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The map label for this gene is serA [H]

Identifier: 13473319

GI number: 13473319

Start: 3111287

End: 3112888

Strand: Reverse

Name: serA [H]

Synonym: mll3875

Alternate gene names: 13473319

Gene position: 3112888-3111287 (Counterclockwise)

Preceding gene: 13473320

Following gene: 13473317

Centisome position: 44.24

GC content: 63.8

Gene sequence:

>1602_bases
ATGGCGCCCCGCGTACTCGTCTCTGACAAACTCTCTCCCACCGCCGTGCAGATCTTCAAGGATCGCGGCGTCGAGGTCGA
CTATCTGCCCGACCTCGGCAAGGACAAGGAAAAGCTGCTCGAAGTGATCGACCAGTATGACGGCCTTGCCATCCGCTCGG
CGACCAAAGTCACCGAAAAGCTGATCAACGCCGCCACCAGGCTCAAGGTCATCGGCCGCGCCGGCATCGGCGTCGACAAT
GTCGATATCCCGGCGGCGAGCCGCAAGGGTATCATCGTGATGAACACGCCCTTCGGCAATTCGATCACGACGGCCGAGCA
CGCCGTGGCGATGATCTTCGCGCTGGCGCGCCAGATCCCGGAAGCCAACGCCTCGACCCATGCCGGCAAGTGGGAGAAGA
ACCGCTTCATGGGTGTCGAGATCACCGGCAAGACGCTGGGCGTCATCGGCTGCGGCAATATCGGTTCGATCGTCGCCACA
CGCGGCGTCGGCCTGAAGATGCATGTCGTCGCCTTCGACCCGTTCCTGTCGGACAAGCGTGCCGAGGAGCTCGGCGTCGA
GAAGGTCGAGCTCGATGAGCTGTTCGCGCGCGCGGACTTCATTACGTTGCACACGCCGCTGACCGACAAGACGCGCAACA
TCATCGATGCCGGGGCAATCGCCAAGATGAAGAACGGCGTGCGCATCATCAACTGCGCGCGTGGCGGGCTGATCGTCGAG
GCCGACCTGATCGCGGCGCTGAAGAGCGGCAAGGTGGCGGGCGCCGGCATCGACGTGTTCGAGGTCGAGCCGGCCGAGCA
GAACGCCTTGTTCGGCATGGAGAACGTGGTGGCGACGCCGCATCTCGGCGCCTCGACGGCGGAAGCGCAGGAGAATGTCG
CGCTGCAGGTCGCCGAGCAGATGTCGGACTATCTGATCAAGGGCGCGGTCTCCAACGCCATCAACATGCCGTCGATCACG
GCGGAAGAAGCGCCACGGCTGAAGCCCTTCGTCAAGCTCGCCGAAGTGCTCGGCGCCTTTGTCGGCCAGGTCACCGAGGA
TCCGATCATGGAGGTCGAGATCCTGTTCGACGGCTCGACCGCGACGATGAACACGCGCGCGCTGATCAGCGCGACGCTTG
CCGGGCTGATCCGGCCGCAGGTCTCCGACGTCAACATGGTTTCGGCACCGATCATGGTGAAGGAGCGCGGCATCATTGTA
GCCGAGGTCAAGCGCGACAAGTCGGGTGTGTTCGATGGCTACATCAAGCTGACGGTCAAGACCGAGCACAGGACGCGCTC
GATCGCCGGCACTTGCTTCTCGGACGGCAAGCCGCGCTTCATCCAGATCAAGGGCATCAACCTCGACGCCGAGGTCGGTC
AGCACATGCTCTACACCACCAATGCCGATGCGCCCGGTATCATCGGCCTGCTCGGCACAGTGTGCGGCGAGAATGGCGTC
AACATCGCCAACTTCCAGCTTGGCCGCAACCGGCCGGGCGGCGACGCCATAGCGCTGCTCTATCTCGACGCGCCGTTCCC
GGAAAAGGTGCTGGAGCAGGTGCGGGCGCACAAGTCGATCGACTCGGCCAAGCGGCTGCAGTTCGACGTCGGCGGGATCT
GA

Upstream 100 bases:

>100_bases
CGCCGCGCAAAAGGCGTCGCTGAAAGCGGCGGCCTGAGACTTTCCGTGGCGGCCCGCGGGCCGCCCATTCCCGGATCAAT
CCCATTTCAAGGAGGCCGCC

Downstream 100 bases:

>100_bases
TCCGCCTTTTCGCCAGGATCGGAAGGCGCGGCGTTTGTCGCGCCTTCTTGCGGCTCAGCGCGCCCTGGCTGGCGGGGTCA
TCGCCATCTTGCGCCCGCTA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MAPRVLVSDKLSPTAVQIFKDRGVEVDYLPDLGKDKEKLLEVIDQYDGLAIRSATKVTEKLINAATRLKVIGRAGIGVDN
VDIPAASRKGIIVMNTPFGNSITTAEHAVAMIFALARQIPEANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSIVAT
RGVGLKMHVVAFDPFLSDKRAEELGVEKVELDELFARADFITLHTPLTDKTRNIIDAGAIAKMKNGVRIINCARGGLIVE
ADLIAALKSGKVAGAGIDVFEVEPAEQNALFGMENVVATPHLGASTAEAQENVALQVAEQMSDYLIKGAVSNAINMPSIT
AEEAPRLKPFVKLAEVLGAFVGQVTEDPIMEVEILFDGSTATMNTRALISATLAGLIRPQVSDVNMVSAPIMVKERGIIV
AEVKRDKSGVFDGYIKLTVKTEHRTRSIAGTCFSDGKPRFIQIKGINLDAEVGQHMLYTTNADAPGIIGLLGTVCGENGV
NIANFQLGRNRPGGDAIALLYLDAPFPEKVLEQVRAHKSIDSAKRLQFDVGGI

Sequences:

>Translated_533_residues
MAPRVLVSDKLSPTAVQIFKDRGVEVDYLPDLGKDKEKLLEVIDQYDGLAIRSATKVTEKLINAATRLKVIGRAGIGVDN
VDIPAASRKGIIVMNTPFGNSITTAEHAVAMIFALARQIPEANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSIVAT
RGVGLKMHVVAFDPFLSDKRAEELGVEKVELDELFARADFITLHTPLTDKTRNIIDAGAIAKMKNGVRIINCARGGLIVE
ADLIAALKSGKVAGAGIDVFEVEPAEQNALFGMENVVATPHLGASTAEAQENVALQVAEQMSDYLIKGAVSNAINMPSIT
AEEAPRLKPFVKLAEVLGAFVGQVTEDPIMEVEILFDGSTATMNTRALISATLAGLIRPQVSDVNMVSAPIMVKERGIIV
AEVKRDKSGVFDGYIKLTVKTEHRTRSIAGTCFSDGKPRFIQIKGINLDAEVGQHMLYTTNADAPGIIGLLGTVCGENGV
NIANFQLGRNRPGGDAIALLYLDAPFPEKVLEQVRAHKSIDSAKRLQFDVGGI
>Mature_532_residues
APRVLVSDKLSPTAVQIFKDRGVEVDYLPDLGKDKEKLLEVIDQYDGLAIRSATKVTEKLINAATRLKVIGRAGIGVDNV
DIPAASRKGIIVMNTPFGNSITTAEHAVAMIFALARQIPEANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSIVATR
GVGLKMHVVAFDPFLSDKRAEELGVEKVELDELFARADFITLHTPLTDKTRNIIDAGAIAKMKNGVRIINCARGGLIVEA
DLIAALKSGKVAGAGIDVFEVEPAEQNALFGMENVVATPHLGASTAEAQENVALQVAEQMSDYLIKGAVSNAINMPSITA
EEAPRLKPFVKLAEVLGAFVGQVTEDPIMEVEILFDGSTATMNTRALISATLAGLIRPQVSDVNMVSAPIMVKERGIIVA
EVKRDKSGVFDGYIKLTVKTEHRTRSIAGTCFSDGKPRFIQIKGINLDAEVGQHMLYTTNADAPGIIGLLGTVCGENGVN
IANFQLGRNRPGGDAIALLYLDAPFPEKVLEQVRAHKSIDSAKRLQFDVGGI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=399, Percent_Identity=43.3583959899749, Blast_Score=341, Evalue=9e-94,
Organism=Homo sapiens, GI145580578, Length=302, Percent_Identity=32.7814569536424, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI4557499, Length=302, Percent_Identity=32.7814569536424, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI61743967, Length=327, Percent_Identity=29.9694189602446, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4557497, Length=317, Percent_Identity=30.2839116719243, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI145580575, Length=302, Percent_Identity=33.112582781457, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI6912396, Length=265, Percent_Identity=32.4528301886792, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1789279, Length=291, Percent_Identity=38.1443298969072, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=33.457249070632, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=35.6, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081824, Length=263, Percent_Identity=27.3764258555133, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=30.0380228136882, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=45.364238410596, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=34.2857142857143, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=335, Percent_Identity=35.2238805970149, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6320925, Length=335, Percent_Identity=34.3283582089552, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=31.25, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=28.8808664259928, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=28.7878787878788, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=115, Percent_Identity=39.1304347826087, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=44.0397350993377, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=31.0861423220974, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=31.0861423220974, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=31.0861423220974, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45552429, Length=267, Percent_Identity=31.0861423220974, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=31.0861423220974, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=31.6363636363636, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=31.6363636363636, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=31.6363636363636, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=31.6363636363636, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=31.6363636363636, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=27.6872964169381, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=30.9433962264151, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56927; Mature: 56795

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLVSDKLSPTAVQIFKDRGVEVDYLPDLGKDKEKLLEVIDQYDGLAIRSATKVTEK
CCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHH
LINAATRLKVIGRAGIGVDNVDIPAASRKGIIVMNTPFGNSITTAEHAVAMIFALARQIP
HHHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSIVATRGVGLKMHVVAFDPFLSDKR
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHCCCCCEEEEEEEECCCCCCCC
AEELGVEKVELDELFARADFITLHTPLTDKTRNIIDAGAIAKMKNGVRIINCARGGLIVE
HHHHCCCEEEHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEE
ADLIAALKSGKVAGAGIDVFEVEPAEQNALFGMENVVATPHLGASTAEAQENVALQVAEQ
HHHHHHHHCCCEECCCCEEEEECCCCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHH
MSDYLIKGAVSNAINMPSITAEEAPRLKPFVKLAEVLGAFVGQVTEDPIMEVEILFDGST
HHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
ATMNTRALISATLAGLIRPQVSDVNMVSAPIMVKERGIIVAEVKRDKSGVFDGYIKLTVK
CCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCEEEEEECCCCCCCEEEEEEEEEE
TEHRTRSIAGTCFSDGKPRFIQIKGINLDAEVGQHMLYTTNADAPGIIGLLGTVCGENGV
ECCCCCCEEEEEECCCCCCEEEEEECCCCHHHCCEEEEEECCCCCHHHHHHHHHHCCCCC
NIANFQLGRNRPGGDAIALLYLDAPFPEKVLEQVRAHKSIDSAKRLQFDVGGI
EEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHEEEECCCC
>Mature Secondary Structure 
APRVLVSDKLSPTAVQIFKDRGVEVDYLPDLGKDKEKLLEVIDQYDGLAIRSATKVTEK
CCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHH
LINAATRLKVIGRAGIGVDNVDIPAASRKGIIVMNTPFGNSITTAEHAVAMIFALARQIP
HHHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EANASTHAGKWEKNRFMGVEITGKTLGVIGCGNIGSIVATRGVGLKMHVVAFDPFLSDKR
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHCCCCCEEEEEEEECCCCCCCC
AEELGVEKVELDELFARADFITLHTPLTDKTRNIIDAGAIAKMKNGVRIINCARGGLIVE
HHHHCCCEEEHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEE
ADLIAALKSGKVAGAGIDVFEVEPAEQNALFGMENVVATPHLGASTAEAQENVALQVAEQ
HHHHHHHHCCCEECCCCEEEEECCCCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHH
MSDYLIKGAVSNAINMPSITAEEAPRLKPFVKLAEVLGAFVGQVTEDPIMEVEILFDGST
HHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
ATMNTRALISATLAGLIRPQVSDVNMVSAPIMVKERGIIVAEVKRDKSGVFDGYIKLTVK
CCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCEEEEEECCCCCCCEEEEEEEEEE
TEHRTRSIAGTCFSDGKPRFIQIKGINLDAEVGQHMLYTTNADAPGIIGLLGTVCGENGV
ECCCCCCEEEEEECCCCCCEEEEEECCCCHHHCCEEEEEECCCCCHHHHHHHHHHCCCCC
NIANFQLGRNRPGGDAIALLYLDAPFPEKVLEQVRAHKSIDSAKRLQFDVGGI
EEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]