Click here to switch to the map view.

The map label for this gene is dht [H]

Identifier: 13471607

GI number: 13471607

Start: 1353382

End: 1354833

Strand: Reverse

Name: dht [H]

Synonym: mll1629

Alternate gene names: 13471607

Gene position: 1354833-1353382 (Counterclockwise)

Preceding gene: 13471608

Following gene: 13471606

Centisome position: 19.26

GC content: 63.29

Gene sequence:

>1452_bases
ATGACCAAAGTCATCAAGAACGGCACCATCGTCACCGCCGACCGAACGTGGAAGGCGGATGTGCTGGTCAAGCACGGCAA
GATCGTTGCCATCGGTTCGGATCTGCATGGCGACCACGAGTTCGATGCCACCGGCTGTTATGTCATGCCGGGTGGCATCG
ACCCGCACACCCATCTCGAAATGCCATTCATGGGCACCTATTCGGCCGATGATTTCGAATCCGGCACGCGGGCCGCCCTT
GCCGGCGGCACCACGATGGTGGTCGATTTCTGCCTGCCGGCGCCGCAGCAATCGCTGTTAGAGGCCCTGCAGATGTGGGA
CAACAAGACGTCCAAGGCTGCCTGCGACTATTCCTTCCACATGGCCATCACCTGGTGGGGCAAGCAGGTGTTCGACGAGA
TGGCGACCGTCGTCGACAAGGGCATCACCTCGTTCAAGCACTTCATGGCCTACAAAGGCGCGCTGATGGTGGACGACGAC
GAGATGTATGCGTCGTTCCAGCGCTGCGCCGACCTTGGCGCGCTGCCGCTGGTGCATGCCGAGAATGGCGACGTGGTCGC
GGCCCTGTCGCAGAAACTGCTCGCCGCCGGCAACAACGGTCCCGAGGGCCATGCCTATTCGCGGCCGCCGGAAGTGGAAG
GCGAGGCGACAAATCGGGCCATCATGATCGCCGACATGGCCGGCGTGCCGCTCTATGTCGTGCATGTCTCCTGCGAGCAG
GCGCACGAGGCGATCCGCCGGGCACGCCAGAAAGGCATGCGCGTGTTCGGCGAACCGCTGGTCCAGCATCTGACGCTCGA
CGAGACGGAGTATTTCAACAAGGATTGGGACCATGCGGCGCGCCGCGTGATGAGCCCGCCCTTCCGCAACAAATTGCATC
AGGATTCGCTGTGGGCCGGCCTGCAGGCCGGGTCGCTGCAGGTGGTGGCGACCGACCATTGCGCCTTCACCACCAAGCAG
AAGCGCTTCGGCGTCGGCGATTTCACCAAGATCCCCAACGGCACAGGCGGCCTCGAGGACCGTCTGCCGGTGCTGTGGAC
CAAGGGCGTCAACACCGGGCGGCTGACGATGAATGAGTTCGTCGCGGTGACCTCGACCAACATCGCCAAGATCCTCAACA
TGTATCCGAAGAAGGGCGCCATCGTCGAAGGCGCCGACGCCGACATCATCGTCTGGGATCCGAAGCGCAAGAAAACCATC
ACCTCGAAGAAGCAGCAGTCGGTCATCGACTACAACGTCTTCGAAGGCGTCGAGGTGACCGGCCTGCCGCGCTTCGTCTT
CTCCCGCGGCGAATTGTCGATCGAGGAGGCCGAGGTGAAGACAAAGCCCGGCCACGGCCAGTTCGTCGGCCGCGAGCCGA
ACGCCGCGGTCAACCGGGCGCTGTCGACGTGGAAGGAGATCACCGCGCCACGCAAGGTGGAACGCACCGGCATCCCGGCG
ACGGGGGTTTAA

Upstream 100 bases:

>100_bases
ACGCGGTTGTGGAGACCGCCGTCATCGTAGAGTGAACTTAGCCATCTAGATTCCAAACGCCGCTCGCAAAGAAGCGCGAA
GAGAACAAGGGAACAAGACA

Downstream 100 bases:

>100_bases
GCTTGGCGCGTTCGGCCGCGCTCATCTCGATGGTCTTGGCGGCAGTTGCCGGTGGCCCGGCGACCGCGGCTGGCGTGCTG
GCAGGCTCCTGGGGCAATGA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTKVIKNGTIVTADRTWKADVLVKHGKIVAIGSDLHGDHEFDATGCYVMPGGIDPHTHLEMPFMGTYSADDFESGTRAAL
AGGTTMVVDFCLPAPQQSLLEALQMWDNKTSKAACDYSFHMAITWWGKQVFDEMATVVDKGITSFKHFMAYKGALMVDDD
EMYASFQRCADLGALPLVHAENGDVVAALSQKLLAAGNNGPEGHAYSRPPEVEGEATNRAIMIADMAGVPLYVVHVSCEQ
AHEAIRRARQKGMRVFGEPLVQHLTLDETEYFNKDWDHAARRVMSPPFRNKLHQDSLWAGLQAGSLQVVATDHCAFTTKQ
KRFGVGDFTKIPNGTGGLEDRLPVLWTKGVNTGRLTMNEFVAVTSTNIAKILNMYPKKGAIVEGADADIIVWDPKRKKTI
TSKKQQSVIDYNVFEGVEVTGLPRFVFSRGELSIEEAEVKTKPGHGQFVGREPNAAVNRALSTWKEITAPRKVERTGIPA
TGV

Sequences:

>Translated_483_residues
MTKVIKNGTIVTADRTWKADVLVKHGKIVAIGSDLHGDHEFDATGCYVMPGGIDPHTHLEMPFMGTYSADDFESGTRAAL
AGGTTMVVDFCLPAPQQSLLEALQMWDNKTSKAACDYSFHMAITWWGKQVFDEMATVVDKGITSFKHFMAYKGALMVDDD
EMYASFQRCADLGALPLVHAENGDVVAALSQKLLAAGNNGPEGHAYSRPPEVEGEATNRAIMIADMAGVPLYVVHVSCEQ
AHEAIRRARQKGMRVFGEPLVQHLTLDETEYFNKDWDHAARRVMSPPFRNKLHQDSLWAGLQAGSLQVVATDHCAFTTKQ
KRFGVGDFTKIPNGTGGLEDRLPVLWTKGVNTGRLTMNEFVAVTSTNIAKILNMYPKKGAIVEGADADIIVWDPKRKKTI
TSKKQQSVIDYNVFEGVEVTGLPRFVFSRGELSIEEAEVKTKPGHGQFVGREPNAAVNRALSTWKEITAPRKVERTGIPA
TGV
>Mature_482_residues
TKVIKNGTIVTADRTWKADVLVKHGKIVAIGSDLHGDHEFDATGCYVMPGGIDPHTHLEMPFMGTYSADDFESGTRAALA
GGTTMVVDFCLPAPQQSLLEALQMWDNKTSKAACDYSFHMAITWWGKQVFDEMATVVDKGITSFKHFMAYKGALMVDDDE
MYASFQRCADLGALPLVHAENGDVVAALSQKLLAAGNNGPEGHAYSRPPEVEGEATNRAIMIADMAGVPLYVVHVSCEQA
HEAIRRARQKGMRVFGEPLVQHLTLDETEYFNKDWDHAARRVMSPPFRNKLHQDSLWAGLQAGSLQVVATDHCAFTTKQK
RFGVGDFTKIPNGTGGLEDRLPVLWTKGVNTGRLTMNEFVAVTSTNIAKILNMYPKKGAIVEGADADIIVWDPKRKKTIT
SKKQQSVIDYNVFEGVEVTGLPRFVFSRGELSIEEAEVKTKPGHGQFVGREPNAAVNRALSTWKEITAPRKVERTGIPAT
GV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=483, Percent_Identity=47.2049689440994, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI190194363, Length=455, Percent_Identity=46.1538461538462, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI4503379, Length=476, Percent_Identity=43.2773109243698, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4503377, Length=456, Percent_Identity=44.9561403508772, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI4503051, Length=455, Percent_Identity=44.8351648351648, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI62422571, Length=455, Percent_Identity=44.8351648351648, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI19923821, Length=480, Percent_Identity=42.5, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI18105007, Length=458, Percent_Identity=24.8908296943231, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082175, Length=460, Percent_Identity=38.2608695652174, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1786722, Length=410, Percent_Identity=30.4878048780488, Blast_Score=164, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=47.8260869565217, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71989490, Length=482, Percent_Identity=44.6058091286307, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI86575075, Length=457, Percent_Identity=31.5098468271335, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI193204318, Length=426, Percent_Identity=25.3521126760563, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=417, Percent_Identity=25.4196642685851, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=44.8351648351648, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=43.4878587196468, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=45.2380952380952, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24644289, Length=258, Percent_Identity=44.5736434108527, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24642586, Length=407, Percent_Identity=28.009828009828, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18859883, Length=440, Percent_Identity=24.0909090909091, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 53010; Mature: 52879

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVIKNGTIVTADRTWKADVLVKHGKIVAIGSDLHGDHEFDATGCYVMPGGIDPHTHLE
CCCEEECCEEEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEC
MPFMGTYSADDFESGTRAALAGGTTMVVDFCLPAPQQSLLEALQMWDNKTSKAACDYSFH
CCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEECCEEEE
MAITWWGKQVFDEMATVVDKGITSFKHFMAYKGALMVDDDEMYASFQRCADLGALPLVHA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCCCEEEEC
ENGDVVAALSQKLLAAGNNGPEGHAYSRPPEVEGEATNRAIMIADMAGVPLYVVHVSCEQ
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECHHH
AHEAIRRARQKGMRVFGEPLVQHLTLDETEYFNKDWDHAARRVMSPPFRNKLHQDSLWAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCHHHHHCCHHHHHHC
LQAGSLQVVATDHCAFTTKQKRFGVGDFTKIPNGTGGLEDRLPVLWTKGVNTGRLTMNEF
CCCCCEEEEEECCEEEECCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEHHHE
VAVTSTNIAKILNMYPKKGAIVEGADADIIVWDPKRKKTITSKKQQSVIDYNVFEGVEVT
EEEECHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHCCHHHCCEEEC
GLPRFVFSRGELSIEEAEVKTKPGHGQFVGREPNAAVNRALSTWKEITAPRKVERTGIPA
CCCHHHCCCCCCEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCC
TGV
CCC
>Mature Secondary Structure 
TKVIKNGTIVTADRTWKADVLVKHGKIVAIGSDLHGDHEFDATGCYVMPGGIDPHTHLE
CCEEECCEEEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEC
MPFMGTYSADDFESGTRAALAGGTTMVVDFCLPAPQQSLLEALQMWDNKTSKAACDYSFH
CCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEECCEEEE
MAITWWGKQVFDEMATVVDKGITSFKHFMAYKGALMVDDDEMYASFQRCADLGALPLVHA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCCCEEEEC
ENGDVVAALSQKLLAAGNNGPEGHAYSRPPEVEGEATNRAIMIADMAGVPLYVVHVSCEQ
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECHHH
AHEAIRRARQKGMRVFGEPLVQHLTLDETEYFNKDWDHAARRVMSPPFRNKLHQDSLWAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCHHHHHCCHHHHHHC
LQAGSLQVVATDHCAFTTKQKRFGVGDFTKIPNGTGGLEDRLPVLWTKGVNTGRLTMNEF
CCCCCEEEEEECCEEEECCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEHHHE
VAVTSTNIAKILNMYPKKGAIVEGADADIIVWDPKRKKTITSKKQQSVIDYNVFEGVEVT
EEEECHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHCCHHHCCEEEC
GLPRFVFSRGELSIEEAEVKTKPGHGQFVGREPNAAVNRALSTWKEITAPRKVERTGIPA
CCCHHHCCCCCCEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCC
TGV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]