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The map label for this gene is hldE

Identifier: 13472309

GI number: 13472309

Start: 2073022

End: 2074512

Strand: Reverse

Name: hldE

Synonym: mll2562

Alternate gene names: 13472309

Gene position: 2074512-2073022 (Counterclockwise)

Preceding gene: 13472310

Following gene: 13472308

Centisome position: 29.48

GC content: 67.81

Gene sequence:

>1491_bases
ATGATCAAGCACAATCCGCCTTCTCCCGAACCCCTGCACCGCGCCATTGCCCGCTTTGGCGGCGTCACCGTGCTGGTGGT
CGGCGACCTTATCCTCGACCGCTTCGTCAACGGCGTCATCGAGCGGATTTCGCCTGAGGCGCCGATCCCTGTGCTGCATG
GGCGCGGCGAAACCTCGGCCATGGGCGGCGCCGGCAATGTCGTGGCCAACATCGTCTCGCTTGGCGCGCGGGCCATCCCG
GTTTCGGTGATCGGCACGGACACCGCCGGCGACAGCCTGGTGCGCATGCTCGCCGAGCTTGGAGCCGAGACAGCGGGGCT
TTCGCAGCAGCGCGGCCGCATGACGTCGTCGAAGAGCCGCTTCAGCGCGCTCAATCAGCAGGTGTTGCGCTTCGACGAGG
AAGAGATCAAACCATTGGACGAGACGGAGCGGGCAGGGCTGATCCGGCATTTCCGTGCCGCACTGGCGGGGGCCGAGATC
GTCATCCTGTCCGACTACGGCAAGGGCATCCTGCTCGACGGCGTTGCCGCCGAACTCATCGCCATCTGCCGCGAGGCCGG
CAAGCCGGTGCTGGTCGATCCCAAGGGCCGCGATTATGCGCGCTATGCCGGCGCGACCGCCATCACCCCCAACCGCAAGG
AACTTGGCGAGGCCGTCGGCCATGCCGTGTTCGCCGATGACGAGATCGTGGCCGCGGCGCGCGAACTGATTTCGGCGCAT
GGTTTCGACTTCGTCGTCGCCACGCGCAGCGAAAAGGGCATGAGCGTGGTCGGCCCTGACGAGGCGCGCCACATCGCCAC
CCAGGCGCGCGAAGTGTTCGACGTCTCTGGCGCCGGCGACACGGTCATCGCGACGTTCGCGCTGGCGCTAGCCTCGGGGG
CCGATCCCGTCGCGGCGGCCTCGATCGCCAATGCCGCCGGCGGCGTCGTGGTGGGAAAACGCGGCACCGCGCGGCTGACG
GTCGAGGAGCTTACCGGCGCGCTGTTTCGCTCGCATGGACCGACCGCCCACAAGGACGCCATCCTCGATGCCTCGTCGGC
CGCGCGCATGGTGGCGGCCTGGAAGGAAGAAGGCCTCAGCGTCGGCTTCACCAATGGCTGCTTCGACATATTGCATGCCG
GCCATGTCAGCCTGCTGCACGCGGCGCGCAGCCAGTGCGACCGGCTGGTGCTCGGCCTCAACAGCGACGCCTCGGTGCGG
CGGCTGAAAGGCCCGGGCCGCCCGGTCAACGACCAGCATGATCGTGCCTGCGTGCTTGCCGCGCTTGCCTCGGTCGATGC
CGTCGTTGTCTTCGAGGAGGATACGCCGCTGGCGCTGATCGAGGCGCTGCTGCCCGATATCCTGGTCAAGGGCGCGGATT
ATACGATCGACACCGTGGTCGGCGCCGACGTCGTGCAGAAGGCCGGTGGGCGCGTCGTGCTGGTCGATCTCGTCGCCGGC
AAGAGCACCACCGGCACAATCGGCAAATTGCGCGCCGGCTCTACAAGCTGA

Upstream 100 bases:

>100_bases
TGCGCCGGTTCGAATTGCGGTATATCGGCAGGCATGAACGTCCGCCAGCCGACACCCTATATGTTTCAGCGACTGTTTTT
CCCCGCGCGTTGCCAGTGAT

Downstream 100 bases:

>100_bases
GGTTTTGATGTCTGAACTGAACGACTATCTGGTCCGCTCGGCGGCCGCGATCACGGCGATGGTCGAGCGTGACCTGACCG
GCGAGATGGAGCGGGCGGCG

Product: ADP-heptose synthase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MIKHNPPSPEPLHRAIARFGGVTVLVVGDLILDRFVNGVIERISPEAPIPVLHGRGETSAMGGAGNVVANIVSLGARAIP
VSVIGTDTAGDSLVRMLAELGAETAGLSQQRGRMTSSKSRFSALNQQVLRFDEEEIKPLDETERAGLIRHFRAALAGAEI
VILSDYGKGILLDGVAAELIAICREAGKPVLVDPKGRDYARYAGATAITPNRKELGEAVGHAVFADDEIVAAARELISAH
GFDFVVATRSEKGMSVVGPDEARHIATQAREVFDVSGAGDTVIATFALALASGADPVAAASIANAAGGVVVGKRGTARLT
VEELTGALFRSHGPTAHKDAILDASSAARMVAAWKEEGLSVGFTNGCFDILHAGHVSLLHAARSQCDRLVLGLNSDASVR
RLKGPGRPVNDQHDRACVLAALASVDAVVVFEEDTPLALIEALLPDILVKGADYTIDTVVGADVVQKAGGRVVLVDLVAG
KSTTGTIGKLRAGSTS

Sequences:

>Translated_496_residues
MIKHNPPSPEPLHRAIARFGGVTVLVVGDLILDRFVNGVIERISPEAPIPVLHGRGETSAMGGAGNVVANIVSLGARAIP
VSVIGTDTAGDSLVRMLAELGAETAGLSQQRGRMTSSKSRFSALNQQVLRFDEEEIKPLDETERAGLIRHFRAALAGAEI
VILSDYGKGILLDGVAAELIAICREAGKPVLVDPKGRDYARYAGATAITPNRKELGEAVGHAVFADDEIVAAARELISAH
GFDFVVATRSEKGMSVVGPDEARHIATQAREVFDVSGAGDTVIATFALALASGADPVAAASIANAAGGVVVGKRGTARLT
VEELTGALFRSHGPTAHKDAILDASSAARMVAAWKEEGLSVGFTNGCFDILHAGHVSLLHAARSQCDRLVLGLNSDASVR
RLKGPGRPVNDQHDRACVLAALASVDAVVVFEEDTPLALIEALLPDILVKGADYTIDTVVGADVVQKAGGRVVLVDLVAG
KSTTGTIGKLRAGSTS
>Mature_496_residues
MIKHNPPSPEPLHRAIARFGGVTVLVVGDLILDRFVNGVIERISPEAPIPVLHGRGETSAMGGAGNVVANIVSLGARAIP
VSVIGTDTAGDSLVRMLAELGAETAGLSQQRGRMTSSKSRFSALNQQVLRFDEEEIKPLDETERAGLIRHFRAALAGAEI
VILSDYGKGILLDGVAAELIAICREAGKPVLVDPKGRDYARYAGATAITPNRKELGEAVGHAVFADDEIVAAARELISAH
GFDFVVATRSEKGMSVVGPDEARHIATQAREVFDVSGAGDTVIATFALALASGADPVAAASIANAAGGVVVGKRGTARLT
VEELTGALFRSHGPTAHKDAILDASSAARMVAAWKEEGLSVGFTNGCFDILHAGHVSLLHAARSQCDRLVLGLNSDASVR
RLKGPGRPVNDQHDRACVLAALASVDAVVVFEEDTPLALIEALLPDILVKGADYTIDTVVGADVVQKAGGRVVLVDLVAG
KSTTGTIGKLRAGSTS

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=477, Percent_Identity=43.6058700209644, Blast_Score=330, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_RHILO (Q98I54)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103876.1
- ProteinModelPortal:   Q98I54
- SMR:   Q98I54
- GeneID:   1226537
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll2562
- NMPDR:   fig|266835.1.peg.1980
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 51450; Mature: 51450

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKHNPPSPEPLHRAIARFGGVTVLVVGDLILDRFVNGVIERISPEAPIPVLHGRGETSA
CCCCCCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
MGGAGNVVANIVSLGARAIPVSVIGTDTAGDSLVRMLAELGAETAGLSQQRGRMTSSKSR
CCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHH
FSALNQQVLRFDEEEIKPLDETERAGLIRHFRAALAGAEIVILSDYGKGILLDGVAAELI
HHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHH
AICREAGKPVLVDPKGRDYARYAGATAITPNRKELGEAVGHAVFADDEIVAAARELISAH
HHHHHCCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GFDFVVATRSEKGMSVVGPDEARHIATQAREVFDVSGAGDTVIATFALALASGADPVAAA
CCEEEEEECCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHH
SIANAAGGVVVGKRGTARLTVEELTGALFRSHGPTAHKDAILDASSAARMVAAWKEEGLS
HHHHCCCCEEECCCCCCEEEHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHCCCE
VGFTNGCFDILHAGHVSLLHAARSQCDRLVLGLNSDASVRRLKGPGRPVNDQHDRACVLA
ECCCCHHHHHHHCCHHHHHHHHHHHHCEEEEECCCCCCHHHHCCCCCCCCCCCHHHHHHH
ALASVDAVVVFEEDTPLALIEALLPDILVKGADYTIDTVVGADVVQKAGGRVVLVDLVAG
HHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCEEEEEEECC
KSTTGTIGKLRAGSTS
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKHNPPSPEPLHRAIARFGGVTVLVVGDLILDRFVNGVIERISPEAPIPVLHGRGETSA
CCCCCCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
MGGAGNVVANIVSLGARAIPVSVIGTDTAGDSLVRMLAELGAETAGLSQQRGRMTSSKSR
CCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHH
FSALNQQVLRFDEEEIKPLDETERAGLIRHFRAALAGAEIVILSDYGKGILLDGVAAELI
HHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHH
AICREAGKPVLVDPKGRDYARYAGATAITPNRKELGEAVGHAVFADDEIVAAARELISAH
HHHHHCCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
GFDFVVATRSEKGMSVVGPDEARHIATQAREVFDVSGAGDTVIATFALALASGADPVAAA
CCEEEEEECCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHH
SIANAAGGVVVGKRGTARLTVEELTGALFRSHGPTAHKDAILDASSAARMVAAWKEEGLS
HHHHCCCCEEECCCCCCEEEHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHCCCE
VGFTNGCFDILHAGHVSLLHAARSQCDRLVLGLNSDASVRRLKGPGRPVNDQHDRACVLA
ECCCCHHHHHHHCCHHHHHHHHHHHHCEEEEECCCCCCHHHHCCCCCCCCCCCHHHHHHH
ALASVDAVVVFEEDTPLALIEALLPDILVKGADYTIDTVVGADVVQKAGGRVVLVDLVAG
HHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCEEEEEEECC
KSTTGTIGKLRAGSTS
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968