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The map label for this gene is yeiA [H]

Identifier: 13471617

GI number: 13471617

Start: 1362521

End: 1363834

Strand: Reverse

Name: yeiA [H]

Synonym: mll1643

Alternate gene names: 13471617

Gene position: 1363834-1362521 (Counterclockwise)

Preceding gene: 13471618

Following gene: 13471616

Centisome position: 19.38

GC content: 63.93

Gene sequence:

>1314_bases
ATGGCAGACCTCCGCAACAATTTCGTCGGCATCAAATCGCCAAATCCGTTCTGGCTGGCTTCGGCGCCGCCGACCGACAA
AGCCTACAATGTCATCCGCGCCTTCAAGGCAGGCTGGGGTGGCGTGGTGTGGAAGACGCTGGGCGAGGAAGGCCCGCCGG
TCGTCAACGTCAACGGCCCGCGCTATGGCGCGATCTGGGGCGCCGACCGGCGCCTGCTTGGCCTCAACAACATCGAGCTG
ATCACCGACCGCGACCTGCAGACCAATCTGCGCGAGATGAAGCAGGTCAAGATGGACTGGCCCGACCGCGCGCTGATCGC
CTCGATCATGGTGCCTTGCGAAGAGGCAAGCTGGAAAGCCATCCTGCCGCTGGTCGAGGAGACCGGCGCCGACGGCATCG
AGCTCAATTTCGGCTGCCCGCATGGCATGTCGGAACGCGGCATGGGGGCGGCCGTCGGCCAGGTGCCGGAATATATCGAA
ATGGTGGTGCGCTGGTGCAAGCAGTATACGCGCATGCCCGTCATCACCAAGCTGACGCCCAACATCACCGACATCCGCAA
GCCCGCGCGTGCCGCGCATGCCGGCGGCACCGACGCGGTGTCGCTGATCAACACCATCAATTCGATCACTGGTGTCGACC
TCGACAGTTTCGCGCCGATGCCGACCATCGATGGCAAGGGCTCGCATGGCGGCTATTGCGGCCCGGCGGTGAAGCCGATC
GCCATGAACATGGTGGCTGAAATCGCGCGCGATCCAGAGACACGCGGCCTGCCGATCTCGGGCATTGGCGGCATCACCAC
CTGGCGCGACGCCGCCGAATTCCTGGCGCTCGGCGCCGGCAATGTGCAGGTCTGCACGGCGGCGATGACCTACGGCTTCA
AGATCGTGCAGGAGATGATCGCGGGTCTCGAAAACTGGATGGACGAGAAGGGCCACCGCTCGCTCGACGACATTATCGGC
CGCGCCACGCCCAACGTCACCGACTGGCAGTATCTCAACCTCAACTATGTCGCCAAGGCGCATATCGACCAGGACGCTTG
CATCAAATGCGGCCGCTGCCACATCGCCTGCGAGGACACTTCGCACCAGGCGATCACCAGCATGGTCGATGGCGTGAGGC
ATTTCGAGGTGATCGAGGCCGAATGCGTCGGCTGCAATCTGTGCGTCAATGTCTGCCCGGTCGAGAACTGCATCACCATG
GAGCCGCTGGCCGCCGGCGTCATGGACCAGCGCACCGGCAAGCCGGTGTCGCCGATCTACGCCAACTGGACGACGCATCC
GAACAACCCGATGGCCAAGGTGGCCGCGGAGTAG

Upstream 100 bases:

>100_bases
GGATGCCCGCAGCAAGATCGCCAATATCACCGCCGCGCTTGAAGGCGGTATTCTCGCACCCGTTGAACTGCTTCTTCGTC
TCGGCTGAAAGGGACCTGTC

Downstream 100 bases:

>100_bases
GGGCGGCATTCAACAAAAAAGCGGCGCCTTCGGGCGCCGTTTTTCATTTTCCTATTGCAGATGAAAAGTATCCACGATAA
AAGATATCCATGAAATGGAG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVIRAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGLNNIEL
ITDRDLQTNLREMKQVKMDWPDRALIASIMVPCEEASWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYIE
MVVRWCKQYTRMPVITKLTPNITDIRKPARAAHAGGTDAVSLINTINSITGVDLDSFAPMPTIDGKGSHGGYCGPAVKPI
AMNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGNVQVCTAAMTYGFKIVQEMIAGLENWMDEKGHRSLDDIIG
RATPNVTDWQYLNLNYVAKAHIDQDACIKCGRCHIACEDTSHQAITSMVDGVRHFEVIEAECVGCNLCVNVCPVENCITM
EPLAAGVMDQRTGKPVSPIYANWTTHPNNPMAKVAAE

Sequences:

>Translated_437_residues
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVIRAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGLNNIEL
ITDRDLQTNLREMKQVKMDWPDRALIASIMVPCEEASWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYIE
MVVRWCKQYTRMPVITKLTPNITDIRKPARAAHAGGTDAVSLINTINSITGVDLDSFAPMPTIDGKGSHGGYCGPAVKPI
AMNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGNVQVCTAAMTYGFKIVQEMIAGLENWMDEKGHRSLDDIIG
RATPNVTDWQYLNLNYVAKAHIDQDACIKCGRCHIACEDTSHQAITSMVDGVRHFEVIEAECVGCNLCVNVCPVENCITM
EPLAAGVMDQRTGKPVSPIYANWTTHPNNPMAKVAAE
>Mature_436_residues
ADLRNNFVGIKSPNPFWLASAPPTDKAYNVIRAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGLNNIELI
TDRDLQTNLREMKQVKMDWPDRALIASIMVPCEEASWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYIEM
VVRWCKQYTRMPVITKLTPNITDIRKPARAAHAGGTDAVSLINTINSITGVDLDSFAPMPTIDGKGSHGGYCGPAVKPIA
MNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGNVQVCTAAMTYGFKIVQEMIAGLENWMDEKGHRSLDDIIGR
ATPNVTDWQYLNLNYVAKAHIDQDACIKCGRCHIACEDTSHQAITSMVDGVRHFEVIEAECVGCNLCVNVCPVENCITME
PLAAGVMDQRTGKPVSPIYANWTTHPNNPMAKVAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=334, Percent_Identity=36.5269461077844, Blast_Score=212, Evalue=6e-55,
Organism=Escherichia coli, GI87082059, Length=398, Percent_Identity=42.713567839196, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI71984108, Length=332, Percent_Identity=38.2530120481928, Blast_Score=218, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6322633, Length=327, Percent_Identity=26.9113149847095, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640763, Length=320, Percent_Identity=38.125, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI18858217, Length=320, Percent_Identity=38.125, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47445; Mature: 47314

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVIRAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGLNNIELITDRDLQTNLREMKQVKMDWPDRALIASIMVPCEEASWKA
CEEEEECCCCEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHH
ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVVRWCKQYTRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NITDIRKPARAAHAGGTDAVSLINTINSITGVDLDSFAPMPTIDGKGSHGGYCGPAVKPI
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHH
AMNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGNVQVCTAAMTYGFKIVQEMI
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AGLENWMDEKGHRSLDDIIGRATPNVTDWQYLNLNYVAKAHIDQDACIKCGRCHIACEDT
HHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCHHHHHCCCCEEEEECCC
SHQAITSMVDGVRHFEVIEAECVGCNLCVNVCPVENCITMEPLAAGVMDQRTGKPVSPIY
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCCCEE
ANWTTHPNNPMAKVAAE
ECCCCCCCCCHHHCCCC
>Mature Secondary Structure 
ADLRNNFVGIKSPNPFWLASAPPTDKAYNVIRAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGLNNIELITDRDLQTNLREMKQVKMDWPDRALIASIMVPCEEASWKA
CEEEEECCCCEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHH
ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVVRWCKQYTRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NITDIRKPARAAHAGGTDAVSLINTINSITGVDLDSFAPMPTIDGKGSHGGYCGPAVKPI
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHH
AMNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGNVQVCTAAMTYGFKIVQEMI
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AGLENWMDEKGHRSLDDIIGRATPNVTDWQYLNLNYVAKAHIDQDACIKCGRCHIACEDT
HHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCHHHHHCCCCEEEEECCC
SHQAITSMVDGVRHFEVIEAECVGCNLCVNVCPVENCITMEPLAAGVMDQRTGKPVSPIY
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCCCEE
ANWTTHPNNPMAKVAAE
ECCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]