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The map label for this gene is pth

Identifier: 13472407

GI number: 13472407

Start: 2166713

End: 2167435

Strand: Direct

Name: pth

Synonym: mlr2694

Alternate gene names: 13472407

Gene position: 2166713-2167435 (Clockwise)

Preceding gene: 13472406

Following gene: 13472408

Centisome position: 30.79

GC content: 62.66

Gene sequence:

>723_bases
ATGCTTGTCTTTGCAGGCCTCGGCAATCCGGGCGCGAAATACGCTGATAACCGGCACAATGTCGGCTTCATGGCGGCGGA
CGCAATCGCCCGCCGCCATTCCTTTTCGCCCTGGTCGAAGAAATTCCAGGGCCTGATCGCCGAGGGCACGATTGCCGGCG
AAAAGATCATCCTGATCAAGCCCCAAACCTTCATGAACCTGTCCGGCCAGTCGGTCGGCGAAGCGCTGCGCTTCTACAAG
CTCGAGCTTTCCGCGCTCACCGTCTTCTATGACGAGATCGACCTCGCCGAAGGCAAGCTGCGCATCAAGACCGGCGGCGG
CGCCGGCGGCCACAACGGCATCCGCTCGATCGACGGCCATATCGGCAACGCCTATCGCCGCGTGCGCATCGGCGTCGGCC
ATCCCGGCATCAAGGAAATGGTCCAGCATCATGTGCTCGGCGACTTCGCCAAGGCCGACCGCGAATGGCTCGATCCCTTG
CTCGATGCGATCGCCGACAACGCCGCCATGATCGTCAAGGGCGACGAATCCGGCTTCATGAACAAGGCCGCCCTCGCCGT
CCAGGGTAAGGCGATAGCCGAGCTGGAAAAGCCGGCGCAGAAGCAGCAGCCCAAACAACAGAGCCACATCCGCCAGGCGC
GGTCGCAACAAGCACCCGCCAAACTGCCGGAGACCGGCCCGATGGCCGCCATGCTGAAGAAACTCTTCGGCAACAAGGAC
TGA

Upstream 100 bases:

>100_bases
TCGGCGATGAAGCCGGAGGCGGAAGAGACGGTCGAAGTGGCTGCACCTGAGGCGGCTCCTGTCGCCGAAGAGAAGTAACT
CTTTCCGCCCGGAGCAGACG

Downstream 100 bases:

>100_bases
GCGGGCCCGCATGCGGCCCTACAGGGCTTGACGTAGATCACCCCTATCGCCCATAGCCCTCATCAAATTTCGCTTTTCCG
ACAGGACTGGACAAAATGGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MLVFAGLGNPGAKYADNRHNVGFMAADAIARRHSFSPWSKKFQGLIAEGTIAGEKIILIKPQTFMNLSGQSVGEALRFYK
LELSALTVFYDEIDLAEGKLRIKTGGGAGGHNGIRSIDGHIGNAYRRVRIGVGHPGIKEMVQHHVLGDFAKADREWLDPL
LDAIADNAAMIVKGDESGFMNKAALAVQGKAIAELEKPAQKQQPKQQSHIRQARSQQAPAKLPETGPMAAMLKKLFGNKD

Sequences:

>Translated_240_residues
MLVFAGLGNPGAKYADNRHNVGFMAADAIARRHSFSPWSKKFQGLIAEGTIAGEKIILIKPQTFMNLSGQSVGEALRFYK
LELSALTVFYDEIDLAEGKLRIKTGGGAGGHNGIRSIDGHIGNAYRRVRIGVGHPGIKEMVQHHVLGDFAKADREWLDPL
LDAIADNAAMIVKGDESGFMNKAALAVQGKAIAELEKPAQKQQPKQQSHIRQARSQQAPAKLPETGPMAAMLKKLFGNKD
>Mature_240_residues
MLVFAGLGNPGAKYADNRHNVGFMAADAIARRHSFSPWSKKFQGLIAEGTIAGEKIILIKPQTFMNLSGQSVGEALRFYK
LELSALTVFYDEIDLAEGKLRIKTGGGAGGHNGIRSIDGHIGNAYRRVRIGVGHPGIKEMVQHHVLGDFAKADREWLDPL
LDAIADNAAMIVKGDESGFMNKAALAVQGKAIAELEKPAQKQQPKQQSHIRQARSQQAPAKLPETGPMAAMLKKLFGNKD

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=36.9047619047619, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1787455, Length=172, Percent_Identity=39.5348837209302, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_RHILO (Q98HV6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103974.1
- ProteinModelPortal:   Q98HV6
- SMR:   Q98HV6
- GeneID:   1226635
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr2694
- NMPDR:   fig|266835.1.peg.2078
- HOGENOM:   HBG610927
- OMA:   HIRERSQ
- ProtClustDB:   PRK05426
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 25992; Mature: 25992

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVFAGLGNPGAKYADNRHNVGFMAADAIARRHSFSPWSKKFQGLIAEGTIAGEKIILIK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHCCEECCCEEEEEC
PQTFMNLSGQSVGEALRFYKLELSALTVFYDEIDLAEGKLRIKTGGGAGGHNGIRSIDGH
CHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCEEEEEECCCCCCCCCCHHHCCH
IGNAYRRVRIGVGHPGIKEMVQHHVLGDFAKADREWLDPLLDAIADNAAMIVKGDESGFM
HCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
NKAALAVQGKAIAELEKPAQKQQPKQQSHIRQARSQQAPAKLPETGPMAAMLKKLFGNKD
HHHHHEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLVFAGLGNPGAKYADNRHNVGFMAADAIARRHSFSPWSKKFQGLIAEGTIAGEKIILIK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHCCEECCCEEEEEC
PQTFMNLSGQSVGEALRFYKLELSALTVFYDEIDLAEGKLRIKTGGGAGGHNGIRSIDGH
CHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCEEEEEECCCCCCCCCCHHHCCH
IGNAYRRVRIGVGHPGIKEMVQHHVLGDFAKADREWLDPLLDAIADNAAMIVKGDESGFM
HCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
NKAALAVQGKAIAELEKPAQKQQPKQQSHIRQARSQQAPAKLPETGPMAAMLKKLFGNKD
HHHHHEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968