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The map label for this gene is hutH [H]

Identifier: 13471681

GI number: 13471681

Start: 1445234

End: 1446742

Strand: Direct

Name: hutH [H]

Synonym: mlr1730

Alternate gene names: 13471681

Gene position: 1445234-1446742 (Clockwise)

Preceding gene: 13471680

Following gene: 13471696

Centisome position: 20.54

GC content: 67.99

Gene sequence:

>1509_bases
ATGAGCGCGCTCATCCTCACCGGAGCCGGCGTCGGTGTCGGCGATGTCGCCACCGTCGCCCGCCAGGGGCGCAAGGTGGA
GATCGGACCCGAAATCATCGGCAGGCTCGACAAGGCGCGAAAAGTGCTCGACCAGGCCGCCGCCTCCGGCCAGCAGATCT
ACGGCCTGAACACCGGGCTCGGCGCCAATCTCGGCACAACAGTCGACGGCGATGCCAGCGCCTTCCAGCGCCAGTTGCTG
GAAGGCCGCAGCGGCGCGGTCGGCGAAACTCTGCCGATCGAGACCGTGCGCGCCACCATGGTCGCCCGCGCCTCGATGCT
GTCGGCCGGCGGCTCCGGCCTTTCGCCCACCGTGTTCGTTGCGCTGGTCGATGCGCTCAATGCCGGTGTCCATCCGGTGA
TGCCGTCGCTCGGCTCGATCGGCGCCGGCGACCTCGTGCTGATGACCGCGCTTGCCCGCCTGCTGATCGGCGAAGGCGAA
GCCGATTACCAAGGCCGCCGCATGCCGGCGGCCAAGGCGCTGATGATGGCCCGCCTCGCGCCGATCAGCCTGGCGCCGAA
AGACGGGCTGTCGCTGATCAACGCCTCGGCGGTCTCCGCCGGCAGCGGCGCCCTCGCGATCACGGATGCGCTGGCGGCGC
TGGCCCAGCAGCAGCAGGCCGGCGCGCTGACCATGGAAGGTTTTGGTGCCAACCGCACCATCCTCGATCCACGCCTGCAG
ATGGCGCGGCCGGCTGCCGGACAGCAGGAGGCGGCGAAGGCCTTGCATGACCTTCTCGCCCGCGACGAGATGCCGGCGCC
CACGACGATTCAGGATCCCCTGTCGATCCGCTGTATGCCGTCGATCCACGGCGCGCTGATCGAGGCTATCGGCCAGGCAA
AACGCGCCGTCGAGATCGAACTCAACGCCGCCGCCGACAACCCGCTGGTGATCGGCGACGACGAACTGGTGCTGTCGACC
GGCAATTTCCACACGGCCTCACTCTCGCTTGCTTTCGAGACGCTCGGCCTGGCCATCGCGCAATGCGCCGCCGCGAGCGT
CGCGCGCTTCATCCAGCTCACCGGCTCGGGCCGCAACGGCCTGACCAAATATCTGTCGCCGATCGGCGGCGCCTCGGCCG
GTTTCGTGCCGTTGCAGAAGACGGCGACGTCGATCCTGGCTGCCATCCGCCACAAGGCCAATCCGGTGATGCTCGACTTC
CTGCCCGTTTCGGAAGGCGTCGAGGACCATGCGACCCAGTCGCCCCTCGCCGTTTCGAAATGCGCCGGAATGATCGCGCT
GTGGCGGCGGCTGATCGCCTTCGAATTGATGGCTGCCGCCCAGGCCGTCGATTTGCGTGAAGGATTGACGCTGGCGCCGC
GCACCGGCGCGATCTATGCGGCGGTACGCGCGCATGTGTCGATGCTGAAAGACGACCGGCCGCTTGGGAACGACGCCGAG
GTGCTCCACGCCATGCTCGCCGATGGAGCGTGGCGAGGCGCAGCGATGATCAGCAAAGAATCCGAATAA

Upstream 100 bases:

>100_bases
TGTTCTGGCATCGCGGCCTGTCGCTCTCCGACATTGCGCTGGGCAAGGCGATGCTGGCCAAGGCAGGGGAAAAAGGCATC
GGCCAGAGGCTGCGTTTCGC

Downstream 100 bases:

>100_bases
TCAGCTCTTTGCGTCTACCCTTTTCATGAACAGGCTGAGCTCGGCCGGGTCCATGTGCACGACGTGCCTGTCCTCGGGAT
AGGCGCCGCTGTTGACGTCG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSALILTGAGVGVGDVATVARQGRKVEIGPEIIGRLDKARKVLDQAAASGQQIYGLNTGLGANLGTTVDGDASAFQRQLL
EGRSGAVGETLPIETVRATMVARASMLSAGGSGLSPTVFVALVDALNAGVHPVMPSLGSIGAGDLVLMTALARLLIGEGE
ADYQGRRMPAAKALMMARLAPISLAPKDGLSLINASAVSAGSGALAITDALAALAQQQQAGALTMEGFGANRTILDPRLQ
MARPAAGQQEAAKALHDLLARDEMPAPTTIQDPLSIRCMPSIHGALIEAIGQAKRAVEIELNAAADNPLVIGDDELVLST
GNFHTASLSLAFETLGLAIAQCAAASVARFIQLTGSGRNGLTKYLSPIGGASAGFVPLQKTATSILAAIRHKANPVMLDF
LPVSEGVEDHATQSPLAVSKCAGMIALWRRLIAFELMAAAQAVDLREGLTLAPRTGAIYAAVRAHVSMLKDDRPLGNDAE
VLHAMLADGAWRGAAMISKESE

Sequences:

>Translated_502_residues
MSALILTGAGVGVGDVATVARQGRKVEIGPEIIGRLDKARKVLDQAAASGQQIYGLNTGLGANLGTTVDGDASAFQRQLL
EGRSGAVGETLPIETVRATMVARASMLSAGGSGLSPTVFVALVDALNAGVHPVMPSLGSIGAGDLVLMTALARLLIGEGE
ADYQGRRMPAAKALMMARLAPISLAPKDGLSLINASAVSAGSGALAITDALAALAQQQQAGALTMEGFGANRTILDPRLQ
MARPAAGQQEAAKALHDLLARDEMPAPTTIQDPLSIRCMPSIHGALIEAIGQAKRAVEIELNAAADNPLVIGDDELVLST
GNFHTASLSLAFETLGLAIAQCAAASVARFIQLTGSGRNGLTKYLSPIGGASAGFVPLQKTATSILAAIRHKANPVMLDF
LPVSEGVEDHATQSPLAVSKCAGMIALWRRLIAFELMAAAQAVDLREGLTLAPRTGAIYAAVRAHVSMLKDDRPLGNDAE
VLHAMLADGAWRGAAMISKESE
>Mature_501_residues
SALILTGAGVGVGDVATVARQGRKVEIGPEIIGRLDKARKVLDQAAASGQQIYGLNTGLGANLGTTVDGDASAFQRQLLE
GRSGAVGETLPIETVRATMVARASMLSAGGSGLSPTVFVALVDALNAGVHPVMPSLGSIGAGDLVLMTALARLLIGEGEA
DYQGRRMPAAKALMMARLAPISLAPKDGLSLINASAVSAGSGALAITDALAALAQQQQAGALTMEGFGANRTILDPRLQM
ARPAAGQQEAAKALHDLLARDEMPAPTTIQDPLSIRCMPSIHGALIEAIGQAKRAVEIELNAAADNPLVIGDDELVLSTG
NFHTASLSLAFETLGLAIAQCAAASVARFIQLTGSGRNGLTKYLSPIGGASAGFVPLQKTATSILAAIRHKANPVMLDFL
PVSEGVEDHATQSPLAVSKCAGMIALWRRLIAFELMAAAQAVDLREGLTLAPRTGAIYAAVRAHVSMLKDDRPLGNDAEV
LHAMLADGAWRGAAMISKESE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=502, Percent_Identity=29.2828685258964, Blast_Score=206, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17567831, Length=501, Percent_Identity=28.9421157684631, Blast_Score=192, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 51553; Mature: 51422

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALILTGAGVGVGDVATVARQGRKVEIGPEIIGRLDKARKVLDQAAASGQQIYGLNTGL
CCEEEEECCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GANLGTTVDGDASAFQRQLLEGRSGAVGETLPIETVRATMVARASMLSAGGSGLSPTVFV
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ALVDALNAGVHPVMPSLGSIGAGDLVLMTALARLLIGEGEADYQGRRMPAAKALMMARLA
HHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
PISLAPKDGLSLINASAVSAGSGALAITDALAALAQQQQAGALTMEGFGANRTILDPRLQ
CCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCEECCHHH
MARPAAGQQEAAKALHDLLARDEMPAPTTIQDPLSIRCMPSIHGALIEAIGQAKRAVEIE
HCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCEEEEE
LNAAADNPLVIGDDELVLSTGNFHTASLSLAFETLGLAIAQCAAASVARFIQLTGSGRNG
EECCCCCCEEECCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LTKYLSPIGGASAGFVPLQKTATSILAAIRHKANPVMLDFLPVSEGVEDHATQSPLAVSK
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCHHHHH
CAGMIALWRRLIAFELMAAAQAVDLREGLTLAPRTGAIYAAVRAHVSMLKDDRPLGNDAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCHHH
VLHAMLADGAWRGAAMISKESE
HHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SALILTGAGVGVGDVATVARQGRKVEIGPEIIGRLDKARKVLDQAAASGQQIYGLNTGL
CEEEEECCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GANLGTTVDGDASAFQRQLLEGRSGAVGETLPIETVRATMVARASMLSAGGSGLSPTVFV
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ALVDALNAGVHPVMPSLGSIGAGDLVLMTALARLLIGEGEADYQGRRMPAAKALMMARLA
HHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
PISLAPKDGLSLINASAVSAGSGALAITDALAALAQQQQAGALTMEGFGANRTILDPRLQ
CCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCEECCHHH
MARPAAGQQEAAKALHDLLARDEMPAPTTIQDPLSIRCMPSIHGALIEAIGQAKRAVEIE
HCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCEEEEE
LNAAADNPLVIGDDELVLSTGNFHTASLSLAFETLGLAIAQCAAASVARFIQLTGSGRNG
EECCCCCCEEECCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LTKYLSPIGGASAGFVPLQKTATSILAAIRHKANPVMLDFLPVSEGVEDHATQSPLAVSK
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCHHHHH
CAGMIALWRRLIAFELMAAAQAVDLREGLTLAPRTGAIYAAVRAHVSMLKDDRPLGNDAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCHHH
VLHAMLADGAWRGAAMISKESE
HHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA