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The map label for this gene is gpmA

Identifier: 13473897

GI number: 13473897

Start: 3681874

End: 3682494

Strand: Direct

Name: gpmA

Synonym: mlr4643

Alternate gene names: 13473897

Gene position: 3681874-3682494 (Clockwise)

Preceding gene: 13473896

Following gene: 13473898

Centisome position: 52.33

GC content: 65.22

Gene sequence:

>621_bases
ATGTCGAGAACCCTTGTGCTCGTGCGCCATGGCCAGAGCGAATGGAATTTGAAAAACCTGTTCACCGGTTGGCGTGACGT
TGACCTGACCGAGCAGGGTCATGCCGAGGCCAAGGCCGCCGGGCAGAAACTCAAGGCGCGCGGCCTGAAGTTCGACATCG
CCTTCACCTCGGCGCTGAGCCGCGCGCAAAAGACCTGCCAGCATATTCTCGACGCCGTCGGCCAGAGCGATCTCAAGACC
ATCCGCGACCAGGCACTCAACGAGCGCGACTATGGCGACCTTTCCGGCCTCAACAAGGACGACGCCCGCAAGAAATGGGG
CGAGGAGCAGGTGCATGTCTGGCGCCGCTCCTACGACGTGTCGCCGCCCGGCGGCGAAAGCCTGAAGGACACCGGCGCCC
GCGTCTGGCCTTACTACCTGCACGACCTGCAGCCGCACGTGCTGCGCGGCGGCACCGTGCTGGTCGCCGCCCACGGCAAT
TCGCTGCGCGCGCTGATCATGGCGCTGGACGGCAAGTCGGGCGAGGAGATCGTCAAGCTGGAGCTCGGCACCGGCGTGCC
GGTCATCTACCAGCTCAACGCCGATTCGACCGTGGCGTCGAAGGAAGTGCTGGAGGGCTGA

Upstream 100 bases:

>100_bases
GGCCCGTGGCAAGAAGCCAGGACTCTATTCGATGCGGGACGTGCTCGGCCTGAGCTGAAACGGCCAATCTGCCCATTTTG
CCAATCTGAAGGGAGCAAAC

Downstream 100 bases:

>100_bases
AGGTCCTGAGCCGGCAAGCGGAGCCCGAGGCTCTGGCTGGACCAAGCTCTTCTGCCCTAGCTGCGTTCCAGCTTTCGGCG
TTATGGTCCAAAAAGCGCGT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSRTLVLVRHGQSEWNLKNLFTGWRDVDLTEQGHAEAKAAGQKLKARGLKFDIAFTSALSRAQKTCQHILDAVGQSDLKT
IRDQALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDVSPPGGESLKDTGARVWPYYLHDLQPHVLRGGTVLVAAHGN
SLRALIMALDGKSGEEIVKLELGTGVPVIYQLNADSTVASKEVLEG

Sequences:

>Translated_206_residues
MSRTLVLVRHGQSEWNLKNLFTGWRDVDLTEQGHAEAKAAGQKLKARGLKFDIAFTSALSRAQKTCQHILDAVGQSDLKT
IRDQALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDVSPPGGESLKDTGARVWPYYLHDLQPHVLRGGTVLVAAHGN
SLRALIMALDGKSGEEIVKLELGTGVPVIYQLNADSTVASKEVLEG
>Mature_205_residues
SRTLVLVRHGQSEWNLKNLFTGWRDVDLTEQGHAEAKAAGQKLKARGLKFDIAFTSALSRAQKTCQHILDAVGQSDLKTI
RDQALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDVSPPGGESLKDTGARVWPYYLHDLQPHVLRGGTVLVAAHGNS
LRALIMALDGKSGEEIVKLELGTGVPVIYQLNADSTVASKEVLEG

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4505753, Length=218, Percent_Identity=45.4128440366972, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI50593010, Length=218, Percent_Identity=42.6605504587156, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI71274132, Length=218, Percent_Identity=42.6605504587156, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI4502445, Length=220, Percent_Identity=39.5454545454545, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI40353764, Length=220, Percent_Identity=39.5454545454545, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI310129614, Length=160, Percent_Identity=46.875, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1786970, Length=216, Percent_Identity=45.3703703703704, Blast_Score=181, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322697, Length=216, Percent_Identity=41.6666666666667, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320183, Length=274, Percent_Identity=25.5474452554745, Blast_Score=88, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324516, Length=266, Percent_Identity=25.5639097744361, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324857, Length=107, Percent_Identity=32.7102803738318, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646216, Length=217, Percent_Identity=41.9354838709677, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI85725270, Length=219, Percent_Identity=42.4657534246575, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI85725272, Length=219, Percent_Identity=42.4657534246575, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24650981, Length=219, Percent_Identity=42.4657534246575, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28571815, Length=223, Percent_Identity=33.6322869955157, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28571817, Length=223, Percent_Identity=33.6322869955157, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24648979, Length=223, Percent_Identity=33.6322869955157, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_RHILO (Q98DM0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105465.1
- ProteinModelPortal:   Q98DM0
- SMR:   Q98DM0
- GeneID:   1228126
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4643
- NMPDR:   fig|266835.1.peg.3569
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK01295
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 22742; Mature: 22611

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 10-10 ACT_SITE 158-158

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTLVLVRHGQSEWNLKNLFTGWRDVDLTEQGHAEAKAAGQKLKARGLKFDIAFTSALS
CCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
RAQKTCQHILDAVGQSDLKTIRDQALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDV
HHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCC
SPPGGESLKDTGARVWPYYLHDLQPHVLRGGTVLVAAHGNSLRALIMALDGKSGEEIVKL
CCCCCCCHHHCCCEECHHHHHCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCCEEEEE
ELGTGVPVIYQLNADSTVASKEVLEG
EECCCCCEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
SRTLVLVRHGQSEWNLKNLFTGWRDVDLTEQGHAEAKAAGQKLKARGLKFDIAFTSALS
CCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
RAQKTCQHILDAVGQSDLKTIRDQALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDV
HHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCC
SPPGGESLKDTGARVWPYYLHDLQPHVLRGGTVLVAAHGNSLRALIMALDGKSGEEIVKL
CCCCCCCHHHCCCEECHHHHHCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCCEEEEE
ELGTGVPVIYQLNADSTVASKEVLEG
EECCCCCEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968