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The map label for this gene is ptxR [H]

Identifier: 13472958

GI number: 13472958

Start: 2744491

End: 2745426

Strand: Direct

Name: ptxR [H]

Synonym: mlr3418

Alternate gene names: 13472958

Gene position: 2744491-2745426 (Clockwise)

Preceding gene: 13472955

Following gene: 13472961

Centisome position: 39.01

GC content: 65.49

Gene sequence:

>936_bases
TTGGCCGACCTTCTGAACCTCAATCGGCTCGTCTACTTCACCACCGTGATGGAAGCCGGCTCGTTCACGTCGGCCGCGGA
CCGGCTTGGCGTCGCCAAGGCCGTGGTCAGCCATCAAGTCAGCAAGCTCGAAGATGAGCTGGGCGCAACGCTGCTGCAGC
GCACGACGCGGCGCGTCACCCCGACGGAAGACGGTCGCCTGTTTTATGATCGCGCGATGATCATCCTGCGCGAGGCGGAG
GCAGCCTATGGCGAGATCTCGCATGGCGCGGTCGAACCGAGCGGAACGCTGAGGCTGACTGCGCCGCTCGACTACGGCAC
CAGAGTGGTGGCGCCGGTCATGGCGGCATATCTGAAGGCCTATCCGCAGATGCGCGTCGAAGCGATCTTCGACGACGCGG
TGAGCAATCTGGTCGATGAGCAGATCGATCTCGGCATCCGTGTCGGCTGGCTTGCCGATTCCTCCAACCAGGCACGGCGA
CTGGGCACGATTCGGCAGATCGTCGTTGCGAGCCCGACCTTCGCGGCAAGCCTGCCCGCGGATGCGAACCCGAACCAGGC
ACGATCGCTGGCCTGGGTCGGCAATGCTCAGTTGCGCGGCGTCGGCCAATGGCTGTTTTCCAGGAACGGCGAGACGGTGC
TGACCGAACTCAATCCCGTCGTCGTCTGCGACAAAAGCCCGGCGGCCTACGCTTGCGTGCTCGCCGGCATCGGTCTGGGT
ATATTTCCCGACTATGCGGTCGATGAGGATATCGCCGGGGGTCGGCTCGTGCGGATATTCGCGCAGTGGACCTTGCCGAC
CGGCGGCATCCACGCTGTGTTCCCGCCAGCCCGCTTCCGGCCCGCCAAGGTGCGCGCCTTCGTCGAATTGCTCGCCGCGG
CCGAGAGAAAGCGGGCGCGCGGCGTCGCCAGGGGTGACGCCGGACACAGCACGTAA

Upstream 100 bases:

>100_bases
GCCGCCAAATGTCCTGGCGATATGTGGCAGGCGGAGGTCTTGCGATAAATGGCACCCAATAATACAAACTGTCTGATCAG
ATCAGACAAAGGCAATCACC

Downstream 100 bases:

>100_bases
TGTCAGTGGAGGCTTACATCGGAACGCTTTGGCCTTAGCCGTGTTTCGATCGTGCCCCAAACGCAAACGGCCCGCTGGTT
GAGCCATGCGGGCCGATTTG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MADLLNLNRLVYFTTVMEAGSFTSAADRLGVAKAVVSHQVSKLEDELGATLLQRTTRRVTPTEDGRLFYDRAMIILREAE
AAYGEISHGAVEPSGTLRLTAPLDYGTRVVAPVMAAYLKAYPQMRVEAIFDDAVSNLVDEQIDLGIRVGWLADSSNQARR
LGTIRQIVVASPTFAASLPADANPNQARSLAWVGNAQLRGVGQWLFSRNGETVLTELNPVVVCDKSPAAYACVLAGIGLG
IFPDYAVDEDIAGGRLVRIFAQWTLPTGGIHAVFPPARFRPAKVRAFVELLAAAERKRARGVARGDAGHST

Sequences:

>Translated_311_residues
MADLLNLNRLVYFTTVMEAGSFTSAADRLGVAKAVVSHQVSKLEDELGATLLQRTTRRVTPTEDGRLFYDRAMIILREAE
AAYGEISHGAVEPSGTLRLTAPLDYGTRVVAPVMAAYLKAYPQMRVEAIFDDAVSNLVDEQIDLGIRVGWLADSSNQARR
LGTIRQIVVASPTFAASLPADANPNQARSLAWVGNAQLRGVGQWLFSRNGETVLTELNPVVVCDKSPAAYACVLAGIGLG
IFPDYAVDEDIAGGRLVRIFAQWTLPTGGIHAVFPPARFRPAKVRAFVELLAAAERKRARGVARGDAGHST
>Mature_310_residues
ADLLNLNRLVYFTTVMEAGSFTSAADRLGVAKAVVSHQVSKLEDELGATLLQRTTRRVTPTEDGRLFYDRAMIILREAEA
AYGEISHGAVEPSGTLRLTAPLDYGTRVVAPVMAAYLKAYPQMRVEAIFDDAVSNLVDEQIDLGIRVGWLADSSNQARRL
GTIRQIVVASPTFAASLPADANPNQARSLAWVGNAQLRGVGQWLFSRNGETVLTELNPVVVCDKSPAAYACVLAGIGLGI
FPDYAVDEDIAGGRLVRIFAQWTLPTGGIHAVFPPARFRPAKVRAFVELLAAAERKRARGVARGDAGHST

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=284, Percent_Identity=30.6338028169014, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI87081978, Length=293, Percent_Identity=33.4470989761092, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787589, Length=288, Percent_Identity=28.125, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI145693193, Length=295, Percent_Identity=28.4745762711864, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789639, Length=288, Percent_Identity=29.5138888888889, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787128, Length=293, Percent_Identity=23.8907849829352, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789440, Length=302, Percent_Identity=24.8344370860927, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788297, Length=149, Percent_Identity=31.5436241610738, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788481, Length=148, Percent_Identity=31.0810810810811, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082132, Length=274, Percent_Identity=24.4525547445255, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790399, Length=141, Percent_Identity=30.4964539007092, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI157672245, Length=138, Percent_Identity=29.7101449275362, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786448, Length=276, Percent_Identity=24.6376811594203, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786508, Length=269, Percent_Identity=23.0483271375465, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33518; Mature: 33386

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50931 HTH_LYSR ; PS00310 LAMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLLNLNRLVYFTTVMEAGSFTSAADRLGVAKAVVSHQVSKLEDELGATLLQRTTRRVT
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PTEDGRLFYDRAMIILREAEAAYGEISHGAVEPSGTLRLTAPLDYGTRVVAPVMAAYLKA
CCCCCEEEEEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
YPQMRVEAIFDDAVSNLVDEQIDLGIRVGWLADSSNQARRLGTIRQIVVASPTFAASLPA
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHEECCCHHCCCCC
DANPNQARSLAWVGNAQLRGVGQWLFSRNGETVLTELNPVVVCDKSPAAYACVLAGIGLG
CCCCCHHCEEEEECCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCHHHHHHHHHCCCC
IFPDYAVDEDIAGGRLVRIFAQWTLPTGGIHAVFPPARFRPAKVRAFVELLAAAERKRAR
CCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GVARGDAGHST
CCCCCCCCCCC
>Mature Secondary Structure 
ADLLNLNRLVYFTTVMEAGSFTSAADRLGVAKAVVSHQVSKLEDELGATLLQRTTRRVT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PTEDGRLFYDRAMIILREAEAAYGEISHGAVEPSGTLRLTAPLDYGTRVVAPVMAAYLKA
CCCCCEEEEEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
YPQMRVEAIFDDAVSNLVDEQIDLGIRVGWLADSSNQARRLGTIRQIVVASPTFAASLPA
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHEECCCHHCCCCC
DANPNQARSLAWVGNAQLRGVGQWLFSRNGETVLTELNPVVVCDKSPAAYACVLAGIGLG
CCCCCHHCEEEEECCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCHHHHHHHHHCCCC
IFPDYAVDEDIAGGRLVRIFAQWTLPTGGIHAVFPPARFRPAKVRAFVELLAAAERKRAR
CCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GVARGDAGHST
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]