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The map label for this gene is patA [H]

Identifier: 13471321

GI number: 13471321

Start: 1059775

End: 1061247

Strand: Reverse

Name: patA [H]

Synonym: mll1261

Alternate gene names: 13471321

Gene position: 1061247-1059775 (Counterclockwise)

Preceding gene: 13471322

Following gene: 13471320

Centisome position: 15.08

GC content: 62.66

Gene sequence:

>1473_bases
ATGACCGTCATGGCCAAGCCCGAACAGACGAATGCGCGCACCCTGGTGAGCGCGCCGGCACTGTCGCCCGCAGCAATAGC
CAAGCCCGATCTGATCAGTGTCGAGCAGGCCAAGGCGATGGACGTGGCTGGAATGACCGACCTGTTCAAGGCGCATCTCA
ATCCCGGCCAGCTGCATTTCATGAAGCTGCTCGGCTTCCACAAGATCAAGATCGAGCGTGCCGAAGGCATGTTCTACATC
GACCAGAACGGCCGCAAGATCCTCGATTTCTTCGGTGGCTTCGGTTCGCTGGCCTTCGGCCACAACCACCCACGTATCCT
GGACGCACGCAAAAAATTCCAGGAGGAGAAGCGCCAGGAAATCGCCATCGCCTTCATGTCGCAATATGCGGCAGCGCTGG
CGCACAACCTCGCCAAATGCTCACCCGGCGATCTCGACATGGTGTTCTTGGGCTCGTCCGGCTCGGAGGCGATGGAAGCG
GCGGTGAAGCTCGCCGAACGCGCCGCCGGCCCGAAGCGGCCGAAGGTGGTCTATGCCGAGAATTCCTTCCACGGCAAGAC
CAAGGGCGTGCTCGGCATCACCGACGGCCAGCTCTACCGCGCCGATTTCAAGGTGGCCGACAATACGGTGCGCATTCCCT
TCGGTGACATCGAGGCGGTGGAGCGGCTGTTCCGCAGCGATCCGGAGGTCGGCGTCATCGTGCTCGAAACCATCCAGGGC
GGTGGCGGCATCATCCAGGCGGAGGCGCAATACTGGCAGAAGCTGCGCGCGCTCTGCGACCAGTATGGCGTGCTGTGGGT
GGCCGATGAAGTGCAGTGCGGCTATGGCCGCTCGGGCCGCTTCTATGCCTTCGAACATTACGGCGTCGTGCCTGACGTGA
CCGCGCTGGCCAAGTCGCTCGGCGGCGGCAAGGCGGCTGTCGGTGCCATGATCGCCAGGCGTGAAATCTATATGAAGGCC
TATGGCACGCCCAAGACGGCGATGATCCATGCCATGGCGACCTTTGGCGGCATGGGCGAGGCGTGCGTTACCTCGATCGA
GGCGCTCAACGTGCTTTATGACGAGGGGCTGATCGACAACGCCGCCGTCACCGGCGACTATCTGCTGCAGCGGCTACGGG
CGCTCAAGGAAAAGTACCCGAAGATCATCAAGGACGTGCGCGGCAAGGGCCTTATGGTCGGCCTCGAGTTCCACGACTTC
TCGCAGACCCTGCCGATGGTGCTGCGCCCGATCGTCAGCGTGCTCGACGACAAGCTGAAGGGCTCGCTGTCCGGCTTTGT
CGGCGCGCTGCTGCTGCGCGACTACGACGTGCTCGTCGCCTTCACCGAATACAACCGCAACGTCATCCGGCTCGAGCCGC
CGCTGATCTGCCAGCGCGAGCATGTCGACCGCTTCGTCGATGCCTTCGACAGCCTGCTGTCGCGCGGCATCGTGTCGATC
GTGAAGGATTTCGTCAAAAGCCAGGTCCGTTAA

Upstream 100 bases:

>100_bases
CGCCGGGCCTGCTGTCGCCACCAAACATGTGCCCGCCGAGTAGTGGTCCCGCCAAATTTATGGCGCACGACGCTGGTCGT
AGCGCGGACAGGAGATTGAA

Downstream 100 bases:

>100_bases
AGAAAGTCCGTTGAGCACAAAAATGCTGACCAGGTCTCCCGCTACGCAAAACCCGCTCGACCGGCTCACCGAGACCGGTC
TGGCGTGGGGCGAGGGGACC

Product: aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTVMAKPEQTNARTLVSAPALSPAAIAKPDLISVEQAKAMDVAGMTDLFKAHLNPGQLHFMKLLGFHKIKIERAEGMFYI
DQNGRKILDFFGGFGSLAFGHNHPRILDARKKFQEEKRQEIAIAFMSQYAAALAHNLAKCSPGDLDMVFLGSSGSEAMEA
AVKLAERAAGPKRPKVVYAENSFHGKTKGVLGITDGQLYRADFKVADNTVRIPFGDIEAVERLFRSDPEVGVIVLETIQG
GGGIIQAEAQYWQKLRALCDQYGVLWVADEVQCGYGRSGRFYAFEHYGVVPDVTALAKSLGGGKAAVGAMIARREIYMKA
YGTPKTAMIHAMATFGGMGEACVTSIEALNVLYDEGLIDNAAVTGDYLLQRLRALKEKYPKIIKDVRGKGLMVGLEFHDF
SQTLPMVLRPIVSVLDDKLKGSLSGFVGALLLRDYDVLVAFTEYNRNVIRLEPPLICQREHVDRFVDAFDSLLSRGIVSI
VKDFVKSQVR

Sequences:

>Translated_490_residues
MTVMAKPEQTNARTLVSAPALSPAAIAKPDLISVEQAKAMDVAGMTDLFKAHLNPGQLHFMKLLGFHKIKIERAEGMFYI
DQNGRKILDFFGGFGSLAFGHNHPRILDARKKFQEEKRQEIAIAFMSQYAAALAHNLAKCSPGDLDMVFLGSSGSEAMEA
AVKLAERAAGPKRPKVVYAENSFHGKTKGVLGITDGQLYRADFKVADNTVRIPFGDIEAVERLFRSDPEVGVIVLETIQG
GGGIIQAEAQYWQKLRALCDQYGVLWVADEVQCGYGRSGRFYAFEHYGVVPDVTALAKSLGGGKAAVGAMIARREIYMKA
YGTPKTAMIHAMATFGGMGEACVTSIEALNVLYDEGLIDNAAVTGDYLLQRLRALKEKYPKIIKDVRGKGLMVGLEFHDF
SQTLPMVLRPIVSVLDDKLKGSLSGFVGALLLRDYDVLVAFTEYNRNVIRLEPPLICQREHVDRFVDAFDSLLSRGIVSI
VKDFVKSQVR
>Mature_489_residues
TVMAKPEQTNARTLVSAPALSPAAIAKPDLISVEQAKAMDVAGMTDLFKAHLNPGQLHFMKLLGFHKIKIERAEGMFYID
QNGRKILDFFGGFGSLAFGHNHPRILDARKKFQEEKRQEIAIAFMSQYAAALAHNLAKCSPGDLDMVFLGSSGSEAMEAA
VKLAERAAGPKRPKVVYAENSFHGKTKGVLGITDGQLYRADFKVADNTVRIPFGDIEAVERLFRSDPEVGVIVLETIQGG
GGIIQAEAQYWQKLRALCDQYGVLWVADEVQCGYGRSGRFYAFEHYGVVPDVTALAKSLGGGKAAVGAMIARREIYMKAY
GTPKTAMIHAMATFGGMGEACVTSIEALNVLYDEGLIDNAAVTGDYLLQRLRALKEKYPKIIKDVRGKGLMVGLEFHDFS
QTLPMVLRPIVSVLDDKLKGSLSGFVGALLLRDYDVLVAFTEYNRNVIRLEPPLICQREHVDRFVDAFDSLLSRGIVSIV
KDFVKSQVR

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=434, Percent_Identity=27.6497695852535, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI13994255, Length=505, Percent_Identity=24.7524752475248, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI37574042, Length=454, Percent_Identity=25.3303964757709, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=25.9860788863109, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=456, Percent_Identity=24.5614035087719, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI226442709, Length=403, Percent_Identity=24.8138957816377, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=28.2674772036474, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI188536080, Length=456, Percent_Identity=22.8070175438596, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI38679950, Length=456, Percent_Identity=22.8070175438596, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI38679946, Length=456, Percent_Identity=22.8070175438596, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI145693181, Length=456, Percent_Identity=32.4561403508772, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1789016, Length=358, Percent_Identity=33.7988826815642, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789759, Length=331, Percent_Identity=33.5347432024169, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788044, Length=414, Percent_Identity=30.9178743961353, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787560, Length=347, Percent_Identity=31.4121037463977, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786349, Length=353, Percent_Identity=30.028328611898, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786991, Length=267, Percent_Identity=29.9625468164794, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=441, Percent_Identity=29.7052154195011, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=29.9086757990868, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=315, Percent_Identity=30.1587301587302, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=445, Percent_Identity=25.1685393258427, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=397, Percent_Identity=22.9219143576826, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=426, Percent_Identity=30.2816901408451, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324432, Length=411, Percent_Identity=27.7372262773723, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324386, Length=372, Percent_Identity=24.4623655913978, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=27.7272727272727, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI28574759, Length=446, Percent_Identity=29.1479820627803, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161085790, Length=461, Percent_Identity=28.6334056399132, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=28.009828009828, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281366494, Length=430, Percent_Identity=25.1162790697674, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667139, Length=430, Percent_Identity=25.1162790697674, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667143, Length=430, Percent_Identity=25.1162790697674, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 53804; Mature: 53673

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMAKPEQTNARTLVSAPALSPAAIAKPDLISVEQAKAMDVAGMTDLFKAHLNPGQLHF
CCCCCCCCCCCCCEEEECCCCCCHHCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCHHHH
MKLLGFHKIKIERAEGMFYIDQNGRKILDFFGGFGSLAFGHNHPRILDARKKFQEEKRQE
HHHHCHHEEEEEECCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IAIAFMSQYAAALAHNLAKCSPGDLDMVFLGSSGSEAMEAAVKLAERAAGPKRPKVVYAE
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
NSFHGKTKGVLGITDGQLYRADFKVADNTVRIPFGDIEAVERLFRSDPEVGVIVLETIQG
CCCCCCCCCEEEECCCCEEEEEEEECCCEEEECCCCHHHHHHHHHCCCCCEEEEEEEECC
GGGIIQAEAQYWQKLRALCDQYGVLWVADEVQCGYGRSGRFYAFEHYGVVPDVTALAKSL
CCCEEEHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHC
GGGKAAVGAMIARREIYMKAYGTPKTAMIHAMATFGGMGEACVTSIEALNVLYDEGLIDN
CCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
AAVTGDYLLQRLRALKEKYPKIIKDVRGKGLMVGLEFHDFSQTLPMVLRPIVSVLDDKLK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
GSLSGFVGALLLRDYDVLVAFTEYNRNVIRLEPPLICQREHVDRFVDAFDSLLSRGIVSI
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VKDFVKSQVR
HHHHHHHCCC
>Mature Secondary Structure 
TVMAKPEQTNARTLVSAPALSPAAIAKPDLISVEQAKAMDVAGMTDLFKAHLNPGQLHF
CCCCCCCCCCCCEEEECCCCCCHHCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCHHHH
MKLLGFHKIKIERAEGMFYIDQNGRKILDFFGGFGSLAFGHNHPRILDARKKFQEEKRQE
HHHHCHHEEEEEECCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IAIAFMSQYAAALAHNLAKCSPGDLDMVFLGSSGSEAMEAAVKLAERAAGPKRPKVVYAE
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
NSFHGKTKGVLGITDGQLYRADFKVADNTVRIPFGDIEAVERLFRSDPEVGVIVLETIQG
CCCCCCCCCEEEECCCCEEEEEEEECCCEEEECCCCHHHHHHHHHCCCCCEEEEEEEECC
GGGIIQAEAQYWQKLRALCDQYGVLWVADEVQCGYGRSGRFYAFEHYGVVPDVTALAKSL
CCCEEEHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHC
GGGKAAVGAMIARREIYMKAYGTPKTAMIHAMATFGGMGEACVTSIEALNVLYDEGLIDN
CCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
AAVTGDYLLQRLRALKEKYPKIIKDVRGKGLMVGLEFHDFSQTLPMVLRPIVSVLDDKLK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
GSLSGFVGALLLRDYDVLVAFTEYNRNVIRLEPPLICQREHVDRFVDAFDSLLSRGIVSI
HHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VKDFVKSQVR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA