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The map label for this gene is hflC [H]

Identifier: 13471473

GI number: 13471473

Start: 1212307

End: 1213266

Strand: Reverse

Name: hflC [H]

Synonym: mll1454

Alternate gene names: 13471473

Gene position: 1213266-1212307 (Counterclockwise)

Preceding gene: 13471474

Following gene: 13471472

Centisome position: 17.24

GC content: 65.0

Gene sequence:

>960_bases
ATGGCCAACCGTCTTCCCATTTTCGTCGTCATCGCGGCGGTCATCCTGTTCCTGATCTATTCCTCGGTCTTCGTGGTCAA
TGCGCGCCAGCAAGCGCTGGTGTTGAGGTTCGGCGAGATCGTCGACGTCAAGACCGAGCCCGGCATCTATTTCAAGGCGC
CGTTCTCGTTCTTCGACGCCGACACGGTGCAACTGATCGAGAACAGGGTGCTGCGCTTCGACCTCGACAACATCCGCGTC
CAGGTGTCGGGCGGCAAGTTCTATGAGGTCGATGCCTTCATCGCCTACCGCATCTCGGATCCGCGCGTCTTCCGTGCCGC
CGTGTCCGGTCAGATCGAATTGGCCGAGGCGCGGCTGAGGACGCGTCTCGACGCTGCCTTGCGCCGCGTTTACGGTCTGC
GCGATTTCGAGGCGGCGCTCTCGGAGCAGCGTGCGGTGATGATGCGCGAAGTGCGCGATCAACTCCGGCCCGACGCCACC
TCGCTCGGCCTGCAGATCGAGGATGTCCGCATCCGCCGCACCGACCTCACGGCCGAGGTTTCACAGCAGACCTACGACCG
CATGAAGGCGGAACGCCTGGCCGAGGCCGCCCGGCTTAGGGCACGCGGCAATGAAGCGGCACAGCGCATCACGGCACGCG
CCGATCGTGAAGTGGTCGAGATCGTTGCCGAAGCGCAGAAGGAGTCCGAGATCCTGCGCGGCGAGGGCGAAGCCCAGCGC
AGCGCCACCTTCGCGGACGCCTACAAGCGCGACCCGGCCTTCTTCGACTTCTACCGGTCGATGAATGCCTATGGCACGGC
CCTGGACAATACCGGGACGACCATGGTGCTGTCGCCGAGTTCGGAGTTCTTCCGCTACTTCCGCGACCCCGACGGCAAGG
AAGGGCCGGCGAAACCGGCGGCACCCGCCTCACCGACGCCGGCGGCGCCTGCGACACAACCCAGCACCGGCAAGCAATAG

Upstream 100 bases:

>100_bases
GCAACGGACAAGGTGTCGTGCCTTATCTGCCGCTGCCGGCATTGCAGCCGAAACCGCCGGCTCCGGCCGCGCCTGCCGCG
AACACGGGAGGTACCCAGTG

Downstream 100 bases:

>100_bases
CCGGTGCAGGACTTTTTCGCGGCAATAGGCCTGGTCCTTGTCATAGAGGGCCTGGTCTATGGCGGCTTTCCCGGCTTGGC
GAAGAAGCTCGCGGGCGAGG

Product: ftsH protease activity modulator hflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MANRLPIFVVIAAVILFLIYSSVFVVNARQQALVLRFGEIVDVKTEPGIYFKAPFSFFDADTVQLIENRVLRFDLDNIRV
QVSGGKFYEVDAFIAYRISDPRVFRAAVSGQIELAEARLRTRLDAALRRVYGLRDFEAALSEQRAVMMREVRDQLRPDAT
SLGLQIEDVRIRRTDLTAEVSQQTYDRMKAERLAEAARLRARGNEAAQRITARADREVVEIVAEAQKESEILRGEGEAQR
SATFADAYKRDPAFFDFYRSMNAYGTALDNTGTTMVLSPSSEFFRYFRDPDGKEGPAKPAAPASPTPAAPATQPSTGKQ

Sequences:

>Translated_319_residues
MANRLPIFVVIAAVILFLIYSSVFVVNARQQALVLRFGEIVDVKTEPGIYFKAPFSFFDADTVQLIENRVLRFDLDNIRV
QVSGGKFYEVDAFIAYRISDPRVFRAAVSGQIELAEARLRTRLDAALRRVYGLRDFEAALSEQRAVMMREVRDQLRPDAT
SLGLQIEDVRIRRTDLTAEVSQQTYDRMKAERLAEAARLRARGNEAAQRITARADREVVEIVAEAQKESEILRGEGEAQR
SATFADAYKRDPAFFDFYRSMNAYGTALDNTGTTMVLSPSSEFFRYFRDPDGKEGPAKPAAPASPTPAAPATQPSTGKQ
>Mature_318_residues
ANRLPIFVVIAAVILFLIYSSVFVVNARQQALVLRFGEIVDVKTEPGIYFKAPFSFFDADTVQLIENRVLRFDLDNIRVQ
VSGGKFYEVDAFIAYRISDPRVFRAAVSGQIELAEARLRTRLDAALRRVYGLRDFEAALSEQRAVMMREVRDQLRPDATS
LGLQIEDVRIRRTDLTAEVSQQTYDRMKAERLAEAARLRARGNEAAQRITARADREVVEIVAEAQKESEILRGEGEAQRS
ATFADAYKRDPAFFDFYRSMNAYGTALDNTGTTMVLSPSSEFFRYFRDPDGKEGPAKPAAPASPTPAAPATQPSTGKQ

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=317, Percent_Identity=34.384858044164, Blast_Score=168, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 35765; Mature: 35634

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRLPIFVVIAAVILFLIYSSVFVVNARQQALVLRFGEIVDVKTEPGIYFKAPFSFFDA
CCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHHEECCCEEEEECCCCEEEECCCCCCCH
DTVQLIENRVLRFDLDNIRVQVSGGKFYEVDAFIAYRISDPRVFRAAVSGQIELAEARLR
HHHHHHHHHHEEEEECCEEEEECCCEEEEEEEEEEEEECCCHHHHHHHCCCHHHHHHHHH
TRLDAALRRVYGLRDFEAALSEQRAVMMREVRDQLRPDATSLGLQIEDVRIRRTDLTAEV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEEEEEEEEECCCHHHH
SQQTYDRMKAERLAEAARLRARGNEAAQRITARADREVVEIVAEAQKESEILRGEGEAQR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
SATFADAYKRDPAFFDFYRSMNAYGTALDNTGTTMVLSPSSEFFRYFRDPDGKEGPAKPA
HHHHHHHHHCCCHHHHHHHHHHHHCCEECCCCCEEEECCCHHHHHHHCCCCCCCCCCCCC
APASPTPAAPATQPSTGKQ
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANRLPIFVVIAAVILFLIYSSVFVVNARQQALVLRFGEIVDVKTEPGIYFKAPFSFFDA
CCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHHEECCCEEEEECCCCEEEECCCCCCCH
DTVQLIENRVLRFDLDNIRVQVSGGKFYEVDAFIAYRISDPRVFRAAVSGQIELAEARLR
HHHHHHHHHHEEEEECCEEEEECCCEEEEEEEEEEEEECCCHHHHHHHCCCHHHHHHHHH
TRLDAALRRVYGLRDFEAALSEQRAVMMREVRDQLRPDATSLGLQIEDVRIRRTDLTAEV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEEEEEEEEECCCHHHH
SQQTYDRMKAERLAEAARLRARGNEAAQRITARADREVVEIVAEAQKESEILRGEGEAQR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
SATFADAYKRDPAFFDFYRSMNAYGTALDNTGTTMVLSPSSEFFRYFRDPDGKEGPAKPA
HHHHHHHHHCCCHHHHHHHHHHHHCCEECCCCCEEEECCCHHHHHHHCCCCCCCCCCCCC
APASPTPAAPATQPSTGKQ
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]