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The map label for this gene is hcrA [H]

Identifier: 13472099

GI number: 13472099

Start: 1846017

End: 1848281

Strand: Reverse

Name: hcrA [H]

Synonym: mll2287

Alternate gene names: 13472099

Gene position: 1848281-1846017 (Counterclockwise)

Preceding gene: 13472100

Following gene: 13472098

Centisome position: 26.27

GC content: 66.58

Gene sequence:

>2265_bases
ATGAATTTCGATCCGCGTTTTTCCGGGCGTAAATTCGCATCCGTCGGCACGCGCCCCATCCGCCCCGACGGCGTCGACAA
GGTGACGGGCCGCGCCCGCTACGGCGCCGACTTCAACATGGCCGGCCAGCTGGTCGGCCGCGTTCTGCGCAGCCCGCATG
CGCACGCCAAGATCCTCAAGATCGACACGTCGAAGGCGGAAAAGCTGAACGGCGTGAAGGCGGTGATCACGGCGAAAGAC
CTGCCCGACCTCACCGATGGCGATGCCGCCATGTACGACATCCTCGACAATTGCATGGCGCGCACCAAGGCGCTCTATGA
CGGCCATGCGGTGGCCGCGGTCGCCGCGGTCGATGCCCGTACGGCAAGGCAGGCGCTGAAGCTGATCGAGGTCGAGTACG
AGATCCTGCCGCATGTCACCGATGTCGACGAGGCGATGCAGCACCACGCGCCGCTGATCAACGACACGATCTTCACCGAG
GGGCTGGAGGAAAAGCCGGTAAAACCCTCCAACGTCACCAAGCGCAGCCAGTTCGGCCATGGCGACGTCCATCAGGGCTT
TGGGCACGCCGACTTCATCGTCGAGCGCTCCTTCAAGACCGAGCAGACGCACCAGGGCTATATCGAGCCGCATGCCTGCG
TGGCGAGCGTCTCGTCCGACGGCACCGCCGACCTCTGGGTCTGCACGCAGGGCCATTTCGTCTACCGCCAGCACTGCGCC
CAGCTGCTCGGCATGGAAGCCTCGAAGCTGCGCGTCACCTCGTCGGAGATCGGCGGCGGCTTCGGCGGCAAGACCCATGT
CTGGGCCGAGCCGGTGGCGCTTGCCTTGTCACGCAAGGCCGGGCGGCCGGTGAAGCTGGTGATGACCCGCGACGAGGTGT
TCCGCGCCTCAGGGCCAACCAGCGCCACCTCGATCGACGTCAAGATCGGCGCCCGCAAGGACGGCACCATCACTGCCGCC
GAAGCGACGCTGCGCTACAGCGCCGGCCCCTATGCCGGCTCCTGGGCCGAGATCGGCGCCATGACGGCCTTCGCCTGCTA
CAAGCTCGATAACGTCAAGACGGTCGGTTACGAAGTGCTGGTCAACCGGCCCAAGACCGCGGCCTATCGCGCGCCCTCCG
CACCGATGGCGGCCTTCGCGGTGGAAAGTGCGGTCGACGAGCTCGCCAAGGAGCTCGGCATGGACCCGGTCGACTTCCGC
ATCAAGAACGCCGCGCAGGAAGGAACACGCTCGTCCTACGGCCCGGTCTATGGCCCGATCGGCATCGGCCCGACGCTGGA
AGCGGTGAAGCACCATCCGCACATGAAGGCGCCGCTCAAAAAGAACCAGGGCAGGGGCATGGCCTGCGGCTTCTGGTTCA
ATTTCGGCGGCCAGACCTGCGTGGACCTCAACATCGGCATGGACGGCTCGGTCTCGCTCGCCGTCGGCACGGTGGACGTG
GGCGGTTCCCGCGCGTCGCTGTCGCTGGTGGCGGCGGAGGAGCTCGGTATCGACTATGCCCAGCTCAAGGCGGTGGTCGC
CGACACCTCTTCGCTCGGTTATAACGACATGACCGACGGCAGCCGCGGCACCTTCTCCTCCTCCATGGCGACCATCTCGG
CCGCCCGCAACGCGATAAAAATCCTGCGCGAGCGCGCCGCGCAGATGTGGGACATTTCCGTCGACGACGTGGTCTGGGAA
CTGGGCCATGCGGTCGCCAAGGGCGAGAAGCACGGCAATCTCGGCAAACTGTCGCTGAAGGAGATCGCGGCCCAGTCCGG
CAAGACCGGCGGGCCGATCGCCGGCCACAGCGAGCTCGTCGCCGACGGCGCCGGCGTCTCCTTCGCCACCCACATATGCG
ACATCGAGGTCGACCCCGAGACCGGCTCGACCCGGGTGATCCGCTACACGGTGGTGCAGGATGCCGGCAAGGCGGTGCAC
CCGACCTATGTCGAGGGCCAGTACCAGGGCGGTGCGGCGCAAGGCATCGGCTGGGCGCTCAACGAGGAGTATATTTACGG
CAAGGACGGAAGGCTGCAGAACGCCGGCTTCCTCGACTACCGCATCCCGGTGTGCTCCGACCTGCCGATGATCGACACGC
AGATCCTGGAAATCCCCAACCCCAACCACCCCTATGGCGTGCGCGGCGTCGGCGAAACCTCGATCGTGCCGCCGCTGGCG
GCGATCGCCAACGCGGTGTCGAACGCGGCCGGCGTGCGCATGACCCACATCCCGATGTCGCCGCCACGCATCCTGGCGGC
CATCGAAGCGGAACGGGGAGAGTAG

Upstream 100 bases:

>100_bases
TCCGCTTCGGCCTCGCCGGCAATCTCTGCCGCTGCACCGGCTATGACAAGATCGTGCGCGCCGTCCAGGACGCCGCAATT
GTGATGAAGGGAGCCTGAAG

Downstream 100 bases:

>100_bases
ATCTGGTCGAAGTCACCCTCTGGGGCGCGCTCGGCCAGCTCGCCGGCGGCAAGAGCAAGGTCGAGGTCGAGGCCAAGGAC
ATCAGGGAACTGTTCAGGAA

Product: 4-hydroxybenzoyl-CoA reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MNFDPRFSGRKFASVGTRPIRPDGVDKVTGRARYGADFNMAGQLVGRVLRSPHAHAKILKIDTSKAEKLNGVKAVITAKD
LPDLTDGDAAMYDILDNCMARTKALYDGHAVAAVAAVDARTARQALKLIEVEYEILPHVTDVDEAMQHHAPLINDTIFTE
GLEEKPVKPSNVTKRSQFGHGDVHQGFGHADFIVERSFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
QLLGMEASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPTSATSIDVKIGARKDGTITAA
EATLRYSAGPYAGSWAEIGAMTAFACYKLDNVKTVGYEVLVNRPKTAAYRAPSAPMAAFAVESAVDELAKELGMDPVDFR
IKNAAQEGTRSSYGPVYGPIGIGPTLEAVKHHPHMKAPLKKNQGRGMACGFWFNFGGQTCVDLNIGMDGSVSLAVGTVDV
GGSRASLSLVAAEELGIDYAQLKAVVADTSSLGYNDMTDGSRGTFSSSMATISAARNAIKILRERAAQMWDISVDDVVWE
LGHAVAKGEKHGNLGKLSLKEIAAQSGKTGGPIAGHSELVADGAGVSFATHICDIEVDPETGSTRVIRYTVVQDAGKAVH
PTYVEGQYQGGAAQGIGWALNEEYIYGKDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
AIANAVSNAAGVRMTHIPMSPPRILAAIEAERGE

Sequences:

>Translated_754_residues
MNFDPRFSGRKFASVGTRPIRPDGVDKVTGRARYGADFNMAGQLVGRVLRSPHAHAKILKIDTSKAEKLNGVKAVITAKD
LPDLTDGDAAMYDILDNCMARTKALYDGHAVAAVAAVDARTARQALKLIEVEYEILPHVTDVDEAMQHHAPLINDTIFTE
GLEEKPVKPSNVTKRSQFGHGDVHQGFGHADFIVERSFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
QLLGMEASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPTSATSIDVKIGARKDGTITAA
EATLRYSAGPYAGSWAEIGAMTAFACYKLDNVKTVGYEVLVNRPKTAAYRAPSAPMAAFAVESAVDELAKELGMDPVDFR
IKNAAQEGTRSSYGPVYGPIGIGPTLEAVKHHPHMKAPLKKNQGRGMACGFWFNFGGQTCVDLNIGMDGSVSLAVGTVDV
GGSRASLSLVAAEELGIDYAQLKAVVADTSSLGYNDMTDGSRGTFSSSMATISAARNAIKILRERAAQMWDISVDDVVWE
LGHAVAKGEKHGNLGKLSLKEIAAQSGKTGGPIAGHSELVADGAGVSFATHICDIEVDPETGSTRVIRYTVVQDAGKAVH
PTYVEGQYQGGAAQGIGWALNEEYIYGKDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
AIANAVSNAAGVRMTHIPMSPPRILAAIEAERGE
>Mature_754_residues
MNFDPRFSGRKFASVGTRPIRPDGVDKVTGRARYGADFNMAGQLVGRVLRSPHAHAKILKIDTSKAEKLNGVKAVITAKD
LPDLTDGDAAMYDILDNCMARTKALYDGHAVAAVAAVDARTARQALKLIEVEYEILPHVTDVDEAMQHHAPLINDTIFTE
GLEEKPVKPSNVTKRSQFGHGDVHQGFGHADFIVERSFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
QLLGMEASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPTSATSIDVKIGARKDGTITAA
EATLRYSAGPYAGSWAEIGAMTAFACYKLDNVKTVGYEVLVNRPKTAAYRAPSAPMAAFAVESAVDELAKELGMDPVDFR
IKNAAQEGTRSSYGPVYGPIGIGPTLEAVKHHPHMKAPLKKNQGRGMACGFWFNFGGQTCVDLNIGMDGSVSLAVGTVDV
GGSRASLSLVAAEELGIDYAQLKAVVADTSSLGYNDMTDGSRGTFSSSMATISAARNAIKILRERAAQMWDISVDDVVWE
LGHAVAKGEKHGNLGKLSLKEIAAQSGKTGGPIAGHSELVADGAGVSFATHICDIEVDPETGSTRVIRYTVVQDAGKAVH
PTYVEGQYQGGAAQGIGWALNEEYIYGKDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
AIANAVSNAAGVRMTHIPMSPPRILAAIEAERGE

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To xanthine oxidases [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=748, Percent_Identity=26.4705882352941, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI71773480, Length=768, Percent_Identity=25.5208333333333, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1789230, Length=765, Percent_Identity=30.4575163398693, Blast_Score=298, Evalue=8e-82,
Organism=Escherichia coli, GI1789246, Length=796, Percent_Identity=29.5226130653266, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI1786478, Length=739, Percent_Identity=27.4695534506089, Blast_Score=158, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17540638, Length=782, Percent_Identity=24.0409207161125, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539860, Length=780, Percent_Identity=23.0769230769231, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32566215, Length=594, Percent_Identity=23.5690235690236, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737937, Length=737, Percent_Identity=26.3229308005427, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24647193, Length=770, Percent_Identity=25.1948051948052, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647199, Length=700, Percent_Identity=23.4285714285714, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647201, Length=703, Percent_Identity=23.0440967283073, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017607
- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 80347; Mature: 80347

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDPRFSGRKFASVGTRPIRPDGVDKVTGRARYGADFNMAGQLVGRVLRSPHAHAKILK
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEEE
IDTSKAEKLNGVKAVITAKDLPDLTDGDAAMYDILDNCMARTKALYDGHAVAAVAAVDAR
EECCHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHH
TARQALKLIEVEYEILPHVTDVDEAMQHHAPLINDTIFTEGLEEKPVKPSNVTKRSQFGH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHCCCCC
GDVHQGFGHADFIVERSFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
CCHHCCCCCHHEEEECCCCCCCCCCCCCCCCHHEEECCCCCCEEEEEEECCCHHHHHHHH
QLLGMEASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPT
HHHCCCHHHEEEEHHHCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCC
SATSIDVKIGARKDGTITAAEATLRYSAGPYAGSWAEIGAMTAFACYKLDNVKTVGYEVL
CCEEEEEEECCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCEEECEEEE
VNRPKTAAYRAPSAPMAAFAVESAVDELAKELGMDPVDFRIKNAAQEGTRSSYGPVYGPI
ECCCCHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEECC
GIGPTLEAVKHHPHMKAPLKKNQGRGMACGFWFNFGGQTCVDLNIGMDGSVSLAVGTVDV
CCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCEEEEEEEEEC
GGSRASLSLVAAEELGIDYAQLKAVVADTSSLGYNDMTDGSRGTFSSSMATISAARNAIK
CCCCCEEEEEEHHHHCCCHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ILRERAAQMWDISVDDVVWELGHAVAKGEKHGNLGKLSLKEIAAQSGKTGGPIAGHSELV
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHE
ADGAGVSFATHICDIEVDPETGSTRVIRYTVVQDAGKAVHPTYVEGQYQGGAAQGIGWAL
ECCCCCEEEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEECCEECCCCCCCCCEEE
NEEYIYGKDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
CCCEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHH
AIANAVSNAAGVRMTHIPMSPPRILAAIEAERGE
HHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MNFDPRFSGRKFASVGTRPIRPDGVDKVTGRARYGADFNMAGQLVGRVLRSPHAHAKILK
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEEE
IDTSKAEKLNGVKAVITAKDLPDLTDGDAAMYDILDNCMARTKALYDGHAVAAVAAVDAR
EECCHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHH
TARQALKLIEVEYEILPHVTDVDEAMQHHAPLINDTIFTEGLEEKPVKPSNVTKRSQFGH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHCCCCC
GDVHQGFGHADFIVERSFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
CCHHCCCCCHHEEEECCCCCCCCCCCCCCCCHHEEECCCCCCEEEEEEECCCHHHHHHHH
QLLGMEASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPT
HHHCCCHHHEEEEHHHCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCC
SATSIDVKIGARKDGTITAAEATLRYSAGPYAGSWAEIGAMTAFACYKLDNVKTVGYEVL
CCEEEEEEECCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCEEECEEEE
VNRPKTAAYRAPSAPMAAFAVESAVDELAKELGMDPVDFRIKNAAQEGTRSSYGPVYGPI
ECCCCHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEECC
GIGPTLEAVKHHPHMKAPLKKNQGRGMACGFWFNFGGQTCVDLNIGMDGSVSLAVGTVDV
CCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCEEEEEEEEEC
GGSRASLSLVAAEELGIDYAQLKAVVADTSSLGYNDMTDGSRGTFSSSMATISAARNAIK
CCCCCEEEEEEHHHHCCCHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ILRERAAQMWDISVDDVVWELGHAVAKGEKHGNLGKLSLKEIAAQSGKTGGPIAGHSELV
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHE
ADGAGVSFATHICDIEVDPETGSTRVIRYTVVQDAGKAVHPTYVEGQYQGGAAQGIGWAL
ECCCCCEEEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEECCEECCCCCCCCCEEE
NEEYIYGKDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
CCCEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHH
AIANAVSNAAGVRMTHIPMSPPRILAAIEAERGE
HHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]