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The map label for this gene is ubiE [H]

Identifier: 13471618

GI number: 13471618

Start: 1363847

End: 1364689

Strand: Reverse

Name: ubiE [H]

Synonym: mll1644

Alternate gene names: 13471618

Gene position: 1364689-1363847 (Counterclockwise)

Preceding gene: 13471619

Following gene: 13471617

Centisome position: 19.4

GC content: 65.48

Gene sequence:

>843_bases
ATGGCCACGGTGGAACCGGGCATCGCCCGTCACTACGACATAGCGGGTCTCGAGCAGCGCATCCTTGCCGCGCTCGCCGA
TACGGGCGTGGACGTTGCCCATCTGCGTGCCGACGATCTCGAAGCGGTCGACGAATTCCACATTGGCGGTGTCGCCGCCA
CAAGGGAACTCATCGGGCAGATGGGGCTGAAACCAGGAGCCATGCTGCTCGATATTGGTTCCGGTGTGGGCGGTCCCGCC
CGTTTTGCCGCCAACGAAGCCGGCGCCGATGTCACCGGCATCGATCTCACGCAAAGCTATGTCGATATCGCGACCAGCCT
GTCGAAGCGCGCGGGCATGGCCGACAGGACGCACTTCGTGCAAGGCAGCGCGCTGGACATGCCGTTCGCCGATGCCGGCT
TCGACGCGGCCATGATCCTGCATGTCGGCATGAACCTTCCCGACAAGAAAAAGCTGATGGGCGAGGCCGCGCGTGTGCTC
AAGCCGGGCGGCGTCTTCGCCGTCTACGACGTGATGCGGCTCAAGGACGGCGCGCTGACCTATCCGCTGCCATGGGCTTC
GGACGAGAGCATGTCCTTCGTTGCCACGCCCGACGACTATCGCTCGGCTGCCACGGCTTCCGGCTTCTCCGTCGTCGCCG
AGCGGCGGCGCGGTGCTTTCGCCATCGAATTCTTCGCCGCGATGCGTGCCCGGATGGCCGCCGCGCAAGCGGAGGGCAAG
AAGCCGCCGCCCGGCGTCGGCCTCGTCATGGGCGAGGATGCCCGCAGCAAGATCGCCAATATCACCGCCGCGCTTGAAGG
CGGTATTCTCGCACCCGTTGAACTGCTTCTTCGTCTCGGCTGA

Upstream 100 bases:

>100_bases
ACTGCATCTTTGGCGGTGACGACCTGACCGTCTCGGCCGTGGCGCAAGGGCGCGATGCGGCGGAAAGCATACACAGGAGT
CTGACGCAGGGATAAGGATC

Downstream 100 bases:

>100_bases
AAGGGACCTGTCATGGCAGACCTCCGCAACAATTTCGTCGGCATCAAATCGCCAAATCCGTTCTGGCTGGCTTCGGCGCC
GCCGACCGACAAAGCCTACA

Product: sterol methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MATVEPGIARHYDIAGLEQRILAALADTGVDVAHLRADDLEAVDEFHIGGVAATRELIGQMGLKPGAMLLDIGSGVGGPA
RFAANEAGADVTGIDLTQSYVDIATSLSKRAGMADRTHFVQGSALDMPFADAGFDAAMILHVGMNLPDKKKLMGEAARVL
KPGGVFAVYDVMRLKDGALTYPLPWASDESMSFVATPDDYRSAATASGFSVVAERRRGAFAIEFFAAMRARMAAAQAEGK
KPPPGVGLVMGEDARSKIANITAALEGGILAPVELLLRLG

Sequences:

>Translated_280_residues
MATVEPGIARHYDIAGLEQRILAALADTGVDVAHLRADDLEAVDEFHIGGVAATRELIGQMGLKPGAMLLDIGSGVGGPA
RFAANEAGADVTGIDLTQSYVDIATSLSKRAGMADRTHFVQGSALDMPFADAGFDAAMILHVGMNLPDKKKLMGEAARVL
KPGGVFAVYDVMRLKDGALTYPLPWASDESMSFVATPDDYRSAATASGFSVVAERRRGAFAIEFFAAMRARMAAAQAEGK
KPPPGVGLVMGEDARSKIANITAALEGGILAPVELLLRLG
>Mature_279_residues
ATVEPGIARHYDIAGLEQRILAALADTGVDVAHLRADDLEAVDEFHIGGVAATRELIGQMGLKPGAMLLDIGSGVGGPAR
FAANEAGADVTGIDLTQSYVDIATSLSKRAGMADRTHFVQGSALDMPFADAGFDAAMILHVGMNLPDKKKLMGEAARVLK
PGGVFAVYDVMRLKDGALTYPLPWASDESMSFVATPDDYRSAATASGFSVVAERRRGAFAIEFFAAMRARMAAAQAEGKK
PPPGVGLVMGEDARSKIANITAALEGGILAPVELLLRLG

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25143945, Length=117, Percent_Identity=35.042735042735, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323635, Length=109, Percent_Identity=34.8623853211009, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29242; Mature: 29111

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVEPGIARHYDIAGLEQRILAALADTGVDVAHLRADDLEAVDEFHIGGVAATRELIGQ
CCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHH
MGLKPGAMLLDIGSGVGGPARFAANEAGADVTGIDLTQSYVDIATSLSKRAGMADRTHFV
HCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEE
QGSALDMPFADAGFDAAMILHVGMNLPDKKKLMGEAARVLKPGGVFAVYDVMRLKDGALT
CCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCEE
YPLPWASDESMSFVATPDDYRSAATASGFSVVAERRRGAFAIEFFAAMRARMAAAQAEGK
CCCCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
KPPPGVGLVMGEDARSKIANITAALEGGILAPVELLLRLG
CCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
ATVEPGIARHYDIAGLEQRILAALADTGVDVAHLRADDLEAVDEFHIGGVAATRELIGQ
CCCCCCCHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHH
MGLKPGAMLLDIGSGVGGPARFAANEAGADVTGIDLTQSYVDIATSLSKRAGMADRTHFV
HCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEE
QGSALDMPFADAGFDAAMILHVGMNLPDKKKLMGEAARVLKPGGVFAVYDVMRLKDGALT
CCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCEE
YPLPWASDESMSFVATPDDYRSAATASGFSVVAERRRGAFAIEFFAAMRARMAAAQAEGK
CCCCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
KPPPGVGLVMGEDARSKIANITAALEGGILAPVELLLRLG
CCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]