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The map label for this gene is proA [H]

Identifier: 13472133

GI number: 13472133

Start: 1880853

End: 1881602

Strand: Direct

Name: proA [H]

Synonym: mlr2332

Alternate gene names: 13472133

Gene position: 1880853-1881602 (Clockwise)

Preceding gene: 13472132

Following gene: 13472135

Centisome position: 26.73

GC content: 61.87

Gene sequence:

>750_bases
ATGACGCATACCTCCGACATAATCCGGCCGCCCAAGGACCTGATCGAGGGATTGAGGGAGATCGGCGCAGCGACCGTTGC
CGGCACGCTAGGCCATATGGGCTTCCGCAATCCGCATATGGTCGGACCGGTGGCGCAGAACCACGGCAAGTCGATCGTCG
GGCCGGCGCTGACGCTGCAGTTCCTTCCGCAGCGGCCGGACCTCTTCAACGAGGGAGAGTATGCCGACCCGGAGACGCAA
CTGCACCGGCACGTGCTCTATCACGCCCAGGAAGGCGACGTGGTCGTGGTCGACGCGCGCGGCGACATGAGCTCGGGTGT
CTTCGGCGACATGATGTCGACCTACTTCAAGGGCAGAGGCGGCGCCGGCATCGTCATCGATGGATGCATGCGCGACAGGC
CCAATGTCGAAAAACTCGACCTGCCGCTTTGGCTGCGCGGCTGGACGCCCAACTATCATGTGCAGACCAGCATCTATCCC
AATGCCGTCAATGTTCCGATTGCATGCGGCGGCGTCACGGTGATCCCCGGCGACATCATCGTTGCCGACGATGATGGCGT
CGTGGTGGTTCCCGTCGCAATGGCCGCAAAGGTCATCGAAGAAGCGAAGAAGCATCACGATTGGGAAGAGTTCTCGCGAG
AGAAGCTCCTCCAAGGCGCCCCATTGCAACGCTACTATCCGCTGCATGACGACGCGCGCGCAGAGTACGAGGCGTGGCGC
AAAGCAAACGGCTTGGGGAACCCAAATTAG

Upstream 100 bases:

>100_bases
CGATCCAGGCGCAGAGTTTCCGCTTCTGGGAAGCGCCCCACCTCAAGCGCCGCGACGGTTCTGTCACCAACTGGTAGTTC
AATTTCAACCGGAGTCCACC

Downstream 100 bases:

>100_bases
CGCGGGGATCACTCGCTGCGGGCGGCAGCCCTTCCGGCGGCGCGATGGCCTCTCGCCGCAGCGTCGCGCGATATTTTGAG
CCTGCCTCGCCCACGGGCGG

Product: hypothetical protein

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTHTSDIIRPPKDLIEGLREIGAATVAGTLGHMGFRNPHMVGPVAQNHGKSIVGPALTLQFLPQRPDLFNEGEYADPETQ
LHRHVLYHAQEGDVVVVDARGDMSSGVFGDMMSTYFKGRGGAGIVIDGCMRDRPNVEKLDLPLWLRGWTPNYHVQTSIYP
NAVNVPIACGGVTVIPGDIIVADDDGVVVVPVAMAAKVIEEAKKHHDWEEFSREKLLQGAPLQRYYPLHDDARAEYEAWR
KANGLGNPN

Sequences:

>Translated_249_residues
MTHTSDIIRPPKDLIEGLREIGAATVAGTLGHMGFRNPHMVGPVAQNHGKSIVGPALTLQFLPQRPDLFNEGEYADPETQ
LHRHVLYHAQEGDVVVVDARGDMSSGVFGDMMSTYFKGRGGAGIVIDGCMRDRPNVEKLDLPLWLRGWTPNYHVQTSIYP
NAVNVPIACGGVTVIPGDIIVADDDGVVVVPVAMAAKVIEEAKKHHDWEEFSREKLLQGAPLQRYYPLHDDARAEYEAWR
KANGLGNPN
>Mature_248_residues
THTSDIIRPPKDLIEGLREIGAATVAGTLGHMGFRNPHMVGPVAQNHGKSIVGPALTLQFLPQRPDLFNEGEYADPETQL
HRHVLYHAQEGDVVVVDARGDMSSGVFGDMMSTYFKGRGGAGIVIDGCMRDRPNVEKLDLPLWLRGWTPNYHVQTSIYPN
AVNVPIACGGVTVIPGDIIVADDDGVVVVPVAMAAKVIEEAKKHHDWEEFSREKLLQGAPLQRYYPLHDDARAEYEAWRK
ANGLGNPN

Specific function: Plays a role in protocatechuate degradation. Has a broad substrate specificity and catalyzes the aldol cleavage of 4- hydroxy-4-methyl-2-oxoglutarate, 4-hydroxy-2-oxoglutarate and 4- carboxy-4-hydroxy-2-oxoadipate, and the decarboxylation of oxaloacetate.

COG id: COG0684

COG function: function code H; Demethylmenaquinone methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014165
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6 [H]

EC number: =4.1.1.3; =4.1.3.16; =4.1.3.17 [H]

Molecular weight: Translated: 27333; Mature: 27202

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTSDIIRPPKDLIEGLREIGAATVAGTLGHMGFRNPHMVGPVAQNHGKSIVGPALTLQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCHHHEEE
FLPQRPDLFNEGEYADPETQLHRHVLYHAQEGDVVVVDARGDMSSGVFGDMMSTYFKGRG
ECCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
GAGIVIDGCMRDRPNVEKLDLPLWLRGWTPNYHVQTSIYPNAVNVPIACGGVTVIPGDII
CCEEEEECCCCCCCCCCEECCCEEEECCCCCEEEEEEECCCCCCCCEEECCEEEECCCEE
VADDDGVVVVPVAMAAKVIEEAKKHHDWEEFSREKLLQGAPLQRYYPLHDDARAEYEAWR
EECCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHH
KANGLGNPN
HHCCCCCCC
>Mature Secondary Structure 
THTSDIIRPPKDLIEGLREIGAATVAGTLGHMGFRNPHMVGPVAQNHGKSIVGPALTLQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCHHHEEE
FLPQRPDLFNEGEYADPETQLHRHVLYHAQEGDVVVVDARGDMSSGVFGDMMSTYFKGRG
ECCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
GAGIVIDGCMRDRPNVEKLDLPLWLRGWTPNYHVQTSIYPNAVNVPIACGGVTVIPGDII
CCEEEEECCCCCCCCCCEECCCEEEECCCCCEEEEEEECCCCCCCCEEECCEEEECCCEE
VADDDGVVVVPVAMAAKVIEEAKKHHDWEEFSREKLLQGAPLQRYYPLHDDARAEYEAWR
EECCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHH
KANGLGNPN
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11826967 [H]