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The map label for this gene is hemF [H]

Identifier: 13472430

GI number: 13472430

Start: 2186403

End: 2187263

Strand: Direct

Name: hemF [H]

Synonym: mlr2722

Alternate gene names: 13472430

Gene position: 2186403-2187263 (Clockwise)

Preceding gene: 13472428

Following gene: 13472431

Centisome position: 31.07

GC content: 64.34

Gene sequence:

>861_bases
ATGAAGGCCCGCCTGTGGTTCGAGGCGCTTCGCGAACGCATCTGCGGCGCTTTCGAGCAGATCGAGCAGGATCTCCAGGG
CCCTCTCGCCTCATGGTCGCCGGGCCGTTTCGAAAAGACGCCTTGGGAACGCGATGCCGGCAAGGGGGGCGGCGGCACCA
TGTCGATGATGCATGGCCGCGTCTTCGAGAAGGTCGGCGTCCACACCTCGACGGTTTACGGCGAGTTCTCGCCCGAATTC
AGGAAGCAGATGCCCGGTGCCGAGGAAGACCCACGCTTCTGGGCCTCCGGCATCTCGCTGATCGCGCACCCCTGGAACCC
CAACGTTCCGGCCGTGCACATGAACACGCGCATGGTGGTCACCTCGAGGCAATGGTTCGGTGGCGGCGCCGATCTGACGC
CGGTGCTCGACCGCCGCCGCACCCAGGACGACCCTGACACGATAGCCTTCCATCGCGCCATGCAGTTCGCTTGCGAGAAG
AACGTCGCCGTCGCCGACCACCCGAAATTCAAGACTTGGTGCGACGAGTACTTCTTCCTGCCGCACCGCAACGAGCCGCG
CGGCGTTGGCGGCATTTTCTTCGACTGGCTGCATTCTGGCGAGGACAGAGGCGGCTGGAACGCCGACTTCAACTTCGTCC
AGGACGTCGGACGCTCCTTCCTCGTCGTCTACAGCCACCTCGTGCGCGCCAACTTCAACGAGAACTGGACGGATGGCGAC
CGCGACGAACAGCTCATCCGCCGTGGCCGCTATGTCGAATTCAACCTGCTTCACGATCGCGGCACCATCTTCGGCCTGAA
GACCGGCGGCAATGTCGCCTCGATCCTGTCCAGCCTGCCGCCGGAGGTGCGCTGGCCGTAA

Upstream 100 bases:

>100_bases
CGAGTCATTTGTAGGGGCGGCCCGCCCCGCAACCGGAGACGGCATTTTGGAACGACCTGAAATACCGGCGGGCCTGCCCG
TCGACATCGAAGAGAAGAAG

Downstream 100 bases:

>100_bases
GATCAGCCGGAGCAATCCCGTCTGGAATTGCGTCAAATCAAGGAGACAGAGCGGCGCTGCACGATGCTTTGATGCAACCA
GACCGCCCCTCCCGTGTTAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKARLWFEALRERICGAFEQIEQDLQGPLASWSPGRFEKTPWERDAGKGGGGTMSMMHGRVFEKVGVHTSTVYGEFSPEF
RKQMPGAEEDPRFWASGISLIAHPWNPNVPAVHMNTRMVVTSRQWFGGGADLTPVLDRRRTQDDPDTIAFHRAMQFACEK
NVAVADHPKFKTWCDEYFFLPHRNEPRGVGGIFFDWLHSGEDRGGWNADFNFVQDVGRSFLVVYSHLVRANFNENWTDGD
RDEQLIRRGRYVEFNLLHDRGTIFGLKTGGNVASILSSLPPEVRWP

Sequences:

>Translated_286_residues
MKARLWFEALRERICGAFEQIEQDLQGPLASWSPGRFEKTPWERDAGKGGGGTMSMMHGRVFEKVGVHTSTVYGEFSPEF
RKQMPGAEEDPRFWASGISLIAHPWNPNVPAVHMNTRMVVTSRQWFGGGADLTPVLDRRRTQDDPDTIAFHRAMQFACEK
NVAVADHPKFKTWCDEYFFLPHRNEPRGVGGIFFDWLHSGEDRGGWNADFNFVQDVGRSFLVVYSHLVRANFNENWTDGD
RDEQLIRRGRYVEFNLLHDRGTIFGLKTGGNVASILSSLPPEVRWP
>Mature_286_residues
MKARLWFEALRERICGAFEQIEQDLQGPLASWSPGRFEKTPWERDAGKGGGGTMSMMHGRVFEKVGVHTSTVYGEFSPEF
RKQMPGAEEDPRFWASGISLIAHPWNPNVPAVHMNTRMVVTSRQWFGGGADLTPVLDRRRTQDDPDTIAFHRAMQFACEK
NVAVADHPKFKTWCDEYFFLPHRNEPRGVGGIFFDWLHSGEDRGGWNADFNFVQDVGRSFLVVYSHLVRANFNENWTDGD
RDEQLIRRGRYVEFNLLHDRGTIFGLKTGGNVASILSSLPPEVRWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=298, Percent_Identity=39.261744966443, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI1788777, Length=271, Percent_Identity=39.8523985239852, Blast_Score=182, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320249, Length=300, Percent_Identity=37.6666666666667, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17864388, Length=263, Percent_Identity=43.3460076045627, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 32689; Mature: 32689

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARLWFEALRERICGAFEQIEQDLQGPLASWSPGRFEKTPWERDAGKGGGGTMSMMHGR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VFEKVGVHTSTVYGEFSPEFRKQMPGAEEDPRFWASGISLIAHPWNPNVPAVHMNTRMVV
HHHHHCCCCEEEECCCCHHHHHHCCCCCCCCHHHHCCCEEEECCCCCCCCEEEECCEEEE
TSRQWFGGGADLTPVLDRRRTQDDPDTIAFHRAMQFACEKNVAVADHPKFKTWCDEYFFL
EEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHEEC
PHRNEPRGVGGIFFDWLHSGEDRGGWNADFNFVQDVGRSFLVVYSHLVRANFNENWTDGD
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RDEQLIRRGRYVEFNLLHDRGTIFGLKTGGNVASILSSLPPEVRWP
HHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKARLWFEALRERICGAFEQIEQDLQGPLASWSPGRFEKTPWERDAGKGGGGTMSMMHGR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VFEKVGVHTSTVYGEFSPEFRKQMPGAEEDPRFWASGISLIAHPWNPNVPAVHMNTRMVV
HHHHHCCCCEEEECCCCHHHHHHCCCCCCCCHHHHCCCEEEECCCCCCCCEEEECCEEEE
TSRQWFGGGADLTPVLDRRRTQDDPDTIAFHRAMQFACEKNVAVADHPKFKTWCDEYFFL
EEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHEEC
PHRNEPRGVGGIFFDWLHSGEDRGGWNADFNFVQDVGRSFLVVYSHLVRANFNENWTDGD
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RDEQLIRRGRYVEFNLLHDRGTIFGLKTGGNVASILSSLPPEVRWP
HHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA