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The map label for this gene is mraY

Identifier: 13471552

GI number: 13471552

Start: 1297177

End: 1298259

Strand: Reverse

Name: mraY

Synonym: mll1558

Alternate gene names: 13471552

Gene position: 1298259-1297177 (Counterclockwise)

Preceding gene: 13471553

Following gene: 13471551

Centisome position: 18.45

GC content: 61.03

Gene sequence:

>1083_bases
ATGTTTACACTGCTGGTCGATTTCGCGGACAAGATCTCGGTCTTCAATGTCTTCCGCTACATCACGTTCCGCACCGGCGG
AGCGCTGATCACTTCTGCGCTGATCGTCTTCATCTTCGGACCGACCATCATCAATTCGCTGCGGCTCAGGCAAGGCAAGG
GCCAGCCGATCCGCGCCGACGGGCCGCAGACGCATTTCAAGAAGGCGGGTACGCCGACCATGGGCGGGCTGATGATCCTG
TCCGGCATCATCGGCTCATCACTCCTATGGGCGAACCTGTCGAGCATCTATGTCTGGGTGGTGCTGCTGGTGACGCTGGG
CTTCGGCTCGATCGGTTTTTATGACGACTATCTGAAGGTGACCAAGCAGTCGCATCTCGGCTTTTCCGGCAAGGCGCGGC
TGGGGCTCGAATTCATCATCGCCGGCATCGCCGCCTGGGTGATCATGCACAATGGCCAGGCGCCGTTCTCCTCGTCGCTG
ACATTTCCCTTCGCCAAGGAATTCATCATCAACCTCGGCTGGTTCTTCATCCCGTTCTCCTGCTTCGTCATCGTCGGCGC
CGGGAACGCGGTGAACCTCACCGACGGCCTGGACGGGCTGGCAATCGTGCCGATCATGATCGCGGCGGCGTCCTTCGGCG
TCATTGCCTATCTCTCCGGCAATGCGGTGTTCGCCGAATATCTGCAGATCCATTTCGTTCCCGGCACCGGTGAGCTGGCG
GTCGTGCTGGGCGCCGTCATCGGCGCCGGCCTCGGCTTCCTCTGGTTCAACGCGCCGCCGGCGGCGATCTTCATGGGCGA
CACCGGTTCGCTGGCCATGGGCGGCCTGATCGGTACGGTCGCGGTCGCCACCAAGCACGAGATCGTACTCGTCATCGTCG
GTGGCCTGTTCGTGGTCGAGATTTTGTCGGTCATCATCCAGGTCGGCTACTTCAAGATGACCGGCAAGCGCGTGTTCCTG
ATGGCGCCGATCCACCATCATTTCGAAAAGCTCGGCTGGACCGAGAGCCAGGTGGTGATCCGTTTCTGGATCATCGCCGT
CATCCTGGCGCTGGTCGGCCTCTCCACCCTGAAGCTCAGATAG

Upstream 100 bases:

>100_bases
GCATCGGTTTTGCAAAACTGGTCGATGCGCTGCTGGGCAAGTACCCGGCTGAAACGACAACCAGCAAACTGACCTAGGTC
AAGTCGGGGGACGAAAGCGC

Downstream 100 bases:

>100_bases
GAAGCCCTCCCTTGATCCCCGCCGCATCCTTCGCAGGCAAACAGGTTTCGCTCTTCGGCCTCGGTGGCTCGGGGATCGCG
ACCGCGCGGGCATTGATCGA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MFTLLVDFADKISVFNVFRYITFRTGGALITSALIVFIFGPTIINSLRLRQGKGQPIRADGPQTHFKKAGTPTMGGLMIL
SGIIGSSLLWANLSSIYVWVVLLVTLGFGSIGFYDDYLKVTKQSHLGFSGKARLGLEFIIAGIAAWVIMHNGQAPFSSSL
TFPFAKEFIINLGWFFIPFSCFVIVGAGNAVNLTDGLDGLAIVPIMIAAASFGVIAYLSGNAVFAEYLQIHFVPGTGELA
VVLGAVIGAGLGFLWFNAPPAAIFMGDTGSLAMGGLIGTVAVATKHEIVLVIVGGLFVVEILSVIIQVGYFKMTGKRVFL
MAPIHHHFEKLGWTESQVVIRFWIIAVILALVGLSTLKLR

Sequences:

>Translated_360_residues
MFTLLVDFADKISVFNVFRYITFRTGGALITSALIVFIFGPTIINSLRLRQGKGQPIRADGPQTHFKKAGTPTMGGLMIL
SGIIGSSLLWANLSSIYVWVVLLVTLGFGSIGFYDDYLKVTKQSHLGFSGKARLGLEFIIAGIAAWVIMHNGQAPFSSSL
TFPFAKEFIINLGWFFIPFSCFVIVGAGNAVNLTDGLDGLAIVPIMIAAASFGVIAYLSGNAVFAEYLQIHFVPGTGELA
VVLGAVIGAGLGFLWFNAPPAAIFMGDTGSLAMGGLIGTVAVATKHEIVLVIVGGLFVVEILSVIIQVGYFKMTGKRVFL
MAPIHHHFEKLGWTESQVVIRFWIIAVILALVGLSTLKLR
>Mature_360_residues
MFTLLVDFADKISVFNVFRYITFRTGGALITSALIVFIFGPTIINSLRLRQGKGQPIRADGPQTHFKKAGTPTMGGLMIL
SGIIGSSLLWANLSSIYVWVVLLVTLGFGSIGFYDDYLKVTKQSHLGFSGKARLGLEFIIAGIAAWVIMHNGQAPFSSSL
TFPFAKEFIINLGWFFIPFSCFVIVGAGNAVNLTDGLDGLAIVPIMIAAASFGVIAYLSGNAVFAEYLQIHFVPGTGELA
VVLGAVIGAGLGFLWFNAPPAAIFMGDTGSLAMGGLIGTVAVATKHEIVLVIVGGLFVVEILSVIIQVGYFKMTGKRVFL
MAPIHHHFEKLGWTESQVVIRFWIIAVILALVGLSTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=348, Percent_Identity=51.4367816091954, Blast_Score=333, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_RHILO (Q98KB0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103118.1
- GeneID:   1225781
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1558
- NMPDR:   fig|266835.1.peg.1223
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 38622; Mature: 38622

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe3f7a00)-; HASH(0xe659604)-; HASH(0xcad5778)-; HASH(0xdddba28)-; HASH(0xd8f7eb0)-; HASH(0xde4ba64)-; HASH(0xc1bcaa4)-; HASH(0xe4935bc)-; HASH(0xea9133c)-; HASH(0xea90864)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTLLVDFADKISVFNVFRYITFRTGGALITSALIVFIFGPTIINSLRLRQGKGQPIRAD
CEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GPQTHFKKAGTPTMGGLMILSGIIGSSLLWANLSSIYVWVVLLVTLGFGSIGFYDDYLKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TKQSHLGFSGKARLGLEFIIAGIAAWVIMHNGQAPFSSSLTFPFAKEFIINLGWFFIPFS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
CFVIVGAGNAVNLTDGLDGLAIVPIMIAAASFGVIAYLSGNAVFAEYLQIHFVPGTGELA
HEEEEECCCEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCHHEEEEEEEEEECCCCHHH
VVLGAVIGAGLGFLWFNAPPAAIFMGDTGSLAMGGLIGTVAVATKHEIVLVIVGGLFVVE
HHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
ILSVIIQVGYFKMTGKRVFLMAPIHHHFEKLGWTESQVVIRFWIIAVILALVGLSTLKLR
HHHHHHHHCCEEECCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCH
>Mature Secondary Structure
MFTLLVDFADKISVFNVFRYITFRTGGALITSALIVFIFGPTIINSLRLRQGKGQPIRAD
CEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GPQTHFKKAGTPTMGGLMILSGIIGSSLLWANLSSIYVWVVLLVTLGFGSIGFYDDYLKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TKQSHLGFSGKARLGLEFIIAGIAAWVIMHNGQAPFSSSLTFPFAKEFIINLGWFFIPFS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
CFVIVGAGNAVNLTDGLDGLAIVPIMIAAASFGVIAYLSGNAVFAEYLQIHFVPGTGELA
HEEEEECCCEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCHHEEEEEEEEEECCCCHHH
VVLGAVIGAGLGFLWFNAPPAAIFMGDTGSLAMGGLIGTVAVATKHEIVLVIVGGLFVVE
HHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
ILSVIIQVGYFKMTGKRVFLMAPIHHHFEKLGWTESQVVIRFWIIAVILALVGLSTLKLR
HHHHHHHHCCEEECCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968