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The map label for this gene is dprE1 [H]

Identifier: 13471324

GI number: 13471324

Start: 1062868

End: 1064217

Strand: Reverse

Name: dprE1 [H]

Synonym: mll1265

Alternate gene names: 13471324

Gene position: 1064217-1062868 (Counterclockwise)

Preceding gene: 161621452

Following gene: 13471323

Centisome position: 15.13

GC content: 65.85

Gene sequence:

>1350_bases
ATGGCCGAACGTTTTTTGAGCTTCGGCCTTGCCACGCCGCCTGCGCCACGCGCGATCCACGCCGACGCTGCCATTGCGCT
GCTGAAGAGCGGTCAGGCGAAGGAAGCCTCACTGCTCGCCTATGGCAATGGGCGTTCCTACGGCGATTCCTGCCAGAACC
AGGCCGGGGCGGTCGTCGACATGCGCACCCTGAACCATATCGGAGCCTTCAACGCCGAGACGGGCGTGCTCGAAGCCGAC
GCCGGTGTGCTGCTATCCGACATCATCGCGCACGCGGCACCTTACGGTTTCTTTCCGGCCGTCGTCCCGGGCACGCAATT
CGTCACGCTCGGTGGTGCCATCGCCAATGACGTGCACGGCAAGAACCACCACCGGCGCGGCACGTTCGGCTGCCATGTCG
AAAGCTTCACGCTGCTGCGGTCCGATGGAAAGACCTATCGCTGCTCGGCCACGGACAATCCGCGCCTGTTTGCGGCCACC
ATCGGCGGCATGGGGCTGACCGGCCTGATGCTCTCGGCCTCGATCCGGTTGATGCGGGTGCCTTCGCTCGACATCGTCGA
GAAGACGGCGCCGTTTCGTGATCTCGGCGAATTCTTCGATCTGGCCGAAGCGGCGGACCAGGCCAATGAATATGCGGTGG
CCTGGATCGATCAGCTCGCCGGCGGCCGCAACAGTGGGCGCGGGTTGCTGTTCACCGCTAACCACGCCGAGCATGGCTCG
CACGAGGCCTCCCGCGCCGGCAGCAATCTTTCCGTGCCGTTCCAGCCGCCGTTCAATGTGCTCAACCGGCCGTTCCTGAC
CGCTTTCAACGCCGCCTACCGGTGGGAGAAAGGTCGCGCGATCGCGCCGCGCCAGGCCGGCTATCAAGGCTTTTTCTTCC
CGCTTGACAGTGTGCGCGACTGGAACCGGCTTTATGGCCCCAATGGGCTGTTCCAGCACCAGAGCGTGGTGCCGGAGGAG
GCCGCACGCATCGTTGTACCTGAACTGCTCGCGACGGCCCGCCGGGTGAGGCAGGGCTCCTTCCTCACCGTGCTGAAACG
CTTCGGTTCGATCCGCTCGCCGGCGCTGCTGTCATTCCCACGGCCCGGCTACACGCTGACGCTGGATTTCCCCAACAAGG
GAGCAGCGACGCTCGCCTTGCTTGGCGAACTCGACCGCATCACCGTCGCGGCCGGCGGGGCGGTCAATCCCTACAAGGAT
GCGCGCATGGGCGCTGAAATTTTCGCCGCCTCCTTCGCGGACTGGCCGAGGATGGAAGTGCTGCGCGACCCTGCCTTCAT
GTCCGATTTCTGGGCGCGCACGGCCGGCGGCATCGACCTGCGGCGGCGCGGCGCGCAGGCCGCCGAATAG

Upstream 100 bases:

>100_bases
AGATGAACGACGACCCGGTCGTCTTCATCATCCGTGACTGGCGCAGCCAGATCGTTGTGGCGATCGGCGCCGTGCTGCTG
GTCATCGGGGGCTGGTAGGC

Downstream 100 bases:

>100_bases
ATAGAATTGGAATGAATCGTAGTTAGCGAATGATTAACGGCAAGTTTACTCAAAACAGTCTTGTGAGTTCACGAAATCTT
TTCGGGTTTGTATTACTAGA

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAERFLSFGLATPPAPRAIHADAAIALLKSGQAKEASLLAYGNGRSYGDSCQNQAGAVVDMRTLNHIGAFNAETGVLEAD
AGVLLSDIIAHAAPYGFFPAVVPGTQFVTLGGAIANDVHGKNHHRRGTFGCHVESFTLLRSDGKTYRCSATDNPRLFAAT
IGGMGLTGLMLSASIRLMRVPSLDIVEKTAPFRDLGEFFDLAEAADQANEYAVAWIDQLAGGRNSGRGLLFTANHAEHGS
HEASRAGSNLSVPFQPPFNVLNRPFLTAFNAAYRWEKGRAIAPRQAGYQGFFFPLDSVRDWNRLYGPNGLFQHQSVVPEE
AARIVVPELLATARRVRQGSFLTVLKRFGSIRSPALLSFPRPGYTLTLDFPNKGAATLALLGELDRITVAAGGAVNPYKD
ARMGAEIFAASFADWPRMEVLRDPAFMSDFWARTAGGIDLRRRGAQAAE

Sequences:

>Translated_449_residues
MAERFLSFGLATPPAPRAIHADAAIALLKSGQAKEASLLAYGNGRSYGDSCQNQAGAVVDMRTLNHIGAFNAETGVLEAD
AGVLLSDIIAHAAPYGFFPAVVPGTQFVTLGGAIANDVHGKNHHRRGTFGCHVESFTLLRSDGKTYRCSATDNPRLFAAT
IGGMGLTGLMLSASIRLMRVPSLDIVEKTAPFRDLGEFFDLAEAADQANEYAVAWIDQLAGGRNSGRGLLFTANHAEHGS
HEASRAGSNLSVPFQPPFNVLNRPFLTAFNAAYRWEKGRAIAPRQAGYQGFFFPLDSVRDWNRLYGPNGLFQHQSVVPEE
AARIVVPELLATARRVRQGSFLTVLKRFGSIRSPALLSFPRPGYTLTLDFPNKGAATLALLGELDRITVAAGGAVNPYKD
ARMGAEIFAASFADWPRMEVLRDPAFMSDFWARTAGGIDLRRRGAQAAE
>Mature_448_residues
AERFLSFGLATPPAPRAIHADAAIALLKSGQAKEASLLAYGNGRSYGDSCQNQAGAVVDMRTLNHIGAFNAETGVLEADA
GVLLSDIIAHAAPYGFFPAVVPGTQFVTLGGAIANDVHGKNHHRRGTFGCHVESFTLLRSDGKTYRCSATDNPRLFAATI
GGMGLTGLMLSASIRLMRVPSLDIVEKTAPFRDLGEFFDLAEAADQANEYAVAWIDQLAGGRNSGRGLLFTANHAEHGSH
EASRAGSNLSVPFQPPFNVLNRPFLTAFNAAYRWEKGRAIAPRQAGYQGFFFPLDSVRDWNRLYGPNGLFQHQSVVPEEA
ARIVVPELLATARRVRQGSFLTVLKRFGSIRSPALLSFPRPGYTLTLDFPNKGAATLALLGELDRITVAAGGAVNPYKDA
RMGAEIFAASFADWPRMEVLRDPAFMSDFWARTAGGIDLRRRGAQAAE

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 48367; Mature: 48236

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERFLSFGLATPPAPRAIHADAAIALLKSGQAKEASLLAYGNGRSYGDSCQNQAGAVVD
CCCHHHHCCCCCCCCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHCCCCEEE
MRTLNHIGAFNAETGVLEADAGVLLSDIIAHAAPYGFFPAVVPGTQFVTLGGAIANDVHG
EHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHCCCC
KNHHRRGTFGCHVESFTLLRSDGKTYRCSATDNPRLFAATIGGMGLTGLMLSASIRLMRV
CCCCCCCCEEEEEEEEEEEECCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHCEEEEEC
PSLDIVEKTAPFRDLGEFFDLAEAADQANEYAVAWIDQLAGGRNSGRGLLFTANHAEHGS
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
HEASRAGSNLSVPFQPPFNVLNRPFLTAFNAAYRWEKGRAIAPRQAGYQGFFFPLDSVRD
CHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHEECCCCEECCHHCCCCEEEEEHHHHHH
WNRLYGPNGLFQHQSVVPEEAARIVVPELLATARRVRQGSFLTVLKRFGSIRSPALLSFP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEECC
RPGYTLTLDFPNKGAATLALLGELDRITVAAGGAVNPYKDARMGAEIFAASFADWPRMEV
CCCEEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
LRDPAFMSDFWARTAGGIDLRRRGAQAAE
HHCCHHHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure 
AERFLSFGLATPPAPRAIHADAAIALLKSGQAKEASLLAYGNGRSYGDSCQNQAGAVVD
CCHHHHCCCCCCCCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHCCCCEEE
MRTLNHIGAFNAETGVLEADAGVLLSDIIAHAAPYGFFPAVVPGTQFVTLGGAIANDVHG
EHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHCCCC
KNHHRRGTFGCHVESFTLLRSDGKTYRCSATDNPRLFAATIGGMGLTGLMLSASIRLMRV
CCCCCCCCEEEEEEEEEEEECCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHCEEEEEC
PSLDIVEKTAPFRDLGEFFDLAEAADQANEYAVAWIDQLAGGRNSGRGLLFTANHAEHGS
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
HEASRAGSNLSVPFQPPFNVLNRPFLTAFNAAYRWEKGRAIAPRQAGYQGFFFPLDSVRD
CHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHEECCCCEECCHHCCCCEEEEEHHHHHH
WNRLYGPNGLFQHQSVVPEEAARIVVPELLATARRVRQGSFLTVLKRFGSIRSPALLSFP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEECC
RPGYTLTLDFPNKGAATLALLGELDRITVAAGGAVNPYKDARMGAEIFAASFADWPRMEV
CCCEEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
LRDPAFMSDFWARTAGGIDLRRRGAQAAE
HHCCHHHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]