Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 13472640

GI number: 13472640

Start: 2408140

End: 2409675

Strand: Reverse

Name: atoC [H]

Synonym: mll3001

Alternate gene names: 13472640

Gene position: 2409675-2408140 (Counterclockwise)

Preceding gene: 13472647

Following gene: 13472639

Centisome position: 34.25

GC content: 65.23

Gene sequence:

>1536_bases
ATGACAGGTTCCATACTCATAGTCGATGACGATCCCGTGCAGCGCCGGCTGCTCGAGGCGGCGGTGACGCGGTTCGGCCA
CACGGCAATCGTTGTCGACGGCGGCGAGGCTGGCCTCGACGCGCTCGACGGGCCTGGTGCCCGCGACATCTGCGTGGTCA
TTCTCGACCTGGTCATGCCCGGTCTCGACGGCATCGGCGTGCTGAAAGCCATGCGCGAACGCGACATCACCGTCCCGGTC
ATCGTGCAGACCGCCCAGGGCGGCATCGAAACCGTGGTGTTGGCGATGCGCCACGGCGCCTTCGATTTCGTCGTCAAGCC
GGCGTCACCCGACAGGCTGCAGGCCTCGATCGCCAATGCGCTCAAGGTCGAGGCAGTCGAGGGCGAGGTCAAGCGCACGT
CGCGCAAGCGCGGCGGGTTGCTGACATTCAGGGACATGATCACCCACAGTCCGGCCATGGACAGGGTGATACGCCTCGGC
CAGAAAGCGGCCGGATCCAGCATCCCGATCCTGATCGAAGGCGAATCCGGCGTCGGCAAGGAACTGGTGGCGCGTGCCAT
CCAGGGCAGCGGCGACCGCCGCTCGAAACCCTTCGTCACCGTCAATTGCGGCGCCATTCCCGACAATCTGGTCGAATCGA
TCCTGTTCGGCCACGAGAAGGGCTCGTTCACCGGCGCCACCGACAAGCACACCGGCAAATTCGTCGAAGCGCATTCGGGC
ACGCTGTTCCTCGACGAGATCGGCGACCTGCCGCTCGACGTGCAGGTCAAGCTGTTGCGCGCCGTGCAGGAGGGCGAGGT
CGATCCGGTCGGCGGCCGTTCGACCGTCAAGGTCGACATCAGGCTGATCTCGGCGACGCATCGCAACCTCCTGCAGCAGG
TCAAGGACGGCAAGTTCCGCGAAGACCTGTTCTACCGGCTCAATGTCTACCCGATCTTCGTGCCGCCGCTGCGCGACCGC
CGTGACGACATTCCGCATCTGGTAACGCATTTCATGGAGAAGGTCGCGCCCGCCGACCCGCGTCGTCGCCTGCAAGGCAT
TTCGCCGGCAGCGCTTGCCGTGCTGGAGGCCTATGACTGGCCCGGCAACATAAGGCAGCTCGAAAACGCCGTCTTCCGCG
CCTCGGTGCTGTGTGAAGGCGACGTGCTCGATGTCGATGATTTTCCGCAGATCCGCGCGCAGGTGGAAGGCACCGTCAAT
CTCGAAACGGACGACGCAGCACCTCGCCTCTCATCGCCTCCGGAGCTTCGCGATGAGGGGGGGCCGGCCGGCGATGACGC
TCCAGCCGCCGAGCCAGACCGGCCGGCCGTGCTTCAGCCCAGATTCGGCACACTGCGGGCGCTCGACGAACGCGGCAATG
TGCGGGCGCTGGCCGATGTCGAACTCGAGATGATCAAGCTTGCCATCGACCACTACAACGGCCAGATGAGCGAAGTCGCG
CGCCGCCTCGGCATCGGCCGCTCGACGCTCTACCGCAAACTTAAGGAATACGGCATCGACCCGGAGACGGGTCGTGTCGA
CCGCCTCGCTTCCTAA

Upstream 100 bases:

>100_bases
AATCGTAAGGAATTCGTTCACCGGGTTTTTTGAAACCTTATTTAGAACCCTGTGCCAAGATGATCCATGGGGATTTCGGG
CGCGGGCAGTCAAGACAGTC

Downstream 100 bases:

>100_bases
GGTGCGTTGATATTCGGGTGAGGCCGGCCTGCAAACGGCGGCTTGCTGCGCTTCCCCGTTCTACTGCGTCGCAGTAGGTC
GGCCTGACCTGAATCTCAAC

Product: response regulatory protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTGSILIVDDDPVQRRLLEAAVTRFGHTAIVVDGGEAGLDALDGPGARDICVVILDLVMPGLDGIGVLKAMRERDITVPV
IVQTAQGGIETVVLAMRHGAFDFVVKPASPDRLQASIANALKVEAVEGEVKRTSRKRGGLLTFRDMITHSPAMDRVIRLG
QKAAGSSIPILIEGESGVGKELVARAIQGSGDRRSKPFVTVNCGAIPDNLVESILFGHEKGSFTGATDKHTGKFVEAHSG
TLFLDEIGDLPLDVQVKLLRAVQEGEVDPVGGRSTVKVDIRLISATHRNLLQQVKDGKFREDLFYRLNVYPIFVPPLRDR
RDDIPHLVTHFMEKVAPADPRRRLQGISPAALAVLEAYDWPGNIRQLENAVFRASVLCEGDVLDVDDFPQIRAQVEGTVN
LETDDAAPRLSSPPELRDEGGPAGDDAPAAEPDRPAVLQPRFGTLRALDERGNVRALADVELEMIKLAIDHYNGQMSEVA
RRLGIGRSTLYRKLKEYGIDPETGRVDRLAS

Sequences:

>Translated_511_residues
MTGSILIVDDDPVQRRLLEAAVTRFGHTAIVVDGGEAGLDALDGPGARDICVVILDLVMPGLDGIGVLKAMRERDITVPV
IVQTAQGGIETVVLAMRHGAFDFVVKPASPDRLQASIANALKVEAVEGEVKRTSRKRGGLLTFRDMITHSPAMDRVIRLG
QKAAGSSIPILIEGESGVGKELVARAIQGSGDRRSKPFVTVNCGAIPDNLVESILFGHEKGSFTGATDKHTGKFVEAHSG
TLFLDEIGDLPLDVQVKLLRAVQEGEVDPVGGRSTVKVDIRLISATHRNLLQQVKDGKFREDLFYRLNVYPIFVPPLRDR
RDDIPHLVTHFMEKVAPADPRRRLQGISPAALAVLEAYDWPGNIRQLENAVFRASVLCEGDVLDVDDFPQIRAQVEGTVN
LETDDAAPRLSSPPELRDEGGPAGDDAPAAEPDRPAVLQPRFGTLRALDERGNVRALADVELEMIKLAIDHYNGQMSEVA
RRLGIGRSTLYRKLKEYGIDPETGRVDRLAS
>Mature_510_residues
TGSILIVDDDPVQRRLLEAAVTRFGHTAIVVDGGEAGLDALDGPGARDICVVILDLVMPGLDGIGVLKAMRERDITVPVI
VQTAQGGIETVVLAMRHGAFDFVVKPASPDRLQASIANALKVEAVEGEVKRTSRKRGGLLTFRDMITHSPAMDRVIRLGQ
KAAGSSIPILIEGESGVGKELVARAIQGSGDRRSKPFVTVNCGAIPDNLVESILFGHEKGSFTGATDKHTGKFVEAHSGT
LFLDEIGDLPLDVQVKLLRAVQEGEVDPVGGRSTVKVDIRLISATHRNLLQQVKDGKFREDLFYRLNVYPIFVPPLRDRR
DDIPHLVTHFMEKVAPADPRRRLQGISPAALAVLEAYDWPGNIRQLENAVFRASVLCEGDVLDVDDFPQIRAQVEGTVNL
ETDDAAPRLSSPPELRDEGGPAGDDAPAAEPDRPAVLQPRFGTLRALDERGNVRALADVELEMIKLAIDHYNGQMSEVAR
RLGIGRSTLYRKLKEYGIDPETGRVDRLAS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=501, Percent_Identity=40.3193612774451, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1790299, Length=500, Percent_Identity=39.6, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1790437, Length=491, Percent_Identity=40.122199592668, Blast_Score=328, Evalue=6e-91,
Organism=Escherichia coli, GI1788905, Length=381, Percent_Identity=39.1076115485564, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI87082117, Length=262, Percent_Identity=48.8549618320611, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789233, Length=351, Percent_Identity=41.025641025641, Blast_Score=248, Evalue=1e-66,
Organism=Escherichia coli, GI1789087, Length=361, Percent_Identity=37.9501385041551, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87082152, Length=237, Percent_Identity=46.4135021097046, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786524, Length=365, Percent_Identity=38.0821917808219, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1787583, Length=243, Percent_Identity=41.5637860082305, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI87081872, Length=206, Percent_Identity=43.2038834951456, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081858, Length=362, Percent_Identity=29.5580110497238, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789828, Length=254, Percent_Identity=35.4330708661417, Blast_Score=145, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 55506; Mature: 55375

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSILIVDDDPVQRRLLEAAVTRFGHTAIVVDGGEAGLDALDGPGARDICVVILDLVMP
CCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHC
GLDGIGVLKAMRERDITVPVIVQTAQGGIETVVLAMRHGAFDFVVKPASPDRLQASIANA
CCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
LKVEAVEGEVKRTSRKRGGLLTFRDMITHSPAMDRVIRLGQKAAGSSIPILIEGESGVGK
HEEEECCCHHHHHHHHCCCEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCH
ELVARAIQGSGDRRSKPFVTVNCGAIPDNLVESILFGHEKGSFTGATDKHTGKFVEAHSG
HHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCC
TLFLDEIGDLPLDVQVKLLRAVQEGEVDPVGGRSTVKVDIRLISATHRNLLQQVKDGKFR
EEEEHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHCCCHH
EDLFYRLNVYPIFVPPLRDRRDDIPHLVTHFMEKVAPADPRRRLQGISPAALAVLEAYDW
HHHEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCC
PGNIRQLENAVFRASVLCEGDVLDVDDFPQIRAQVEGTVNLETDDAAPRLSSPPELRDEG
CCHHHHHHHHHHHHHEEECCCEECCCCCHHHHHEECCEEEECCCCCCCCCCCCCCCCCCC
GPAGDDAPAAEPDRPAVLQPRFGTLRALDERGNVRALADVELEMIKLAIDHYNGQMSEVA
CCCCCCCCCCCCCCCCEECCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHH
RRLGIGRSTLYRKLKEYGIDPETGRVDRLAS
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGSILIVDDDPVQRRLLEAAVTRFGHTAIVVDGGEAGLDALDGPGARDICVVILDLVMP
CCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHC
GLDGIGVLKAMRERDITVPVIVQTAQGGIETVVLAMRHGAFDFVVKPASPDRLQASIANA
CCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
LKVEAVEGEVKRTSRKRGGLLTFRDMITHSPAMDRVIRLGQKAAGSSIPILIEGESGVGK
HEEEECCCHHHHHHHHCCCEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCH
ELVARAIQGSGDRRSKPFVTVNCGAIPDNLVESILFGHEKGSFTGATDKHTGKFVEAHSG
HHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCC
TLFLDEIGDLPLDVQVKLLRAVQEGEVDPVGGRSTVKVDIRLISATHRNLLQQVKDGKFR
EEEEHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHCCCHH
EDLFYRLNVYPIFVPPLRDRRDDIPHLVTHFMEKVAPADPRRRLQGISPAALAVLEAYDW
HHHEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCC
PGNIRQLENAVFRASVLCEGDVLDVDDFPQIRAQVEGTVNLETDDAAPRLSSPPELRDEG
CCHHHHHHHHHHHHHEEECCCEECCCCCHHHHHEECCEEEECCCCCCCCCCCCCCCCCCC
GPAGDDAPAAEPDRPAVLQPRFGTLRALDERGNVRALADVELEMIKLAIDHYNGQMSEVA
CCCCCCCCCCCCCCCCEECCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCHHHHHH
RRLGIGRSTLYRKLKEYGIDPETGRVDRLAS
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]