTVFGIILAGLLRRRDEGTVPFTVMSCDNIPHNGHVTSDGVIGLARLIDEDLAGWVSSNVAFPNGMVDRITPATTDRER
GILAKDFGVEDAWPVFCEPFRQWVLEDHFTDGRPPLEKVGVQFVRDVAPYELMKIRILNGGHATIAYPAGLMDIHFVHEA
MQEPLVRGFLDKLEHDEIIPTVPPVPDTVLEDYYQLIEKRFSNPKIGDTIRRLCLDGSNRQPKFIIPTIADRLKAGKGVA
GLALESALWCRYCFGTSDSGAVIEPNDPSWDRLQATAKAAKDAPAAWLAMEDIYGDVGRATAFVEAFGHALNVLWANGAR
ATLTRYIAGKL

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=480, Percent_Identity=37.9166666666667, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1790779, Length=478, Percent_Identity=38.0753138075314, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1787823, Length=481, Percent_Identity=37.6299376299376, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI48994885, Length=483, Percent_Identity=25.2587991718427, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=484, Percent_Identity=38.2231404958678, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320765, Length=484, Percent_Identity=38.2231404958678, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.67 [H]

Molecular weight: Translated: 53519; Mature: 53388

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKLSSSNLSSLPGNVAGPKYDRSKLKAGIVHFGVGNFHRSHQAVYLDDLFNSGVGHDW
CEEEECCCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCEEEHHHHHCCCCCCCE
ALVGAGVFEGEKIGRGKLEEQDWLTTVVEQDEGHMSARVTGAMIDFLMPGDAAGIIDRLA
EEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
DPAIKIVSLTITEGGYFIDPASGKFNPAHPDIVADAQPGATPKTVFGIILAGLLRRRDEG
CCCEEEEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
TVPFTVMSCDNIPHNGHVTSDGVIGLARLIDEDLAGWVSSNVAFPNGMVDRITPATTDRE
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHH
RGILAKDFGVEDAWPVFCEPFRQWVLEDHFTDGRPPLEKVGVQFVRDVAPYELMKIRILN
CCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEC
GGHATIAYPAGLMDIHFVHEAMQEPLVRGFLDKLEHDEIIPTVPPVPDTVLEDYYQLIEK
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
RFSNPKIGDTIRRLCLDGSNRQPKFIIPTIADRLKAGKGVAGLALESALWCRYCFGTSDS
HCCCCCHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
GAVIEPNDPSWDRLQATAKAAKDAPAAWLAMEDIYGDVGRATAFVEAFGHALNVLWANGA
CCEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RATLTRYIAGKL
HHHHHHHHHCCC
>Mature Secondary Structure 
TVKLSSSNLSSLPGNVAGPKYDRSKLKAGIVHFGVGNFHRSHQAVYLDDLFNSGVGHDW
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCEEEHHHHHCCCCCCCE
ALVGAGVFEGEKIGRGKLEEQDWLTTVVEQDEGHMSARVTGAMIDFLMPGDAAGIIDRLA
EEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
DPAIKIVSLTITEGGYFIDPASGKFNPAHPDIVADAQPGATPKTVFGIILAGLLRRRDEG
CCCEEEEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
TVPFTVMSCDNIPHNGHVTSDGVIGLARLIDEDLAGWVSSNVAFPNGMVDRITPATTDRE
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHH
RGILAKDFGVEDAWPVFCEPFRQWVLEDHFTDGRPPLEKVGVQFVRDVAPYELMKIRILN
CCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEC
GGHATIAYPAGLMDIHFVHEAMQEPLVRGFLDKLEHDEIIPTVPPVPDTVLEDYYQLIEK
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
RFSNPKIGDTIRRLCLDGSNRQPKFIIPTIADRLKAGKGVAGLALESALWCRYCFGTSDS
HCCCCCHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
GAVIEPNDPSWDRLQATAKAAKDAPAAWLAMEDIYGDVGRATAFVEAFGHALNVLWANGA
CCEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RATLTRYIAGKL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8254318 [H]