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The map label for this gene is deoA

Identifier: 13472758

GI number: 13472758

Start: 2530917

End: 2532236

Strand: Direct

Name: deoA

Synonym: mlr3160

Alternate gene names: 13472758

Gene position: 2530917-2532236 (Clockwise)

Preceding gene: 13472757

Following gene: 13472762

Centisome position: 35.97

GC content: 68.18

Gene sequence:

>1320_bases
ATGCTTCCGCAGGAAATCATCCGCCACAAGCGAGACGGCCACAGGCTCTCGGCCGGTGAAATCGCTGCCTTCATCGGCGG
CGTTACCTCGGGCGCCGTCACCGACGGCCAGGCCGCGGCTTTCGCCATGGCGGTGTTCTTCAACGGCATGAATCGCGACG
AGGCCGTGGCGTTGACGCTGGCCATGCGCGATTCCGGCGACGTGCTCGACTGGTCGGACCTGCCCGGCCCGGTCACCGAC
AAACATTCGACCGGCGGCGTCGGCGACAATGTCTCGCTGATGCTGGCGCCGATCGTCGCCGCCTGCGGCGCCTATGTGCC
GATGATCTCAGGCCGTGGCCTTGGCCATACCGGCGGCACGCTGGACAAGATGGATGCGATCCCCGGCTACATCAGCCAGC
CCGATATCGCGTTGTTTCGCCAGGCGGTGCTGGAAACCGGCTGCGCCATCATCGGCCAGACCGCCGATCTGGCGCCCGCC
GACCGCCGTCTCTATGCCATCCGCGACGTCACCGGCACCGTGGAATCGGTGCCGCTGATCACTGCCTCGATCCTGTCGAA
GAAGCTGGCCGCCGGACTGGGCTCGCTGGTGCTCGACGTCAAGGTCGGCAATGGCGCCTTCATGGAGAGGTCGCGCGACG
CGACCGCGCTCGCCAACAGTCTCGTCGAGGTCGCCAGTGGCGCCGGACTGAAGGTCTCGGCACTGATCACCGGCATGAAC
GAACCGCTGGCCTCGGCCGCCGGCAATGCCGTCGAGGTGCACAACGCCGTCGATTTCCTGACCGGCCGCCTGCGCGACCG
ACGGCTGGAGGACGTGACGCTGGCGCTGGCCGCCGAAATGCTGCAGTCGACGGGACTGGTGTCGTCCAACCAGGACGGCT
TGCGGCGCGCCACCGAGACGCTCACCAGCGGCCGCGCCGCGGCCACTTTCGCACGTATGGTGGCGGTGCTTGGCGGCCCC
GCCGATTTCATCGAGAAGCCGGAAAAATATTTGGCCGTGGCGCCAACGGAATTCGCGGTCAGGGCGACGACGGACGGCTT
CGTCACCGGCATCGCCACGCGCGACATCGGCCTTGCGGTGGTCGGCCTGGGCGGCGGGCGCACGAGGCCTGACGACAAGA
TCGACCCCAGCGTCGGTATCACCCGGCTGCTGCCCATAGGCGCGGAAGTCCATGCCGGAGACGCGCTGGCACTGGTCCAC
GCCCGCTCACCCGCCGATGCCGAGGCGGCGGCCGCGACTGTGGTTTCGGCCTATGCGATCGGCGCCTCGAAACCAGCGGC
GGACAAAACCGTCATGCGGCGGATCCTGCCGCGCGGTTGA

Upstream 100 bases:

>100_bases
AGCTTTCGCATCAGGAGACCAAGGACATGGCGCCAGTCGGCGGGTCGCGGCTGGCAACGGTCCTGCACAGAGTGTTCCGC
GACGGACTGCTGGAGAGCTG

Downstream 100 bases:

>100_bases
TTACTGGACGAGCAGCAGCGTACCGTTTTCGGCCTGATATTTGCCGAGCCGGTTGAGAAAGCTCATGCCGATCAGGTTGG
TGCTGAGCGCCTTGTCGTCA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLPQEIIRHKRDGHRLSAGEIAAFIGGVTSGAVTDGQAAAFAMAVFFNGMNRDEAVALTLAMRDSGDVLDWSDLPGPVTD
KHSTGGVGDNVSLMLAPIVAACGAYVPMISGRGLGHTGGTLDKMDAIPGYISQPDIALFRQAVLETGCAIIGQTADLAPA
DRRLYAIRDVTGTVESVPLITASILSKKLAAGLGSLVLDVKVGNGAFMERSRDATALANSLVEVASGAGLKVSALITGMN
EPLASAAGNAVEVHNAVDFLTGRLRDRRLEDVTLALAAEMLQSTGLVSSNQDGLRRATETLTSGRAAATFARMVAVLGGP
ADFIEKPEKYLAVAPTEFAVRATTDGFVTGIATRDIGLAVVGLGGGRTRPDDKIDPSVGITRLLPIGAEVHAGDALALVH
ARSPADAEAAAATVVSAYAIGASKPAADKTVMRRILPRG

Sequences:

>Translated_439_residues
MLPQEIIRHKRDGHRLSAGEIAAFIGGVTSGAVTDGQAAAFAMAVFFNGMNRDEAVALTLAMRDSGDVLDWSDLPGPVTD
KHSTGGVGDNVSLMLAPIVAACGAYVPMISGRGLGHTGGTLDKMDAIPGYISQPDIALFRQAVLETGCAIIGQTADLAPA
DRRLYAIRDVTGTVESVPLITASILSKKLAAGLGSLVLDVKVGNGAFMERSRDATALANSLVEVASGAGLKVSALITGMN
EPLASAAGNAVEVHNAVDFLTGRLRDRRLEDVTLALAAEMLQSTGLVSSNQDGLRRATETLTSGRAAATFARMVAVLGGP
ADFIEKPEKYLAVAPTEFAVRATTDGFVTGIATRDIGLAVVGLGGGRTRPDDKIDPSVGITRLLPIGAEVHAGDALALVH
ARSPADAEAAAATVVSAYAIGASKPAADKTVMRRILPRG
>Mature_439_residues
MLPQEIIRHKRDGHRLSAGEIAAFIGGVTSGAVTDGQAAAFAMAVFFNGMNRDEAVALTLAMRDSGDVLDWSDLPGPVTD
KHSTGGVGDNVSLMLAPIVAACGAYVPMISGRGLGHTGGTLDKMDAIPGYISQPDIALFRQAVLETGCAIIGQTADLAPA
DRRLYAIRDVTGTVESVPLITASILSKKLAAGLGSLVLDVKVGNGAFMERSRDATALANSLVEVASGAGLKVSALITGMN
EPLASAAGNAVEVHNAVDFLTGRLRDRRLEDVTLALAAEMLQSTGLVSSNQDGLRRATETLTSGRAAATFARMVAVLGGP
ADFIEKPEKYLAVAPTEFAVRATTDGFVTGIATRDIGLAVVGLGGGRTRPDDKIDPSVGITRLLPIGAEVHAGDALALVH
ARSPADAEAAAATVVSAYAIGASKPAADKTVMRRILPRG

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=417, Percent_Identity=41.0071942446043, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI4503445, Length=417, Percent_Identity=41.0071942446043, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI166158922, Length=417, Percent_Identity=41.0071942446043, Blast_Score=260, Evalue=2e-69,
Organism=Escherichia coli, GI1790842, Length=437, Percent_Identity=54.0045766590389, Blast_Score=440, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_RHILO (Q98GV5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104325.1
- ProteinModelPortal:   Q98GV5
- SMR:   Q98GV5
- GeneID:   1226986
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr3160
- NMPDR:   fig|266835.1.peg.2429
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BRENDA:   2.4.2.4
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 45095; Mature: 45095

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPQEIIRHKRDGHRLSAGEIAAFIGGVTSGAVTDGQAAAFAMAVFFNGMNRDEAVALTL
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEE
AMRDSGDVLDWSDLPGPVTDKHSTGGVGDNVSLMLAPIVAACGAYVPMISGRGLGHTGGT
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKMDAIPGYISQPDIALFRQAVLETGCAIIGQTADLAPADRRLYAIRDVTGTVESVPLI
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
TASILSKKLAAGLGSLVLDVKVGNGAFMERSRDATALANSLVEVASGAGLKVSALITGMN
HHHHHHHHHHHCCCCEEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCC
EPLASAAGNAVEVHNAVDFLTGRLRDRRLEDVTLALAAEMLQSTGLVSSNQDGLRRATET
CCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LTSGRAAATFARMVAVLGGPADFIEKPEKYLAVAPTEFAVRATTDGFVTGIATRDIGLAV
HHCCHHHHHHHHHHHHHCCCHHHHHCCCCEEEECCCCEEEEECCCCEEEEEEECCCCEEE
VGLGGGRTRPDDKIDPSVGITRLLPIGAEVHAGDALALVHARSPADAEAAAATVVSAYAI
EECCCCCCCCCCCCCCCCCHHHEEECCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHH
GASKPAADKTVMRRILPRG
CCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLPQEIIRHKRDGHRLSAGEIAAFIGGVTSGAVTDGQAAAFAMAVFFNGMNRDEAVALTL
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEE
AMRDSGDVLDWSDLPGPVTDKHSTGGVGDNVSLMLAPIVAACGAYVPMISGRGLGHTGGT
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKMDAIPGYISQPDIALFRQAVLETGCAIIGQTADLAPADRRLYAIRDVTGTVESVPLI
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
TASILSKKLAAGLGSLVLDVKVGNGAFMERSRDATALANSLVEVASGAGLKVSALITGMN
HHHHHHHHHHHCCCCEEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCC
EPLASAAGNAVEVHNAVDFLTGRLRDRRLEDVTLALAAEMLQSTGLVSSNQDGLRRATET
CCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LTSGRAAATFARMVAVLGGPADFIEKPEKYLAVAPTEFAVRATTDGFVTGIATRDIGLAV
HHCCHHHHHHHHHHHHHCCCHHHHHCCCCEEEECCCCEEEEECCCCEEEEEEECCCCEEE
VGLGGGRTRPDDKIDPSVGITRLLPIGAEVHAGDALALVHARSPADAEAAAATVVSAYAI
EECCCCCCCCCCCCCCCCCHHHEEECCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHH
GASKPAADKTVMRRILPRG
CCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968