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The map label for this gene is lspA

Identifier: 13472802

GI number: 13472802

Start: 2567882

End: 2568388

Strand: Direct

Name: lspA

Synonym: mlr3211

Alternate gene names: 13472802

Gene position: 2567882-2568388 (Clockwise)

Preceding gene: 13472801

Following gene: 13472803

Centisome position: 36.5

GC content: 61.93

Gene sequence:

>507_bases
GTGAGATCATGGTCCCCCTACGCGCTGCTCGTCGTCGCGGCCATCGCGCTCGATCAGTGGATCAAACATCTGGTCGAGAC
CGGCCTGCCCTTCCAGGAAAAGCTCGATCTGGTGCCGTTCCTGGCGCTGTTTCGCACCTACAACACCGGCATCGCCTTCT
CGATGTTCTCCTCCTTCGGCGACACGGGCCTGGTGGTGATCGCCGTTCTGGTCGTGGCTTTCGTGCTCTACCTCGCCACG
CGAACGCCATCGGGCCATGTCATCGCCCGCACCGGCTTTGCCCTGATCATCGGCGGCGCGCTGGGCAATCTGATCGACCG
CGCCGTCTACGGCCACGTCATCGACTACATCCTGTTCCACACGCCGGTCTGGTCCTTTGCCATCTTCAACCTCGCCGACG
CCTTCATTTCCGTAGGTGCGGCACTGGTCGTCTTCGACGAACTCATCGGCTGGCGCCGCGAGCCTTCGAACGCCAAGCCT
TCCAAAGCCAAGCCTTCCAAAGATTGA

Upstream 100 bases:

>100_bases
CTCAATCTCGCCGTCGCCACCGGCATCATGCTGTTCGAGATCCGGCGGGGCGCGCTGAAGCTCGAACCAATCGCCGACCA
GCAATGAAGGTTGCCCGCCC

Downstream 100 bases:

>100_bases
CCCCACGCGGCCGCCGCCGCACAGTCCAGGACGCCAAGCAAGCGCGCGGAGAAAAAGATGTCCGAAACCTTCAAAGCCAT
CCTCGTCTCGCGCGACGCCG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MRSWSPYALLVVAAIALDQWIKHLVETGLPFQEKLDLVPFLALFRTYNTGIAFSMFSSFGDTGLVVIAVLVVAFVLYLAT
RTPSGHVIARTGFALIIGGALGNLIDRAVYGHVIDYILFHTPVWSFAIFNLADAFISVGAALVVFDELIGWRREPSNAKP
SKAKPSKD

Sequences:

>Translated_168_residues
MRSWSPYALLVVAAIALDQWIKHLVETGLPFQEKLDLVPFLALFRTYNTGIAFSMFSSFGDTGLVVIAVLVVAFVLYLAT
RTPSGHVIARTGFALIIGGALGNLIDRAVYGHVIDYILFHTPVWSFAIFNLADAFISVGAALVVFDELIGWRREPSNAKP
SKAKPSKD
>Mature_168_residues
MRSWSPYALLVVAAIALDQWIKHLVETGLPFQEKLDLVPFLALFRTYNTGIAFSMFSSFGDTGLVVIAVLVVAFVLYLAT
RTPSGHVIARTGFALIIGGALGNLIDRAVYGHVIDYILFHTPVWSFAIFNLADAFISVGAALVVFDELIGWRREPSNAKP
SKAKPSKD

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=158, Percent_Identity=36.0759493670886, Blast_Score=83, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_RHILO (Q98GR1)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104369.1
- MEROPS:   A08.001
- GeneID:   1227030
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr3211
- NMPDR:   fig|266835.1.peg.2473
- HOGENOM:   HBG724422
- OMA:   ITIWIAK
- ProtClustDB:   PRK14795
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18385; Mature: 18385

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 106-106 ACT_SITE 133-133

Signals:

None

Transmembrane regions:

HASH(0x11cf6f28)-; HASH(0x11d1e59c)-; HASH(0x11492d74)-; HASH(0x111063c0)-; HASH(0x10199338)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSWSPYALLVVAAIALDQWIKHLVETGLPFQEKLDLVPFLALFRTYNTGIAFSMFSSFG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DTGLVVIAVLVVAFVLYLATRTPSGHVIARTGFALIIGGALGNLIDRAVYGHVIDYILFH
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPVWSFAIFNLADAFISVGAALVVFDELIGWRREPSNAKPSKAKPSKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MRSWSPYALLVVAAIALDQWIKHLVETGLPFQEKLDLVPFLALFRTYNTGIAFSMFSSFG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DTGLVVIAVLVVAFVLYLATRTPSGHVIARTGFALIIGGALGNLIDRAVYGHVIDYILFH
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPVWSFAIFNLADAFISVGAALVVFDELIGWRREPSNAKPSKAKPSKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968