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The map label for this gene is ispA [C]

Identifier: 13473247

GI number: 13473247

Start: 3040106

End: 3041023

Strand: Direct

Name: ispA [C]

Synonym: mlr3784

Alternate gene names: 13473247

Gene position: 3040106-3041023 (Clockwise)

Preceding gene: 13473243

Following gene: 13473248

Centisome position: 43.21

GC content: 68.95

Gene sequence:

>918_bases
ATGACGAATGACGACGAAATGGCGTTCGAAATGGCGCTCATCAGGCGGGCAGCCGCCGTCGAGGTGCTGCTGCGGCGCTT
GCTCGACGATCGCCCGCTTTCGGGAGAGATCGCGCGGCCCGACCGCCTGATGGCGGCGATGCGCCATGGCGTGCTGAACG
GCGGCAAGCGCCTGCGCCCCTTCCTGGTCATGGAAAGTGCCGCCCTTTTCTCCGCCGATGGCGAAGCAGCACTGCGCGTC
GCGGCGGCACTCGAATGCGTGCATTGCTATTCACTGATCCATGACGACCTGCCGGCGATGGACGATGATGATCTGCGCCG
CGGCCAGCCGACCGTGCACAAGGCCTTCGACGAGGCAACCGCGATCCTGGCCGGCGACGCCTTGCTGACGCTGGCCTTCG
ACATCGTCGCCAGCGAGGCGACCGTCCTGCCGGCGGATCGGCGAGCGGCCTTGGTGCTGGCGCTTGCCCGTGCGGCCGGA
GCCGGCGGCATGGTCGGTGGCCAGAAGCTCGACCTCGAAGCCGAGCAGACACCGCCCGACGAAGCGGGCATCATAACGCT
GCAGGCGATGAAGACCGGCGCCCTGATCCGCTTCGCCTGCGAGGCCGGCGCCATCATCGCCGGCGCTCCGGCCGAGGACC
GCGAAAGGCTGGCCGAGTTCGGCTCGGCCATCGGCCTTGCCTTCCAGCTTGCCGACGACCTGCTCGATTTGACCGCCGAC
GCCGGCCAGATGGGCAAGGCGACCGGCAAGGACGCCGCCGCCGGCAAGGGAACGCTGGTGGCGTTGCATGGCGCGAATTG
GGCGCACAGCCAGTTGCACGGCCTTGTCGGGCAGGCCCACGCGCTGCTCGACCCCTATGGCGACCGGGCGGCGCTGCTGA
AGGAGGCTGCGACCTTCGTCGCGACGCGCAACAGTTGA

Upstream 100 bases:

>100_bases
TCGGTTCCGCCAAGCCGCCCAACCCGTGCTTCTCCTCGCTCCGGCATAATGGCGCTTGCCTTCTTGCGCAACGTCTGAGT
GTCGGCTACCGGTCCCGATC

Downstream 100 bases:

>100_bases
GCGCGGGCCGCGACGTCGGCGCGGGTTGAGACAAATGGGAGATCAGCTTCGATGTCGGCCAATCTGTTCGATCTCAGCGG
GCGCCAGGCGCTCGTAACCG

Product: geranyltranstransferase (farnesyl-diphosphate synthase)

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTNDDEMAFEMALIRRAAAVEVLLRRLLDDRPLSGEIARPDRLMAAMRHGVLNGGKRLRPFLVMESAALFSADGEAALRV
AAALECVHCYSLIHDDLPAMDDDDLRRGQPTVHKAFDEATAILAGDALLTLAFDIVASEATVLPADRRAALVLALARAAG
AGGMVGGQKLDLEAEQTPPDEAGIITLQAMKTGALIRFACEAGAIIAGAPAEDRERLAEFGSAIGLAFQLADDLLDLTAD
AGQMGKATGKDAAAGKGTLVALHGANWAHSQLHGLVGQAHALLDPYGDRAALLKEAATFVATRNS

Sequences:

>Translated_305_residues
MTNDDEMAFEMALIRRAAAVEVLLRRLLDDRPLSGEIARPDRLMAAMRHGVLNGGKRLRPFLVMESAALFSADGEAALRV
AAALECVHCYSLIHDDLPAMDDDDLRRGQPTVHKAFDEATAILAGDALLTLAFDIVASEATVLPADRRAALVLALARAAG
AGGMVGGQKLDLEAEQTPPDEAGIITLQAMKTGALIRFACEAGAIIAGAPAEDRERLAEFGSAIGLAFQLADDLLDLTAD
AGQMGKATGKDAAAGKGTLVALHGANWAHSQLHGLVGQAHALLDPYGDRAALLKEAATFVATRNS
>Mature_304_residues
TNDDEMAFEMALIRRAAAVEVLLRRLLDDRPLSGEIARPDRLMAAMRHGVLNGGKRLRPFLVMESAALFSADGEAALRVA
AALECVHCYSLIHDDLPAMDDDDLRRGQPTVHKAFDEATAILAGDALLTLAFDIVASEATVLPADRRAALVLALARAAGA
GGMVGGQKLDLEAEQTPPDEAGIITLQAMKTGALIRFACEAGAIIAGAPAEDRERLAEFGSAIGLAFQLADDLLDLTADA
GQMGKATGKDAAAGKGTLVALHGANWAHSQLHGLVGQAHALLDPYGDRAALLKEAATFVATRNS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=212, Percent_Identity=31.6037735849057, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786623, Length=274, Percent_Identity=44.1605839416058, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789578, Length=214, Percent_Identity=34.5794392523364, Blast_Score=116, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24651612, Length=213, Percent_Identity=32.3943661971831, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31934; Mature: 31803

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDDEMAFEMALIRRAAAVEVLLRRLLDDRPLSGEIARPDRLMAAMRHGVLNGGKRLRP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
FLVMESAALFSADGEAALRVAAALECVHCYSLIHDDLPAMDDDDLRRGQPTVHKAFDEAT
HHEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHH
AILAGDALLTLAFDIVASEATVLPADRRAALVLALARAAGAGGMVGGQKLDLEAEQTPPD
HHHHCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCC
EAGIITLQAMKTGALIRFACEAGAIIAGAPAEDRERLAEFGSAIGLAFQLADDLLDLTAD
CCCEEEEEECCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGQMGKATGKDAAAGKGTLVALHGANWAHSQLHGLVGQAHALLDPYGDRAALLKEAATFV
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ATRNS
EECCC
>Mature Secondary Structure 
TNDDEMAFEMALIRRAAAVEVLLRRLLDDRPLSGEIARPDRLMAAMRHGVLNGGKRLRP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
FLVMESAALFSADGEAALRVAAALECVHCYSLIHDDLPAMDDDDLRRGQPTVHKAFDEAT
HHEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHH
AILAGDALLTLAFDIVASEATVLPADRRAALVLALARAAGAGGMVGGQKLDLEAEQTPPD
HHHHCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCC
EAGIITLQAMKTGALIRFACEAGAIIAGAPAEDRERLAEFGSAIGLAFQLADDLLDLTAD
CCCEEEEEECCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGQMGKATGKDAAAGKGTLVALHGANWAHSQLHGLVGQAHALLDPYGDRAALLKEAATFV
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ATRNS
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]