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The map label for this gene is rppH

Identifier: 13473410

GI number: 13473410

Start: 3196953

End: 3197474

Strand: Reverse

Name: rppH

Synonym: mll3998

Alternate gene names: 13473410

Gene position: 3197474-3196953 (Counterclockwise)

Preceding gene: 13473411

Following gene: 13473409

Centisome position: 45.44

GC content: 63.41

Gene sequence:

>522_bases
ATGCCAAAGACGAAGAAGGTCGACCGCGAAACGCTGCCCTACCGTCCCTGTGTCGGGCTGATGATCCTCAATGGCGAGGG
CCTGGTCTGGGTCGGGCATCGCATTGCCGAACCCGACAGCGAATTCGCCGGCACGACGCAGCTCTGGCAGATGCCGCAGG
GCGGCATCGACAAGGGTGAGGAGCCGCTGCAGGCGGCCGAGCGCGAGCTTTATGAGGAGACCGGCATGCGCAGCGTCTCG
CTGCTCGCCGAAGCGCCGGACTGGATCAATTACGACCTGCCGGACCATCTCGTCGGCATTGCCTTCAAGGGTCGATATCG
CGGCCAGATGCAGAAATGGTTCGCCTTCCGCTTCCATGGCGACGGCAGCGAGATCCAGATCAATCCGCCGCCGGGCGGCC
ACACCGCCGAATTCGACAAATGGTCGTGGCGGCCGATGCAAGATCTGCCCGACCTGATCGTGCCGTTCAAGCGCAAGGTC
TATGAAGAGGTGGTGGCGGCGTTCAGCCATCTGGCGCGTTAG

Upstream 100 bases:

>100_bases
AAGAAGCGCGGCATCGAGATCGTGCCGATTTCAGCGGTGGCGATCGATCCGCAAAAGGGCTAGGCGATGCCCTTCTGAAG
ATGGCTGGAGAGACTGACTG

Downstream 100 bases:

>100_bases
CCGCGTCGAGGTTGCCGCGTTGGTGCGGGGGTCGTATTGATGGCCGATGCAATGAGGGTCGCCATGAACGACGCCGTCAA
TCCGACTGCTGCGAAAACCG

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MPKTKKVDRETLPYRPCVGLMILNGEGLVWVGHRIAEPDSEFAGTTQLWQMPQGGIDKGEEPLQAAERELYEETGMRSVS
LLAEAPDWINYDLPDHLVGIAFKGRYRGQMQKWFAFRFHGDGSEIQINPPPGGHTAEFDKWSWRPMQDLPDLIVPFKRKV
YEEVVAAFSHLAR

Sequences:

>Translated_173_residues
MPKTKKVDRETLPYRPCVGLMILNGEGLVWVGHRIAEPDSEFAGTTQLWQMPQGGIDKGEEPLQAAERELYEETGMRSVS
LLAEAPDWINYDLPDHLVGIAFKGRYRGQMQKWFAFRFHGDGSEIQINPPPGGHTAEFDKWSWRPMQDLPDLIVPFKRKV
YEEVVAAFSHLAR
>Mature_172_residues
PKTKKVDRETLPYRPCVGLMILNGEGLVWVGHRIAEPDSEFAGTTQLWQMPQGGIDKGEEPLQAAERELYEETGMRSVSL
LAEAPDWINYDLPDHLVGIAFKGRYRGQMQKWFAFRFHGDGSEIQINPPPGGHTAEFDKWSWRPMQDLPDLIVPFKRKVY
EEVVAAFSHLAR

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=161, Percent_Identity=36.6459627329193, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_RHILO (Q98F04)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104977.1
- ProteinModelPortal:   Q98F04
- SMR:   Q98F04
- GeneID:   1227638
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll3998
- NMPDR:   fig|266835.1.peg.3081
- HOGENOM:   HBG302451
- OMA:   AGRAWKG
- ProtClustDB:   PRK00714
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19767; Mature: 19636

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTKKVDRETLPYRPCVGLMILNGEGLVWVGHRIAEPDSEFAGTTQLWQMPQGGIDKGE
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCEECCCCCHHCCCHHHHCCCCCCCCCCC
EPLQAAERELYEETGMRSVSLLAEAPDWINYDLPDHLVGIAFKGRYRGQMQKWFAFRFHG
HHHHHHHHHHHHHHCCCEEHHHHCCCCCCCCCCCHHHEEEEECCCHHHHHCEEEEEEECC
DGSEIQINPPPGGHTAEFDKWSWRPMQDLPDLIVPFKRKVYEEVVAAFSHLAR
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKTKKVDRETLPYRPCVGLMILNGEGLVWVGHRIAEPDSEFAGTTQLWQMPQGGIDKGE
CCCCCCCCCCCCCCCCEEEEEECCCCEEEECCEECCCCCHHCCCHHHHCCCCCCCCCCC
EPLQAAERELYEETGMRSVSLLAEAPDWINYDLPDHLVGIAFKGRYRGQMQKWFAFRFHG
HHHHHHHHHHHHHHCCCEEHHHHCCCCCCCCCCCHHHEEEEECCCHHHHHCEEEEEEECC
DGSEIQINPPPGGHTAEFDKWSWRPMQDLPDLIVPFKRKVYEEVVAAFSHLAR
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968