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The map label for this gene is cysK [H]

Identifier: 13473904

GI number: 13473904

Start: 3689316

End: 3690404

Strand: Direct

Name: cysK [H]

Synonym: mlr4651

Alternate gene names: 13473904

Gene position: 3689316-3690404 (Clockwise)

Preceding gene: 13473900

Following gene: 13473905

Centisome position: 52.43

GC content: 67.22

Gene sequence:

>1089_bases
ATGTTGAATCGACAGAAAATCAGGACCACCGCCGGGCGCGGCCGCCTGTTCGACAGCATTCTCGACACCGTCGGCGACAC
GCCGGTGATCCGCGTCAACAATCTCGGGCCGGCCCATGCGACGGTCTACGTCAAGGCCGAGTTCTTCAACCCCGCCGCCT
CGGTCAAGGACCGGCTGGCGCTCAACATCATCGAGGAGGGCGAGCGCAGCGGTGCGTTGAAGCCCGGCCAGACGGTGGTC
GAGGCCACCAGTGGCAACACCGGCATTGGGCTGGCCATGGTCTGCGCGCAAAAGGGCTATCCGCTGGTCGTCACCATGGC
CGACAGCTTTTCCGTCGAGCGCCGCAAGCTGATGCGCATGCTGGGCGCCAAGGTGGTGCTGACGCCGCGCGCCGAAAAGG
GTTTTGGCATGTACAAGAAGGCGGTGGAGCTGGCCGAGGCCAATGGCTGGTTCCTCGCCCGCCAGTTCGAGACCGCCGCC
AACGCCGCCATCCACGAGGCGACCACGGCGCGCGAGATCATCAATGATTTCGCCGGCTCGCGGCTCGACTGCTTCGTCAC
CGGCTACGGCACCGGCGGCACCGTCGTCGGCGTGGCGCGTGTGCTGCGCCGCGAGCGGCCGGACACCCGCATCGTGCTCT
CCGAACCGGCCAATGCGCAGCTCATTGGCAGCGGCAAGGCACAGCAGCGCGGTGCCCATGGCGCCCCTGCCGCCAGCCAT
CCGGCCTTCGAGCCGCATCCGATCCAGGGCTGGACGCCGGACTTCATCCCCAATGTGCTGCAAGAGGCGATCGACGCCAG
CCTCTATGACGAGGTGATGCCGATTGCCGGGCCCGAAGGCATCAAATGGGCCAAGGCACTGGCTCAGAAGGAGGGCATCT
TTACCGGAATTTCCGGCGGCGCCACCTTCGCCGTGGCACGGCAGGTCGCGGAAAAGGCGCCGGCCGGATCGGTGATCCTG
TGCATGCTGCCCGACACCGGCGAGCGCTACATGTCGACGCCGCTGTTCGACGGCATCGAGGCCGAGATGGATGCCGAGGA
GATGGCGCTGTCGCGCTCGACGCCCGGCGGCCAGTTCCCGGCGGCTTGA

Upstream 100 bases:

>100_bases
GGCATGTCAGTCCTAGCGCGGCCATGTCTCGAAACCTCGCCGCCCAAGCCGCCGGTTTGTAACCGGCCTGTGAAGACGAA
CACGATCGAGGAGATCAAAC

Downstream 100 bases:

>100_bases
CGGGAGCCCGGTCATGGACATCGCGCAGGAAACCGTCGGCACCGAGGAAACGCTCGACCCCGCCGACTGGGCCGCAGTGC
AAGCCCTGTCGCACCAGGTC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MLNRQKIRTTAGRGRLFDSILDTVGDTPVIRVNNLGPAHATVYVKAEFFNPAASVKDRLALNIIEEGERSGALKPGQTVV
EATSGNTGIGLAMVCAQKGYPLVVTMADSFSVERRKLMRMLGAKVVLTPRAEKGFGMYKKAVELAEANGWFLARQFETAA
NAAIHEATTAREIINDFAGSRLDCFVTGYGTGGTVVGVARVLRRERPDTRIVLSEPANAQLIGSGKAQQRGAHGAPAASH
PAFEPHPIQGWTPDFIPNVLQEAIDASLYDEVMPIAGPEGIKWAKALAQKEGIFTGISGGATFAVARQVAEKAPAGSVIL
CMLPDTGERYMSTPLFDGIEAEMDAEEMALSRSTPGGQFPAA

Sequences:

>Translated_362_residues
MLNRQKIRTTAGRGRLFDSILDTVGDTPVIRVNNLGPAHATVYVKAEFFNPAASVKDRLALNIIEEGERSGALKPGQTVV
EATSGNTGIGLAMVCAQKGYPLVVTMADSFSVERRKLMRMLGAKVVLTPRAEKGFGMYKKAVELAEANGWFLARQFETAA
NAAIHEATTAREIINDFAGSRLDCFVTGYGTGGTVVGVARVLRRERPDTRIVLSEPANAQLIGSGKAQQRGAHGAPAASH
PAFEPHPIQGWTPDFIPNVLQEAIDASLYDEVMPIAGPEGIKWAKALAQKEGIFTGISGGATFAVARQVAEKAPAGSVIL
CMLPDTGERYMSTPLFDGIEAEMDAEEMALSRSTPGGQFPAA
>Mature_362_residues
MLNRQKIRTTAGRGRLFDSILDTVGDTPVIRVNNLGPAHATVYVKAEFFNPAASVKDRLALNIIEEGERSGALKPGQTVV
EATSGNTGIGLAMVCAQKGYPLVVTMADSFSVERRKLMRMLGAKVVLTPRAEKGFGMYKKAVELAEANGWFLARQFETAA
NAAIHEATTAREIINDFAGSRLDCFVTGYGTGGTVVGVARVLRRERPDTRIVLSEPANAQLIGSGKAQQRGAHGAPAASH
PAFEPHPIQGWTPDFIPNVLQEAIDASLYDEVMPIAGPEGIKWAKALAQKEGIFTGISGGATFAVARQVAEKAPAGSVIL
CMLPDTGERYMSTPLFDGIEAEMDAEEMALSRSTPGGQFPAA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=331, Percent_Identity=35.3474320241692, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI295821200, Length=331, Percent_Identity=35.3474320241692, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI4557415, Length=331, Percent_Identity=35.3474320241692, Blast_Score=188, Evalue=6e-48,
Organism=Escherichia coli, GI1788754, Length=338, Percent_Identity=39.3491124260355, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI2367138, Length=321, Percent_Identity=35.8255451713396, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=320, Percent_Identity=36.875, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17562970, Length=347, Percent_Identity=34.2939481268012, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI115535073, Length=333, Percent_Identity=38.7387387387387, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=315, Percent_Identity=35.5555555555556, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17561720, Length=326, Percent_Identity=34.3558282208589, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=340, Percent_Identity=32.3529411764706, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=338, Percent_Identity=31.6568047337278, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=261, Percent_Identity=31.4176245210728, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17539800, Length=229, Percent_Identity=27.9475982532751, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539640, Length=345, Percent_Identity=25.7971014492754, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996324, Length=339, Percent_Identity=23.8938053097345, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=333, Percent_Identity=31.8318318318318, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6321449, Length=345, Percent_Identity=31.8840579710145, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24643623, Length=340, Percent_Identity=31.4705882352941, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI20129101, Length=340, Percent_Identity=31.4705882352941, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38512; Mature: 38512

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRQKIRTTAGRGRLFDSILDTVGDTPVIRVNNLGPAHATVYVKAEFFNPAASVKDRLA
CCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHHHHH
LNIIEEGERSGALKPGQTVVEATSGNTGIGLAMVCAQKGYPLVVTMADSFSVERRKLMRM
HHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHEEECCCCCCEEEEECCCCCHHHHHHHHH
LGAKVVLTPRAEKGFGMYKKAVELAEANGWFLARQFETAANAAIHEATTAREIINDFAGS
HCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RLDCFVTGYGTGGTVVGVARVLRRERPDTRIVLSEPANAQLIGSGKAQQRGAHGAPAASH
CEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCHHHCCCCCCCCCCC
PAFEPHPIQGWTPDFIPNVLQEAIDASLYDEVMPIAGPEGIKWAKALAQKEGIFTGISGG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCCC
ATFAVARQVAEKAPAGSVILCMLPDTGERYMSTPLFDGIEAEMDAEEMALSRSTPGGQFP
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCC
AA
CC
>Mature Secondary Structure
MLNRQKIRTTAGRGRLFDSILDTVGDTPVIRVNNLGPAHATVYVKAEFFNPAASVKDRLA
CCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHHHHH
LNIIEEGERSGALKPGQTVVEATSGNTGIGLAMVCAQKGYPLVVTMADSFSVERRKLMRM
HHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHEEECCCCCCEEEEECCCCCHHHHHHHHH
LGAKVVLTPRAEKGFGMYKKAVELAEANGWFLARQFETAANAAIHEATTAREIINDFAGS
HCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RLDCFVTGYGTGGTVVGVARVLRRERPDTRIVLSEPANAQLIGSGKAQQRGAHGAPAASH
CEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCHHHCCCCCCCCCCC
PAFEPHPIQGWTPDFIPNVLQEAIDASLYDEVMPIAGPEGIKWAKALAQKEGIFTGISGG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCCC
ATFAVARQVAEKAPAGSVILCMLPDTGERYMSTPLFDGIEAEMDAEEMALSRSTPGGQFP
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA