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The map label for this gene is hmuU [H]

Identifier: 13471234

GI number: 13471234

Start: 962902

End: 964005

Strand: Reverse

Name: hmuU [H]

Synonym: mll1150

Alternate gene names: 13471234

Gene position: 964005-962902 (Counterclockwise)

Preceding gene: 13471235

Following gene: 13471233

Centisome position: 13.7

GC content: 67.57

Gene sequence:

>1104_bases
ATGGTCGATCAATCGATCGCCGGCCCGGTGAAGGTCATGGCGAATGCATCCGAAGGTGACCGCTCCGGCCGCGCCCGCAT
CGTCATCCTGTTGCTGTGCCTCGGGCTCGCGGCCGCCATGCTTTTGTCGCTCACGTCAGGGGCATCGGATGCTTCGGCCG
TCAGCGTCCTCAAGGGCTCGCTTCTTGGGGGCATCCCGAGCGATGCGGCGCTGAGTGCGCGCGACAGTCTGATCATTTAC
GACATCCGTTTGCCGCGCATCGTTCTCGGCATGCTGGTCGGCGCGGCGCTCGCGGTCTCGGGCGCCGTCATGCAGGGGCT
GTTCCGCAATCCGCTGGCCGATCCCGGCCTGATCGGCGTTTCTGCCGGCTCCAGCCTCGGCGCGGTGGCCATCATCGTGC
TCGGCACCACGGTGCTGGCGCCCGTGATGGCCTTGCTCGGCACGCCTGCGCTGCCGTTGGCGGCCTTCTTCGGGGGCCTT
GCCTCGACACTGGTGCTTTATCAGGTCGCGACGCGACGTGGCCAAACCTCGGTCGCCACCATGCTGCTTGCCGGCATCGC
CCTGGCAGCCTTTGCCATGGCGTTGACCGGCATCCTCATCTTCATGGCGGACGATCGCCAGCTGCGCGACCTGACGTTCT
GGTCACTCGGATCGCTTGGCGGCGCGACATGGGCGAAGATCGGTTCCGTCGGACCGATCATCATACTGGCGCTGGCGGCG
ATGCCTTTCCTGGCGCGCGGCCTCAACGCGCTGGCGCTGGGCGAGGCGACCGCCGGCCATCTCGGCATTCCGGTACAGCG
GCTGAAATACACGGCGATCATCGGTGTCTCGGCGGCGATCGGCGCCTCCGTCGCCGTCAGCGGCGGCATCGGCTTCGTCG
GCATCGTCGTGCCGCATCTGCTGCGCCTGCTGATCGGTCCGGACAATCGCTATCTCTTGCCGGCTTCGGCGCTGCTTGGC
GCCTCGCTGCTGCTGTTGGCCGATGCCGTCGCGCGCACCGTCGTGTCGCCGGCCGAATTGCCGATCGGCATCGTCACCGC
GATCGCGGGCGCGCCGTTCTTCCTGTGGATCCTGCTGCGCAAGCGCGGCGTGGTCGATCTCTGA

Upstream 100 bases:

>100_bases
GCGGCTATCTGCTCGGCTTCGGGCCACGCACGGCCGACGCCATTCACGACCTCGCCGTCTCGCTCTATGGCGCTGAAGTC
ACGGACTGAGCGGGCAGATC

Downstream 100 bases:

>100_bases
GACCTATGAGGCGTTGATGATCGAGGCAAGGGATGTTTCCGTCGATATCGCCGGCAAGCGCATCGTCGGCGGTGTCGATT
TCGACGCCCGGCCCGGCGAA

Product: permease protein of ABC transporter

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MVDQSIAGPVKVMANASEGDRSGRARIVILLLCLGLAAAMLLSLTSGASDASAVSVLKGSLLGGIPSDAALSARDSLIIY
DIRLPRIVLGMLVGAALAVSGAVMQGLFRNPLADPGLIGVSAGSSLGAVAIIVLGTTVLAPVMALLGTPALPLAAFFGGL
ASTLVLYQVATRRGQTSVATMLLAGIALAAFAMALTGILIFMADDRQLRDLTFWSLGSLGGATWAKIGSVGPIIILALAA
MPFLARGLNALALGEATAGHLGIPVQRLKYTAIIGVSAAIGASVAVSGGIGFVGIVVPHLLRLLIGPDNRYLLPASALLG
ASLLLLADAVARTVVSPAELPIGIVTAIAGAPFFLWILLRKRGVVDL

Sequences:

>Translated_367_residues
MVDQSIAGPVKVMANASEGDRSGRARIVILLLCLGLAAAMLLSLTSGASDASAVSVLKGSLLGGIPSDAALSARDSLIIY
DIRLPRIVLGMLVGAALAVSGAVMQGLFRNPLADPGLIGVSAGSSLGAVAIIVLGTTVLAPVMALLGTPALPLAAFFGGL
ASTLVLYQVATRRGQTSVATMLLAGIALAAFAMALTGILIFMADDRQLRDLTFWSLGSLGGATWAKIGSVGPIIILALAA
MPFLARGLNALALGEATAGHLGIPVQRLKYTAIIGVSAAIGASVAVSGGIGFVGIVVPHLLRLLIGPDNRYLLPASALLG
ASLLLLADAVARTVVSPAELPIGIVTAIAGAPFFLWILLRKRGVVDL
>Mature_367_residues
MVDQSIAGPVKVMANASEGDRSGRARIVILLLCLGLAAAMLLSLTSGASDASAVSVLKGSLLGGIPSDAALSARDSLIIY
DIRLPRIVLGMLVGAALAVSGAVMQGLFRNPLADPGLIGVSAGSSLGAVAIIVLGTTVLAPVMALLGTPALPLAAFFGGL
ASTLVLYQVATRRGQTSVATMLLAGIALAAFAMALTGILIFMADDRQLRDLTFWSLGSLGGATWAKIGSVGPIIILALAA
MPFLARGLNALALGEATAGHLGIPVQRLKYTAIIGVSAAIGASVAVSGGIGFVGIVVPHLLRLLIGPDNRYLLPASALLG
ASLLLLADAVARTVVSPAELPIGIVTAIAGAPFFLWILLRKRGVVDL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=301, Percent_Identity=44.8504983388704, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790740, Length=335, Percent_Identity=37.3134328358209, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1790741, Length=286, Percent_Identity=38.1118881118881, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=38.4879725085911, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786804, Length=341, Percent_Identity=32.8445747800587, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786347, Length=284, Percent_Identity=32.7464788732394, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36956; Mature: 36956

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQSIAGPVKVMANASEGDRSGRARIVILLLCLGLAAAMLLSLTSGASDASAVSVLKGS
CCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LLGGIPSDAALSARDSLIIYDIRLPRIVLGMLVGAALAVSGAVMQGLFRNPLADPGLIGV
HHCCCCCCCHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
SAGSSLGAVAIIVLGTTVLAPVMALLGTPALPLAAFFGGLASTLVLYQVATRRGQTSVAT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MLLAGIALAAFAMALTGILIFMADDRQLRDLTFWSLGSLGGATWAKIGSVGPIIILALAA
HHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHH
MPFLARGLNALALGEATAGHLGIPVQRLKYTAIIGVSAAIGASVAVSGGIGFVGIVVPHL
HHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHEEHHHHHCCHHEECCCCHHHHHHHHHH
LRLLIGPDNRYLLPASALLGASLLLLADAVARTVVSPAELPIGIVTAIAGAPFFLWILLR
HHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCHHHHHHHHHH
KRGVVDL
HCCCCCC
>Mature Secondary Structure
MVDQSIAGPVKVMANASEGDRSGRARIVILLLCLGLAAAMLLSLTSGASDASAVSVLKGS
CCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LLGGIPSDAALSARDSLIIYDIRLPRIVLGMLVGAALAVSGAVMQGLFRNPLADPGLIGV
HHCCCCCCCHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
SAGSSLGAVAIIVLGTTVLAPVMALLGTPALPLAAFFGGLASTLVLYQVATRRGQTSVAT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MLLAGIALAAFAMALTGILIFMADDRQLRDLTFWSLGSLGGATWAKIGSVGPIIILALAA
HHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHH
MPFLARGLNALALGEATAGHLGIPVQRLKYTAIIGVSAAIGASVAVSGGIGFVGIVVPHL
HHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHEEHHHHHCCHHEECCCCHHHHHHHHHH
LRLLIGPDNRYLLPASALLGASLLLLADAVARTVVSPAELPIGIVTAIAGAPFFLWILLR
HHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCHHHHHHHHHH
KRGVVDL
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]