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The map label for this gene is ddc [H]

Identifier: 13473905

GI number: 13473905

Start: 3690346

End: 3691899

Strand: Direct

Name: ddc [H]

Synonym: mlr4653

Alternate gene names: 13473905

Gene position: 3690346-3691899 (Clockwise)

Preceding gene: 13473904

Following gene: 13473906

Centisome position: 52.45

GC content: 66.67

Gene sequence:

>1554_bases
ATGCCGAGGAGATGGCGCTGTCGCGCTCGACGCCCGGCGGCCAGTTCCCGGCGGCTTGACGGGAGCCCGGTCATGGACAT
CGCGCAGGAAACCGTCGGCACCGAGGAAACGCTCGACCCCGCCGACTGGGCCGCAGTGCAAGCCCTGTCGCACCAGGTCA
TCGACGATGCCGTCGACTATCTCAGCGACATCAGGGACCGCCCGGCCTGGCGCGAGATGCCGGCGGAGGTGCGAGAAGCC
TTCGCGGCACCTCTGCCGCGATCGCCGGTGCCGCTGGCCGCCGTCTATGACGAGGTCTCGCGCACGGTGATGTCCTATCC
GATGGGCAACATCCATCCGCGATTCTGGGCCTGGTATATGGGGTCGAGCAACTTCACCGGCGCGCTCGGCGACTTCCTGG
CGGCAATCCAGGGTTCCAACCTCGGCGGCGGCAACCACGCCGCCGGGCTGATGGACAGCCAGGTGGTCAACTGGTGCAAG
CAGATGCTGGGCTTTCCGGCTTCCGCCTCCGGCACGCTGGTCAGCGGCGGCTCGATGGCCAACGTGATCGGCCTGACCGT
GGCGCGCAACGCCAAGGCCGGCATCGACGTGCGCGAGCACGGCGTCGCGGCGATCGAAAAGCCGCTGCGCTTCTATGGCT
CGGACCAGATCCATTCCTGCCACCGCAAGGCAATGGAAGCACTTGGCCTCGGCAACCGGGCGCTGCGGCGCATCCCGACG
GATGCCGACCTGCGCATCGACATACCGGCCTTGCGCGCGGCGATCGTTGAGGACCGCGAAGCCGGTTTCAAGCCGGCCTG
CGTCATCGGCAATGCCGGCACGGTCAACACCGGCGCGATCGACGATTTGCGGGCGCTTGCCAAACTCGCGCATGAGGAAG
GCCTATGGTTCCATGTCGATGGCTGCATCGGCGCGCTGATCGCGATCGCCCCCGACAATGCGCATCGCGTTGCCGGCATC
GAATGGGCGGATTCCGTCGCGCTCGATCCGCACAAATGGCTGCATGCCCCGTTCGAGGTCGGCTGCGCCCTGGTCAGGGA
TGCCGTCGCCCACCGCCGGACCTTCGCGGTGACGCCGGAATATCTGGAATCGACGCCGCGCGGCCTTGCCTCCGGCGAAT
GGCTGCACGATTACGGCCTGCAGACGTCGCGCGGCTTTCGCGCGCTGAAAGTCTGGATGGCGCTGAAGGAACATGGTGTC
GACAAATTCGGCCGCCTGATCGACCAGAACATCGCGCAAGCCTCCTATCTCGCCGGGGTGGTCGAGGCCGAGCCGCTGAT
GGAGCTGGCGACGTCGCCGACCATCAACATCGTCTGCTTCCGCTACCAGCCCGGCGTCACCGGCGAGGCGCTGAAGGTGC
TCAACACCGAGATCATGCTGCGGCTGCAGGAACAGGGCATCGCCGTCCTTTCCGACACTACCGTGCATGGCGAACACTGG
CTGCGCGTGGCGATCGCCAACCACCGCACAAGGCGCGAGGACCTCGACCTTCTGGTCGAGGAAACGGTGCGGTTGGGACG
TGAGATCGCAGCAGAAGGCTCCCCCCGGAAATAG

Upstream 100 bases:

>100_bases
GAAAAGGCGCCGGCCGGATCGGTGATCCTGTGCATGCTGCCCGACACCGGCGAGCGCTACATGTCGACGCCGCTGTTCGA
CGGCATCGAGGCCGAGATGG

Downstream 100 bases:

>100_bases
TTCCAAAAGCGAGCGACAGGCATGGGCGGCCATGCGATTCTGCGGCGGTGATTCGGGAGGTCCGACCGTGACGCTGTTTC
GTATGGCCGTGCTCGCGGCG

Product: aromatic-L-amino-acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MPRRWRCRARRPAASSRRLDGSPVMDIAQETVGTEETLDPADWAAVQALSHQVIDDAVDYLSDIRDRPAWREMPAEVREA
FAAPLPRSPVPLAAVYDEVSRTVMSYPMGNIHPRFWAWYMGSSNFTGALGDFLAAIQGSNLGGGNHAAGLMDSQVVNWCK
QMLGFPASASGTLVSGGSMANVIGLTVARNAKAGIDVREHGVAAIEKPLRFYGSDQIHSCHRKAMEALGLGNRALRRIPT
DADLRIDIPALRAAIVEDREAGFKPACVIGNAGTVNTGAIDDLRALAKLAHEEGLWFHVDGCIGALIAIAPDNAHRVAGI
EWADSVALDPHKWLHAPFEVGCALVRDAVAHRRTFAVTPEYLESTPRGLASGEWLHDYGLQTSRGFRALKVWMALKEHGV
DKFGRLIDQNIAQASYLAGVVEAEPLMELATSPTINIVCFRYQPGVTGEALKVLNTEIMLRLQEQGIAVLSDTTVHGEHW
LRVAIANHRTRREDLDLLVEETVRLGREIAAEGSPRK

Sequences:

>Translated_517_residues
MPRRWRCRARRPAASSRRLDGSPVMDIAQETVGTEETLDPADWAAVQALSHQVIDDAVDYLSDIRDRPAWREMPAEVREA
FAAPLPRSPVPLAAVYDEVSRTVMSYPMGNIHPRFWAWYMGSSNFTGALGDFLAAIQGSNLGGGNHAAGLMDSQVVNWCK
QMLGFPASASGTLVSGGSMANVIGLTVARNAKAGIDVREHGVAAIEKPLRFYGSDQIHSCHRKAMEALGLGNRALRRIPT
DADLRIDIPALRAAIVEDREAGFKPACVIGNAGTVNTGAIDDLRALAKLAHEEGLWFHVDGCIGALIAIAPDNAHRVAGI
EWADSVALDPHKWLHAPFEVGCALVRDAVAHRRTFAVTPEYLESTPRGLASGEWLHDYGLQTSRGFRALKVWMALKEHGV
DKFGRLIDQNIAQASYLAGVVEAEPLMELATSPTINIVCFRYQPGVTGEALKVLNTEIMLRLQEQGIAVLSDTTVHGEHW
LRVAIANHRTRREDLDLLVEETVRLGREIAAEGSPRK
>Mature_516_residues
PRRWRCRARRPAASSRRLDGSPVMDIAQETVGTEETLDPADWAAVQALSHQVIDDAVDYLSDIRDRPAWREMPAEVREAF
AAPLPRSPVPLAAVYDEVSRTVMSYPMGNIHPRFWAWYMGSSNFTGALGDFLAAIQGSNLGGGNHAAGLMDSQVVNWCKQ
MLGFPASASGTLVSGGSMANVIGLTVARNAKAGIDVREHGVAAIEKPLRFYGSDQIHSCHRKAMEALGLGNRALRRIPTD
ADLRIDIPALRAAIVEDREAGFKPACVIGNAGTVNTGAIDDLRALAKLAHEEGLWFHVDGCIGALIAIAPDNAHRVAGIE
WADSVALDPHKWLHAPFEVGCALVRDAVAHRRTFAVTPEYLESTPRGLASGEWLHDYGLQTSRGFRALKVWMALKEHGVD
KFGRLIDQNIAQASYLAGVVEAEPLMELATSPTINIVCFRYQPGVTGEALKVLNTEIMLRLQEQGIAVLSDTTVHGEHWL
RVAIANHRTRREDLDLLVEETVRLGREIAAEGSPRK

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI92110055, Length=490, Percent_Identity=25.9183673469388, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4503281, Length=410, Percent_Identity=25.3658536585366, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI132814448, Length=410, Percent_Identity=25.3658536585366, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI197276620, Length=455, Percent_Identity=25.4945054945055, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4503875, Length=455, Percent_Identity=25.4945054945055, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI194294551, Length=486, Percent_Identity=26.5432098765432, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI58331246, Length=481, Percent_Identity=25.5717255717256, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI197383062, Length=479, Percent_Identity=24.0083507306889, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17534817, Length=468, Percent_Identity=25.2136752136752, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17534819, Length=468, Percent_Identity=25.2136752136752, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555682, Length=500, Percent_Identity=23, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71993062, Length=412, Percent_Identity=25.2427184466019, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI133931025, Length=404, Percent_Identity=24.7524752475248, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71993058, Length=412, Percent_Identity=23.7864077669903, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71981211, Length=497, Percent_Identity=22.5352112676056, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71981217, Length=506, Percent_Identity=21.9367588932806, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17551992, Length=507, Percent_Identity=21.8934911242604, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17543922, Length=377, Percent_Identity=20.159151193634, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24652373, Length=469, Percent_Identity=28.997867803838, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28573972, Length=473, Percent_Identity=25.7928118393235, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24585139, Length=516, Percent_Identity=25.3875968992248, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI221476190, Length=483, Percent_Identity=26.2939958592132, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24585143, Length=483, Percent_Identity=26.2939958592132, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17136190, Length=477, Percent_Identity=24.7379454926625, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24586044, Length=480, Percent_Identity=24.1666666666667, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356415, Length=456, Percent_Identity=24.780701754386, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24657193, Length=475, Percent_Identity=23.7894736842105, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24657185, Length=475, Percent_Identity=23.7894736842105, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24657188, Length=475, Percent_Identity=23.7894736842105, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585135, Length=488, Percent_Identity=24.7950819672131, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136594, Length=380, Percent_Identity=25.2631578947368, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 56407; Mature: 56276

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRRWRCRARRPAASSRRLDGSPVMDIAQETVGTEETLDPADWAAVQALSHQVIDDAVDY
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LSDIRDRPAWREMPAEVREAFAAPLPRSPVPLAAVYDEVSRTVMSYPMGNIHPRFWAWYM
HHHHHCCCCHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
GSSNFTGALGDFLAAIQGSNLGGGNHAAGLMDSQVVNWCKQMLGFPASASGTLVSGGSMA
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHH
NVIGLTVARNAKAGIDVREHGVAAIEKPLRFYGSDQIHSCHRKAMEALGLGNRALRRIPT
HHHHHEEECCCCCCCCHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCC
DADLRIDIPALRAAIVEDREAGFKPACVIGNAGTVNTGAIDDLRALAKLAHEEGLWFHVD
CCCEEEEHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
GCIGALIAIAPDNAHRVAGIEWADSVALDPHKWLHAPFEVGCALVRDAVAHRRTFAVTPE
HHHEEEEEECCCCCCEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCEEECCHH
YLESTPRGLASGEWLHDYGLQTSRGFRALKVWMALKEHGVDKFGRLIDQNIAQASYLAGV
HHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VEAEPLMELATSPTINIVCFRYQPGVTGEALKVLNTEIMLRLQEQGIAVLSDTTVHGEHW
HHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHEEECCCCEEEEECCEECCCCE
LRVAIANHRTRREDLDLLVEETVRLGREIAAEGSPRK
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PRRWRCRARRPAASSRRLDGSPVMDIAQETVGTEETLDPADWAAVQALSHQVIDDAVDY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LSDIRDRPAWREMPAEVREAFAAPLPRSPVPLAAVYDEVSRTVMSYPMGNIHPRFWAWYM
HHHHHCCCCHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
GSSNFTGALGDFLAAIQGSNLGGGNHAAGLMDSQVVNWCKQMLGFPASASGTLVSGGSMA
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHH
NVIGLTVARNAKAGIDVREHGVAAIEKPLRFYGSDQIHSCHRKAMEALGLGNRALRRIPT
HHHHHEEECCCCCCCCHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCC
DADLRIDIPALRAAIVEDREAGFKPACVIGNAGTVNTGAIDDLRALAKLAHEEGLWFHVD
CCCEEEEHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
GCIGALIAIAPDNAHRVAGIEWADSVALDPHKWLHAPFEVGCALVRDAVAHRRTFAVTPE
HHHEEEEEECCCCCCEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCEEECCHH
YLESTPRGLASGEWLHDYGLQTSRGFRALKVWMALKEHGVDKFGRLIDQNIAQASYLAGV
HHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VEAEPLMELATSPTINIVCFRYQPGVTGEALKVLNTEIMLRLQEQGIAVLSDTTVHGEHW
HHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHEEECCCCEEEEECCEECCCCE
LRVAIANHRTRREDLDLLVEETVRLGREIAAEGSPRK
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]