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The map label for this gene is hbdA [H]

Identifier: 13473014

GI number: 13473014

Start: 2813484

End: 2814362

Strand: Direct

Name: hbdA [H]

Synonym: mlr3490

Alternate gene names: 13473014

Gene position: 2813484-2814362 (Clockwise)

Preceding gene: 13473013

Following gene: 13473018

Centisome position: 39.99

GC content: 62.91

Gene sequence:

>879_bases
ATGAGCAAGATCGAGACGATCGGCATCATCGGCGCGGGCCAGATGGGCGGGGGTATCGCCCATGTCTCCGCGCTATCGGG
CTACAAGGTGCTGATCTACGATATTTCGCCCGACCGCATTGAAAAGGGCATCGCCACCATCAGCGGCAACATGGCCCGCC
AGGTGGGCTCCGGCAAGCTTGACGAGAAGCTTCGCAACCAGGCGATGGCGCGCATTGCCTCGGCACCGGCTATGGCCGAT
CTCGCCGGCGCCGATCTGGTGATCGAGGCGGCGACCGAGGACGAGACGATCAAGCGCAAGATCTACGCGCAGCTCTGTCC
GCAGCTCAATCCCGAAGCCATACTGGCGACCAACACCTCGTCGATCTCGATCACGCGGCTTGCCGCGCAGACCGACCGGC
CGGAGCGCTTCATCGGCATACATTTCATGAACCCGGTGCCGCTGATGAAGCTGGTCGAGCTGGTGCGCGGCATCGCCACC
GAGGACCAGACCTTCGAGGCGGCCAAGACCTATGTGAAGCAGCTCGACAAGACGATCACGGTCTCGGAAGATTTCCCGGC
CTTCATCGTCAACCGCATCCTGCTGCCGATGATCAACGAGGCGATCTACACGCTCTATGAGGGTGTCGGCTCGGTCGACG
CCATCGACACCGCCATGCGGCTCGGAGCCAACCATCCGATGGGACCGCTGCAGCTGGCCGATTTCATCGGCCTCGACACC
TGCCTGTCGATCATGCAGGTGCTGCATGACGGCCTGTCGGATTCGAAGTACCGCCCCTGCCCGCTGCTGGTGAAATATGT
CGAAGCTGGTTGGCTCGGCCGCAAGACCGGGCGCGGTTTCTACGACTATCGCGGCGAGCACCCCGTTCCGACGCGCTGA

Upstream 100 bases:

>100_bases
GTATTAAATGCTTGGGGTGGGGTAGACGAAATCGCCCCGCCCTTTTAGTTTGCACCGCACAAAAAGCAGGCTGCAAAAGC
CTTTGGACGGGATCGGTGTA

Downstream 100 bases:

>100_bases
CGCGTCCGTTCATGACGCCGCGGCAAGCGGCGCGGGCGGCTCCGACTTGTCGTCGGGCGCCACGCAGACGCATCCGCGGC
CGGCCGCCTTGGCGGCATAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSKIETIGIIGAGQMGGGIAHVSALSGYKVLIYDISPDRIEKGIATISGNMARQVGSGKLDEKLRNQAMARIASAPAMAD
LAGADLVIEAATEDETIKRKIYAQLCPQLNPEAILATNTSSISITRLAAQTDRPERFIGIHFMNPVPLMKLVELVRGIAT
EDQTFEAAKTYVKQLDKTITVSEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMRLGANHPMGPLQLADFIGLDT
CLSIMQVLHDGLSDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR

Sequences:

>Translated_292_residues
MSKIETIGIIGAGQMGGGIAHVSALSGYKVLIYDISPDRIEKGIATISGNMARQVGSGKLDEKLRNQAMARIASAPAMAD
LAGADLVIEAATEDETIKRKIYAQLCPQLNPEAILATNTSSISITRLAAQTDRPERFIGIHFMNPVPLMKLVELVRGIAT
EDQTFEAAKTYVKQLDKTITVSEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMRLGANHPMGPLQLADFIGLDT
CLSIMQVLHDGLSDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
>Mature_291_residues
SKIETIGIIGAGQMGGGIAHVSALSGYKVLIYDISPDRIEKGIATISGNMARQVGSGKLDEKLRNQAMARIASAPAMADL
AGADLVIEAATEDETIKRKIYAQLCPQLNPEAILATNTSSISITRLAAQTDRPERFIGIHFMNPVPLMKLVELVRGIATE
DQTFEAAKTYVKQLDKTITVSEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMRLGANHPMGPLQLADFIGLDTC
LSIMQVLHDGLSDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=38.0622837370242, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=36.8078175895765, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI20127408, Length=293, Percent_Identity=31.740614334471, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=28.9655172413793, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=28.9655172413793, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI115430219, Length=232, Percent_Identity=28.0172413793103, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1787661, Length=288, Percent_Identity=39.9305555555556, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=35.4716981132075, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=31.0861423220974, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=291, Percent_Identity=40.2061855670103, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=295, Percent_Identity=40.3389830508475, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=292, Percent_Identity=36.3013698630137, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=32.3843416370107, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=32.3843416370107, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=32.3843416370107, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=30.9608540925267, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=27.3049645390071, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=25.7142857142857, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19921000, Length=293, Percent_Identity=34.1296928327645, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583077, Length=293, Percent_Identity=34.1296928327645, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583079, Length=293, Percent_Identity=34.1296928327645, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=27.5, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=23.9819004524887, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31766; Mature: 31635

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIETIGIIGAGQMGGGIAHVSALSGYKVLIYDISPDRIEKGIATISGNMARQVGSGKL
CCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHCCCHH
DEKLRNQAMARIASAPAMADLAGADLVIEAATEDETIKRKIYAQLCPQLNPEAILATNTS
HHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCC
SISITRLAAQTDRPERFIGIHFMNPVPLMKLVELVRGIATEDQTFEAAKTYVKQLDKTIT
CEEEEEEHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEE
VSEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMRLGANHPMGPLQLADFIGLDT
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
CLSIMQVLHDGLSDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKIETIGIIGAGQMGGGIAHVSALSGYKVLIYDISPDRIEKGIATISGNMARQVGSGKL
CCCEEEEEEECCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHCCCHH
DEKLRNQAMARIASAPAMADLAGADLVIEAATEDETIKRKIYAQLCPQLNPEAILATNTS
HHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCC
SISITRLAAQTDRPERFIGIHFMNPVPLMKLVELVRGIATEDQTFEAAKTYVKQLDKTIT
CEEEEEEHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEE
VSEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMRLGANHPMGPLQLADFIGLDT
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
CLSIMQVLHDGLSDSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]