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The map label for this gene is xdhB [H]

Identifier: 13472101

GI number: 13472101

Start: 1848760

End: 1849620

Strand: Reverse

Name: xdhB [H]

Synonym: mll2291

Alternate gene names: 13472101

Gene position: 1849620-1848760 (Counterclockwise)

Preceding gene: 13472106

Following gene: 13472100

Centisome position: 26.29

GC content: 67.94

Gene sequence:

>861_bases
ATGCGCTACATACGTCCGCTTTCAATCGAAGATGCCGTCGGCCAATTGGCCGGATCGGCTGGCACGGCCGCCATTCTGGC
CGGAGGCAGCGACCTGCTGGTGAGGATGAAGGGGGGCTTTGTCGAGCCCGACCTGATCGTCGACATCAAGTCGATCGCGG
GCCTGAGCGACATCCGCGAAACCGCCGACGGCTTCAGCATTGGTGCCGCCGTCCCCTGCGCCGTGCTGGGCGAGAACGCC
GCCTTGAAGAAGGCATGGCCCGGCGTCGTCGAGGCGGCCAAGCTGATCGGCTCCAAGCAGGTGCAGGGACGCTGCACCAT
CACCGGCAATCTGTGCAACGCCTCGCCGGCGGCGGACAGCGTGCCGGCGCTGGTGGCCGCGGGCGCCAAGGCAGTGATCG
CCGGACCCTCGGGCAAACGCACCATCGCCGTTGAGGCCGTGCCGACCGGGCCGGGCAAGACGTCGCTCGCCAAGGGCGAG
ATCATCGAGGCGATCCTGCTCGACAAGCGCTCGCCGCGCTCGGGCGATGCCTATCTGCGCTTCATTCCGCGCACCGAGAT
GGACATCGCCGTGGTCAGCGCCGGGGTGAACCTGACGATCGACGAGCATGGCGTCGTCACGGCGGCCCGCGTGGCGCTGG
GTGCTGCGGCGCCGACGGTGCTGCTGGTGGAAGAAGCCGCCGAGGCTCTGATCGGCAGGAAGCTCGACGAGGCAGCACTC
GAGCGGCTGGCAAAAGTCTGCGCGGGCGCCTGCCGCCCGATCGACGACAAGCGCGGTACCATCGAATTCAGACGCAAAGT
TGCGGGCGTGCTGGCCAGGAGAGCCGCCACGACCGCCTACGCACGTGCAGGAGGCAAATAA

Upstream 100 bases:

>100_bases
TGCGGCGGCTGGACCAATCGTCGCAAATGACGAACCCGATAGCCATTATGAGGAGAGTGTTTATAACGGTCGCTGAAATC
GCGATATCCAAGGGGAGACG

Downstream 100 bases:

>100_bases
TGGCTGGCATTGCAGTCTCGACGACAATCAACGGCGACAATATCGAGTATCTCTGCCAGCCTGACGAGACGCTGCTCGAC
GTGCTGCGCGACCGGCTCGG

Product: carbon-monoxide dehydrogenase medium chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MRYIRPLSIEDAVGQLAGSAGTAAILAGGSDLLVRMKGGFVEPDLIVDIKSIAGLSDIRETADGFSIGAAVPCAVLGENA
ALKKAWPGVVEAAKLIGSKQVQGRCTITGNLCNASPAADSVPALVAAGAKAVIAGPSGKRTIAVEAVPTGPGKTSLAKGE
IIEAILLDKRSPRSGDAYLRFIPRTEMDIAVVSAGVNLTIDEHGVVTAARVALGAAAPTVLLVEEAAEALIGRKLDEAAL
ERLAKVCAGACRPIDDKRGTIEFRRKVAGVLARRAATTAYARAGGK

Sequences:

>Translated_286_residues
MRYIRPLSIEDAVGQLAGSAGTAAILAGGSDLLVRMKGGFVEPDLIVDIKSIAGLSDIRETADGFSIGAAVPCAVLGENA
ALKKAWPGVVEAAKLIGSKQVQGRCTITGNLCNASPAADSVPALVAAGAKAVIAGPSGKRTIAVEAVPTGPGKTSLAKGE
IIEAILLDKRSPRSGDAYLRFIPRTEMDIAVVSAGVNLTIDEHGVVTAARVALGAAAPTVLLVEEAAEALIGRKLDEAAL
ERLAKVCAGACRPIDDKRGTIEFRRKVAGVLARRAATTAYARAGGK
>Mature_286_residues
MRYIRPLSIEDAVGQLAGSAGTAAILAGGSDLLVRMKGGFVEPDLIVDIKSIAGLSDIRETADGFSIGAAVPCAVLGENA
ALKKAWPGVVEAAKLIGSKQVQGRCTITGNLCNASPAADSVPALVAAGAKAVIAGPSGKRTIAVEAVPTGPGKTSLAKGE
IIEAILLDKRSPRSGDAYLRFIPRTEMDIAVVSAGVNLTIDEHGVVTAARVALGAAAPTVLLVEEAAEALIGRKLDEAAL
ERLAKVCAGACRPIDDKRGTIEFRRKVAGVLARRAATTAYARAGGK

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1319

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=260, Percent_Identity=26.5384615384615, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789231, Length=286, Percent_Identity=30.0699300699301, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540638, Length=253, Percent_Identity=24.1106719367589, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737937, Length=261, Percent_Identity=25.2873563218391, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 29138; Mature: 29138

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIRPLSIEDAVGQLAGSAGTAAILAGGSDLLVRMKGGFVEPDLIVDIKSIAGLSDIRE
CCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHHEEEHHHHCCHHHHHH
TADGFSIGAAVPCAVLGENAALKKAWPGVVEAAKLIGSKQVQGRCTITGNLCNASPAADS
HHCCCCCCCCCCHHHCCCCCHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
VPALVAAGAKAVIAGPSGKRTIAVEAVPTGPGKTSLAKGEIIEAILLDKRSPRSGDAYLR
CCHHHHCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEE
FIPRTEMDIAVVSAGVNLTIDEHGVVTAARVALGAAAPTVLLVEEAAEALIGRKLDEAAL
EECCCCCCEEEEECCCEEEECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHH
ERLAKVCAGACRPIDDKRGTIEFRRKVAGVLARRAATTAYARAGGK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRYIRPLSIEDAVGQLAGSAGTAAILAGGSDLLVRMKGGFVEPDLIVDIKSIAGLSDIRE
CCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHHEEEHHHHCCHHHHHH
TADGFSIGAAVPCAVLGENAALKKAWPGVVEAAKLIGSKQVQGRCTITGNLCNASPAADS
HHCCCCCCCCCCHHHCCCCCHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
VPALVAAGAKAVIAGPSGKRTIAVEAVPTGPGKTSLAKGEIIEAILLDKRSPRSGDAYLR
CCHHHHCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEE
FIPRTEMDIAVVSAGVNLTIDEHGVVTAARVALGAAAPTVLLVEEAAEALIGRKLDEAAL
EECCCCCCEEEEECCCEEEECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHH
ERLAKVCAGACRPIDDKRGTIEFRRKVAGVLARRAATTAYARAGGK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]