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The map label for this gene is gntZ [H]

Identifier: 13472886

GI number: 13472886

Start: 2674166

End: 2675593

Strand: Reverse

Name: gntZ [H]

Synonym: mll3321

Alternate gene names: 13472886

Gene position: 2675593-2674166 (Counterclockwise)

Preceding gene: 13472887

Following gene: 13472884

Centisome position: 38.03

GC content: 64.57

Gene sequence:

>1428_bases
ATGGAAAAAGCCGAAATCGGCCTGATCGGCCTTGGCACGATGGGCTCCAACCTGGCGCTGAACATCGCCGAACACGGACA
CCGCATCGCCGTCTTCAATCGCACCAGGGCACGTACCGACGCTTTCGTCGAGAATGCCGGCGCGCTGAAGGACATGGTGG
TGCCCTGCTACAGCCTGGAAGAACTTGCCGCCGCGATCCGGCCGCCGCGCCCGATCATCATCATGGTGCTGGCCGGCAAG
CCGGTCGATGAGCAGATCGAAGCCTTGCGTGGCGTGCTGTCCGGCAACGACATCGTCATCGATGCCGGCAACGCCAATTT
CCGCGATACGATGCGGCGCTTCTCCGAACTGTCCGGTTCCGGGCTGACCTTCATCGGCATGGGCGTGTCCGGCGGCGAGG
AGGGCGCGCGCCATGGTCCGTCGATCATGGTCGGCGGCACGGAGGATTCGTGGAAGCGGGTCGAGAAAGTGCTGACCGCC
ATCTCCGCCAAGTTCAAGGACGAGCCCTGTGCCGCCTGGCTCGGCACCGATGGCGCCGGGCATTTCGTCAAGACCATCCA
CAACGGCATCGAATATGCCGACATGCAGATGATTGCCGAGATCTACGGCATCCTGCGTGATGGGCTCGGCATGGGGCCGA
AGGACATCGGCACGGTGTTCTCCAACTGGAACAAGGGCCGGCTCAACTCCTACCTGATCGAGATCACCGCCAAGGTGCTG
GCCGCCGACGATCCCAAGACCGGCAAGCCGGTGGTCGACATTATCCTCGACCGCGCCGGCCAGAAGGGCACCGGCAAATG
GTCCGTCATCGAGGCGCAGCAGCTCGGCATTCCGGCGACAGCGATCGAGGCGGCCGTGGCGGCCCGCGTGCTGTCGTCGA
TCAAGGACGAGCGGCTGGCGGCCGAGAAAGCCTACGGTAACATCGGGGTATCGAAGATTTCCGGCGACAAGGATGCGCTG
CTGAAAGATCTCGAACTGGCGCTGTTCGCCGGCAAGATCGCGGCCTATGCGCAGGGCTTCGCGGTGATGAGCGGCGCCTC
GAAGGAGTTCAACTGGAACCTGCCGATGCCGACCATCGCCCGGATCTGGCGCGCCGGCTGCATCATCCGCTCGCAGATGC
TGGATACGATGGCCGAGGCCTTCAGCAGCGGCGGCGCTTCGACCAATCTTTTGATGGCGCCGGCTTTCATCAGCTTGATG
CAGGAAGCGCATCCGTCGCTGCGGCGCATCGTGGCAAAGGCTTCCGAGGCCGGCGCGCCGGTGCCGGCGCTGTCTTCGGC
ACTTGCCTATTTCGACAGCTATCGCCAGGGCCGCGGCACTTCGAACCTGATCCAGGCACAGCGCGACTTCTTCGGCGCGC
ATGGCTTCGAACGCATCGACGAGCAGGGTGCCTTCCACGGCCCGTGGGGCAGCGGCGCCGCCGGTTAG

Upstream 100 bases:

>100_bases
TTGACGCGGCCCGAAAGGCCCGTCAATCATCCCGGGAAGAACGGGCATCCGGTAAAATCGCGGGCTCCAACCAACAAGAT
CCGAAAGCAGGGAAGAAACG

Downstream 100 bases:

>100_bases
TCCGTGGAGCGCTGGTAGGCCAGGACCTCGCCCGGCACGCTGAGACTTTGCAGCGAGCCGGGTGCGGCGCCGCCGATCCA
GCCGAGCACGGAGCGGGCGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MEKAEIGLIGLGTMGSNLALNIAEHGHRIAVFNRTRARTDAFVENAGALKDMVVPCYSLEELAAAIRPPRPIIIMVLAGK
PVDEQIEALRGVLSGNDIVIDAGNANFRDTMRRFSELSGSGLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTA
ISAKFKDEPCAAWLGTDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGMGPKDIGTVFSNWNKGRLNSYLIEITAKVL
AADDPKTGKPVVDIILDRAGQKGTGKWSVIEAQQLGIPATAIEAAVAARVLSSIKDERLAAEKAYGNIGVSKISGDKDAL
LKDLELALFAGKIAAYAQGFAVMSGASKEFNWNLPMPTIARIWRAGCIIRSQMLDTMAEAFSSGGASTNLLMAPAFISLM
QEAHPSLRRIVAKASEAGAPVPALSSALAYFDSYRQGRGTSNLIQAQRDFFGAHGFERIDEQGAFHGPWGSGAAG

Sequences:

>Translated_475_residues
MEKAEIGLIGLGTMGSNLALNIAEHGHRIAVFNRTRARTDAFVENAGALKDMVVPCYSLEELAAAIRPPRPIIIMVLAGK
PVDEQIEALRGVLSGNDIVIDAGNANFRDTMRRFSELSGSGLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTA
ISAKFKDEPCAAWLGTDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGMGPKDIGTVFSNWNKGRLNSYLIEITAKVL
AADDPKTGKPVVDIILDRAGQKGTGKWSVIEAQQLGIPATAIEAAVAARVLSSIKDERLAAEKAYGNIGVSKISGDKDAL
LKDLELALFAGKIAAYAQGFAVMSGASKEFNWNLPMPTIARIWRAGCIIRSQMLDTMAEAFSSGGASTNLLMAPAFISLM
QEAHPSLRRIVAKASEAGAPVPALSSALAYFDSYRQGRGTSNLIQAQRDFFGAHGFERIDEQGAFHGPWGSGAAG
>Mature_475_residues
MEKAEIGLIGLGTMGSNLALNIAEHGHRIAVFNRTRARTDAFVENAGALKDMVVPCYSLEELAAAIRPPRPIIIMVLAGK
PVDEQIEALRGVLSGNDIVIDAGNANFRDTMRRFSELSGSGLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTA
ISAKFKDEPCAAWLGTDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGMGPKDIGTVFSNWNKGRLNSYLIEITAKVL
AADDPKTGKPVVDIILDRAGQKGTGKWSVIEAQQLGIPATAIEAAVAARVLSSIKDERLAAEKAYGNIGVSKISGDKDAL
LKDLELALFAGKIAAYAQGFAVMSGASKEFNWNLPMPTIARIWRAGCIIRSQMLDTMAEAFSSGGASTNLLMAPAFISLM
QEAHPSLRRIVAKASEAGAPVPALSSALAYFDSYRQGRGTSNLIQAQRDFFGAHGFERIDEQGAFHGPWGSGAAG

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=46.072186836518, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788341, Length=471, Percent_Identity=46.4968152866242, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17542558, Length=476, Percent_Identity=44.9579831932773, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321695, Length=471, Percent_Identity=46.072186836518, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321977, Length=466, Percent_Identity=45.0643776824034, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24639279, Length=473, Percent_Identity=44.1860465116279, Blast_Score=386, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 50479; Mature: 50479

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAEIGLIGLGTMGSNLALNIAEHGHRIAVFNRTRARTDAFVENAGALKDMVVPCYSLE
CCCCCEEEEEECCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHCCCHHHHHHCCCCCHH
ELAAAIRPPRPIIIMVLAGKPVDEQIEALRGVLSGNDIVIDAGNANFRDTMRRFSELSGS
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCC
GLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTAISAKFKDEPCAAWLGTDGAG
CCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGLGMGPKDIGTVFSNWNKGRLNSYLIEITAKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AADDPKTGKPVVDIILDRAGQKGTGKWSVIEAQQLGIPATAIEAAVAARVLSSIKDERLA
CCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AEKAYGNIGVSKISGDKDALLKDLELALFAGKIAAYAQGFAVMSGASKEFNWNLPMPTIA
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RIWRAGCIIRSQMLDTMAEAFSSGGASTNLLMAPAFISLMQEAHPSLRRIVAKASEAGAP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHCCCC
VPALSSALAYFDSYRQGRGTSNLIQAQRDFFGAHGFERIDEQGAFHGPWGSGAAG
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKAEIGLIGLGTMGSNLALNIAEHGHRIAVFNRTRARTDAFVENAGALKDMVVPCYSLE
CCCCCEEEEEECCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHCCCHHHHHHCCCCCHH
ELAAAIRPPRPIIIMVLAGKPVDEQIEALRGVLSGNDIVIDAGNANFRDTMRRFSELSGS
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCC
GLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTAISAKFKDEPCAAWLGTDGAG
CCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGLGMGPKDIGTVFSNWNKGRLNSYLIEITAKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AADDPKTGKPVVDIILDRAGQKGTGKWSVIEAQQLGIPATAIEAAVAARVLSSIKDERLA
CCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AEKAYGNIGVSKISGDKDALLKDLELALFAGKIAAYAQGFAVMSGASKEFNWNLPMPTIA
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RIWRAGCIIRSQMLDTMAEAFSSGGASTNLLMAPAFISLMQEAHPSLRRIVAKASEAGAP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHCCCC
VPALSSALAYFDSYRQGRGTSNLIQAQRDFFGAHGFERIDEQGAFHGPWGSGAAG
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3020045; 7584049; 9384377; 1659648 [H]