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The map label for this gene is coaBC [H]

Identifier: 13472764

GI number: 13472764

Start: 2537457

End: 2538761

Strand: Direct

Name: coaBC [H]

Synonym: mlr3167

Alternate gene names: 13472764

Gene position: 2537457-2538761 (Clockwise)

Preceding gene: 13472763

Following gene: 13472766

Centisome position: 36.06

GC content: 66.74

Gene sequence:

>1305_bases
TTGCGCGAACTGACCAGCACGCACAATGCGGCGACCCCGGTTGCGACCCCTGCAGGCAGGACCCTTCCGCAGGGTACGCT
TTCCGGCAAGCGCATCCTGCTCATCATCGGCGGCGGCATCGCCGCCTACAAGGCGCTCGACCTGATCCGCCGGTTGCGCG
AGCGCGGTGCGGCGGTGCGGGTGGTGATGACAGCGGCTGCACGGGAATTCGTCACCACCCTGTCGGTAGGCGCGCTGTCG
ACCGACCACGTCTTCACCGAACTGTTCGACCGCAATGACGAGCATGATGTCGGCCATATCAGGCTGTCGCGCGAGGCTGA
TCTTCTGGTCGTGGCGCCCGCCACCGCCGATCTGATGGCCAAGCTCGCCAACGGCCATGCCAACGATCTCGCCTCCACCG
TGCTGCTGGCCACCGACAAGCCGGTGCTGATGGCGCCGGCGATGAATCCGAAAATGTGGTCGCATGCCGCGACCCGCCGC
AACCGTGCGACCTTGGGCAAGGACGGCGTCACTTTCGTCGGCCCGGCCAGGGGCGAGATGGCCGAAAGCAATGAGGCAGG
CGAAGGCCGCATGGCCGAACCGCTGGAGATCGTCGCCGCGGTCGAGGCGCGGCTCGATGCCGGCCCCAGGCCGTTGGCAG
GGCGCAAGATCATCGTCACCTCCGGCCCGACGCACGAACCGATCGACCCGGTGCGCTATATCGCCAACCGTTCCTCCGGC
AAGCAGGGCCATGCCATCGCCGCGGCGTTGGCGAGGCTTGGCGCCGATGTGCACCTCGTCTCCGGTCCTGTAAGCATCGC
CGACCCAGCCGGTGTGAAGACCATTCATGTCGAGCGCGCGCAAGAGATGCGCGATGCGGTTGAACAGCTTCTGCCCGCCG
ACGCCGCGGTGTTCGTCGCCGCCGTCGCCGACTGGCGCAGCGAGAATTCGGCCGACGAGAAGATCAAGAAGGTGGCGGGT
GAAGGACCGCCAGTGCTGCGCATGATCGAGAACCCCGACATCCTTGCCGGCGTCGGCCATCACAGCCAGCGGCCCGGCTT
GGTCGTCGGCTTCGCCGCCGAGACGCAGGATCTTTTGCGCAACGCCCAGGCCAAGCTCGCGAAGAAAGGCGCCGACCTGA
TCGTCGCCAACGATGTGTCGCACGAAAGCGGCATCGGCCCTTCAGGCGTCATGGGCGGCGATCGCAACCGGGTGCGGATC
GTGTCGAAGGCCGGCGTCGAGGAATGGCCTGAGATGACCAAGGACGAGGTGGCGGCGCGGCTCGCCACCTTCATTGCCGA
GCGGCTGAAAACGATCGTCGTTTGA

Upstream 100 bases:

>100_bases
GGAAAACAACCGCTCCATGGAAGAACAGGCGCGGGTGATGATCCGGGCCGCTGTCGACGGCCAGATCGGGCCCGGCCGCA
TCGACCAGATCGAAAAGACC

Downstream 100 bases:

>100_bases
ACTGTATTGGACGCGCGGTGCCAGTTGGGCGCCGCGCGTCAAATTCCGGCCTCAGGCCGTCAGTTGGACAAAAGTTCCGC
CGTGCGGGCGAGCGCGCCAC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRELTSTHNAATPVATPAGRTLPQGTLSGKRILLIIGGGIAAYKALDLIRRLRERGAAVRVVMTAAAREFVTTLSVGALS
TDHVFTELFDRNDEHDVGHIRLSREADLLVVAPATADLMAKLANGHANDLASTVLLATDKPVLMAPAMNPKMWSHAATRR
NRATLGKDGVTFVGPARGEMAESNEAGEGRMAEPLEIVAAVEARLDAGPRPLAGRKIIVTSGPTHEPIDPVRYIANRSSG
KQGHAIAAALARLGADVHLVSGPVSIADPAGVKTIHVERAQEMRDAVEQLLPADAAVFVAAVADWRSENSADEKIKKVAG
EGPPVLRMIENPDILAGVGHHSQRPGLVVGFAAETQDLLRNAQAKLAKKGADLIVANDVSHESGIGPSGVMGGDRNRVRI
VSKAGVEEWPEMTKDEVAARLATFIAERLKTIVV

Sequences:

>Translated_434_residues
MRELTSTHNAATPVATPAGRTLPQGTLSGKRILLIIGGGIAAYKALDLIRRLRERGAAVRVVMTAAAREFVTTLSVGALS
TDHVFTELFDRNDEHDVGHIRLSREADLLVVAPATADLMAKLANGHANDLASTVLLATDKPVLMAPAMNPKMWSHAATRR
NRATLGKDGVTFVGPARGEMAESNEAGEGRMAEPLEIVAAVEARLDAGPRPLAGRKIIVTSGPTHEPIDPVRYIANRSSG
KQGHAIAAALARLGADVHLVSGPVSIADPAGVKTIHVERAQEMRDAVEQLLPADAAVFVAAVADWRSENSADEKIKKVAG
EGPPVLRMIENPDILAGVGHHSQRPGLVVGFAAETQDLLRNAQAKLAKKGADLIVANDVSHESGIGPSGVMGGDRNRVRI
VSKAGVEEWPEMTKDEVAARLATFIAERLKTIVV
>Mature_434_residues
MRELTSTHNAATPVATPAGRTLPQGTLSGKRILLIIGGGIAAYKALDLIRRLRERGAAVRVVMTAAAREFVTTLSVGALS
TDHVFTELFDRNDEHDVGHIRLSREADLLVVAPATADLMAKLANGHANDLASTVLLATDKPVLMAPAMNPKMWSHAATRR
NRATLGKDGVTFVGPARGEMAESNEAGEGRMAEPLEIVAAVEARLDAGPRPLAGRKIIVTSGPTHEPIDPVRYIANRSSG
KQGHAIAAALARLGADVHLVSGPVSIADPAGVKTIHVERAQEMRDAVEQLLPADAAVFVAAVADWRSENSADEKIKKVAG
EGPPVLRMIENPDILAGVGHHSQRPGLVVGFAAETQDLLRNAQAKLAKKGADLIVANDVSHESGIGPSGVMGGDRNRVRI
VSKAGVEEWPEMTKDEVAARLATFIAERLKTIVV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=34.6368715083799, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=45.4320987654321, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17560194, Length=187, Percent_Identity=34.7593582887701, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24657262, Length=180, Percent_Identity=32.2222222222222, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 45866; Mature: 45866

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELTSTHNAATPVATPAGRTLPQGTLSGKRILLIIGGGIAAYKALDLIRRLRERGAAVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEE
VVMTAAAREFVTTLSVGALSTDHVFTELFDRNDEHDVGHIRLSREADLLVVAPATADLMA
EHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHH
KLANGHANDLASTVLLATDKPVLMAPAMNPKMWSHAATRRNRATLGKDGVTFVGPARGEM
HHHCCCHHHHHHEEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCC
AESNEAGEGRMAEPLEIVAAVEARLDAGPRPLAGRKIIVTSGPTHEPIDPVRYIANRSSG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCC
KQGHAIAAALARLGADVHLVSGPVSIADPAGVKTIHVERAQEMRDAVEQLLPADAAVFVA
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHH
AVADWRSENSADEKIKKVAGEGPPVLRMIENPDILAGVGHHSQRPGLVVGFAAETQDLLR
HHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCEEEEECHHHHHHHH
NAQAKLAKKGADLIVANDVSHESGIGPSGVMGGDRNRVRIVSKAGVEEWPEMTKDEVAAR
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
LATFIAERLKTIVV
HHHHHHHHHHHHCC
>Mature Secondary Structure
MRELTSTHNAATPVATPAGRTLPQGTLSGKRILLIIGGGIAAYKALDLIRRLRERGAAVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEE
VVMTAAAREFVTTLSVGALSTDHVFTELFDRNDEHDVGHIRLSREADLLVVAPATADLMA
EHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHH
KLANGHANDLASTVLLATDKPVLMAPAMNPKMWSHAATRRNRATLGKDGVTFVGPARGEM
HHHCCCHHHHHHEEEEECCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCC
AESNEAGEGRMAEPLEIVAAVEARLDAGPRPLAGRKIIVTSGPTHEPIDPVRYIANRSSG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCC
KQGHAIAAALARLGADVHLVSGPVSIADPAGVKTIHVERAQEMRDAVEQLLPADAAVFVA
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHH
AVADWRSENSADEKIKKVAGEGPPVLRMIENPDILAGVGHHSQRPGLVVGFAAETQDLLR
HHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCEEEEECHHHHHHHH
NAQAKLAKKGADLIVANDVSHESGIGPSGVMGGDRNRVRIVSKAGVEEWPEMTKDEVAAR
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
LATFIAERLKTIVV
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA