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The map label for this gene is phhA

Identifier: 13474045

GI number: 13474045

Start: 3842192

End: 3843019

Strand: Direct

Name: phhA

Synonym: mlr4831

Alternate gene names: 13474045

Gene position: 3842192-3843019 (Clockwise)

Preceding gene: 13474041

Following gene: 13474047

Centisome position: 54.61

GC content: 63.29

Gene sequence:

>828_bases
ATGAGTGTTGCCGAATATGCCCGCGATTGCGCGGCGCAGGGGCTGCGCGGCGACTATTCGGTCTGCCGTGCCGATTTCAC
CGTGGCCCAGGATTATGACTACAGCGACGAGGAACAGGCGGTGTGGCGCACGCTGTGCGACCGCCAGACCAAGCTGACGC
GCAAGCTCGCCCACCATTCCTATCTCGACGGTGTCGAAAAACTCGGCCTGCTCGACCGCATTCCCGATTTCGAGGACGTC
AGCACCAAGCTGCGCAAGCTCACCGGCTGGGAGATCATCGCCGTGCCCGGCCTCATTCCCGCCGCTCCCTTCTTCGACCA
TCTCGCCAACCGCCGTTTCCCGGTCACCAACTGGCTGCGCACCAGGCAGGAGCTCGACTACATCGTCGAGCCGGACATGT
TCCATGATTTCTTCGGCCACGTGCCGGTTCTGTCGCAGCCGGTGTTCGCCGACTTCATGCAGATGTATGGCAAGAAGGCC
GGCGACATCATCGCGCTCGGCGGTGACGAGATGATCACCCGGCTCTACTGGTACACGGCCGAATATGGCCTGGTGCAGGA
GGCCGGCCAGCCGTTGAAGGCCTTTGGCGCCGGCCTGATGTCGTCCTTCACCGAACTGCAGTTCGCCGTCGAGGGCAAGG
ACGCCCACCATGTGCCTTTCGACCTCGAAACGGTGATGCGCACCGGCTACGAGATTGACAAGTTCCAGCGCGCCTATTTC
GTGCTGCCGTCTTTCGACGCCTTGCGCGACGCCTTCCAGACCGCCGATTTCGAGGCGATCGTCGCGCGCCGCAAGGACCA
GAAGGCGCTCGACCCGGCGACGGTCTAG

Upstream 100 bases:

>100_bases
ATCGCTAATGAGCCATCATCAAAACCAAATTGCCTCGCCAAATCCGGCTACCCTGCACGTCTGCCATTGCCGGTTTGCGA
GGAGAAAAACCATGACGACG

Downstream 100 bases:

>100_bases
CAAGTCCAGGGCCGGTGTTTAAGGCGCTCCGCCCGGAAACAAAGACCTGAAGCGCGTCGCATGAATCCGTTTCAACGCGA
CGCGCTTTGGACGCTTTGAT

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSVAEYARDCAAQGLRGDYSVCRADFTVAQDYDYSDEEQAVWRTLCDRQTKLTRKLAHHSYLDGVEKLGLLDRIPDFEDV
STKLRKLTGWEIIAVPGLIPAAPFFDHLANRRFPVTNWLRTRQELDYIVEPDMFHDFFGHVPVLSQPVFADFMQMYGKKA
GDIIALGGDEMITRLYWYTAEYGLVQEAGQPLKAFGAGLMSSFTELQFAVEGKDAHHVPFDLETVMRTGYEIDKFQRAYF
VLPSFDALRDAFQTADFEAIVARRKDQKALDPATV

Sequences:

>Translated_275_residues
MSVAEYARDCAAQGLRGDYSVCRADFTVAQDYDYSDEEQAVWRTLCDRQTKLTRKLAHHSYLDGVEKLGLLDRIPDFEDV
STKLRKLTGWEIIAVPGLIPAAPFFDHLANRRFPVTNWLRTRQELDYIVEPDMFHDFFGHVPVLSQPVFADFMQMYGKKA
GDIIALGGDEMITRLYWYTAEYGLVQEAGQPLKAFGAGLMSSFTELQFAVEGKDAHHVPFDLETVMRTGYEIDKFQRAYF
VLPSFDALRDAFQTADFEAIVARRKDQKALDPATV
>Mature_274_residues
SVAEYARDCAAQGLRGDYSVCRADFTVAQDYDYSDEEQAVWRTLCDRQTKLTRKLAHHSYLDGVEKLGLLDRIPDFEDVS
TKLRKLTGWEIIAVPGLIPAAPFFDHLANRRFPVTNWLRTRQELDYIVEPDMFHDFFGHVPVLSQPVFADFMQMYGKKAG
DIIALGGDEMITRLYWYTAEYGLVQEAGQPLKAFGAGLMSSFTELQFAVEGKDAHHVPFDLETVMRTGYEIDKFQRAYFV
LPSFDALRDAFQTADFEAIVARRKDQKALDPATV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

Homologues:

Organism=Homo sapiens, GI4557819, Length=240, Percent_Identity=35, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI4759248, Length=240, Percent_Identity=34.1666666666667, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI88900503, Length=234, Percent_Identity=33.7606837606838, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI88900505, Length=234, Percent_Identity=33.7606837606838, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI88900501, Length=234, Percent_Identity=33.7606837606838, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI31795563, Length=240, Percent_Identity=34.5833333333333, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531391, Length=230, Percent_Identity=36.5217391304348, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71980736, Length=229, Percent_Identity=35.8078602620087, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI115533973, Length=238, Percent_Identity=32.7731092436975, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI115532103, Length=238, Percent_Identity=32.7731092436975, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=154, Percent_Identity=34.4155844155844, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI62472054, Length=240, Percent_Identity=34.5833333333333, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24660393, Length=240, Percent_Identity=34.5833333333333, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17136776, Length=230, Percent_Identity=35.6521739130435, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17136774, Length=230, Percent_Identity=35.6521739130435, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24654994, Length=226, Percent_Identity=31.4159292035398, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PH4H_RHILO (Q98D72)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105613.1
- ProteinModelPortal:   Q98D72
- SMR:   Q98D72
- GeneID:   1228274
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4831
- NMPDR:   fig|266835.1.peg.3717
- HOGENOM:   HBG403840
- OMA:   YKIDSYQ
- ProtClustDB:   PRK11913
- BRENDA:   1.14.16.1
- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960
- Gene3D:   G3DSA:1.10.800.10
- PANTHER:   PTHR11473
- PRINTS:   PR00372
- TIGRFAMs:   TIGR01267

Pfam domain/function: PF00351 Biopterin_H; SSF56534 Aaa_hydroxylase

EC number: =1.14.16.1

Molecular weight: Translated: 31348; Mature: 31217

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00367 BH4_AAA_HYDROXYL_1; PS51410 BH4_AAA_HYDROXYL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVAEYARDCAAQGLRGDYSVCRADFTVAQDYDYSDEEQAVWRTLCDRQTKLTRKLAHHS
CHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLDGVEKLGLLDRIPDFEDVSTKLRKLTGWEIIAVPGLIPAAPFFDHLANRRFPVTNWLR
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCHHHHHH
TRQELDYIVEPDMFHDFFGHVPVLSQPVFADFMQMYGKKAGDIIALGGDEMITRLYWYTA
HHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHH
EYGLVQEAGQPLKAFGAGLMSSFTELQFAVEGKDAHHVPFDLETVMRTGYEIDKFQRAYF
HHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHE
VLPSFDALRDAFQTADFEAIVARRKDQKALDPATV
ECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968