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The map label for this gene is gcvT [H]

Identifier: 13472226

GI number: 13472226

Start: 1990265

End: 1992703

Strand: Reverse

Name: gcvT [H]

Synonym: mll2449

Alternate gene names: 13472226

Gene position: 1992703-1990265 (Counterclockwise)

Preceding gene: 13472227

Following gene: 13472224

Centisome position: 28.32

GC content: 65.56

Gene sequence:

>2439_bases
ATGCAGACGCATGCGCGGGTGGTGGTTGTTGGTGGCGGGTGCGTCGGCGCGGGCATCCTCTACGGTCTGGCCAAGCGCGG
CTGGGCCGACGTCGCGCTGCTCGAACGCACGCAGTTGACCGCCGGCTCGACCTGGCACGCGGCGGGCCTCGTCCCGTCCT
ATGCCCGCAACATCAATATCGGCCGGATGATCAACAAGACCATCGAGATCTATGAAGGGCTGGAGGCCGAGACCGGGCAG
CCGGTCGGCTGGCACAAATGCGGCCAGCTGCGCATCGCCAATTCCAGGGACCGGCTCGACGAATACAAGAGCTATATGAG
CGTCGCCGACGTTCAGGGCATGCGGGCGCATTTGCTGTCGCCGACGGAGGCGAGGGCGCTTTGCCCGCTTCTCGATAACA
AGCATATGCTGGGTGCGCTCTATCATCCCGATGACGGCCATATCGCGCCAGCCGACGTGACCCATGCCATGGCCAAGGGT
GCGCGGGATCTGGGCGCCAAGATTTACCTGAACACCGAGGTGACCGGCTTTCAGCGGACCGCTGGCGGCGAATGGCGGGT
CCAGACGAACAAGGGCGACATCATCTGCGAGCATGTGGTCTGCGCGACCGGCAATTACGCCCGCCAGACCGGCGCGCTGC
TCGGCCTCGACATCCCCGCCATCCCGATCCTGCACCAGTACTGGATCACCGAGCCGGTGCCGGAGATCGTAGAGCGCAAG
AAGCAGGGACGCGCCGAGATGCCGATCCTGCGCGACGAGGGTTTTGAGGGCTATCTGCGCGAGGAGGGCGACGGCTTCAT
GTTCGGGCCCTACGAGCGCACCGAACACCTCAAACTGTTCGCCGAGGACGGCGTTCCCGCCTGGTTCGGCGCCGATCTCG
TCGAAGAGGATTTCGAGGCGGTGTCGTGGAACTGGGAACAGGCAACACAGCTCGTGCCGGCGCTGGGACGCGCCGGGATC
AAGGCCAATGTGCGGGGTCCCTTCCAGATGACGGCGGACGAGCTTCCGCTGATGGGACCGGCCTGGGGCCTGCCCAATGT
GTGGCTGGCCGAGGGCGTGCCGGGCGGCATATTGTGGGGCGGCACGATCGGCTACTACCTGTCGGAGCGGATCGTCGAAG
GCGGCAACAGCCTCGACACCTCCGATCTCGATCCGCGCCGCTTCGGCGACTACGCCAACAAGGCCTGGACGCGCGAGAAG
GTCCGCGAGGCCTGGGGCACGCATGCGGAGCAAAAGTACCCGGGACAGGACATGCCCGCCGCCCGGCCGCAGAAGACCGC
GCCATCCTATGCGCGGCTGACCGAACTGGGTGCGGTCTGGGGCGTGCTCAACGGCTGGGAAATGCCGAACTGGTTCGCGC
CCAAGGGCGTCGAGGCCAAGGACCAGTACAGCTGGCGCTGGACCGAAAAGGGCGTGTTCGTTGGCGAGGAGGTGGAGGCC
GTGCGCAACGCCGTCGGCCTGGTCGAGATGACGCCGATGACCAAGTTCGAAGTGTCGGGGCCGAACGCGGCCGCCTGGCT
CGACAGGATCCTCGCCAACCGGCTTCCCGCGGTCGGCAAAGCGACGCTGGCGCATCACCTGACGGCGGGCGGCGGCGTGC
AAGCGGAATACATGGTGGCGGGGCTTGGCGAAGACAGTTTCTATCTCGTTTCGACGCCACGCGCCGAGCGCTGGAATTTC
GATGATCTCTCAAAGCTGCTTCCCGCCGACGGCAGCGTCAGCCTGAAGAACGTCACCAACGAGCGCGGCTGCTTCACGAT
TGTCGGGCCGAAGGCGCGGGACGTGCTGCAACCACTCACCGAGATCGACCTGTCGAATGCCGGCTTTCCCTGGTTCGGGG
TGAAGACCGGCAGCGTGGCGCTTGCCAGCGACGTGCGGCTGCTGCGCGTGAACTACGAGGGCGAGCTCGGCTGGGAACTC
TATCATCCCATGGCCTACCAGCGGCAATTGCTCGACGCGATCCTGGGAGAGGGCGAGAAGCACGGCATGCGGCTCGTCGG
GCTGCATGCGCTGGAATCGCTGCGGCTCGAAAAATCCTACCGCGCCATGTACCGCGACATGAATCCAGAGCTCAACGCGC
TGGAGAGCGGGCTCGAACGCTTCATCCGCCTCGACAAGGGCGATTTCGTCGGCCGCGACGCGGTCCTGAAATACAAGGCG
AGGAACGACCAGCGCCGATCGGTGACGCTCAGAATAGAGACCGACGGCGCCAGCACGCTCGCTTCCGAAGGTCTGTACAT
CGGCGGCGAGCTGGTCGGGCGCATCACATCGGGCGGCTATGGCTACACGCTCGGCCATGATGTGGCGCTGGCGCTGTTGC
CGGAACGTCTCGGCACGCCCGGCACGAAGCTTGACGTCGCGATCCTGGGAGAATGGAAGACCGCCGAGGTCATCGCGGAT
TCACCCTATGATCCCTCTTCGGCCAGGGCGCGGATGTAA

Upstream 100 bases:

>100_bases
AGCTTATCATCACCCCTAGTTTTTGAAGACGTTACAGGGTCTTTCGCCATCTGTAGCTTCGACTCTACACATTGGAAATG
ACTGGGGATTTGGTGGGTCG

Downstream 100 bases:

>100_bases
CGCGCAGCAGACGTGAGCGAAGGTGTCGGGGGCACGCTTCCAGCTTCAGTTGTTTTTTGCATAGGACTGTCGGCGCCCGA
AAGCGGCTTCGGTCATCACT

Product: dimethylglycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 812; Mature: 812

Protein sequence:

>812_residues
MQTHARVVVVGGGCVGAGILYGLAKRGWADVALLERTQLTAGSTWHAAGLVPSYARNINIGRMINKTIEIYEGLEAETGQ
PVGWHKCGQLRIANSRDRLDEYKSYMSVADVQGMRAHLLSPTEARALCPLLDNKHMLGALYHPDDGHIAPADVTHAMAKG
ARDLGAKIYLNTEVTGFQRTAGGEWRVQTNKGDIICEHVVCATGNYARQTGALLGLDIPAIPILHQYWITEPVPEIVERK
KQGRAEMPILRDEGFEGYLREEGDGFMFGPYERTEHLKLFAEDGVPAWFGADLVEEDFEAVSWNWEQATQLVPALGRAGI
KANVRGPFQMTADELPLMGPAWGLPNVWLAEGVPGGILWGGTIGYYLSERIVEGGNSLDTSDLDPRRFGDYANKAWTREK
VREAWGTHAEQKYPGQDMPAARPQKTAPSYARLTELGAVWGVLNGWEMPNWFAPKGVEAKDQYSWRWTEKGVFVGEEVEA
VRNAVGLVEMTPMTKFEVSGPNAAAWLDRILANRLPAVGKATLAHHLTAGGGVQAEYMVAGLGEDSFYLVSTPRAERWNF
DDLSKLLPADGSVSLKNVTNERGCFTIVGPKARDVLQPLTEIDLSNAGFPWFGVKTGSVALASDVRLLRVNYEGELGWEL
YHPMAYQRQLLDAILGEGEKHGMRLVGLHALESLRLEKSYRAMYRDMNPELNALESGLERFIRLDKGDFVGRDAVLKYKA
RNDQRRSVTLRIETDGASTLASEGLYIGGELVGRITSGGYGYTLGHDVALALLPERLGTPGTKLDVAILGEWKTAEVIAD
SPYDPSSARARM

Sequences:

>Translated_812_residues
MQTHARVVVVGGGCVGAGILYGLAKRGWADVALLERTQLTAGSTWHAAGLVPSYARNINIGRMINKTIEIYEGLEAETGQ
PVGWHKCGQLRIANSRDRLDEYKSYMSVADVQGMRAHLLSPTEARALCPLLDNKHMLGALYHPDDGHIAPADVTHAMAKG
ARDLGAKIYLNTEVTGFQRTAGGEWRVQTNKGDIICEHVVCATGNYARQTGALLGLDIPAIPILHQYWITEPVPEIVERK
KQGRAEMPILRDEGFEGYLREEGDGFMFGPYERTEHLKLFAEDGVPAWFGADLVEEDFEAVSWNWEQATQLVPALGRAGI
KANVRGPFQMTADELPLMGPAWGLPNVWLAEGVPGGILWGGTIGYYLSERIVEGGNSLDTSDLDPRRFGDYANKAWTREK
VREAWGTHAEQKYPGQDMPAARPQKTAPSYARLTELGAVWGVLNGWEMPNWFAPKGVEAKDQYSWRWTEKGVFVGEEVEA
VRNAVGLVEMTPMTKFEVSGPNAAAWLDRILANRLPAVGKATLAHHLTAGGGVQAEYMVAGLGEDSFYLVSTPRAERWNF
DDLSKLLPADGSVSLKNVTNERGCFTIVGPKARDVLQPLTEIDLSNAGFPWFGVKTGSVALASDVRLLRVNYEGELGWEL
YHPMAYQRQLLDAILGEGEKHGMRLVGLHALESLRLEKSYRAMYRDMNPELNALESGLERFIRLDKGDFVGRDAVLKYKA
RNDQRRSVTLRIETDGASTLASEGLYIGGELVGRITSGGYGYTLGHDVALALLPERLGTPGTKLDVAILGEWKTAEVIAD
SPYDPSSARARM
>Mature_812_residues
MQTHARVVVVGGGCVGAGILYGLAKRGWADVALLERTQLTAGSTWHAAGLVPSYARNINIGRMINKTIEIYEGLEAETGQ
PVGWHKCGQLRIANSRDRLDEYKSYMSVADVQGMRAHLLSPTEARALCPLLDNKHMLGALYHPDDGHIAPADVTHAMAKG
ARDLGAKIYLNTEVTGFQRTAGGEWRVQTNKGDIICEHVVCATGNYARQTGALLGLDIPAIPILHQYWITEPVPEIVERK
KQGRAEMPILRDEGFEGYLREEGDGFMFGPYERTEHLKLFAEDGVPAWFGADLVEEDFEAVSWNWEQATQLVPALGRAGI
KANVRGPFQMTADELPLMGPAWGLPNVWLAEGVPGGILWGGTIGYYLSERIVEGGNSLDTSDLDPRRFGDYANKAWTREK
VREAWGTHAEQKYPGQDMPAARPQKTAPSYARLTELGAVWGVLNGWEMPNWFAPKGVEAKDQYSWRWTEKGVFVGEEVEA
VRNAVGLVEMTPMTKFEVSGPNAAAWLDRILANRLPAVGKATLAHHLTAGGGVQAEYMVAGLGEDSFYLVSTPRAERWNF
DDLSKLLPADGSVSLKNVTNERGCFTIVGPKARDVLQPLTEIDLSNAGFPWFGVKTGSVALASDVRLLRVNYEGELGWEL
YHPMAYQRQLLDAILGEGEKHGMRLVGLHALESLRLEKSYRAMYRDMNPELNALESGLERFIRLDKGDFVGRDAVLKYKA
RNDQRRSVTLRIETDGASTLASEGLYIGGELVGRITSGGYGYTLGHDVALALLPERLGTPGTKLDVAILGEWKTAEVIAD
SPYDPSSARARM

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=817, Percent_Identity=37.4541003671971, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI197927446, Length=877, Percent_Identity=30.4446978335234, Blast_Score=355, Evalue=8e-98,
Organism=Homo sapiens, GI21361378, Length=877, Percent_Identity=30.4446978335234, Blast_Score=355, Evalue=8e-98,
Organism=Homo sapiens, GI194306651, Length=793, Percent_Identity=30.390920554855, Blast_Score=322, Evalue=1e-87,
Organism=Homo sapiens, GI44662838, Length=338, Percent_Identity=27.2189349112426, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI257796256, Length=298, Percent_Identity=29.5302013422819, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI257796258, Length=319, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789272, Length=366, Percent_Identity=25.6830601092896, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=803, Percent_Identity=28.7671232876712, Blast_Score=307, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71994052, Length=810, Percent_Identity=28.3950617283951, Blast_Score=303, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI32563613, Length=848, Percent_Identity=27.3584905660377, Blast_Score=226, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17560118, Length=383, Percent_Identity=23.2375979112272, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=24.0932642487047, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20130091, Length=866, Percent_Identity=31.986143187067, Blast_Score=343, Evalue=3e-94,
Organism=Drosophila melanogaster, GI28571104, Length=776, Percent_Identity=28.0927835051546, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI20129441, Length=327, Percent_Identity=23.5474006116208, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 89259; Mature: 89259

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTHARVVVVGGGCVGAGILYGLAKRGWADVALLERTQLTAGSTWHAAGLVPSYARNINI
CCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEHHCCCHHHHHCCCH
GRMINKTIEIYEGLEAETGQPVGWHKCGQLRIANSRDRLDEYKSYMSVADVQGMRAHLLS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
PTEARALCPLLDNKHMLGALYHPDDGHIAPADVTHAMAKGARDLGAKIYLNTEVTGFQRT
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHCCCEEEEECCCCCEEEC
AGGEWRVQTNKGDIICEHVVCATGNYARQTGALLGLDIPAIPILHQYWITEPVPEIVERK
CCCEEEEECCCCCEEEEEEEECCCCHHHHCCCEEECCCCCHHHHHHHHCCCCHHHHHHHH
KQGRAEMPILRDEGFEGYLREEGDGFMFGPYERTEHLKLFAEDGVPAWFGADLVEEDFEA
HCCCCCCCEEECCCCCCCEEECCCCCEECCCCCCCEEEEEECCCCCHHHCCHHHHHHHHH
VSWNWEQATQLVPALGRAGIKANVRGPFQMTADELPLMGPAWGLPNVWLAEGVPGGILWG
HCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCCCCCCCCCCCCEECCCCCCCEEEC
GTIGYYLSERIVEGGNSLDTSDLDPRRFGDYANKAWTREKVREAWGTHAEQKYPGQDMPA
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ARPQKTAPSYARLTELGAVWGVLNGWEMPNWFAPKGVEAKDQYSWRWTEKGVFVGEEVEA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEECHHHHH
VRNAVGLVEMTPMTKFEVSGPNAAAWLDRILANRLPAVGKATLAHHLTAGGGVQAEYMVA
HHHHCCEEEECCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEE
GLGEDSFYLVSTPRAERWNFDDLSKLLPADGSVSLKNVTNERGCFTIVGPKARDVLQPLT
ECCCCCEEEEECCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHH
EIDLSNAGFPWFGVKTGSVALASDVRLLRVNYEGELGWELYHPMAYQRQLLDAILGEGEK
HCCCCCCCCCEEECCCCCEEEECCEEEEEEECCCCCCHHHHCHHHHHHHHHHHHHCCCCC
HGMRLVGLHALESLRLEKSYRAMYRDMNPELNALESGLERFIRLDKGDFVGRDAVLKYKA
CCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
RNDQRRSVTLRIETDGASTLASEGLYIGGELVGRITSGGYGYTLGHDVALALLPERLGTP
CCCCCEEEEEEEECCCCHHHHHCCEEECCHHEEEEECCCCCEECHHHHHHHHHHHHHCCC
GTKLDVAILGEWKTAEVIADSPYDPSSARARM
CCEEEEEEECCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MQTHARVVVVGGGCVGAGILYGLAKRGWADVALLERTQLTAGSTWHAAGLVPSYARNINI
CCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEHHCCCHHHHHCCCH
GRMINKTIEIYEGLEAETGQPVGWHKCGQLRIANSRDRLDEYKSYMSVADVQGMRAHLLS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
PTEARALCPLLDNKHMLGALYHPDDGHIAPADVTHAMAKGARDLGAKIYLNTEVTGFQRT
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHCCCEEEEECCCCCEEEC
AGGEWRVQTNKGDIICEHVVCATGNYARQTGALLGLDIPAIPILHQYWITEPVPEIVERK
CCCEEEEECCCCCEEEEEEEECCCCHHHHCCCEEECCCCCHHHHHHHHCCCCHHHHHHHH
KQGRAEMPILRDEGFEGYLREEGDGFMFGPYERTEHLKLFAEDGVPAWFGADLVEEDFEA
HCCCCCCCEEECCCCCCCEEECCCCCEECCCCCCCEEEEEECCCCCHHHCCHHHHHHHHH
VSWNWEQATQLVPALGRAGIKANVRGPFQMTADELPLMGPAWGLPNVWLAEGVPGGILWG
HCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCCCCCCCCCCCCEECCCCCCCEEEC
GTIGYYLSERIVEGGNSLDTSDLDPRRFGDYANKAWTREKVREAWGTHAEQKYPGQDMPA
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ARPQKTAPSYARLTELGAVWGVLNGWEMPNWFAPKGVEAKDQYSWRWTEKGVFVGEEVEA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEECHHHHH
VRNAVGLVEMTPMTKFEVSGPNAAAWLDRILANRLPAVGKATLAHHLTAGGGVQAEYMVA
HHHHCCEEEECCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEE
GLGEDSFYLVSTPRAERWNFDDLSKLLPADGSVSLKNVTNERGCFTIVGPKARDVLQPLT
ECCCCCEEEEECCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHH
EIDLSNAGFPWFGVKTGSVALASDVRLLRVNYEGELGWELYHPMAYQRQLLDAILGEGEK
HCCCCCCCCCEEECCCCCEEEECCEEEEEEECCCCCCHHHHCHHHHHHHHHHHHHCCCCC
HGMRLVGLHALESLRLEKSYRAMYRDMNPELNALESGLERFIRLDKGDFVGRDAVLKYKA
CCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
RNDQRRSVTLRIETDGASTLASEGLYIGGELVGRITSGGYGYTLGHDVALALLPERLGTP
CCCCCEEEEEEEECCCCHHHHHCCEEECCHHEEEEECCCCCEECHHHHHHHHHHHHHCCC
GTKLDVAILGEWKTAEVIADSPYDPSSARARM
CCEEEEEEECCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA