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The map label for this gene is ykvO [H]

Identifier: 13471613

GI number: 13471613

Start: 1360240

End: 1360962

Strand: Direct

Name: ykvO [H]

Synonym: mlr1638

Alternate gene names: 13471613

Gene position: 1360240-1360962 (Clockwise)

Preceding gene: 13471612

Following gene: 13471621

Centisome position: 19.33

GC content: 65.56

Gene sequence:

>723_bases
ATGACCAACAGAACAGAACACACAGTCATCATCGGCGGCTCATCCGGCATCGGCCTGGCAACCGCGCGAAAATTGCTCGG
CCCGGGCATGAAGGTGACGATCACCGGGCGCAACCAGGACAAGCTCATCAGCGCTTGGAAGAGCCTCGGCGGTGCCGCCG
ACAAGGCCGCGTTCGATGCATCGAAGCCGGACGAGGTCCGCCAGTTCTTCGAGCGCCTCGGCCCGTTCGACCACCTCGTC
CTGGCGGCCAGCGGCGGCAAGGGCCTCGGCCCGTTCGAAACGCTTGACCTTGCCGATATCGGCAGCGGCGTCGAAGAGAA
AGTGCGGCCGCAACTGTCCTGCCTGCAGGCCGCTTTGCCGACACTGAACAAATCGGGCTCGGTCACCTTCATATCGGCGG
TGTCGGCTCAGGCCACAATGCCTGGCATCGCGGGTATCGGCGCCATCAACGGCATGCTCTTGACCGTGGCGCCGATCCTG
GCGGTCGAACTGAAGCCGCTGCGCGTCAACGTCGTGGCGCCCGGCGTCATCGACACGCCGTGGTGGGACTTTTTGCCCGA
CGAACAGCGGCAAGCGGTCTTTGCCGAGTACGCCGGCAAGACGCCGGTCGGCCGCATCGGCCGCGCCGAGGATGTCGCCT
CCGCGATAGCCTTCCTCGTCTCCAACGGCTTCATGACCGGCCAGGTGCTGACCTGTGACGGTGGGTTGCGGTTCGCGGCG
TGA

Upstream 100 bases:

>100_bases
CCGATGCCCAGGCCTACGACGCCACGGCAAGACAACAATTGCGAAGCCTCAGCCGCGACCTTGTCGGCGCGGCCTCCTCA
AAATCCAGGGAACGGCACTC

Downstream 100 bases:

>100_bases
CGTCGACTGTCAGAGCGACTGTGCGATCAGAGTCAGGAAACCGCCGCCCAGCGCGACATTGCCGACGAAGCCGTTGATGC
GCGCCGCGCGGTCCGGGCCC

Product: oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTNRTEHTVIIGGSSGIGLATARKLLGPGMKVTITGRNQDKLISAWKSLGGAADKAAFDASKPDEVRQFFERLGPFDHLV
LAASGGKGLGPFETLDLADIGSGVEEKVRPQLSCLQAALPTLNKSGSVTFISAVSAQATMPGIAGIGAINGMLLTVAPIL
AVELKPLRVNVVAPGVIDTPWWDFLPDEQRQAVFAEYAGKTPVGRIGRAEDVASAIAFLVSNGFMTGQVLTCDGGLRFAA

Sequences:

>Translated_240_residues
MTNRTEHTVIIGGSSGIGLATARKLLGPGMKVTITGRNQDKLISAWKSLGGAADKAAFDASKPDEVRQFFERLGPFDHLV
LAASGGKGLGPFETLDLADIGSGVEEKVRPQLSCLQAALPTLNKSGSVTFISAVSAQATMPGIAGIGAINGMLLTVAPIL
AVELKPLRVNVVAPGVIDTPWWDFLPDEQRQAVFAEYAGKTPVGRIGRAEDVASAIAFLVSNGFMTGQVLTCDGGLRFAA
>Mature_239_residues
TNRTEHTVIIGGSSGIGLATARKLLGPGMKVTITGRNQDKLISAWKSLGGAADKAAFDASKPDEVRQFFERLGPFDHLVL
AASGGKGLGPFETLDLADIGSGVEEKVRPQLSCLQAALPTLNKSGSVTFISAVSAQATMPGIAGIGAINGMLLTVAPILA
VELKPLRVNVVAPGVIDTPWWDFLPDEQRQAVFAEYAGKTPVGRIGRAEDVASAIAFLVSNGFMTGQVLTCDGGLRFAA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=30.5439330543933, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=28.8065843621399, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=26.4227642276423, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=29.3388429752066, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=27.4590163934426, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=246, Percent_Identity=31.3008130081301, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=28.2868525896414, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=24.6031746031746, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=259, Percent_Identity=27.4131274131274, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=245, Percent_Identity=31.0204081632653, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=31.0204081632653, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355319, Length=241, Percent_Identity=26.9709543568465, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=242, Percent_Identity=33.0578512396694, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357041, Length=242, Percent_Identity=33.0578512396694, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=26.8595041322314, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24974; Mature: 24843

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRTEHTVIIGGSSGIGLATARKLLGPGMKVTITGRNQDKLISAWKSLGGAADKAAFDA
CCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHCCC
SKPDEVRQFFERLGPFDHLVLAASGGKGLGPFETLDLADIGSGVEEKVRPQLSCLQAALP
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHH
TLNKSGSVTFISAVSAQATMPGIAGIGAINGMLLTVAPILAVELKPLRVNVVAPGVIDTP
CCCCCCCEEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHEECCEEEEEEECCCCCCC
WWDFLPDEQRQAVFAEYAGKTPVGRIGRAEDVASAIAFLVSNGFMTGQVLTCDGGLRFAA
CCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEECC
>Mature Secondary Structure 
TNRTEHTVIIGGSSGIGLATARKLLGPGMKVTITGRNQDKLISAWKSLGGAADKAAFDA
CCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHCCC
SKPDEVRQFFERLGPFDHLVLAASGGKGLGPFETLDLADIGSGVEEKVRPQLSCLQAALP
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHH
TLNKSGSVTFISAVSAQATMPGIAGIGAINGMLLTVAPILAVELKPLRVNVVAPGVIDTP
CCCCCCCEEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHEECCEEEEEEECCCCCCC
WWDFLPDEQRQAVFAEYAGKTPVGRIGRAEDVASAIAFLVSNGFMTGQVLTCDGGLRFAA
CCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]