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The map label for this gene is hisC2

Identifier: 13473053

GI number: 13473053

Start: 2852404

End: 2853513

Strand: Reverse

Name: hisC2

Synonym: mll3536

Alternate gene names: 13473053

Gene position: 2853513-2852404 (Counterclockwise)

Preceding gene: 13473056

Following gene: 13473052

Centisome position: 40.56

GC content: 64.32

Gene sequence:

>1110_bases
ATGAACCAGACACCGGATCAGGCACGTCCAACCCCGCGCGCGGGCATCATGGACATCGACGCCTATGTGCCGGGCAAGAG
CGCCGCACCCGCCGGTGTCGCCAAGGTCTACAAACTGTCGTCCAACGAGAATCCGCTTGGCCCTTCACCGAAGGCGATCG
AGGCCGCGCGTGAAGTCGCCGCCAGGCTCGACATCTATCCCGACGGCACCGCCAGACGGCTGCGCGAGGCGATCGCGGAA
GTGCATGGCCTCACCGCGCAGAACATCATCTGCTCCAACGGCTCCGACGAGATCCTCGGGCTGCTGGCGCAGACCTATCT
GGCACCCGGCGACGAGGCGATTTTCACCGAACACGCCTTCATGGTCTACAAAATCTACATCCAGTCGGCCGGGGCTGCGC
CGATCGCCGTCAAGGAGACCGACGAGCGCGCCGACATCGATGCGATGCTGGCGGCCGTCACGCCGCGCACGAAAATCGTG
TTCCTCGCCAATCCCAACAATCCGACCGGCACCTATGTGCCGTTCCAGGAGGTGCGCCGCCTGCATGCCGGCCTGCCCAG
GCATGTGCTGCTGGTGCTCGACGCGGCCTATGCCGAATATGTCCGCCGCAATGACTATGAAGCCGGCATCGAACTGGTCC
GCAGTGCAGAGAATGTGGTCATGACCCGCACCTTCTCCAAGATCGGCCTTGGTGGCGCGCGGATCGGCTGGATGTATGCG
CCCATGCACATCGTCGACGCCATCAACCGCGTGCGCGGTCCCTTCAACGTCAACGCGACGGCGATCGAGGCCGGCATCGC
GGCAATCCGCGACCGCGCCCATGTCGAGCGCAGCGTGACGCACAACGAGACCTGGCTGACCTGGCTGAGCCAAGAGATGA
CCGGGCTCGGGTTGCGGGTGACGCCCAGCGTCGGCAATTTCCTGCTCATTCACTTTCCCGATGATCAGAAGCATTCGGCG
GCTGCGGCGGACGACTATCTGACCGCGCGCGGCTATATATTGCGGCGCGTTTCCGGCTACGGCTTTCCCAACGCGCTGCG
CATGACCGTCGGCACGGAAGAGGCCAATCGCGGCGTCGTCGCCGCGCTCACGACATTCCTGAAAAGCTAG

Upstream 100 bases:

>100_bases
CGGCTGCTGGCACCACTGCCACCTCTCGACATTATCGGCCACGGCTTGTATTTCCGCTGCGGCCTCCGGATCGAGGCATT
TTCGACGGATTTTGAGAAAA

Downstream 100 bases:

>100_bases
AGCGCCCGAAAAGCAGGAACACCATGACATCACCGATGTTTGAAAAGATCGCGCTGGTCGGCATCGGCCTGATCGGCTCG
TCGCTGGCCCGCGTCATCCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNQTPDQARPTPRAGIMDIDAYVPGKSAAPAGVAKVYKLSSNENPLGPSPKAIEAAREVAARLDIYPDGTARRLREAIAE
VHGLTAQNIICSNGSDEILGLLAQTYLAPGDEAIFTEHAFMVYKIYIQSAGAAPIAVKETDERADIDAMLAAVTPRTKIV
FLANPNNPTGTYVPFQEVRRLHAGLPRHVLLVLDAAYAEYVRRNDYEAGIELVRSAENVVMTRTFSKIGLGGARIGWMYA
PMHIVDAINRVRGPFNVNATAIEAGIAAIRDRAHVERSVTHNETWLTWLSQEMTGLGLRVTPSVGNFLLIHFPDDQKHSA
AAADDYLTARGYILRRVSGYGFPNALRMTVGTEEANRGVVAALTTFLKS

Sequences:

>Translated_369_residues
MNQTPDQARPTPRAGIMDIDAYVPGKSAAPAGVAKVYKLSSNENPLGPSPKAIEAAREVAARLDIYPDGTARRLREAIAE
VHGLTAQNIICSNGSDEILGLLAQTYLAPGDEAIFTEHAFMVYKIYIQSAGAAPIAVKETDERADIDAMLAAVTPRTKIV
FLANPNNPTGTYVPFQEVRRLHAGLPRHVLLVLDAAYAEYVRRNDYEAGIELVRSAENVVMTRTFSKIGLGGARIGWMYA
PMHIVDAINRVRGPFNVNATAIEAGIAAIRDRAHVERSVTHNETWLTWLSQEMTGLGLRVTPSVGNFLLIHFPDDQKHSA
AAADDYLTARGYILRRVSGYGFPNALRMTVGTEEANRGVVAALTTFLKS
>Mature_369_residues
MNQTPDQARPTPRAGIMDIDAYVPGKSAAPAGVAKVYKLSSNENPLGPSPKAIEAAREVAARLDIYPDGTARRLREAIAE
VHGLTAQNIICSNGSDEILGLLAQTYLAPGDEAIFTEHAFMVYKIYIQSAGAAPIAVKETDERADIDAMLAAVTPRTKIV
FLANPNNPTGTYVPFQEVRRLHAGLPRHVLLVLDAAYAEYVRRNDYEAGIELVRSAENVVMTRTFSKIGLGGARIGWMYA
PMHIVDAINRVRGPFNVNATAIEAGIAAIRDRAHVERSVTHNETWLTWLSQEMTGLGLRVTPSVGNFLLIHFPDDQKHSA
AAADDYLTARGYILRRVSGYGFPNALRMTVGTEEANRGVVAALTTFLKS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=313, Percent_Identity=26.1980830670927, Blast_Score=82, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_RHILO (Q98G10)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104620.1
- ProteinModelPortal:   Q98G10
- SMR:   Q98G10
- GeneID:   1227281
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll3536
- NMPDR:   fig|266835.1.peg.2724
- HOGENOM:   HBG646350
- OMA:   PRTKIVF
- ProtClustDB:   PRK02731
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40107; Mature: 40107

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTPDQARPTPRAGIMDIDAYVPGKSAAPAGVAKVYKLSSNENPLGPSPKAIEAAREVA
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHEEEECCCCCCCCCCCHHHHHHHHHH
ARLDIYPDGTARRLREAIAEVHGLTAQNIICSNGSDEILGLLAQTYLAPGDEAIFTEHAF
HHCCCCCCHHHHHHHHHHHHHHCCCHHCEEECCCCHHHHHHHHHHHCCCCCCCEEHHHHE
MVYKIYIQSAGAAPIAVKETDERADIDAMLAAVTPRTKIVFLANPNNPTGTYVPFQEVRR
EEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
LHAGLPRHVLLVLDAAYAEYVRRNDYEAGIELVRSAENVVMTRTFSKIGLGGARIGWMYA
HHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEHHHHCCCCCEEHHEEH
PMHIVDAINRVRGPFNVNATAIEAGIAAIRDRAHVERSVTHNETWLTWLSQEMTGLGLRV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEE
TPSVGNFLLIHFPDDQKHSAAAADDYLTARGYILRRVSGYGFPNALRMTVGTEEANRGVV
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHH
AALTTFLKS
HHHHHHHCC
>Mature Secondary Structure
MNQTPDQARPTPRAGIMDIDAYVPGKSAAPAGVAKVYKLSSNENPLGPSPKAIEAAREVA
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHEEEECCCCCCCCCCCHHHHHHHHHH
ARLDIYPDGTARRLREAIAEVHGLTAQNIICSNGSDEILGLLAQTYLAPGDEAIFTEHAF
HHCCCCCCHHHHHHHHHHHHHHCCCHHCEEECCCCHHHHHHHHHHHCCCCCCCEEHHHHE
MVYKIYIQSAGAAPIAVKETDERADIDAMLAAVTPRTKIVFLANPNNPTGTYVPFQEVRR
EEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
LHAGLPRHVLLVLDAAYAEYVRRNDYEAGIELVRSAENVVMTRTFSKIGLGGARIGWMYA
HHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEHHHHCCCCCEEHHEEH
PMHIVDAINRVRGPFNVNATAIEAGIAAIRDRAHVERSVTHNETWLTWLSQEMTGLGLRV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEE
TPSVGNFLLIHFPDDQKHSAAAADDYLTARGYILRRVSGYGFPNALRMTVGTEEANRGVV
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHH
AALTTFLKS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968