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The map label for this gene is yitJ [H]

Identifier: 13471305

GI number: 13471305

Start: 1042010

End: 1043101

Strand: Direct

Name: yitJ [H]

Synonym: mlr1241

Alternate gene names: 13471305

Gene position: 1042010-1043101 (Clockwise)

Preceding gene: 13471304

Following gene: 13471306

Centisome position: 14.81

GC content: 64.65

Gene sequence:

>1092_bases
ATGAGCGCCCGTCAGCGCGACGAGAACCCGGCAGGCATTCACCTGCCGCTCGATCCCCTGCCCGGCCACTCGTCCCGCGG
CCGGCTGGAGCGCGTGCTGCGGCGCGGTGAATTCGCCGTGACGACCGAGCTCAATCCCCCTGACAGCGCCGATCCGGAGG
ACGTCTACAACAGGGCCAAGATCTTCGACGGCTGGGTCGACGCCATCAACGCCGTCGATGCCTCCGGCGCCAACTGCCAC
ATGTCCTCGGTCGGCATCTGCGCGCTGCTGACCCGCATGGGCTATGCCCCGATCATGCAGATCGCCTGCCGCGACAAGAA
CCGCATCGCCATCCAGGGCGACGTGTTGGGCGGTGCCGCCATGGGTGTCGCCAACATGCTGTGCCTGACCGGCGACGGCG
TGCAGGCCGGCGACCAGCCCGGTGCCAAGCCGGTGTTCGACCTCGATTCCATGTCGCTGCTCGAAACCATCCGCATCATG
CGCGACAACGGCAAGTTCCTGTCCGGCCGCAAGCTGACGACGCCGCCGCAGGTGTTCCTCGGCGCTGCCGTCAATCCGTT
CGCGCCGCCCTTCGACTTCCGCCCGATCCATCTCGGCAAGAAGATCGCCGCCGGCGCGCAGTTCGTGCAGACGCAGTATT
GTTTCGACGTGCCGATGTTCAGGACCTTCATGCAGAAGGCGCGCGATCTCGGCCACACCGAGAAGGTATTCGTCCTGTGC
GGCGTTGGCCCGCTCGCCTCGGCCAAGACCGCCAAATGGATCCGCTCAAACGTGCCCGGCATCCACATCCCGGATGCCGT
CATCAAGCGGCTGGAGGGCGCGCAGGATCAGAAGAAGGAAGGCAAGCAGCTCTGCATCGACATCATCAACGAGGTGAAGG
AAATCCCCGGCATCTCGGGCGTGCATGTGATGGCCTACCGCCAGGAGGAATATGTCGCCGAAATCGTCGATGAATCGGGC
GTGCTCAAAGGCCGCCAGCCCTGGAAGCGCGAAATCCGTCGCGACGACCAGATGGTTGCCGACCGGCTCGACCACATCCT
GCACGACGAGATTACCGAAACCCAGGTGGATATGGTGAAGACCGCGCATTGA

Upstream 100 bases:

>100_bases
TCGACCAGTCGCTGCGCGAAACCTCCGCCTGGCTGCGGGTCACCGCGCAGGCCGCCGCCGCCCGTGAAGCCGCGGCCGCG
CCAAAGACCGGAGCCGCCGC

Downstream 100 bases:

>100_bases
TCCGCGCGGAGGACCACCATTCGCTTGATCGAAAAGAGATAACGATATAAAGAACTCTTTATATCACGACGGAGAGATTT
CATGACCCGGACCATCGTTG

Product: hypothetical protein

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSARQRDENPAGIHLPLDPLPGHSSRGRLERVLRRGEFAVTTELNPPDSADPEDVYNRAKIFDGWVDAINAVDASGANCH
MSSVGICALLTRMGYAPIMQIACRDKNRIAIQGDVLGGAAMGVANMLCLTGDGVQAGDQPGAKPVFDLDSMSLLETIRIM
RDNGKFLSGRKLTTPPQVFLGAAVNPFAPPFDFRPIHLGKKIAAGAQFVQTQYCFDVPMFRTFMQKARDLGHTEKVFVLC
GVGPLASAKTAKWIRSNVPGIHIPDAVIKRLEGAQDQKKEGKQLCIDIINEVKEIPGISGVHVMAYRQEEYVAEIVDESG
VLKGRQPWKREIRRDDQMVADRLDHILHDEITETQVDMVKTAH

Sequences:

>Translated_363_residues
MSARQRDENPAGIHLPLDPLPGHSSRGRLERVLRRGEFAVTTELNPPDSADPEDVYNRAKIFDGWVDAINAVDASGANCH
MSSVGICALLTRMGYAPIMQIACRDKNRIAIQGDVLGGAAMGVANMLCLTGDGVQAGDQPGAKPVFDLDSMSLLETIRIM
RDNGKFLSGRKLTTPPQVFLGAAVNPFAPPFDFRPIHLGKKIAAGAQFVQTQYCFDVPMFRTFMQKARDLGHTEKVFVLC
GVGPLASAKTAKWIRSNVPGIHIPDAVIKRLEGAQDQKKEGKQLCIDIINEVKEIPGISGVHVMAYRQEEYVAEIVDESG
VLKGRQPWKREIRRDDQMVADRLDHILHDEITETQVDMVKTAH
>Mature_362_residues
SARQRDENPAGIHLPLDPLPGHSSRGRLERVLRRGEFAVTTELNPPDSADPEDVYNRAKIFDGWVDAINAVDASGANCHM
SSVGICALLTRMGYAPIMQIACRDKNRIAIQGDVLGGAAMGVANMLCLTGDGVQAGDQPGAKPVFDLDSMSLLETIRIMR
DNGKFLSGRKLTTPPQVFLGAAVNPFAPPFDFRPIHLGKKIAAGAQFVQTQYCFDVPMFRTFMQKARDLGHTEKVFVLCG
VGPLASAKTAKWIRSNVPGIHIPDAVIKRLEGAQDQKKEGKQLCIDIINEVKEIPGISGVHVMAYRQEEYVAEIVDESGV
LKGRQPWKREIRRDDQMVADRLDHILHDEITETQVDMVKTAH

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI25147436, Length=319, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147441, Length=319, Percent_Identity=24.1379310344828, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 39928; Mature: 39797

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARQRDENPAGIHLPLDPLPGHSSRGRLERVLRRGEFAVTTELNPPDSADPEDVYNRAK
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
IFDGWVDAINAVDASGANCHMSSVGICALLTRMGYAPIMQIACRDKNRIAIQGDVLGGAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCCHHH
MGVANMLCLTGDGVQAGDQPGAKPVFDLDSMSLLETIRIMRDNGKFLSGRKLTTPPQVFL
HHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHH
GAAVNPFAPPFDFRPIHLGKKIAAGAQFVQTQYCFDVPMFRTFMQKARDLGHTEKVFVLC
CCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEE
GVGPLASAKTAKWIRSNVPGIHIPDAVIKRLEGAQDQKKEGKQLCIDIINEVKEIPGISG
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VHVMAYRQEEYVAEIVDESGVLKGRQPWKREIRRDDQMVADRLDHILHDEITETQVDMVK
EEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAH
CCC
>Mature Secondary Structure 
SARQRDENPAGIHLPLDPLPGHSSRGRLERVLRRGEFAVTTELNPPDSADPEDVYNRAK
CCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
IFDGWVDAINAVDASGANCHMSSVGICALLTRMGYAPIMQIACRDKNRIAIQGDVLGGAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCCHHH
MGVANMLCLTGDGVQAGDQPGAKPVFDLDSMSLLETIRIMRDNGKFLSGRKLTTPPQVFL
HHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHH
GAAVNPFAPPFDFRPIHLGKKIAAGAQFVQTQYCFDVPMFRTFMQKARDLGHTEKVFVLC
CCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEE
GVGPLASAKTAKWIRSNVPGIHIPDAVIKRLEGAQDQKKEGKQLCIDIINEVKEIPGISG
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VHVMAYRQEEYVAEIVDESGVLKGRQPWKREIRRDDQMVADRLDHILHDEITETQVDMVK
EEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]