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The map label for this gene is glcD [H]

Identifier: 13471498

GI number: 13471498

Start: 1236731

End: 1238458

Strand: Reverse

Name: glcD [H]

Synonym: mll1488

Alternate gene names: 13471498

Gene position: 1238458-1236731 (Counterclockwise)

Preceding gene: 13471501

Following gene: 13471497

Centisome position: 17.6

GC content: 64.0

Gene sequence:

>1728_bases
ATGGACTTCGGCGGTGTAGATGGTGAGACGGCGCTGTTTCACATAGTCCAGCCCCATGCCCATCGCCTCGAAGGCCTCGT
CCGAGCAGCGGTCGAACAGCACGTTGTAATAGGCCATGTTGAGATGGCCGTTGTAGTCGATCCAGTCCTTCTCGATGTCC
ATGGGCTTGGAGACGAAGGGGGCGGGGATGGACATGGAAACTTCCTTGTTCTGGTGCTGGACACGGCCTGGTGGGTGAGA
CTACGCATCCATAATCGCATAACAAGCGTGGACGCTGGTCCATTCGCGGAGGAATTCATGGCTCTGAGCGACCTCAATCC
GGTCGAACGCAATGAGGAAGGCATCGCGGCGGTGCTCGGCATCCTCAAGCAGCAGCTGGGCGAGCGCTTTCAGACCGGCC
AGGCGATCCGCGCCCAGCATGCGCACACCACCACCTATATACCGACCCAGGCGCCAGATGGTGTCGCTTTCCCCGAGACG
ACCGCCGAGGTGCAGGAGATCGTGCGCGCCTGCGCCGCGCATCGCGTGCCGGTGATCGCCTTTGGCGTCGGCTCCTCGCT
GGAAGGCCACACCAACGCGCCCGGCGGCGGCATCTCGGTCGATACATCGCGCATGAACCGCATCCTTGCGGTCAATCCGC
AGGATCTCGACTGCACGGTCGAACCCGGCGTGACGCGCGAGGACCTGAACCGTCATCTGCGCGACACCGGCCTGTTCTTC
CCGATCGATCCTGGCGCCAATGCCTCGCTCGGCGGCATGGCGGCGACGCGGGCGTCCGGCACCAATGCGGTGCGCTACGG
CACCATGCGCGAGAACGTGCTGTCGCTGACGGCCGTCATGGCCGACGGCGAGACAGTGACGACCGGCAAGCGGGCGAAAA
AGAGCTCGGCCGGCTACGATCTGACGCGGCTGCTGGTCGGCTCGGAAGGCACGCTCGGCATCATCACCTCGCTGACGCTG
AAGCTGCAAGGCATTCCGCAGGCGATCTCGGGCGGCGTCTGCCCGTTTCCAAGTGTCGAGGCGGCCTGCAACGCCGTCAT
CGCGACGATCCAGATGGGCATTCCGGTGGCGCGCATCGAGCTGGTCAACGCGCTGCAGATGCGGGCGATGAAGAATTATT
CCAAGCTCGATTATCCCGAGAGCCCGTGCCTGTTCGTCGAGTTCCACGGCAGCGATGCCGGCGTGGCCGAACAGGCCGAG
ACCTTTGGCATGATTGCCGAGGAAAATGGCGGCGGGCCGTTCCTGTGGACCAGCGTCGCCGAGGAACGCACCAAACTGTG
GAAGGCCAGGCACGATGCCTACTGGGCCTCGCTGACGCTGCGGCCGGGCGCCAAGGGCCTGTCGACCGATGTCTGCGTGC
CGATCTCGCGCTTTGCCGAATGCGTCACCGAGACCGAGGCCGATATCGCCGAAATGGGCTTGATCGCGCCGATCGTCGGC
CATGCCGGCGACGGCAATTTCCACGTGCTGGTGCTGATGGATGTCAACGACCCCAAGGAGATCGCGCTGTCGGAGAAATT
CGTCGCGCGGCTCAACCTGCGGGCGATCGCCATGGACGGCACCTGCACCGGCGAGCATGGCATCGGCCAGGGCAAGATCG
GCTTCCTGCGGCCCGAACTCGGCCACGGTGTCGATATCATGCGTTCCATCAAGCAGGCGCTCGACCCGCAAAACATCATG
AATCCCGGCAAGATATTGCCGGCTGTGGGGTGGATCGGTCGAGGTTAG

Upstream 100 bases:

>100_bases
GGATTTCCTGGTAGGCCCTGAGCCGCTTCTCGTCATGGTCGATGAGCTGGAAGGACACCTGGACCTTGTGGTCCAGATGC
AGTTCCTGGACGTAGCAGAC

Downstream 100 bases:

>100_bases
AAAATTGGCAGGTGCGCAAGCCAACTACCCGCATTTACGGTCTGTCCGCCAGTAGCTCGCTCAAACTGATTTCGACAAAC
TCCGCACCCATCAGTCCATC

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MDFGGVDGETALFHIVQPHAHRLEGLVRAAVEQHVVIGHVEMAVVVDPVLLDVHGLGDEGGGDGHGNFLVLVLDTAWWVR
LRIHNRITSVDAGPFAEEFMALSDLNPVERNEEGIAAVLGILKQQLGERFQTGQAIRAQHAHTTTYIPTQAPDGVAFPET
TAEVQEIVRACAAHRVPVIAFGVGSSLEGHTNAPGGGISVDTSRMNRILAVNPQDLDCTVEPGVTREDLNRHLRDTGLFF
PIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVMADGETVTTGKRAKKSSAGYDLTRLLVGSEGTLGIITSLTL
KLQGIPQAISGGVCPFPSVEAACNAVIATIQMGIPVARIELVNALQMRAMKNYSKLDYPESPCLFVEFHGSDAGVAEQAE
TFGMIAEENGGGPFLWTSVAEERTKLWKARHDAYWASLTLRPGAKGLSTDVCVPISRFAECVTETEADIAEMGLIAPIVG
HAGDGNFHVLVLMDVNDPKEIALSEKFVARLNLRAIAMDGTCTGEHGIGQGKIGFLRPELGHGVDIMRSIKQALDPQNIM
NPGKILPAVGWIGRG

Sequences:

>Translated_575_residues
MDFGGVDGETALFHIVQPHAHRLEGLVRAAVEQHVVIGHVEMAVVVDPVLLDVHGLGDEGGGDGHGNFLVLVLDTAWWVR
LRIHNRITSVDAGPFAEEFMALSDLNPVERNEEGIAAVLGILKQQLGERFQTGQAIRAQHAHTTTYIPTQAPDGVAFPET
TAEVQEIVRACAAHRVPVIAFGVGSSLEGHTNAPGGGISVDTSRMNRILAVNPQDLDCTVEPGVTREDLNRHLRDTGLFF
PIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVMADGETVTTGKRAKKSSAGYDLTRLLVGSEGTLGIITSLTL
KLQGIPQAISGGVCPFPSVEAACNAVIATIQMGIPVARIELVNALQMRAMKNYSKLDYPESPCLFVEFHGSDAGVAEQAE
TFGMIAEENGGGPFLWTSVAEERTKLWKARHDAYWASLTLRPGAKGLSTDVCVPISRFAECVTETEADIAEMGLIAPIVG
HAGDGNFHVLVLMDVNDPKEIALSEKFVARLNLRAIAMDGTCTGEHGIGQGKIGFLRPELGHGVDIMRSIKQALDPQNIM
NPGKILPAVGWIGRG
>Mature_575_residues
MDFGGVDGETALFHIVQPHAHRLEGLVRAAVEQHVVIGHVEMAVVVDPVLLDVHGLGDEGGGDGHGNFLVLVLDTAWWVR
LRIHNRITSVDAGPFAEEFMALSDLNPVERNEEGIAAVLGILKQQLGERFQTGQAIRAQHAHTTTYIPTQAPDGVAFPET
TAEVQEIVRACAAHRVPVIAFGVGSSLEGHTNAPGGGISVDTSRMNRILAVNPQDLDCTVEPGVTREDLNRHLRDTGLFF
PIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVMADGETVTTGKRAKKSSAGYDLTRLLVGSEGTLGIITSLTL
KLQGIPQAISGGVCPFPSVEAACNAVIATIQMGIPVARIELVNALQMRAMKNYSKLDYPESPCLFVEFHGSDAGVAEQAE
TFGMIAEENGGGPFLWTSVAEERTKLWKARHDAYWASLTLRPGAKGLSTDVCVPISRFAECVTETEADIAEMGLIAPIVG
HAGDGNFHVLVLMDVNDPKEIALSEKFVARLNLRAIAMDGTCTGEHGIGQGKIGFLRPELGHGVDIMRSIKQALDPQNIM
NPGKILPAVGWIGRG

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=458, Percent_Identity=48.9082969432314, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI37595754, Length=481, Percent_Identity=46.5696465696466, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI119964728, Length=429, Percent_Identity=30.0699300699301, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4501993, Length=468, Percent_Identity=25.2136752136752, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1789351, Length=421, Percent_Identity=30.8788598574822, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1787977, Length=504, Percent_Identity=28.3730158730159, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI48994907, Length=477, Percent_Identity=22.8511530398323, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI48994914, Length=166, Percent_Identity=28.9156626506024, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71992373, Length=442, Percent_Identity=47.0588235294118, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71992381, Length=442, Percent_Identity=45.9276018099548, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71992392, Length=377, Percent_Identity=50.132625994695, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17534361, Length=436, Percent_Identity=25.9174311926606, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=199, Percent_Identity=29.1457286432161, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320027, Length=471, Percent_Identity=40.1273885350318, Blast_Score=322, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6320023, Length=437, Percent_Identity=28.604118993135, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320764, Length=451, Percent_Identity=24.8337028824834, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=27.5294117647059, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=27.5294117647059, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=27.5294117647059, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24653753, Length=529, Percent_Identity=25.7088846880907, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 61206; Mature: 61206

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFGGVDGETALFHIVQPHAHRLEGLVRAAVEQHVVIGHVEMAVVVDPVLLDVHGLGDEG
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEEEEEEEECEEEEEEECCCCCC
GGDGHGNFLVLVLDTAWWVRLRIHNRITSVDAGPFAEEFMALSDLNPVERNEEGIAAVLG
CCCCCCCEEEEEECCCEEEEEEEECHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
ILKQQLGERFQTGQAIRAQHAHTTTYIPTQAPDGVAFPETTAEVQEIVRACAAHRVPVIA
HHHHHHHHHHHCCHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
FGVGSSLEGHTNAPGGGISVDTSRMNRILAVNPQDLDCTVEPGVTREDLNRHLRDTGLFF
EECCCCCCCCCCCCCCCEEEEHHHCCEEEEECCCCCCEEECCCCCHHHHHHHHHHCCCEE
PIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVMADGETVTTGKRAKKSSAGYD
EECCCCCCCCCCCEEECCCCCCEEEECCHHHHHHEEEEEEECCCEEECCCHHCCCCCCCC
LTRLLVGSEGTLGIITSLTLKLQGIPQAISGGVCPFPSVEAACNAVIATIQMGIPVARIE
EEEEEECCCCCEEEEEEEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
LVNALQMRAMKNYSKLDYPESPCLFVEFHGSDAGVAEQAETFGMIAEENGGGPFLWTSVA
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCEEEECCCCCCEEEHHHH
EERTKLWKARHDAYWASLTLRPGAKGLSTDVCVPISRFAECVTETEADIAEMGLIAPIVG
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HAGDGNFHVLVLMDVNDPKEIALSEKFVARLNLRAIAMDGTCTGEHGIGQGKIGFLRPEL
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECCCC
GHGVDIMRSIKQALDPQNIMNPGKILPAVGWIGRG
CCCHHHHHHHHHHCCHHHCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MDFGGVDGETALFHIVQPHAHRLEGLVRAAVEQHVVIGHVEMAVVVDPVLLDVHGLGDEG
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEEEEEEEECEEEEEEECCCCCC
GGDGHGNFLVLVLDTAWWVRLRIHNRITSVDAGPFAEEFMALSDLNPVERNEEGIAAVLG
CCCCCCCEEEEEECCCEEEEEEEECHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
ILKQQLGERFQTGQAIRAQHAHTTTYIPTQAPDGVAFPETTAEVQEIVRACAAHRVPVIA
HHHHHHHHHHHCCHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
FGVGSSLEGHTNAPGGGISVDTSRMNRILAVNPQDLDCTVEPGVTREDLNRHLRDTGLFF
EECCCCCCCCCCCCCCCEEEEHHHCCEEEEECCCCCCEEECCCCCHHHHHHHHHHCCCEE
PIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVMADGETVTTGKRAKKSSAGYD
EECCCCCCCCCCCEEECCCCCCEEEECCHHHHHHEEEEEEECCCEEECCCHHCCCCCCCC
LTRLLVGSEGTLGIITSLTLKLQGIPQAISGGVCPFPSVEAACNAVIATIQMGIPVARIE
EEEEEECCCCCEEEEEEEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
LVNALQMRAMKNYSKLDYPESPCLFVEFHGSDAGVAEQAETFGMIAEENGGGPFLWTSVA
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCEEEECCCCCCEEEHHHH
EERTKLWKARHDAYWASLTLRPGAKGLSTDVCVPISRFAECVTETEADIAEMGLIAPIVG
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HAGDGNFHVLVLMDVNDPKEIALSEKFVARLNLRAIAMDGTCTGEHGIGQGKIGFLRPEL
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECCCC
GHGVDIMRSIKQALDPQNIMNPGKILPAVGWIGRG
CCCHHHHHHHHHHCCHHHCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]