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The map label for this gene is serA [H]

Identifier: 13472919

GI number: 13472919

Start: 2706669

End: 2707661

Strand: Direct

Name: serA [H]

Synonym: mlr3367

Alternate gene names: 13472919

Gene position: 2706669-2707661 (Clockwise)

Preceding gene: 13472918

Following gene: 13472920

Centisome position: 38.47

GC content: 66.26

Gene sequence:

>993_bases
GTGGCCCGGACCGTGCCCAAGATCCTGTCGACCCATCCGCTGCATCCGCGCGCCTCGGCCAAGCTGGCCGGCGCCGGCCA
GCTCGTCATCGCATCGGCGCTCGATCCTGCCACCTTGACCGGGGAGGCCAAGAACGCTGACATCGTCATCGTCCGCGCGC
CCCTGCCGCCGGCGCTGTTCGAGGGCGCCTGGAAGCTACGGGCGGCCATCCGCCATGGCGCCGGGCTCGACATGATCCCG
ATGGAGGCGGCGACCGCCGCCGGAGTGCTGGTGGCCAACGTGCCGGCGGTCAACGCCCGTTCGGTGGCGGAACATGTGAT
GTTCACCGCACTTGCGCTGCTGCGGCAATTCCGCAGGGTCGACCGCGACCTGCGTGCCAAAGGCTGGCTTGCCGGACGCG
AGCACGCCAACGCCAACATCGAGCTCGCGGGCAAGACAATCGGCATTGTCGGTCTCGGCGCCGTCGGCCAGGCTGTCGGC
CATATCGCCGCGCACGGCTTCGACCTGAAGGTAGTGGCAACGACGCGCAGCATGCAGCCGGCACCCGAAAAAGTCGGCTT
TCTGTCGATCGACGCGCTGGTCGAGCAGAGCGACATCATCGTGCTCTGCTGTCCGCTGACGCCGGAGACGCGCGGCCTGA
TCAGCCGCGAGCGCATCGCCCGCATGAAACCCAATGCGCTTTTGATCAACGTTTCGCGTGGGCCGGTCGTCGATGACGAC
GCCCTGATCGAGGCCTTGCGAGAAGGTCGCATCGGCGGTGCGGCGCTCGATGTGTTTTCGACACAGCCGCTGTCGTACAA
TCATCCCTATTTCGGCTTCGACAACGTCATCATCACCCCGCATATGGCGGGCATTACCGAGGAATCGATGATGCGCATGG
GCGTCGGCGCGGTGGGCGAAGCCCTTCTGGTGCTGGCGGGCAAGCTGCCGGTCAATCTGCGCAATCCGGAAGCGGTCGAT
CACTACCGGCAGCGCTTTCCGCTCGACCTATAG

Upstream 100 bases:

>100_bases
TGAGCGCCCACCTGCAAGGGGCGGAGAGCTATTGGAAGGGCCTGATCGAGGGCGGGAATGCGGCTGCGCCCGCGAACTCG
GCGCTCGAACAGGCCTGAGC

Downstream 100 bases:

>100_bases
CAATCGCGGTTTCGCCCCAATTCTCCGCGACGTTGCAGCCATGTCCAGTTTTCGCCTCGCCTTCCTGATTGCCGCAACCT
CGTCGATCGGCCCCTTGCCG

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MARTVPKILSTHPLHPRASAKLAGAGQLVIASALDPATLTGEAKNADIVIVRAPLPPALFEGAWKLRAAIRHGAGLDMIP
MEAATAAGVLVANVPAVNARSVAEHVMFTALALLRQFRRVDRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVG
HIAAHGFDLKVVATTRSMQPAPEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDD
ALIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMAGITEESMMRMGVGAVGEALLVLAGKLPVNLRNPEAVD
HYRQRFPLDL

Sequences:

>Translated_330_residues
MARTVPKILSTHPLHPRASAKLAGAGQLVIASALDPATLTGEAKNADIVIVRAPLPPALFEGAWKLRAAIRHGAGLDMIP
MEAATAAGVLVANVPAVNARSVAEHVMFTALALLRQFRRVDRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVG
HIAAHGFDLKVVATTRSMQPAPEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDD
ALIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMAGITEESMMRMGVGAVGEALLVLAGKLPVNLRNPEAVD
HYRQRFPLDL
>Mature_329_residues
ARTVPKILSTHPLHPRASAKLAGAGQLVIASALDPATLTGEAKNADIVIVRAPLPPALFEGAWKLRAAIRHGAGLDMIPM
EAATAAGVLVANVPAVNARSVAEHVMFTALALLRQFRRVDRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVGH
IAAHGFDLKVVATTRSMQPAPEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDDA
LIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMAGITEESMMRMGVGAVGEALLVLAGKLPVNLRNPEAVDH
YRQRFPLDL

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=33.5849056603774, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=33.5849056603774, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=32.4324324324324, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=32.4324324324324, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=32.4324324324324, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=30.4075235109718, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=32.9268292682927, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=35.3383458646617, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789279, Length=304, Percent_Identity=32.2368421052632, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI87081824, Length=259, Percent_Identity=30.8880308880309, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787645, Length=243, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=32.295719844358, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=267, Percent_Identity=31.0861423220974, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=237, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=237, Percent_Identity=32.9113924050633, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=30.6451612903226, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=113, Percent_Identity=30.9734513274336, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=190, Percent_Identity=30.5263157894737, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=159, Percent_Identity=24.5283018867925, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=298, Percent_Identity=29.8657718120805, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571528, Length=246, Percent_Identity=32.1138211382114, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=31.7343173431734, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=31.7343173431734, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=31.7343173431734, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=31.7343173431734, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=31.7343173431734, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=31.0756972111554, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585514, Length=323, Percent_Identity=28.4829721362229, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574282, Length=323, Percent_Identity=28.4829721362229, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=323, Percent_Identity=28.4829721362229, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45551003, Length=323, Percent_Identity=28.4829721362229, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574284, Length=323, Percent_Identity=28.4829721362229, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=25.4019292604502, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35087; Mature: 34956

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTVPKILSTHPLHPRASAKLAGAGQLVIASALDPATLTGEAKNADIVIVRAPLPPALF
CCCCHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCEECCCCCCCCEEEEECCCCHHHH
EGAWKLRAAIRHGAGLDMIPMEAATAAGVLVANVPAVNARSVAEHVMFTALALLRQFRRV
HHHHHHHHHHHCCCCCCEECHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
DRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVGHIAAHGFDLKVVATTRSMQP
HHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCC
APEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDD
CHHHCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
ALIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMAGITEESMMRMGVGAVGE
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCHHHHHH
ALLVLAGKLPVNLRNPEAVDHYRQRFPLDL
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARTVPKILSTHPLHPRASAKLAGAGQLVIASALDPATLTGEAKNADIVIVRAPLPPALF
CCCHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCEECCCCCCCCEEEEECCCCHHHH
EGAWKLRAAIRHGAGLDMIPMEAATAAGVLVANVPAVNARSVAEHVMFTALALLRQFRRV
HHHHHHHHHHHCCCCCCEECHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
DRDLRAKGWLAGREHANANIELAGKTIGIVGLGAVGQAVGHIAAHGFDLKVVATTRSMQP
HHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCC
APEKVGFLSIDALVEQSDIIVLCCPLTPETRGLISRERIARMKPNALLINVSRGPVVDDD
CHHHCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
ALIEALREGRIGGAALDVFSTQPLSYNHPYFGFDNVIITPHMAGITEESMMRMGVGAVGE
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCHHHHHH
ALLVLAGKLPVNLRNPEAVDHYRQRFPLDL
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]