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The map label for this gene is fabF [H]

Identifier: 13471257

GI number: 13471257

Start: 988966

End: 990216

Strand: Direct

Name: fabF [H]

Synonym: mlr1177

Alternate gene names: 13471257

Gene position: 988966-990216 (Clockwise)

Preceding gene: 13471256

Following gene: 13471258

Centisome position: 14.06

GC content: 65.07

Gene sequence:

>1251_bases
ATGGGCAGGCCCGTCGTCGCCGTCACCGGTATCGGCGTGGTCACTTCGCTCGGCGTCGGCAAGGCTGACAATTGGGCGGC
GCTGACCTCGGGCAAGTCGGGCATCCACCCGATCACCCGCTTTCCGGTCGATCATCTCAACACCCGCATTTCCGGCATGG
TCGACTTCCTGGACTCAAGCTCGAAGGGCGCCAGCCCCCTGACCTACGAGTTGGCCGAAACCGCCGCGCATGAAGCCGTG
GCCGAATCCGGTCTCGATTCCAGCGATTTCGGCGGGCCTCTCTTCCTCGCCTCGCCACCGGTCGAGCTCGACTGGCACGA
ACGCTTCTCGCTCTACAATTCCGACAAGCAGGATGCTGGCGCCGAACGGTTGCTTCGCGTGGCCCGCGCGCTGAAGGAGC
TCGACATTTTCGAGACCACTCAGTTCGGCTCGATCGCCGACCGGCTCGCCGACCGTTTCGGCACGCGCGGCCTGCCTATC
ACGCTGTCGACCGCCTGTGCCTCCGGCGCCACCGCCATCCAGCTCGGCGTCGAGGCGATCCGCCGCGGCGAATGCGACCG
GGCGCTGTCGATCGGCGCCGACGGTTCGGCGACCGCCGAGGCGCTGATCCGCTTCTCGCTGCTGTCGGCGCTGTCGACCC
ACAATGACATCCCGGAAAAGGCGTCAAAACCGTTTTCCAAGGACCGCGATGGTTTTGTCCTCGCCGAAGGTTCGGGCGCG
CTGGTGCTGGAATCGCTGGAGGCAGCCCTTGCCCGTGACGCCACCGTTCTTGGCATTCTGCGCGGCTGCGGCGAAAAGGC
CGATGATTTCCACCGCACCCGCTCCAAGCCTGACGGTTCGCCGGCAATCGCGGCGGTTCGCGCCGCCCTTGCCGATGCGG
GCCTGAGCAAGGACGAGATCGACTACGTCAACGCCCATGGCACCTCGACGCCGGAAAACGACAAGATGGAGCACCTGTCG
CTGTCGACCGTGTTCGGCGAGCGCATCAGCTCGATGCCGGTCTCGTCGAACAAGTCGATGATCGGCCACACGCTGTCGGC
GGCAGGCGCCGTCGAGGCAGCGTTCTCGCTGATGACAATGCGCGAAGGCGTCATTCCACCGACCATCAATTACGACAATC
CCGACCCGGCGATCGTGCTCGACGTGGTGCCCAACAAGAAGCGCAATGCCGAGGTTCGCAGCGTTCTGTCGAACTCCTTC
GGCTTCGGCGGCCAGAACACTTGCCTTGTCATGGCGCGGGAACCGGTCTAA

Upstream 100 bases:

>100_bases
CGAGGGCATGGCGCTGGTCAAGTCGACGTAAGGCGGCGCCCGCCATGTTGTTAGAGACAAACCGCCCGAGGGCTTCCCGA
TGACCAATTTCAGAGATCAC

Downstream 100 bases:

>100_bases
GCGAGCCACTTCCGCTCGAACAGAACCGACAGGCCTTATGCGCGCACTGCAACTTATCGAGGACCGCCGTCTTGAAACGG
TGGACCTGCCGCCTCCCCCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MGRPVVAVTGIGVVTSLGVGKADNWAALTSGKSGIHPITRFPVDHLNTRISGMVDFLDSSSKGASPLTYELAETAAHEAV
AESGLDSSDFGGPLFLASPPVELDWHERFSLYNSDKQDAGAERLLRVARALKELDIFETTQFGSIADRLADRFGTRGLPI
TLSTACASGATAIQLGVEAIRRGECDRALSIGADGSATAEALIRFSLLSALSTHNDIPEKASKPFSKDRDGFVLAEGSGA
LVLESLEAALARDATVLGILRGCGEKADDFHRTRSKPDGSPAIAAVRAALADAGLSKDEIDYVNAHGTSTPENDKMEHLS
LSTVFGERISSMPVSSNKSMIGHTLSAAGAVEAAFSLMTMREGVIPPTINYDNPDPAIVLDVVPNKKRNAEVRSVLSNSF
GFGGQNTCLVMAREPV

Sequences:

>Translated_416_residues
MGRPVVAVTGIGVVTSLGVGKADNWAALTSGKSGIHPITRFPVDHLNTRISGMVDFLDSSSKGASPLTYELAETAAHEAV
AESGLDSSDFGGPLFLASPPVELDWHERFSLYNSDKQDAGAERLLRVARALKELDIFETTQFGSIADRLADRFGTRGLPI
TLSTACASGATAIQLGVEAIRRGECDRALSIGADGSATAEALIRFSLLSALSTHNDIPEKASKPFSKDRDGFVLAEGSGA
LVLESLEAALARDATVLGILRGCGEKADDFHRTRSKPDGSPAIAAVRAALADAGLSKDEIDYVNAHGTSTPENDKMEHLS
LSTVFGERISSMPVSSNKSMIGHTLSAAGAVEAAFSLMTMREGVIPPTINYDNPDPAIVLDVVPNKKRNAEVRSVLSNSF
GFGGQNTCLVMAREPV
>Mature_415_residues
GRPVVAVTGIGVVTSLGVGKADNWAALTSGKSGIHPITRFPVDHLNTRISGMVDFLDSSSKGASPLTYELAETAAHEAVA
ESGLDSSDFGGPLFLASPPVELDWHERFSLYNSDKQDAGAERLLRVARALKELDIFETTQFGSIADRLADRFGTRGLPIT
LSTACASGATAIQLGVEAIRRGECDRALSIGADGSATAEALIRFSLLSALSTHNDIPEKASKPFSKDRDGFVLAEGSGAL
VLESLEAALARDATVLGILRGCGEKADDFHRTRSKPDGSPAIAAVRAALADAGLSKDEIDYVNAHGTSTPENDKMEHLSL
STVFGERISSMPVSSNKSMIGHTLSAAGAVEAAFSLMTMREGVIPPTINYDNPDPAIVLDVVPNKKRNAEVRSVLSNSFG
FGGQNTCLVMAREPV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=435, Percent_Identity=32.4137931034483, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=43.2432432432432, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI41872631, Length=279, Percent_Identity=29.0322580645161, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=35.2380952380952, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788663, Length=428, Percent_Identity=32.4766355140187, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71983541, Length=273, Percent_Identity=35.5311355311355, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=36.1216730038023, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI212642053, Length=277, Percent_Identity=28.8808664259928, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=267, Percent_Identity=27.3408239700375, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=277, Percent_Identity=37.5451263537906, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24644341, Length=432, Percent_Identity=32.8703703703704, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI19920632, Length=362, Percent_Identity=28.4530386740331, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI221330659, Length=362, Percent_Identity=28.4530386740331, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24581345, Length=286, Percent_Identity=29.7202797202797, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43767; Mature: 43635

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS01034 GLYCOSYL_HYDROL_F16

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRPVVAVTGIGVVTSLGVGKADNWAALTSGKSGIHPITRFPVDHLNTRISGMVDFLDSS
CCCCEEEEECCHHHHHCCCCCCCCCEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCC
SKGASPLTYELAETAAHEAVAESGLDSSDFGGPLFLASPPVELDWHERFSLYNSDKQDAG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHH
AERLLRVARALKELDIFETTQFGSIADRLADRFGTRGLPITLSTACASGATAIQLGVEAI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEHHHCCCCHHHHHHHHHH
RRGECDRALSIGADGSATAEALIRFSLLSALSTHNDIPEKASKPFSKDRDGFVLAEGSGA
HCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCC
LVLESLEAALARDATVLGILRGCGEKADDFHRTRSKPDGSPAIAAVRAALADAGLSKDEI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCC
DYVNAHGTSTPENDKMEHLSLSTVFGERISSMPVSSNKSMIGHTLSAAGAVEAAFSLMTM
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
REGVIPPTINYDNPDPAIVLDVVPNKKRNAEVRSVLSNSFGFGGQNTCLVMAREPV
HCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
GRPVVAVTGIGVVTSLGVGKADNWAALTSGKSGIHPITRFPVDHLNTRISGMVDFLDSS
CCCEEEEECCHHHHHCCCCCCCCCEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCC
SKGASPLTYELAETAAHEAVAESGLDSSDFGGPLFLASPPVELDWHERFSLYNSDKQDAG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHH
AERLLRVARALKELDIFETTQFGSIADRLADRFGTRGLPITLSTACASGATAIQLGVEAI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEHHHCCCCHHHHHHHHHH
RRGECDRALSIGADGSATAEALIRFSLLSALSTHNDIPEKASKPFSKDRDGFVLAEGSGA
HCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCC
LVLESLEAALARDATVLGILRGCGEKADDFHRTRSKPDGSPAIAAVRAALADAGLSKDEI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCC
DYVNAHGTSTPENDKMEHLSLSTVFGERISSMPVSSNKSMIGHTLSAAGAVEAAFSLMTM
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
REGVIPPTINYDNPDPAIVLDVVPNKKRNAEVRSVLSNSFGFGGQNTCLVMAREPV
HCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]